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HUMAN:MMP26
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MMP26 | |
| Protein Name(s) | Matrix metalloproteinase-26
MMP-26 Endometase Matrilysin-2 | |
| External Links | ||
| UniProt | Q9NRE1 | |
| EMBL | AF230354 AJ251531 AF248646 AF291664 AF291665 BC101541 BC101543 | |
| CCDS | CCDS7752.1 | |
| RefSeq | NP_068573.2 | |
| UniGene | Hs.204732 | |
| ProteinModelPortal | Q9NRE1 | |
| SMR | Q9NRE1 | |
| STRING | 9606.ENSP00000300762 | |
| BindingDB | Q9NRE1 | |
| ChEMBL | CHEMBL4707 | |
| DrugBank | DB00786 | |
| MEROPS | M10.029 | |
| PhosphoSite | Q9NRE1 | |
| DMDM | 13629493 | |
| Ensembl | ENST00000300762 ENST00000380390 | |
| GeneID | 56547 | |
| KEGG | hsa:56547 | |
| UCSC | uc001lzv.3 | |
| CTD | 56547 | |
| GeneCards | GC11P004726 | |
| HGNC | HGNC:14249 | |
| HPA | HPA022022 | |
| MIM | 605470 | |
| neXtProt | NX_Q9NRE1 | |
| PharmGKB | PA30883 | |
| eggNOG | NOG236071 | |
| GeneTree | ENSGT00760000119132 | |
| HOGENOM | HOG000239471 | |
| HOVERGEN | HBG052484 | |
| InParanoid | Q9NRE1 | |
| KO | K08004 | |
| OMA | HRNGTDL | |
| OrthoDB | EOG7K3TMK | |
| PhylomeDB | Q9NRE1 | |
| TreeFam | TF315428 | |
| GeneWiki | MMP26 | |
| GenomeRNAi | 56547 | |
| NextBio | 62031 | |
| PMAP-CutDB | Q9NRE1 | |
| PRO | PR:Q9NRE1 | |
| Proteomes | UP000005640 | |
| Bgee | Q9NRE1 | |
| CleanEx | HS_MMP26 | |
| Genevestigator | Q9NRE1 | |
| GO | GO:0005578 GO:0004222 GO:0008270 GO:0030574 GO:0006508 | |
| Gene3D | 3.40.390.10 | |
| InterPro | IPR024079 IPR028736 IPR001818 IPR021190 IPR006026 | |
| PANTHER | PTHR10201:SF76 | |
| Pfam | PF00413 | |
| PRINTS | PR00138 | |
| SMART | SM00235 | |
| PROSITE | PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0050728 |
negative regulation of inflammatory response |
ECO:0000315 |
P |
Figure 2 shows that "over-expression of MMP-26...decreased the expression of inflammatory genes, while its down-regulation exhibited an opposite effect," indicating a "novel anti-inflammatory role for MMP-26." |
complete | |||||
|
involved_in |
GO:0050728 |
negative regulation of inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101900 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97005 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Khamis, ZI et al. (2013) The Anti-inflammatory Role of Endometase/Matrilysin-2 in Human Prostate Cancer Cells. J Cancer 4 296-303 PubMed GONUTS page
- ↑ Uría, JA & López-Otín, C (2000) Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity. Cancer Res. 60 4745-51 PubMed GONUTS page
- ↑ Park, HI et al. (2000) Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor. J. Biol. Chem. 275 20540-4 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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