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PSEAE:RHLR
Contents
| Species (Taxon ID) | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228). (208964) | |
| Gene Name(s) | rhlR (synonyms: lasM, vsmR) | |
| Protein Name(s) | Regulatory protein RhlR
Elastase modulator | |
| External Links | ||
| UniProt | P54292 | |
| EMBL | U40458 L08962 U15644 AE004091 L28170 | |
| PIR | B83212 C53652 S70174 | |
| RefSeq | NP_252167.1 | |
| ProteinModelPortal | P54292 | |
| SMR | P54292 | |
| STRING | 208964.PA3477 | |
| ChEMBL | CHEMBL3112386 | |
| EnsemblBacteria | AAG06865 | |
| GeneID | 878968 | |
| KEGG | pae:PA3477 | |
| PATRIC | 19841565 | |
| PseudoCAP | PA3477 | |
| eggNOG | COG2771 | |
| HOGENOM | HOG000111053 | |
| InParanoid | P54292 | |
| KO | K18099 | |
| OMA | VMPPEMK | |
| OrthoDB | EOG6P8TQG | |
| PhylomeDB | P54292 | |
| Proteomes | UP000002438 | |
| GO | GO:0003677 GO:0003700 GO:0010467 GO:0046889 GO:0045862 GO:1900378 GO:0009372 GO:0006351 | |
| Gene3D | 1.10.10.10 3.30.450.80 | |
| InterPro | IPR016032 IPR005143 IPR000792 IPR011991 | |
| Pfam | PF03472 PF00196 | |
| PRINTS | PR00038 | |
| SMART | SM00421 | |
| SUPFAM | SSF46894 SSF75516 | |
| PROSITE | PS00622 PS50043 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006355 |
regulation of transcription, DNA-dependent |
ECO:0000315 |
P |
Table 3 shows that cells containing deficient rhlR significantly decrease the transcription of lasB compared to cells containing a fully functional rhlR. Showing that rhlR is a regulator of transcription. |
complete | |||||
| GO:0009372 |
quorum sensing |
ECO:0000314 |
P |
Figure 1A and B show that rhlR is mroe strongly induced when in the presence of autoinducers which shows that rhlR is involved in quorum sensing of P. aeruginosa. |
complete | |||||
|
involved_in |
GO:0010467 |
gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0010467 |
gene expression |
ECO:0000315 |
P |
Figure 4A shows that RhlR was needed for the expression of rhlA9-lacZ in E. coli DH5a(pECP61.5) |
complete | |||||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0005648 |
luciferase reporter gene assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000288 |
RNA protection assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032993 |
protein-DNA complex |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001217 |
DNA-binding transcription repressor activity |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001217 |
DNA-binding transcription repressor activity |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001216 |
DNA-binding transcription activator activity |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001216 |
DNA-binding transcription activator activity |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001216 |
DNA-binding transcription activator activity |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0005667 |
site-directed mutagenesis evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0001807 |
electrophoretic mobility shift assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900378 |
positive regulation of secondary metabolite biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046889 |
positive regulation of lipid biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045862 |
positive regulation of proteolysis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0001217 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0001217 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009372 |
quorum sensing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Brint, JM & Ohman, DE (1995) Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. J. Bacteriol. 177 7155-63 PubMed GONUTS page
- ↑ Pesci, EC et al. (1997) Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 179 3127-32 PubMed GONUTS page
- ↑ 3.0 3.1 Pearson, JP et al. (1997) Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes. J. Bacteriol. 179 5756-67 PubMed GONUTS page
- ↑ Winzer, K et al. (2000) The Pseudomonas aeruginosa lectins PA-IL and PA-IIL are controlled by quorum sensing and by RpoS. J. Bacteriol. 182 6401-11 PubMed GONUTS page
- ↑ Rahim, R et al. (2001) Cloning and functional characterization of the Pseudomonas aeruginosa rhlC gene that encodes rhamnosyltransferase 2, an enzyme responsible for di-rhamnolipid biosynthesis. Mol. Microbiol. 40 708-18 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 González-Valdez, A et al. (2014) The effect of specific rhlA-las-box mutations on DNA binding and gene activation by Pseudomonas aeruginosa quorum-sensing transcriptional regulators RhlR and LasR. FEMS Microbiol. Lett. 356 217-25 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Aguirre-Ramírez, M et al. (2012) The Pseudomonas aeruginosa rmlBDAC operon, encoding dTDP-L-rhamnose biosynthetic enzymes, is regulated by the quorum-sensing transcriptional regulator RhlR and the alternative sigma factor σS. Microbiology (Reading, Engl.) 158 908-16 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Xiao, G et al. (2006) Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry. Microbiology (Reading, Engl.) 152 1679-86 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Medina, G et al. (2003) Mechanism of Pseudomonas aeruginosa RhlR transcriptional regulation of the rhlAB promoter. J. Bacteriol. 185 5976-83 PubMed GONUTS page
- ↑ Ochsner, UA et al. (1994) Isolation and characterization of a regulatory gene affecting rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa. J. Bacteriol. 176 2044-54 PubMed GONUTS page
b
d
p
- GO:0045862 ! positive regulation of proteolysis
- GO:0045893 ! positive regulation of DNA-templated transcription
- GO:1900378 ! positive regulation of secondary metabolite biosynthetic process
- GO:0046889 ! positive regulation of lipid biosynthetic process
- GO:0032993 ! protein-DNA complex
- Proteobacteria
- Pseudomonadaceae
- Pseudomonadales
- Pseudomonas
- Pseudomonas aeruginosa
