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MOUSE:MEF2C
Contents
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:1904891 |
positive regulation of excitatory synapse assembly |
ECO:0000315 |
P |
Figure 3 shows that in the absence of MEF2C, excitatory synapse density is decreased. |
complete | |||||
GO:1905703 |
negative regulation of inhibitory synapse assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Figure 3 shows that, in the absence of MEF2C, inhibitory synapse density increases. |
complete | ||||
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
ECO:0000315 |
P |
Figure 3 (F and G) shows that MEF2C mutation (MEF2C-VP16) and an MEF2C knockout decreases dendritic spine density. Knockout MEF2C cells supplemented with functional MEF2C-EN are able to restore and maintain dendritic spine density. |
complete | |||||
GO:1902952 |
positive regulation of dendritic spine maintenance |
ECO:0000315 |
P |
Figure 3 (F and G) shows that MEF2C mutation (MEF2C-VP16) and an MEF2C knockout decreases dendritic spine density. Knockout MEF2C cells supplemented with functional MEF2C-EN are able to restore and maintain dendritic spine density. |
complete | |||||
involved_in |
GO:2000311 |
regulation of AMPA receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001885) |
Seeded From UniProt |
complete | ||
GO:0032229 |
negative regulation of synaptic transmission, GABAergic |
ECO:0000315 |
P |
Figure 3 (H and I) shows that MEF2C mutant (MEF2C-VP16) and MEF2C knockout mutants increase GABAergic synapse density. Knockout MEF2C mutants supplemented with functional MEF2C-EN were able to decrease GABAergic synapse density to wildtype levels. By decreasing GABAergic synapse numbers, MEF2C negatively regulates GABAergic synaptic transmission. |
complete | |||||
involved_in |
GO:2000310 |
regulation of NMDA receptor activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001885) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060998 |
regulation of dendritic spine development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001885) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060079 |
excitatory postsynaptic potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060079 |
excitatory postsynaptic potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001885) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060025 |
regulation of synaptic activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060025 |
regulation of synaptic activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0003881) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051966 |
regulation of synaptic transmission, glutamatergic |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001885) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051963 |
regulation of synapse assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001885) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048667 |
cell morphogenesis involved in neuron differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048167 |
regulation of synaptic plasticity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0003881) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046928 |
regulation of neurotransmitter secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(UBERON:0001885) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043523 |
regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007611 |
learning or memory |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001764 |
neuron migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(NCBI_Gene:12715) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(NCBI_Gene:16476) |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0000165) |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
enables |
GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0044212 |
transcription regulatory region DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042826 |
histone deacetylase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001013 |
epithelial cell proliferation involved in renal tubule morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000987 |
positive regulation of behavioral fear response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000727 |
positive regulation of cardiac muscle cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000111 |
positive regulation of macrophage apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072160 |
nephron tubule epithelial cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072102 |
glomerulus morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0071837 |
HMG box domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0071837 |
HMG box domain binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071498 |
cellular response to fluid shear stress |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071374 |
cellular response to parathyroid hormone stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071277 |
cellular response to calcium ion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0061333 |
renal tubule morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060045 |
positive regulation of cardiac muscle cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060025 |
regulation of synaptic activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055012 |
ventricular cardiac muscle cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055007 |
cardiac muscle cell differentiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050853 |
B cell receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050680 |
negative regulation of epithelial cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048666 |
neuron development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048643 |
positive regulation of skeletal muscle tissue development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045669 |
positive regulation of osteoblast differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045666 |
positive regulation of neuron differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045663 |
positive regulation of myoblast differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045652 |
regulation of megakaryocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042100 |
B cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035984 |
cellular response to trichostatin A |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035914 |
skeletal muscle cell differentiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035690 |
cellular response to drug |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030890 |
positive regulation of B cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030501 |
positive regulation of bone mineralization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030318 |
melanocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030279 |
negative regulation of ossification |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030220 |
platelet formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016607 |
nuclear speck |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0014033 |
neural crest cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010694 |
positive regulation of alkaline phosphatase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010629 |
negative regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007611 |
learning or memory |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006959 |
humoral immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002495) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003211 |
cardiac ventricle formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003185 |
sinoatrial valve morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003139 |
secondary heart field specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0003138 |
primary heart field specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002634 |
regulation of germinal center formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002467 |
germinal center formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001947 |
heart looping |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001782 |
B cell homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001649 |
osteoblast differentiation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000165 |
MAPK cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000165 |
MAPK cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042826 |
histone deacetylase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104526 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99458 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99532 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:2001016 |
positive regulation of skeletal muscle cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2000727 |
positive regulation of cardiac muscle cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1905563 |
negative regulation of vascular endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1904753 |
negative regulation of vascular associated smooth muscle cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1904706 |
negative regulation of vascular smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0090073 |
positive regulation of protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071864 |
positive regulation of cell proliferation in bone marrow |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2684360 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071374 |
cellular response to parathyroid hormone stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071363 |
cellular response to growth factor stimulus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0071300 |
cellular response to retinoic acid |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060536 |
cartilage morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3603182 |
P |
has_participant:(EMAPA:17907) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060297 |
regulation of sarcomere organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
regulates_o_occurs_in:(EMAPA:17701) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060290 |
transdifferentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060021 |
roof of mouth development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101926 |
P |
results_in_development_of:(EMAPA:18948) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0055007 |
cardiac muscle cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:102541 |
P |
results_in_acquisition_of_features_of:(CL:0000746) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0055007 |
cardiac muscle cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97350 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0051145 |
smooth muscle cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857491 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048704 |
embryonic skeletal system morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3603182 |
P |
has_participant:(EMAPA:18290)|has_participant:(EMAPA:17928) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0048703 |
embryonic viscerocranium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3603182 |
P |
has_participant:(EMAPA:36570)|has_participant:(EMAPA:17682) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0048643 |
positive regulation of skeletal muscle tissue development |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96919 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97276 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:99533 |
P |
has_regulation_target:(MGI:MGI:2676818)|has_regulation_target:(MGI:MGI:3618746) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:101926 |
P |
has_regulation_target:(MGI:MGI:101925)|has_regulation_target:(MGI:MGI:101927) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:3036234 |
P |
has_regulation_target:(MGI:MGI:88445) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97275 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(MGI:MGI:88445) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857491 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045663 |
positive regulation of myoblast differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045165 |
cell fate commitment |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3603182 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_input:(MGI:MGI:88445) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043537 |
negative regulation of blood vessel endothelial cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035914 |
skeletal muscle cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0033613 |
activating transcription factor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030279 |
negative regulation of ossification |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030224 |
monocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857491 |
P |
|
Seeded From UniProt |
complete | |
part_of |
GO:0030017 |
sarcomere |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0016607 |
nuclear speck |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0014898 |
cardiac muscle hypertrophy in response to stress |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_participant:(EMAPA:32748) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010628 |
positive regulation of gene expression |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010613 |
positive regulation of cardiac muscle hypertrophy |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007521 |
muscle cell fate determination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3718323 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0007519 |
skeletal muscle tissue development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3718323 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007507 |
heart development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857491 |
P |
results_in_development_of:(EMAPA:16105) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0007507 |
heart development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857491 |
P |
results_in_development_of:(EMAPA:16691)|results_in_development_of:(EMAPA:16694)|results_in_development_of:(EMAPA:16695)|results_in_development_of:(EMAPA:16348)|results_in_development_of:(EMAPA:16697) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000305 |
curator inference used in manual assertion |
GO:0003700 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003680 |
AT DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_participant:(MGI:MGI:1891338) |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0003211 |
cardiac ventricle formation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97350 |
P |
results_in_formation_of:(EMAPA:16350) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0003151 |
outflow tract morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97350 |
P |
has_participant:(EMAPA:16346) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0002062 |
chondrocyte differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:99533 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001974 |
blood vessel remodeling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857491 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001974 |
blood vessel remodeling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857491 |
P |
has_participant:(EMAPA:16370)|has_participant:(EMAPA:16104) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001958 |
endochondral ossification |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:99533 |
P |
occurs_in:(EMAPA:18344) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001958 |
endochondral ossification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(EMAPA:18344)|occurs_in:(EMAPA:32740)|occurs_in:(EMAPA:36618) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001649 |
osteoblast differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:99533 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001568 |
blood vessel development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857491 |
P |
occurs_in:(EMAPA:16085)|occurs_in:(EMAPA:16204) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001568 |
blood vessel development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(EMAPA:19103)|occurs_in:(EMAPA:32743) |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_regulation_target:(MGI:MGI:1341430)|has_regulation_target:(MGI:MGI:1328358) |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000987 |
proximal promoter sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_participant:(MGI:MGI:3612190) |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_regulation_target:(MGI:MGI:3618746)|has_regulation_target:(MGI:MGI:2676818) |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_regulation_target:(MGI:MGI:101926)|has_regulation_target:(MGI:MGI:101927) |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1563119 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0000165 |
MAPK cascade |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98834 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0098794 |
postsynapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0060079 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098794 |
postsynapse |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0060079 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:2001016 |
positive regulation of skeletal muscle cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000727 |
positive regulation of cardiac muscle cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1905563 |
negative regulation of vascular endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904753 |
negative regulation of vascular associated smooth muscle cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1904706 |
negative regulation of vascular smooth muscle cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071560 |
cellular response to transforming growth factor beta stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071374 |
cellular response to parathyroid hormone stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048643 |
positive regulation of skeletal muscle tissue development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045663 |
positive regulation of myoblast differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043537 |
negative regulation of blood vessel endothelial cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0033613 |
activating transcription factor binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030279 |
negative regulation of ossification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030182 |
neuron differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016607 |
nuclear speck |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0014902 |
myotube differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007507 |
heart development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003680 |
AT DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000165 |
MAPK cascade |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q06413 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-MMU-9021975 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016528 |
sarcoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Harrington, AJ et al. (2016) MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife 5 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Barbosa, AC et al. (2008) MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc. Natl. Acad. Sci. U.S.A. 105 9391-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Li, H et al. (2008) Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc. Natl. Acad. Sci. U.S.A. 105 9397-402 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Akhtar, MW et al. (2012) In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PLoS ONE 7 e34863 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Molkentin, JD et al. (1996) MEF2B is a potent transactivator expressed in early myogenic lineages. Mol. Cell. Biol. 16 3814-24 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Han, TH & Prywes, R (1995) Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol. Cell. Biol. 15 2907-15 PubMed GONUTS page
- ↑ Dechesne, CA et al. (1994) E-box- and MEF-2-independent muscle-specific expression, positive autoregulation, and cross-activation of the chicken MyoD (CMD1) promoter reveal an indirect regulatory pathway. Mol. Cell. Biol. 14 5474-86 PubMed GONUTS page
- ↑ Lu, J et al. (2000) Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell 6 233-44 PubMed GONUTS page
- ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Li, Z et al. (2008) Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J. Neurosci. 28 6557-68 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Vong, L et al. (2006) MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. Dev. Dyn. 235 1809-21 PubMed GONUTS page
- ↑ 12.0 12.1 Fu, W et al. (2006) MEF2C mediates the activation induced cell death (AICD) of macrophages. Cell Res. 16 559-65 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Hosking, BM et al. (2001) SOX18 directly interacts with MEF2C in endothelial cells. Biochem. Biophys. Res. Commun. 287 493-500 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 14.3 14.4 14.5 14.6 Agarwal, P et al. (2011) The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development 138 2555-65 PubMed GONUTS page
- ↑ 15.0 15.1 Lynch, J et al. (2005) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J. Cell Biol. 170 37-47 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 16.3 16.4 16.5 Khiem, D et al. (2008) A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 105 17067-72 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Al Madhoun, AS et al. (2011) Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 30 2477-89 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 Phan, D et al. (2005) BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development 132 2669-78 PubMed GONUTS page
- ↑ 19.0 19.1 Wei, X et al. (2003) MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells. Eur. J. Immunol. 33 2903-9 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 20.3 20.4 Stephens, AS et al. (2011) Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization. J. Biol. Chem. 286 30071-86 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 Gekas, C et al. (2009) Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood 113 3461-71 PubMed GONUTS page
- ↑ 22.0 22.1 Wilker, PR et al. (2008) Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat. Immunol. 9 603-12 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 Vincentz, JW et al. (2008) Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev. Dyn. 237 3809-19 PubMed GONUTS page
- ↑ Johnnidis, JB et al. (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451 1125-9 PubMed GONUTS page
- ↑ 26.0 26.1 26.2 26.3 26.4 26.5 Verzi, MP et al. (2007) The transcription factor MEF2C is required for craniofacial development. Dev. Cell 12 645-52 PubMed GONUTS page
- ↑ 27.0 27.1 Potthoff, MJ et al. (2007) Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol. Cell. Biol. 27 8143-51 PubMed GONUTS page
- ↑ Ieda, M et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142 375-86 PubMed GONUTS page
- ↑ 29.0 29.1 29.2 Lin, Q et al. (1998) Requirement of the MADS-box transcription factor MEF2C for vascular development. Development 125 4565-74 PubMed GONUTS page
- ↑ Black, BL et al. (1996) Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J. Biol. Chem. 271 26659-63 PubMed GONUTS page
- ↑ 31.0 31.1 Jung, SY & Ko, YG (2010) TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. Biochem. Biophys. Res. Commun. 396 238-45 PubMed GONUTS page
- ↑ 32.0 32.1 Liu, N et al. (2007) An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc. Natl. Acad. Sci. U.S.A. 104 20844-9 PubMed GONUTS page
- ↑ 33.0 33.1 33.2 33.3 33.4 33.5 33.6 33.7 Arnold, MA et al. (2007) MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev. Cell 12 377-89 PubMed GONUTS page
- ↑ Micheli, L et al. (2005) PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C. Mol. Cell. Biol. 25 2242-59 PubMed GONUTS page
- ↑ 35.0 35.1 35.2 Angelelli, C et al. (2008) Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells. Nucleic Acids Res. 36 915-28 PubMed GONUTS page
- ↑ Kobayashi, N et al. (2007) c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. Genes Cells 12 375-85 PubMed GONUTS page
- ↑ Creemers, EE et al. (2006) Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol. Cell 23 83-96 PubMed GONUTS page
- ↑ 38.0 38.1 Lin, Q et al. (1997) Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276 1404-7 PubMed GONUTS page
- ↑ Di Lisi, R et al. (1998) Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo. J. Biol. Chem. 273 25371-80 PubMed GONUTS page
- ↑ Stehling-Sun, S et al. (2009) Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat. Immunol. 10 289-96 PubMed GONUTS page
- ↑ Rajan, S et al. (2012) Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol. Genomics 44 183-97 PubMed GONUTS page
- ↑ Schüler, A et al. (2008) The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate. Blood 111 4532-41 PubMed GONUTS page
- ↑ Kolodziejczyk, SM et al. (1999) MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr. Biol. 9 1203-6 PubMed GONUTS page
- ↑ 44.0 44.1 Potthoff, MJ et al. (2007) Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J. Clin. Invest. 117 2459-67 PubMed GONUTS page
- ↑ 45.0 45.1 Bi, W et al. (1999) The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev. Biol. 211 255-67 PubMed GONUTS page
- ↑ 46.0 46.1 46.2 Lazaro, JB et al. (2002) Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 16 1792-805 PubMed GONUTS page
- ↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
- ↑ McKinsey, TA et al. (2000) Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408 106-11 PubMed GONUTS page
- ↑ Kuratomi, S et al. (2009) The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc. Res. 83 682-7 PubMed GONUTS page
- ↑ Nakagawa, O et al. (2005) Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev. 19 2066-77 PubMed GONUTS page
- ↑ Günther, S et al. (2004) VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Nucleic Acids Res. 32 791-802 PubMed GONUTS page
- ↑ Martin, JF et al. (1993) Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc. Natl. Acad. Sci. U.S.A. 90 5282-6 PubMed GONUTS page
- ↑ Sato, H et al. (1995) Repression of p53-dependent sequence-specific transactivation by MEF2c. Biochem. Biophys. Res. Commun. 214 468-74 PubMed GONUTS page
b
c
- GO:0014898 ! cardiac muscle hypertrophy in response to stress
- GO:0055007 ! cardiac muscle cell differentiation
- GO:0003211 ! cardiac ventricle formation
- GO:0060536 ! cartilage morphogenesis
- GO:0071300 ! cellular response to retinoic acid
- GO:0071374 ! cellular response to parathyroid hormone stimulus
- GO:0071277 ! cellular response to calcium ion
- GO:0071222 ! cellular response to lipopolysaccharide
- GO:0071560 ! cellular response to transforming growth factor beta stimulus
- GO:0071498 ! cellular response to fluid shear stress
- GO:0035984 ! cellular response to trichostatin A
- GO:0035690 ! cellular response to drug
- GO:0071363 ! cellular response to growth factor stimulus
- GO:0030154 ! cell differentiation
- GO:0045165 ! cell fate commitment
- GO:0048667 ! cell morphogenesis involved in neuron differentiation
- GO:0002062 ! chondrocyte differentiation
- Chordata
- GO:0003682 ! chromatin binding
- GO:0000987 ! cis-regulatory region sequence-specific DNA binding
- Craniata
- GO:0005737 ! cytoplasm
d
e
- GO:0048704 ! embryonic skeletal system morphogenesis
- GO:0048703 ! embryonic viscerocranium morphogenesis
- GO:0001958 ! endochondral ossification
- GO:2001013 ! epithelial cell proliferation involved in renal tubule morphogenesis
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0060079 ! excitatory postsynaptic potential
h
m
- Mammalia
- GO:0000165 ! MAPK cascade
- GO:0030318 ! melanocyte differentiation
- Metazoa
- GO:0003680 ! minor groove of adenine-thymine-rich DNA binding
- GO:0030224 ! monocyte differentiation
- GO:0007275 ! multicellular organism development
- Muridae
- Murinae
- Muroidea
- Mus
- GO:0007521 ! muscle cell fate determination
- Mus musculus
- GO:0014902 ! myotube differentiation
n
- GO:0010629 ! negative regulation of gene expression
- GO:0043524 ! negative regulation of neuron apoptotic process
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0050680 ! negative regulation of epithelial cell proliferation
- GO:1905563 ! negative regulation of vascular endothelial cell proliferation
- GO:0032229 ! negative regulation of synaptic transmission, GABAergic
- GO:1905703 ! negative regulation of inhibitory synapse assembly
- GO:0043537 ! negative regulation of blood vessel endothelial cell migration
- GO:1904753 ! negative regulation of vascular associated smooth muscle cell migration
- GO:1904706 ! negative regulation of vascular associated smooth muscle cell proliferation
- GO:0030279 ! negative regulation of ossification
- GO:0072160 ! nephron tubule epithelial cell differentiation
- GO:0007399 ! nervous system development
- GO:0014033 ! neural crest cell differentiation
- GO:0048666 ! neuron development
- GO:0030182 ! neuron differentiation
- GO:0001764 ! neuron migration
- GO:0000790 ! nuclear chromatin
- GO:0016607 ! nuclear speck
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
p
- GO:0030220 ! platelet formation
- GO:0010613 ! positive regulation of cardiac muscle hypertrophy
- GO:1904891 ! positive regulation of excitatory synapse assembly
- GO:0045663 ! positive regulation of myoblast differentiation
- GO:0060045 ! positive regulation of cardiac muscle cell proliferation
- GO:0045669 ! positive regulation of osteoblast differentiation
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:0048643 ! positive regulation of skeletal muscle tissue development
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:2000727 ! positive regulation of cardiac muscle cell differentiation
- GO:0030890 ! positive regulation of B cell proliferation
- GO:0030501 ! positive regulation of bone mineralization
- GO:0010694 ! positive regulation of alkaline phosphatase activity
- GO:0010628 ! positive regulation of gene expression
- GO:0045666 ! positive regulation of neuron differentiation
- GO:2000987 ! positive regulation of behavioral fear response
- GO:2000111 ! positive regulation of macrophage apoptotic process
- GO:2001016 ! positive regulation of skeletal muscle cell differentiation
- GO:0071864 ! positive regulation of cell proliferation in bone marrow
- GO:1902952 ! positive regulation of dendritic spine maintenance
- GO:0061003 ! positive regulation of dendritic spine morphogenesis
- GO:0098794 ! postsynapse
- GO:0003138 ! primary heart field specification
- GO:0032991 ! protein-containing complex
- GO:0046983 ! protein dimerization activity
- GO:0046982 ! protein heterodimerization activity
r
- GO:0060297 ! regulation of sarcomere organization
- GO:0043523 ! regulation of neuron apoptotic process
- GO:0046928 ! regulation of neurotransmitter secretion
- GO:0048167 ! regulation of synaptic plasticity
- GO:0051963 ! regulation of synapse assembly
- GO:0060025 ! regulation of synaptic activity
- GO:0060998 ! regulation of dendritic spine development
- GO:2000310 ! regulation of NMDA receptor activity
- GO:2000311 ! regulation of AMPA receptor activity
- GO:0051966 ! regulation of synaptic transmission, glutamatergic
- GO:0002634 ! regulation of germinal center formation
- GO:0045652 ! regulation of megakaryocyte differentiation
- GO:0006355 ! regulation of DNA-templated transcription
- GO:0061333 ! renal tubule morphogenesis
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0000980 ! RNA polymerase II distal enhancer sequence-specific DNA binding
- GO:0000977 ! RNA polymerase II transcription regulatory region sequence-specific DNA binding
- Rodentia
- GO:0060021 ! roof of mouth development
s
- GO:0030017 ! sarcomere
- GO:0016528 ! sarcoplasm
- Sciurognathi
- GO:0003139 ! secondary heart field specification
- GO:0043565 ! sequence-specific DNA binding
- GO:0003185 ! sinoatrial valve morphogenesis
- GO:0035914 ! skeletal muscle cell differentiation
- GO:0007519 ! skeletal muscle tissue development
- GO:0051145 ! smooth muscle cell differentiation