User:Kelly.huth

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
correctedthroughchallenges	DEIRA:Q9RUY5	2013-03-28 12:15:33 CDT	GO:0019954 asexual reproduction (P)	PMID:23441204	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3A shows that "cells devoid of DR1245 protein showed an important growth defect... The generation time of the Δdr1245 mutant... was approximately three fold that of the wild type strain." This indicates that DR1245 is necessary for cell growth.	challenge
acceptable	HUMAN:MMP26	2013-04-11 11:42:38 CDT	GO:0050728 negative regulation of inflammatory response (P)	PMID:23569462	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2 shows that "over-expression of MMP-26...decreased the expression of inflammatory genes, while its down-regulation exhibited an opposite effect," indicating a "novel anti-inflammatory role for MMP-26."	challenge

acceptable:1
unacceptable:0
requires_changes:0
flagged:0

Annotations challenged by Kelly.huth

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

0 annotations fixed by Kelly.huth

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My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	PSEAE:RHLR	2012-09-22 18:20:09 CDT	GO:0010467 gene expression (P)	PMID:9294432	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4A shows that RhlR was needed for the expression of rhlA9-lacZ in E. coli DH5a(pECP61.5)	challenge
acceptable	PSEAE:LASR	2012-09-18 18:44:02 CDT	GO:0010468 regulation of gene expression (P)	PMID:9294432	ECO:0000314 direct assay evidence used in manual assertion	Table 3 shows that lasB9-lacZ expression in PAI-1 (50 nM) in the presence of LasR was greatly amplified.	challenge
unacceptable	HUMAN:BMP4	2012-09-22 19:57:49 CDT	GO:0007165 signal transduction (P)	PMID:22988237	ECO:0000314 direct assay evidence used in manual assertion	Figure 4D shows the positive regulatory loop of the BMP4 signaling pathway	challenge
acceptable	DANRE:E9QIK2	2012-11-11 20:45:40 CST	GO:0051726 regulation of cell cycle (P)	PMID:23111152	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3(A)(c) shows that in the absence of Mdka, "central retinal progenitors fail to exit the cell cycle at the appropriate developmental stage," implying that "Mdka functions to control cell cycle kinetics."	challenge
acceptable	HORSE:LATH	2012-11-15 08:52:29 CST	GO:0001659 temperature homeostasis (P)	PMID:3753435	ECO:0000314 direct assay evidence used in manual assertion	Table 4 shows that Latherin adsorbs readily to hydrophobic surfaces, rendering them wettable by water at concentrations one or more orders of magnitude lower than of other proteins. This property of the protein may be of functional importance in temperature regulation, as it allows sweat to spread over the animal rather than beading.	challenge
unacceptable	RAT:HMOX1	2012-11-15 19:23:51 CST	GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death (P)	PMID:22989377	ECO:0000314 direct assay evidence used in manual assertion	Figure 1 shows that cells overexpressing HO-1 are protected against peroxide killing	challenge

acceptable:4
unacceptable:2
requires_changes:0
flagged:0

Annotations challenged by Kelly.huth

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

0 annotations fixed by Kelly.huth