MOUSE:MEF2C

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mef2c
Protein Name(s)	Myocyte-specific enhancer factor 2C
External Links
UniProt	Q8CFN5
EMBL	AK009139 BC026841 BC037731 BC057650
CCDS	CCDS26664.1 CCDS49320.1
RefSeq	NP_079558.1 XP_006517183.1 XP_006517184.1 XP_006517185.1 XP_006517186.1 XP_006517187.1 XP_006517189.1 XP_006517192.1 XP_006517195.1 XP_011242794.1 XP_011242795.1 XP_011242796.1
UniGene	Mm.24001 Mm.451574 Mm.487610
ProteinModelPortal	Q8CFN5
SMR	Q8CFN5
BioGrid	201383
DIP	DIP-49524N
IntAct	Q8CFN5
MINT	MINT-1551742
STRING	10090.ENSMUSP00000132547
iPTMnet	Q8CFN5
PhosphoSite	Q8CFN5
EPD	Q8CFN5
MaxQB	Q8CFN5
PaxDb	Q8CFN5
PRIDE	Q8CFN5
Ensembl	ENSMUST00000185052 ENSMUST00000197146 ENSMUST00000197681 ENSMUST00000198199 ENSMUST00000199019 ENSMUST00000199105 ENSMUST00000199450
GeneID	17260
KEGG	mmu:17260
UCSC	uc007rie.2 uc007rih.2 uc007rii.3
CTD	4208
MGI	MGI:99458
eggNOG	KOG0014 COG5068
GeneTree	ENSGT00390000011828
HOGENOM	HOG000230620
HOVERGEN	HBG053944
InParanoid	Q8CFN5
KO	K04454
OrthoDB	EOG793B7D
PhylomeDB	Q8CFN5
TreeFam	TF314067
Reactome	[www.reactome.org/content/detail/R-MMU-375170 R-MMU-375170]
PRO	PR:Q8CFN5
Proteomes	UP000000589
Bgee	Q8CFN5
CleanEx	MM_MEF2C
ExpressionAtlas	Q8CFN5
Genevisible	Q8CFN5
GO	GO:0005737 GO:0005829 GO:0043231 GO:0016607 GO:0005654 GO:0005634 GO:0098794 GO:0043234 GO:0033613 GO:0003680 GO:0003682 GO:0000987 GO:0001046 GO:0003677 GO:0042826 GO:0071837 GO:0035198 GO:0046982 GO:0000978 GO:0000980 GO:0000977 GO:0000981 GO:0043565 GO:0000983 GO:0003705 GO:0003700 GO:0044212 GO:0001077 GO:0001205 GO:0006915 GO:0001782 GO:0042100 GO:0050853 GO:0001568 GO:0001974 GO:0055007 GO:0014898 GO:0003211 GO:0060536 GO:0045165 GO:0048667 GO:0071277 GO:0035690 GO:0071498 GO:0071222 GO:0071374 GO:0071560 GO:0035984 GO:0002062 GO:0048704 GO:0048703 GO:0001958 GO:2001013 GO:0060079 GO:0002467 GO:0072102 GO:0007507 GO:0001947 GO:0006959 GO:0007611 GO:0000165 GO:0030318 GO:0030224 GO:0007521 GO:0014902 GO:0050680 GO:0010629 GO:0043524 GO:0030279 GO:0000122 GO:0072160 GO:0014033 GO:0048666 GO:0030182 GO:0001764 GO:0001649 GO:0003151 GO:0060021 GO:0030220 GO:0010694 GO:0030890 GO:2000987 GO:0030501 GO:2000727 GO:0060045 GO:0071864 GO:0010628 GO:2000111 GO:0043406 GO:0045663 GO:0045666 GO:0045669 GO:0090073 GO:2001016 GO:0048643 GO:0045944 GO:0045893 GO:0003138 GO:2000311 GO:0060998 GO:0002634 GO:0045652 GO:2000310 GO:0043523 GO:0046928 GO:0060297 GO:0051963 GO:0060025 GO:0048167 GO:0051966 GO:0006355 GO:0061333 GO:0002931 GO:0009615 GO:0003139 GO:0003185 GO:0035914 GO:0007519 GO:0051145 GO:0006366 GO:0055012
InterPro	IPR022102 IPR002100
Pfam	PF12347 PF00319
PRINTS	PR00404
SMART	SM00432
SUPFAM	SSF55455
PROSITE	PS00350 PS50066

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1904891	positive regulation of excitatory synapse assembly	PMID:27779093^[1]	ECO:0000315			P		Figure 3 shows that in the absence of MEF2C, excitatory synapse density is decreased.	complete CACAO 12184
	GO:1905703	negative regulation of inhibitory synapse assembly	PMID:27779093^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Figure 3 shows that, in the absence of MEF2C, inhibitory synapse density increases.	complete CACAO 12185
	GO:0061003	positive regulation of dendritic spine morphogenesis	PMID:27779093^[1]	ECO:0000315			P		Figure 3 (F and G) shows that MEF2C mutation (MEF2C-VP16) and an MEF2C knockout decreases dendritic spine density. Knockout MEF2C cells supplemented with functional MEF2C-EN are able to restore and maintain dendritic spine density.	complete CACAO 12186
	GO:1902952	positive regulation of dendritic spine maintenance	PMID:27779093^[1]	ECO:0000315			P		Figure 3 (F and G) shows that MEF2C mutation (MEF2C-VP16) and an MEF2C knockout decreases dendritic spine density. Knockout MEF2C cells supplemented with functional MEF2C-EN are able to restore and maintain dendritic spine density.	complete CACAO 12187
involved_in	GO:2000311	regulation of AMPA receptor activity	PMID:18599438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
	GO:0032229	negative regulation of synaptic transmission, GABAergic	PMID:27779093^[1]	ECO:0000315			P		Figure 3 (H and I) shows that MEF2C mutant (MEF2C-VP16) and MEF2C knockout mutants increase GABAergic synapse density. Knockout MEF2C mutants supplemented with functional MEF2C-EN were able to decrease GABAergic synapse density to wildtype levels. By decreasing GABAergic synapse numbers, MEF2C negatively regulates GABAergic synaptic transmission.	complete CACAO 12188
involved_in	GO:2000310	regulation of NMDA receptor activity	PMID:18599438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0060998	regulation of dendritic spine development	PMID:18599438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:18599437^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:18599438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0060025	regulation of synaptic activity	PMID:18599437^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060025	regulation of synaptic activity	PMID:22496871^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:18599438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0051963	regulation of synapse assembly	PMID:18599438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0048667	cell morphogenesis involved in neuron differentiation	PMID:18599437^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:22496871^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:0046928	regulation of neurotransmitter secretion	PMID:18599438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	PMID:22496871^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:18599437^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:18599437^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8668199^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:12715)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7760790^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:16476)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:8668199^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:7760790^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:8668199^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:7760790^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:8035824^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:10983972^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P56524	F		Seeded From UniProt	complete
involved_in	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis	PMID:20181743^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000987	positive regulation of behavioral fear response	PMID:18579729^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	PMID:16680724^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000111	positive regulation of macrophage apoptotic process	PMID:16775627^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072160	nephron tubule epithelial cell differentiation	PMID:20181743^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072102	glomerulus morphogenesis	PMID:20181743^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	PMID:11554755^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P43680	F		Seeded From UniProt	complete
enables	GO:0071837	HMG box domain binding	PMID:21610032^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04888	F		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	PMID:20181743^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071374	cellular response to parathyroid hormone stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	PMID:15998798^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:18955699^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061333	renal tubule morphogenesis	PMID:20181743^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:16680724^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060025	regulation of synaptic activity	PMID:18599438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055012	ventricular cardiac muscle cell differentiation	PMID:16680724^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055007	cardiac muscle cell differentiation	PMID:21556048^[17]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:18955699^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	PMID:20181743^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:18599437^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15890826^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20181743^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14515274^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11554755^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21610032^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	PMID:21652706^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	PMID:18579729^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
involved_in	GO:0045652	regulation of megakaryocyte differentiation	PMID:19211936^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21610032^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21556048^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:18579729^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	C		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	PMID:18438409^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035984	cellular response to trichostatin A	PMID:20181743^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035914	skeletal muscle cell differentiation	PMID:21556048^[17]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:16775627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:18955699^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	PMID:21652706^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030318	melanocyte differentiation	PMID:21610032^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
involved_in	GO:0030220	platelet formation	PMID:19211936^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:18599437^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	C		Seeded From UniProt	complete
involved_in	GO:0014033	neural crest cell differentiation	PMID:21610032^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010694	positive regulation of alkaline phosphatase activity	PMID:21652706^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:16680724^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:16680724^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21652706^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:18579729^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:18599438^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	PMID:18955699^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20181743^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11554755^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15998798^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002495)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21610032^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0003211	cardiac ventricle formation	PMID:16680724^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003185	sinoatrial valve morphogenesis	PMID:16680724^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003139	secondary heart field specification	PMID:15890826^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003138	primary heart field specification	PMID:16680724^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002634	regulation of germinal center formation	PMID:18438409^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002467	germinal center formation	PMID:18955699^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:16680724^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001782	B cell homeostasis	PMID:19211936^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001649	osteoblast differentiation	PMID:21652706^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20181743^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:20181743^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21610032^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:15890826^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:18955699^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:14515274^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104526 MGI:MGI:99458 MGI:MGI:99533 PANTHER:PTN002278664 UniProtKB:Q02078 UniProtKB:Q02080 UniProtKB:Q14814	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99458 MGI:MGI:99532 MGI:MGI:99533 PANTHER:PTN002278664 UniProtKB:Q02078 UniProtKB:Q02080	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99532 PANTHER:PTN002278664	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001016	positive regulation of skeletal muscle cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000727	positive regulation of cardiac muscle cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905563	negative regulation of vascular endothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090073	positive regulation of protein homodimerization activity	PMID:19035347^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071864	positive regulation of cell proliferation in bone marrow	PMID:18278031^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2684360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071374	cellular response to parathyroid hormone stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071300	cellular response to retinoic acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060536	cartilage morphogenesis	PMID:17420000^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3603182	P	has_participant:(EMAPA:17907)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060297	regulation of sarcomere organization	PMID:17875930^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060290	transdifferentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060021	roof of mouth development	PMID:17420000^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101926 MGI:MGI:101927	P	results_in_development_of:(EMAPA:18948)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055007	cardiac muscle cell differentiation	PMID:20691899^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541 MGI:MGI:95664	P	results_in_acquisition_of_features_of:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055007	cardiac muscle cell differentiation	PMID:19035347^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97350	P	occurs_in:(EMAPA:16353) results_in_acquisition_of_features_of:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051145	smooth muscle cell differentiation	PMID:9778514^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857491	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048704	embryonic skeletal system morphogenesis	PMID:17420000^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3603182	P	has_participant:(EMAPA:18290)\|has_participant:(EMAPA:17928)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048703	embryonic viscerocranium morphogenesis	PMID:17420000^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3603182	P	has_participant:(EMAPA:36570)\|has_participant:(EMAPA:17682)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048643	positive regulation of skeletal muscle tissue development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8900141^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96919 MGI:MGI:98510	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20399744^[31]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18093911^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99533	P	has_regulation_target:(MGI:MGI:2676818)\|has_regulation_target:(MGI:MGI:3618746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17420000^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:101926	P	has_regulation_target:(MGI:MGI:101925)\|has_regulation_target:(MGI:MGI:101927)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17336904^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:3036234	P	has_regulation_target:(MGI:MGI:88445)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15743821^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97275 UniProtKB:P20695 UniProtKB:P56524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18086704^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17352741^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17336904^[33]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:88445)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16818234^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9162005^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857491	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9738004^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045663	positive regulation of myoblast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:19169261^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3603182	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:17336904^[33]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(MGI:MGI:88445)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035914	skeletal muscle cell differentiation	PMID:22147266^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030279	negative regulation of ossification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030224	monocyte differentiation	PMID:18326819^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857491	P	occurs_in:(EMAPA:32760) results_in_acquisition_of_features_of:(CL:0000576)	Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014898	cardiac muscle hypertrophy in response to stress	PMID:10531040^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(EMAPA:32748)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010613	positive regulation of cardiac muscle hypertrophy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007521	muscle cell fate determination	PMID:17786239^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3718323	P	occurs_in:(EMAPA:32716) results_in_determination_of:(CL:0000189)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007519	skeletal muscle tissue development	PMID:17786239^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3718323	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:9778514^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857491	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:10395786^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857491	P	results_in_development_of:(EMAPA:16691)\|results_in_development_of:(EMAPA:16694)\|results_in_development_of:(EMAPA:16695)\|results_in_development_of:(EMAPA:16348)\|results_in_development_of:(EMAPA:16697)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12130539^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[47]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18086704^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11081517^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12130539^[46]	ECO:0000305	curator inference used in manual assertion	GO:0003700	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12130539^[46]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18086704^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:19477969^[49]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16140986^[50]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:1891338)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14762206^[51]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003211	cardiac ventricle formation	PMID:19035347^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97350	P	results_in_formation_of:(EMAPA:16350)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003151	outflow tract morphogenesis	PMID:19035347^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97350	P	has_participant:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002062	chondrocyte differentiation	PMID:17336904^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99533	P	occurs_in:(EMAPA:18344) regulates_o_results_in_acquisition_of_features_of:(CL:0000743)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001974	blood vessel remodeling	PMID:9162005^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857491	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001974	blood vessel remodeling	PMID:10395786^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857491	P	has_participant:(EMAPA:16370)\|has_participant:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001958	endochondral ossification	PMID:17336904^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99533	P	occurs_in:(EMAPA:18344)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001958	endochondral ossification	PMID:17336904^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:18344)\|occurs_in:(EMAPA:32740)\|occurs_in:(EMAPA:36618)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:17336904^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99533	P	occurs_in:(EMAPA:18344) regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:9778514^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857491	P	occurs_in:(EMAPA:16085)\|occurs_in:(EMAPA:16204)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:17336904^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:19103)\|occurs_in:(EMAPA:32743)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:8506376^[52]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:17875930^[27]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:1341430)\|has_regulation_target:(MGI:MGI:1328358)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	PMID:20399744^[31]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:3612190)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:18093911^[32]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:3618746)\|has_regulation_target:(MGI:MGI:2676818)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:17420000^[26]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(MGI:MGI:101926)\|has_regulation_target:(MGI:MGI:101927)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1563119	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:7677753^[53]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98834	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06413	P		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
involved_in	GO:2001016	positive regulation of skeletal muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:1905563	negative regulation of vascular endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0071374	cellular response to parathyroid hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0048643	positive regulation of skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	C		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	C		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	C		Seeded From UniProt	complete
involved_in	GO:0014902	myotube differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	F		Seeded From UniProt	complete
enables	GO:0003680	AT DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06413 ensembl:ENSP00000340874	P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033896	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002100 InterPro:IPR036879	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033896	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002100 InterPro:IPR036879	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9021975	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016528	sarcoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0311	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Harrington, AJ et al. (2016) MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife 5 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Barbosa, AC et al. (2008) MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc. Natl. Acad. Sci. U.S.A. 105 9391-6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Li, H et al. (2008) Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc. Natl. Acad. Sci. U.S.A. 105 9397-402 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Akhtar, MW et al. (2012) In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PLoS ONE 7 e34863 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Molkentin, JD et al. (1996) MEF2B is a potent transactivator expressed in early myogenic lineages. Mol. Cell. Biol. 16 3814-24 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Han, TH & Prywes, R (1995) Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol. Cell. Biol. 15 2907-15 PubMed GONUTS page
↑ Dechesne, CA et al. (1994) E-box- and MEF-2-independent muscle-specific expression, positive autoregulation, and cross-activation of the chicken MyoD (CMD1) promoter reveal an indirect regulatory pathway. Mol. Cell. Biol. 14 5474-86 PubMed GONUTS page
↑ Lu, J et al. (2000) Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell 6 233-44 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Li, Z et al. (2008) Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J. Neurosci. 28 6557-68 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Vong, L et al. (2006) MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. Dev. Dyn. 235 1809-21 PubMed GONUTS page
↑ ^12.0 ^12.1 Fu, W et al. (2006) MEF2C mediates the activation induced cell death (AICD) of macrophages. Cell Res. 16 559-65 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Hosking, BM et al. (2001) SOX18 directly interacts with MEF2C in endothelial cells. Biochem. Biophys. Res. Commun. 287 493-500 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Agarwal, P et al. (2011) The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development 138 2555-65 PubMed GONUTS page
↑ ^15.0 ^15.1 Lynch, J et al. (2005) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J. Cell Biol. 170 37-47 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Khiem, D et al. (2008) A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 105 17067-72 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Al Madhoun, AS et al. (2011) Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 30 2477-89 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Phan, D et al. (2005) BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development 132 2669-78 PubMed GONUTS page
↑ ^19.0 ^19.1 Wei, X et al. (2003) MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells. Eur. J. Immunol. 33 2903-9 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 Stephens, AS et al. (2011) Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization. J. Biol. Chem. 286 30071-86 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Gekas, C et al. (2009) Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood 113 3461-71 PubMed GONUTS page
↑ ^22.0 ^22.1 Wilker, PR et al. (2008) Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat. Immunol. 9 603-12 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Vincentz, JW et al. (2008) Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev. Dyn. 237 3809-19 PubMed GONUTS page
↑ Johnnidis, JB et al. (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451 1125-9 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Verzi, MP et al. (2007) The transcription factor MEF2C is required for craniofacial development. Dev. Cell 12 645-52 PubMed GONUTS page
↑ ^27.0 ^27.1 Potthoff, MJ et al. (2007) Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol. Cell. Biol. 27 8143-51 PubMed GONUTS page
↑ Ieda, M et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142 375-86 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Lin, Q et al. (1998) Requirement of the MADS-box transcription factor MEF2C for vascular development. Development 125 4565-74 PubMed GONUTS page
↑ Black, BL et al. (1996) Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J. Biol. Chem. 271 26659-63 PubMed GONUTS page
↑ ^31.0 ^31.1 Jung, SY & Ko, YG (2010) TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. Biochem. Biophys. Res. Commun. 396 238-45 PubMed GONUTS page
↑ ^32.0 ^32.1 Liu, N et al. (2007) An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc. Natl. Acad. Sci. U.S.A. 104 20844-9 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 ^33.6 ^33.7 Arnold, MA et al. (2007) MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev. Cell 12 377-89 PubMed GONUTS page
↑ Micheli, L et al. (2005) PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C. Mol. Cell. Biol. 25 2242-59 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Angelelli, C et al. (2008) Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells. Nucleic Acids Res. 36 915-28 PubMed GONUTS page
↑ Kobayashi, N et al. (2007) c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. Genes Cells 12 375-85 PubMed GONUTS page
↑ Creemers, EE et al. (2006) Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol. Cell 23 83-96 PubMed GONUTS page
↑ ^38.0 ^38.1 Lin, Q et al. (1997) Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276 1404-7 PubMed GONUTS page
↑ Di Lisi, R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J. Biol. Chem. 273 25371-80 PubMed GONUTS page
↑ Stehling-Sun, S et al. (2009) Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat. Immunol. 10 289-96 PubMed GONUTS page
↑ Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page
↑ Schüler, A et al. (2008) The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. Blood 111 4532-41 PubMed GONUTS page
↑ Kolodziejczyk, SM et al. (1999) MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr. Biol. 9 1203-6 PubMed GONUTS page
↑ ^44.0 ^44.1 Potthoff, MJ et al. (2007) Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J. Clin. Invest. 117 2459-67 PubMed GONUTS page
↑ ^45.0 ^45.1 Bi, W et al. (1999) The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev. Biol. 211 255-67 PubMed GONUTS page
↑ ^46.0 ^46.1 ^46.2 Lazaro, JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 16 1792-805 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ McKinsey, TA et al. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408 106-11 PubMed GONUTS page
↑ Kuratomi, S et al. (2009) The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc. Res. 83 682-7 PubMed GONUTS page
↑ Nakagawa, O et al. (2005) Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev. 19 2066-77 PubMed GONUTS page
↑ Günther, S et al. (2004) VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Nucleic Acids Res. 32 791-802 PubMed GONUTS page
↑ Martin, JF et al. (1993) Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc. Natl. Acad. Sci. U.S.A. 90 5282-6 PubMed GONUTS page
↑ Sato, H et al. (1995) Repression of p53-dependent sequence-specific transactivation by MEF2c. Biochem. Biophys. Res. Commun. 214 468-74 PubMed GONUTS page

[PMID:27779093-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Harrington, AJ et al. (2016) MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife 5 PubMed GONUTS page

[PMID:18599438-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Barbosa, AC et al. (2008) MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc. Natl. Acad. Sci. U.S.A. 105 9391-6 PubMed GONUTS page

[PMID:18599437-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Li, H et al. (2008) Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc. Natl. Acad. Sci. U.S.A. 105 9397-402 PubMed GONUTS page

[PMID:22496871-4] 4.0 ^4.1 ^4.2 Akhtar, MW et al. (2012) In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PLoS ONE 7 e34863 PubMed GONUTS page

[PMID:8668199-5] 5.0 ^5.1 ^5.2 Molkentin, JD et al. (1996) MEF2B is a potent transactivator expressed in early myogenic lineages. Mol. Cell. Biol. 16 3814-24 PubMed GONUTS page

[PMID:7760790-6] 6.0 ^6.1 ^6.2 Han, TH & Prywes, R (1995) Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol. Cell. Biol. 15 2907-15 PubMed GONUTS page

[PMID:8035824-7] Dechesne, CA et al. (1994) E-box- and MEF-2-independent muscle-specific expression, positive autoregulation, and cross-activation of the chicken MyoD (CMD1) promoter reveal an indirect regulatory pathway. Mol. Cell. Biol. 14 5474-86 PubMed GONUTS page

[PMID:10983972-8] Lu, J et al. (2000) Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell 6 233-44 PubMed GONUTS page

[PMID:20181743-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page

[PMID:18579729-10] 10.0 ^10.1 ^10.2 ^10.3 Li, Z et al. (2008) Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J. Neurosci. 28 6557-68 PubMed GONUTS page

[PMID:16680724-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Vong, L et al. (2006) MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. Dev. Dyn. 235 1809-21 PubMed GONUTS page

[PMID:16775627-12] 12.0 ^12.1 Fu, W et al. (2006) MEF2C mediates the activation induced cell death (AICD) of macrophages. Cell Res. 16 559-65 PubMed GONUTS page

[PMID:11554755-13] 13.0 ^13.1 ^13.2 Hosking, BM et al. (2001) SOX18 directly interacts with MEF2C in endothelial cells. Biochem. Biophys. Res. Commun. 287 493-500 PubMed GONUTS page

[PMID:21610032-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Agarwal, P et al. (2011) The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development 138 2555-65 PubMed GONUTS page

[PMID:15998798-15] 15.0 ^15.1 Lynch, J et al. (2005) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J. Cell Biol. 170 37-47 PubMed GONUTS page

[PMID:18955699-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Khiem, D et al. (2008) A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 105 17067-72 PubMed GONUTS page

[PMID:21556048-17] 17.0 ^17.1 ^17.2 Al Madhoun, AS et al. (2011) Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 30 2477-89 PubMed GONUTS page

[PMID:15890826-18] 18.0 ^18.1 ^18.2 Phan, D et al. (2005) BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development 132 2669-78 PubMed GONUTS page

[PMID:14515274-19] 19.0 ^19.1 Wei, X et al. (2003) MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells. Eur. J. Immunol. 33 2903-9 PubMed GONUTS page

[PMID:21652706-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 Stephens, AS et al. (2011) Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization. J. Biol. Chem. 286 30071-86 PubMed GONUTS page

[PMID:19211936-21] 21.0 ^21.1 ^21.2 Gekas, C et al. (2009) Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood 113 3461-71 PubMed GONUTS page

[PMID:18438409-22] 22.0 ^22.1 Wilker, PR et al. (2008) Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat. Immunol. 9 603-12 PubMed GONUTS page

[PMID:21873635-23] 23.0 ^23.1 ^23.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19035347-24] 24.0 ^24.1 ^24.2 ^24.3 Vincentz, JW et al. (2008) Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev. Dyn. 237 3809-19 PubMed GONUTS page

[PMID:18278031-25] Johnnidis, JB et al. (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451 1125-9 PubMed GONUTS page

[PMID:17420000-26] 26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 Verzi, MP et al. (2007) The transcription factor MEF2C is required for craniofacial development. Dev. Cell 12 645-52 PubMed GONUTS page

[PMID:17875930-27] 27.0 ^27.1 Potthoff, MJ et al. (2007) Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol. Cell. Biol. 27 8143-51 PubMed GONUTS page

[PMID:20691899-28] Ieda, M et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142 375-86 PubMed GONUTS page

[PMID:9778514-29] 29.0 ^29.1 ^29.2 Lin, Q et al. (1998) Requirement of the MADS-box transcription factor MEF2C for vascular development. Development 125 4565-74 PubMed GONUTS page

[PMID:8900141-30] Black, BL et al. (1996) Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J. Biol. Chem. 271 26659-63 PubMed GONUTS page

[PMID:20399744-31] 31.0 ^31.1 Jung, SY & Ko, YG (2010) TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. Biochem. Biophys. Res. Commun. 396 238-45 PubMed GONUTS page

[PMID:18093911-32] 32.0 ^32.1 Liu, N et al. (2007) An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc. Natl. Acad. Sci. U.S.A. 104 20844-9 PubMed GONUTS page

[PMID:17336904-33] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 ^33.5 ^33.6 ^33.7 Arnold, MA et al. (2007) MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev. Cell 12 377-89 PubMed GONUTS page

[PMID:15743821-34] Micheli, L et al. (2005) PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C. Mol. Cell. Biol. 25 2242-59 PubMed GONUTS page

[PMID:18086704-35] 35.0 ^35.1 ^35.2 Angelelli, C et al. (2008) Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells. Nucleic Acids Res. 36 915-28 PubMed GONUTS page

[PMID:17352741-36] Kobayashi, N et al. (2007) c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. Genes Cells 12 375-85 PubMed GONUTS page

[PMID:16818234-37] Creemers, EE et al. (2006) Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol. Cell 23 83-96 PubMed GONUTS page

[PMID:9162005-38] 38.0 ^38.1 Lin, Q et al. (1997) Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276 1404-7 PubMed GONUTS page

[PMID:9738004-39] Di Lisi, R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J. Biol. Chem. 273 25371-80 PubMed GONUTS page

[PMID:19169261-40] Stehling-Sun, S et al. (2009) Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat. Immunol. 10 289-96 PubMed GONUTS page

[PMID:22147266-41] Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page

[PMID:18326819-42] Schüler, A et al. (2008) The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. Blood 111 4532-41 PubMed GONUTS page

[PMID:10531040-43] Kolodziejczyk, SM et al. (1999) MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr. Biol. 9 1203-6 PubMed GONUTS page

[PMID:17786239-44] 44.0 ^44.1 Potthoff, MJ et al. (2007) Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J. Clin. Invest. 117 2459-67 PubMed GONUTS page

[PMID:10395786-45] 45.0 ^45.1 Bi, W et al. (1999) The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev. Biol. 211 255-67 PubMed GONUTS page

[PMID:12130539-46] 46.0 ^46.1 ^46.2 Lazaro, JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 16 1792-805 PubMed GONUTS page

[PMID:19796622-47] Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:11081517-48] McKinsey, TA et al. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408 106-11 PubMed GONUTS page

[PMID:19477969-49] Kuratomi, S et al. (2009) The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc. Res. 83 682-7 PubMed GONUTS page

[PMID:16140986-50] Nakagawa, O et al. (2005) Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev. 19 2066-77 PubMed GONUTS page

[PMID:14762206-51] Günther, S et al. (2004) VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Nucleic Acids Res. 32 791-802 PubMed GONUTS page

[PMID:8506376-52] Martin, JF et al. (1993) Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc. Natl. Acad. Sci. U.S.A. 90 5282-6 PubMed GONUTS page

[PMID:7677753-53] Sato, H et al. (1995) Repression of p53-dependent sequence-specific transactivation by MEF2c. Biochem. Biophys. Res. Commun. 214 468-74 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

[49]

[50]

[51]

[52]

[53]

MOUSE:MEF2C

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools