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HUMAN:MMP26

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MMP26
Protein Name(s) Matrix metalloproteinase-26

MMP-26 Endometase Matrilysin-2

External Links
UniProt Q9NRE1
EMBL AF230354
AJ251531
AF248646
AF291664
AF291665
BC101541
BC101543
CCDS CCDS7752.1
RefSeq NP_068573.2
UniGene Hs.204732
ProteinModelPortal Q9NRE1
SMR Q9NRE1
STRING 9606.ENSP00000300762
BindingDB Q9NRE1
ChEMBL CHEMBL4707
DrugBank DB00786
MEROPS M10.029
PhosphoSite Q9NRE1
DMDM 13629493
Ensembl ENST00000300762
ENST00000380390
GeneID 56547
KEGG hsa:56547
UCSC uc001lzv.3
CTD 56547
GeneCards GC11P004726
HGNC HGNC:14249
HPA HPA022022
MIM 605470
neXtProt NX_Q9NRE1
PharmGKB PA30883
eggNOG NOG236071
GeneTree ENSGT00760000119132
HOGENOM HOG000239471
HOVERGEN HBG052484
InParanoid Q9NRE1
KO K08004
OMA HRNGTDL
OrthoDB EOG7K3TMK
PhylomeDB Q9NRE1
TreeFam TF315428
GeneWiki MMP26
GenomeRNAi 56547
NextBio 62031
PMAP-CutDB Q9NRE1
PRO PR:Q9NRE1
Proteomes UP000005640
Bgee Q9NRE1
CleanEx HS_MMP26
Genevestigator Q9NRE1
GO GO:0005578
GO:0004222
GO:0008270
GO:0030574
GO:0006508
Gene3D 3.40.390.10
InterPro IPR024079
IPR028736
IPR001818
IPR021190
IPR006026
PANTHER PTHR10201:SF76
Pfam PF00413
PRINTS PR00138
SMART SM00235
PROSITE PS00142

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050728

negative regulation of inflammatory response

PMID:23569462[1]

ECO:0000315

P

Figure 2 shows that "over-expression of MMP-26...decreased the expression of inflammatory genes, while its down-regulation exhibited an opposite effect," indicating a "novel anti-inflammatory role for MMP-26."

complete
CACAO 7633

involved_in

GO:0050728

negative regulation of inflammatory response

PMID:23569462[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:10987280[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:10801841[3]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030574

collagen catabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101900
MGI:MGI:1276107
MGI:MGI:1340026
MGI:MGI:97008
MGI:MGI:97009
MGI:MGI:97011
PANTHER:PTN001303987
RGD:621316
RGD:621320
UniProtKB:P45452

P

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033438
FB:FBgn0035049
MGI:MGI:1340026
MGI:MGI:1353466
MGI:MGI:97008
MGI:MGI:97011
PANTHER:PTN001303987
UniProtKB:P45452
WB:WBGene00006987
ZFIN:ZDB-GENE-040426-2132

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97005
MGI:MGI:97009
PANTHER:PTN000810753
RGD:3100
RGD:620196
RGD:621316
RGD:621317
RGD:621320
RGD:631408
UniProtKB:B5DFD5
UniProtKB:P02790
UniProtKB:P08253
UniProtKB:P14780
UniProtKB:P22894
UniProtKB:P39900
UniProtKB:P50281
UniProtKB:Q90611

C

Seeded From UniProt

complete

enables

GO:0004222

metalloendopeptidase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033438
MGI:MGI:101900
MGI:MGI:1340026
MGI:MGI:1341867
MGI:MGI:97009
MGI:MGI:97011
PANTHER:PTN001303987
RGD:620196
TAIR:locus:2020548
TAIR:locus:2025891
TAIR:locus:2032467
TAIR:locus:2055605
TAIR:locus:2130928
UniProtKB:O60882
UniProtKB:O75900
UniProtKB:P03956
UniProtKB:P14780
UniProtKB:P39900
UniProtKB:P45452
UniProtKB:P51512
UniProtKB:Q90611
UniProtKB:Q99542

F

Seeded From UniProt

complete

enables

GO:0004222

metalloendopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001818
InterPro:IPR021190
InterPro:IPR028736

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001818
InterPro:IPR006026
InterPro:IPR021190
InterPro:IPR028736

P

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006026
InterPro:IPR024079
InterPro:IPR033739

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001818
InterPro:IPR006026
InterPro:IPR021190
InterPro:IPR033739

F

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001818
InterPro:IPR021190
InterPro:IPR028736

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0008237

metallopeptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0482

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0030574

collagen catabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0177

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Khamis, ZI et al. (2013) The Anti-inflammatory Role of Endometase/Matrilysin-2 in Human Prostate Cancer Cells. J Cancer 4 296-303 PubMed GONUTS page
  2. Uría, JA & López-Otín, C (2000) Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity. Cancer Res. 60 4745-51 PubMed GONUTS page
  3. Park, HI et al. (2000) Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor. J. Biol. Chem. 275 20540-4 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page