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PMID:9162005

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Citation

Lin, Q, Schwarz, J, Bucana, C and Olson, EN (1997) Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276:1404-7

Abstract

Members of the myocyte enhancer factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, serum response factor)-box transcription factors bind an A-T-rich DNA sequence associated with muscle-specific genes. The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube. In mice homozygous for a null mutation of MEF2C, the heart tube did not undergo looping morphogenesis, the future right ventricle did not form, and a subset of cardiac muscle genes was not expressed. The absence of the right ventricular region of the mutant heart correlated with down-regulation of the dHAND gene, which encodes a basic helix-loop-helix transcription factor required for cardiac morphogenesis. Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development.

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PubMed

Keywords

Acyltransferases/metabolism; Animals; Gene Expression Regulation, Developmental; Gene Targeting; Heart/embryology; Heart Ventricles/cytology; Heart Ventricles/embryology; In Situ Hybridization; Mice; Mice, Inbred C57BL; Morphogenesis/genetics; Morphogenesis/physiology; Mutagenesis; Myocardium/cytology; Myogenic Regulatory Factors/genetics; Myogenic Regulatory Factors/physiology; Stem Cells

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


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References

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