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MOUSE:MEF2C

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Mef2c
Protein Name(s) Myocyte-specific enhancer factor 2C
External Links
UniProt Q8CFN5
EMBL AK009139
BC026841
BC037731
BC057650
CCDS CCDS26664.1
CCDS49320.1
RefSeq NP_079558.1
XP_006517183.1
XP_006517184.1
XP_006517185.1
XP_006517186.1
XP_006517187.1
XP_006517189.1
XP_006517192.1
XP_006517195.1
XP_011242794.1
XP_011242795.1
XP_011242796.1
UniGene Mm.24001
Mm.451574
Mm.487610
ProteinModelPortal Q8CFN5
SMR Q8CFN5
BioGrid 201383
DIP DIP-49524N
IntAct Q8CFN5
MINT MINT-1551742
STRING 10090.ENSMUSP00000132547
iPTMnet Q8CFN5
PhosphoSite Q8CFN5
EPD Q8CFN5
MaxQB Q8CFN5
PaxDb Q8CFN5
PRIDE Q8CFN5
Ensembl ENSMUST00000185052
ENSMUST00000197146
ENSMUST00000197681
ENSMUST00000198199
ENSMUST00000199019
ENSMUST00000199105
ENSMUST00000199450
GeneID 17260
KEGG mmu:17260
UCSC uc007rie.2
uc007rih.2
uc007rii.3
CTD 4208
MGI MGI:99458
eggNOG KOG0014
COG5068
GeneTree ENSGT00390000011828
HOGENOM HOG000230620
HOVERGEN HBG053944
InParanoid Q8CFN5
KO K04454
OrthoDB EOG793B7D
PhylomeDB Q8CFN5
TreeFam TF314067
Reactome [www.reactome.org/content/detail/R-MMU-375170 R-MMU-375170]
PRO PR:Q8CFN5
Proteomes UP000000589
Bgee Q8CFN5
CleanEx MM_MEF2C
ExpressionAtlas Q8CFN5
Genevisible Q8CFN5
GO GO:0005737
GO:0005829
GO:0043231
GO:0016607
GO:0005654
GO:0005634
GO:0098794
GO:0043234
GO:0033613
GO:0003680
GO:0003682
GO:0000987
GO:0001046
GO:0003677
GO:0042826
GO:0071837
GO:0035198
GO:0046982
GO:0000978
GO:0000980
GO:0000977
GO:0000981
GO:0043565
GO:0000983
GO:0003705
GO:0003700
GO:0044212
GO:0001077
GO:0001205
GO:0006915
GO:0001782
GO:0042100
GO:0050853
GO:0001568
GO:0001974
GO:0055007
GO:0014898
GO:0003211
GO:0060536
GO:0045165
GO:0048667
GO:0071277
GO:0035690
GO:0071498
GO:0071222
GO:0071374
GO:0071560
GO:0035984
GO:0002062
GO:0048704
GO:0048703
GO:0001958
GO:2001013
GO:0060079
GO:0002467
GO:0072102
GO:0007507
GO:0001947
GO:0006959
GO:0007611
GO:0000165
GO:0030318
GO:0030224
GO:0007521
GO:0014902
GO:0050680
GO:0010629
GO:0043524
GO:0030279
GO:0000122
GO:0072160
GO:0014033
GO:0048666
GO:0030182
GO:0001764
GO:0001649
GO:0003151
GO:0060021
GO:0030220
GO:0010694
GO:0030890
GO:2000987
GO:0030501
GO:2000727
GO:0060045
GO:0071864
GO:0010628
GO:2000111
GO:0043406
GO:0045663
GO:0045666
GO:0045669
GO:0090073
GO:2001016
GO:0048643
GO:0045944
GO:0045893
GO:0003138
GO:2000311
GO:0060998
GO:0002634
GO:0045652
GO:2000310
GO:0043523
GO:0046928
GO:0060297
GO:0051963
GO:0060025
GO:0048167
GO:0051966
GO:0006355
GO:0061333
GO:0002931
GO:0009615
GO:0003139
GO:0003185
GO:0035914
GO:0007519
GO:0051145
GO:0006366
GO:0055012
InterPro IPR022102
IPR002100
Pfam PF12347
PF00319
PRINTS PR00404
SMART SM00432
SUPFAM SSF55455
PROSITE PS00350
PS50066

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:1904891

positive regulation of excitatory synapse assembly

PMID:27779093[1]

ECO:0000315

P

Figure 3 shows that in the absence of MEF2C, excitatory synapse density is decreased.

complete
CACAO 12184

GO:1905703

negative regulation of inhibitory synapse assembly

PMID:27779093[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Figure 3 shows that, in the absence of MEF2C, inhibitory synapse density increases.

complete
CACAO 12185

GO:0061003

positive regulation of dendritic spine morphogenesis

PMID:27779093[1]

ECO:0000315

P

Figure 3 (F and G) shows that MEF2C mutation (MEF2C-VP16) and an MEF2C knockout decreases dendritic spine density. Knockout MEF2C cells supplemented with functional MEF2C-EN are able to restore and maintain dendritic spine density.

complete
CACAO 12186

GO:1902952

positive regulation of dendritic spine maintenance

PMID:27779093[1]

ECO:0000315

P

Figure 3 (F and G) shows that MEF2C mutation (MEF2C-VP16) and an MEF2C knockout decreases dendritic spine density. Knockout MEF2C cells supplemented with functional MEF2C-EN are able to restore and maintain dendritic spine density.

complete
CACAO 12187

involved_in

GO:2000311

regulation of AMPA receptor activity

PMID:18599438[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001885)

Seeded From UniProt

complete

GO:0032229

negative regulation of synaptic transmission, GABAergic

PMID:27779093[1]

ECO:0000315

P

Figure 3 (H and I) shows that MEF2C mutant (MEF2C-VP16) and MEF2C knockout mutants increase GABAergic synapse density. Knockout MEF2C mutants supplemented with functional MEF2C-EN were able to decrease GABAergic synapse density to wildtype levels. By decreasing GABAergic synapse numbers, MEF2C negatively regulates GABAergic synaptic transmission.

complete
CACAO 12188

involved_in

GO:2000310

regulation of NMDA receptor activity

PMID:18599438[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001885)

Seeded From UniProt

complete

involved_in

GO:0060998

regulation of dendritic spine development

PMID:18599438[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001885)

Seeded From UniProt

complete

involved_in

GO:0060079

excitatory postsynaptic potential

PMID:18599437[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060079

excitatory postsynaptic potential

PMID:18599438[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001885)

Seeded From UniProt

complete

involved_in

GO:0060025

regulation of synaptic activity

PMID:18599437[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060025

regulation of synaptic activity

PMID:22496871[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0003881)

Seeded From UniProt

complete

involved_in

GO:0051966

regulation of synaptic transmission, glutamatergic

PMID:18599438[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001885)

Seeded From UniProt

complete

involved_in

GO:0051963

regulation of synapse assembly

PMID:18599438[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001885)

Seeded From UniProt

complete

involved_in

GO:0048667

cell morphogenesis involved in neuron differentiation

PMID:18599437[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048167

regulation of synaptic plasticity

PMID:22496871[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0003881)

Seeded From UniProt

complete

involved_in

GO:0046928

regulation of neurotransmitter secretion

PMID:18599438[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(UBERON:0001885)

Seeded From UniProt

complete

involved_in

GO:0043523

regulation of neuron apoptotic process

PMID:22496871[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007611

learning or memory

PMID:18599437[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001764

neuron migration

PMID:18599437[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:8668199[5]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:12715)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:7760790[6]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:16476)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:8668199[5]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0000165)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:7760790[6]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

enables

GO:0000980

RNA polymerase II distal enhancer sequence-specific DNA binding

PMID:8668199[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:7760790[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:8035824[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:10983972[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P56524

F

Seeded From UniProt

complete

involved_in

GO:2001013

epithelial cell proliferation involved in renal tubule morphogenesis

PMID:20181743[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000987

positive regulation of behavioral fear response

PMID:18579729[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000727

positive regulation of cardiac muscle cell differentiation

PMID:16680724[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000111

positive regulation of macrophage apoptotic process

PMID:16775627[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072160

nephron tubule epithelial cell differentiation

PMID:20181743[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072102

glomerulus morphogenesis

PMID:20181743[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0071837

HMG box domain binding

PMID:11554755[13]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P43680

F

Seeded From UniProt

complete

enables

GO:0071837

HMG box domain binding

PMID:21610032[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q04888

F

Seeded From UniProt

complete

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

involved_in

GO:0071498

cellular response to fluid shear stress

PMID:20181743[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071374

cellular response to parathyroid hormone stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

involved_in

GO:0071277

cellular response to calcium ion

PMID:15998798[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:18955699[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061333

renal tubule morphogenesis

PMID:20181743[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060045

positive regulation of cardiac muscle cell proliferation

PMID:16680724[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060025

regulation of synaptic activity

PMID:18599438[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055012

ventricular cardiac muscle cell differentiation

PMID:16680724[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0055007

cardiac muscle cell differentiation

PMID:21556048[17]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050853

B cell receptor signaling pathway

PMID:18955699[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050680

negative regulation of epithelial cell proliferation

PMID:20181743[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048666

neuron development

PMID:18599437[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048643

positive regulation of skeletal muscle tissue development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15890826[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20181743[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:14515274[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:11554755[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:21610032[14]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

PMID:21652706[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045666

positive regulation of neuron differentiation

PMID:18579729[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045663

positive regulation of myoblast differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

involved_in

GO:0045652

regulation of megakaryocyte differentiation

PMID:19211936[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:21610032[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:21556048[17]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043524

negative regulation of neuron apoptotic process

PMID:18579729[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

C

Seeded From UniProt

complete

involved_in

GO:0042100

B cell proliferation

PMID:18438409[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035984

cellular response to trichostatin A

PMID:20181743[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035914

skeletal muscle cell differentiation

PMID:21556048[17]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

PMID:16775627[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030890

positive regulation of B cell proliferation

PMID:18955699[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030501

positive regulation of bone mineralization

PMID:21652706[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030318

melanocyte differentiation

PMID:21610032[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030279

negative regulation of ossification

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

involved_in

GO:0030220

platelet formation

PMID:19211936[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

PMID:18599437[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

C

Seeded From UniProt

complete

involved_in

GO:0014033

neural crest cell differentiation

PMID:21610032[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010694

positive regulation of alkaline phosphatase activity

PMID:21652706[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:16680724[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:16680724[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:21652706[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:18579729[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007611

learning or memory

PMID:18599438[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006959

humoral immune response

PMID:18955699[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20181743[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11554755[13]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15998798[15]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0002495)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21610032[14]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0003211

cardiac ventricle formation

PMID:16680724[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003185

sinoatrial valve morphogenesis

PMID:16680724[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003139

secondary heart field specification

PMID:15890826[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0003138

primary heart field specification

PMID:16680724[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002634

regulation of germinal center formation

PMID:18438409[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002467

germinal center formation

PMID:18955699[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

PMID:16680724[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001782

B cell homeostasis

PMID:19211936[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

PMID:21652706[20]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:20181743[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:20181743[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21610032[14]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:15890826[18]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

PMID:18955699[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

PMID:14515274[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

enables

GO:0042826

histone deacetylase binding

PMID:21873635[23]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104526
MGI:MGI:99458
MGI:MGI:99533
PANTHER:PTN002278664
UniProtKB:Q02078
UniProtKB:Q02080
UniProtKB:Q14814

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635[23]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99458
MGI:MGI:99532
MGI:MGI:99533
PANTHER:PTN002278664
UniProtKB:Q02078
UniProtKB:Q02080

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:21873635[23]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99532
PANTHER:PTN002278664

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001016

positive regulation of skeletal muscle cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000727

positive regulation of cardiac muscle cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1905563

negative regulation of vascular endothelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904753

negative regulation of vascular associated smooth muscle cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090073

positive regulation of protein homodimerization activity

PMID:19035347[24]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071864

positive regulation of cell proliferation in bone marrow

PMID:18278031[25]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2684360

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071560

cellular response to transforming growth factor beta stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071374

cellular response to parathyroid hormone stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071363

cellular response to growth factor stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071300

cellular response to retinoic acid

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060536

cartilage morphogenesis

PMID:17420000[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3603182

P

has_participant:(EMAPA:17907)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060297

regulation of sarcomere organization

PMID:17875930[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

regulates_o_occurs_in:(EMAPA:17701)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060290

transdifferentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060021

roof of mouth development

PMID:17420000[26]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:101926
MGI:MGI:101927

P

results_in_development_of:(EMAPA:18948)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0055007

cardiac muscle cell differentiation

PMID:20691899[28]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102541
MGI:MGI:95664

P

results_in_acquisition_of_features_of:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0055007

cardiac muscle cell differentiation

PMID:19035347[24]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97350

P

  • occurs_in:(EMAPA:16353)
  • results_in_acquisition_of_features_of:(CL:0000746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051145

smooth muscle cell differentiation

PMID:9778514[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857491

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048704

embryonic skeletal system morphogenesis

PMID:17420000[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3603182

P

has_participant:(EMAPA:18290)|has_participant:(EMAPA:17928)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048703

embryonic viscerocranium morphogenesis

PMID:17420000[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3603182

P

has_participant:(EMAPA:36570)|has_participant:(EMAPA:17682)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048643

positive regulation of skeletal muscle tissue development

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:8900141[30]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96919
MGI:MGI:98510

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20399744[31]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97276

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18093911[32]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99533

P

has_regulation_target:(MGI:MGI:2676818)|has_regulation_target:(MGI:MGI:3618746)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17420000[26]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:101926

P

has_regulation_target:(MGI:MGI:101925)|has_regulation_target:(MGI:MGI:101927)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17336904[33]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:3036234

P

has_regulation_target:(MGI:MGI:88445)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15743821[34]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97275
UniProtKB:P20695
UniProtKB:P56524

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:18086704[35]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17352741[36]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:17336904[33]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(MGI:MGI:88445)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:16818234[37]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:9162005[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857491

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

PMID:9738004[39]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045663

positive regulation of myoblast differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045165

cell fate commitment

PMID:19169261[40]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3603182

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:17336904[33]

ECO:0000314

direct assay evidence used in manual assertion

F

has_input:(MGI:MGI:88445)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043537

negative regulation of blood vessel endothelial cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035914

skeletal muscle cell differentiation

PMID:22147266[41]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0033613

activating transcription factor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030279

negative regulation of ossification

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030224

monocyte differentiation

PMID:18326819[42]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857491

P

  • occurs_in:(EMAPA:32760)
  • results_in_acquisition_of_features_of:(CL:0000576)

Seeded From UniProt

complete

part_of

GO:0030017

sarcomere

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

C

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0014898

cardiac muscle hypertrophy in response to stress

PMID:10531040[43]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_participant:(EMAPA:32748)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010628

positive regulation of gene expression

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010613

positive regulation of cardiac muscle hypertrophy

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007521

muscle cell fate determination

PMID:17786239[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3718323

P

  • occurs_in:(EMAPA:32716)
  • results_in_determination_of:(CL:0000189)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007519

skeletal muscle tissue development

PMID:17786239[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3718323

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:9778514[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857491

P

results_in_development_of:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007507

heart development

PMID:10395786[45]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857491

P

results_in_development_of:(EMAPA:16691)|results_in_development_of:(EMAPA:16694)|results_in_development_of:(EMAPA:16695)|results_in_development_of:(EMAPA:16348)|results_in_development_of:(EMAPA:16697)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006355

regulation of transcription, DNA-templated

PMID:12130539[46]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19796622[47]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18086704[35]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11081517[48]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12130539[46]

ECO:0000305

curator inference used in manual assertion

GO:0003700

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:12130539[46]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

F

Seeded From UniProt

complete

enables

GO:0003682

chromatin binding

PMID:18086704[35]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003680

AT DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:19477969[49]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:16140986[50]

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(MGI:MGI:1891338)

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:14762206[51]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003211

cardiac ventricle formation

PMID:19035347[24]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97350

P

results_in_formation_of:(EMAPA:16350)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0003151

outflow tract morphogenesis

PMID:19035347[24]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97350

P

has_participant:(EMAPA:16346)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002062

chondrocyte differentiation

PMID:17336904[33]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99533

P

  • occurs_in:(EMAPA:18344)
  • regulates_o_results_in_acquisition_of_features_of:(CL:0000743)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001974

blood vessel remodeling

PMID:9162005[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857491

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001974

blood vessel remodeling

PMID:10395786[45]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857491

P

has_participant:(EMAPA:16370)|has_participant:(EMAPA:16104)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001958

endochondral ossification

PMID:17336904[33]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99533

P

occurs_in:(EMAPA:18344)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001958

endochondral ossification

PMID:17336904[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(EMAPA:18344)|occurs_in:(EMAPA:32740)|occurs_in:(EMAPA:36618)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001649

osteoblast differentiation

PMID:17336904[33]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99533

P

  • occurs_in:(EMAPA:18344)
  • regulates_o_results_in_acquisition_of_features_of:(CL:0000062)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001568

blood vessel development

PMID:9778514[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857491

P

occurs_in:(EMAPA:16085)|occurs_in:(EMAPA:16204)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001568

blood vessel development

PMID:17336904[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(EMAPA:19103)|occurs_in:(EMAPA:32743)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:8506376[52]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:17875930[27]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(MGI:MGI:1341430)|has_regulation_target:(MGI:MGI:1328358)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

F

Seeded From UniProt

complete

enables

GO:0000987

proximal promoter sequence-specific DNA binding

PMID:20399744[31]

ECO:0000314

direct assay evidence used in manual assertion

F

has_participant:(MGI:MGI:3612190)

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:18093911[32]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(MGI:MGI:3618746)|has_regulation_target:(MGI:MGI:2676818)

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:17420000[26]

ECO:0000314

direct assay evidence used in manual assertion

F

has_regulation_target:(MGI:MGI:101926)|has_regulation_target:(MGI:MGI:101927)

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1563119

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000165

MAPK cascade

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:7677753[53]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98834

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q06413

P

Seeded From UniProt

complete

part_of

GO:0098794

postsynapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0060079

C

Seeded From UniProt

complete

part_of

GO:0098794

postsynapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0060079

C

Seeded From UniProt

complete

involved_in

GO:2001016

positive regulation of skeletal muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:2000727

positive regulation of cardiac muscle cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:1905563

negative regulation of vascular endothelial cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:1904753

negative regulation of vascular associated smooth muscle cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0071560

cellular response to transforming growth factor beta stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0071374

cellular response to parathyroid hormone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0048643

positive regulation of skeletal muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0045663

positive regulation of myoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0043537

negative regulation of blood vessel endothelial cell migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

C

Seeded From UniProt

complete

enables

GO:0033613

activating transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

C

Seeded From UniProt

complete

involved_in

GO:0030279

negative regulation of ossification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0030182

neuron differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

part_of

GO:0016607

nuclear speck

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

C

Seeded From UniProt

complete

involved_in

GO:0014902

myotube differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

F

Seeded From UniProt

complete

enables

GO:0003680

AT DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

F

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

F

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q06413
ensembl:ENSP00000340874

P

Seeded From UniProt

complete

enables

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033896

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002100
InterPro:IPR036879

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033896

P

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002100
InterPro:IPR036879

F

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-MMU-9021975

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0016528

sarcoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0311

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Harrington, AJ et al. (2016) MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife 5 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Barbosa, AC et al. (2008) MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc. Natl. Acad. Sci. U.S.A. 105 9391-6 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Li, H et al. (2008) Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc. Natl. Acad. Sci. U.S.A. 105 9397-402 PubMed GONUTS page
  4. 4.0 4.1 4.2 Akhtar, MW et al. (2012) In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PLoS ONE 7 e34863 PubMed GONUTS page
  5. 5.0 5.1 5.2 Molkentin, JD et al. (1996) MEF2B is a potent transactivator expressed in early myogenic lineages. Mol. Cell. Biol. 16 3814-24 PubMed GONUTS page
  6. 6.0 6.1 6.2 Han, TH & Prywes, R (1995) Regulatory role of MEF2D in serum induction of the c-jun promoter. Mol. Cell. Biol. 15 2907-15 PubMed GONUTS page
  7. Dechesne, CA et al. (1994) E-box- and MEF-2-independent muscle-specific expression, positive autoregulation, and cross-activation of the chicken MyoD (CMD1) promoter reveal an indirect regulatory pathway. Mol. Cell. Biol. 14 5474-86 PubMed GONUTS page
  8. Lu, J et al. (2000) Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell 6 233-44 PubMed GONUTS page
  9. 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Li, Z et al. (2008) Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells. J. Neurosci. 28 6557-68 PubMed GONUTS page
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  25. Johnnidis, JB et al. (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451 1125-9 PubMed GONUTS page
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  52. Martin, JF et al. (1993) Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc. Natl. Acad. Sci. U.S.A. 90 5282-6 PubMed GONUTS page
  53. Sato, H et al. (1995) Repression of p53-dependent sequence-specific transactivation by MEF2c. Biochem. Biophys. Res. Commun. 214 468-74 PubMed GONUTS page