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PMID:9162005
Citation |
Lin, Q, Schwarz, J, Bucana, C and Olson, EN (1997) Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276:1404-7 |
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Abstract |
Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated with down-regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development. |
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Keywords |
Acyltransferases/metabolism; Animals; Gene Expression Regulation, Developmental; Gene Targeting; Heart/embryology; Heart Ventricles/cytology; Heart Ventricles/embryology; In Situ Hybridization; Mice; Mice, Inbred C57BL; Morphogenesis/genetics; Morphogenesis/physiology; Mutagenesis; Myocardium/cytology; Myogenic Regulatory Factors/genetics; Myogenic Regulatory Factors/physiology; Stem Cells |
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Significance
Annotations
Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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