RAT:HMOX1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Hmox1
Protein Name(s)	Heme oxygenase 1 HO-1 HSP32
External Links
UniProt	P06762
EMBL	J02722 BC091164
PIR	A92645
RefSeq	NP_036712.1
UniGene	Rn.3160
PDB	1DVE 1DVG 1IRM 1IVJ 1IX3 1IX4 1J02 1J2C 1UBB 1ULX 1VGI 2DY5 2E7E 2ZVU 3I9T 3I9U 3WKT 4G7L 4G7P 4G7T 4G7U 4G8P 4G8U 4G8W 4G98 4G99 4MEC
PDBsum	1DVE 1DVG 1IRM 1IVJ 1IX3 1IX4 1J02 1J2C 1UBB 1ULX 1VGI 2DY5 2E7E 2ZVU 3I9T 3I9U 3WKT 4G7L 4G7P 4G7T 4G7U 4G8P 4G8U 4G8W 4G98 4G99 4MEC
ProteinModelPortal	P06762
SMR	P06762
BioGrid	246615
MINT	MINT-4996356
STRING	10116.ENSRNOP00000019192
BindingDB	P06762
ChEMBL	CHEMBL5035
PhosphoSite	P06762
PaxDb	P06762
PRIDE	P06762
Ensembl	ENSRNOT00000019192
GeneID	24451
KEGG	rno:24451
UCSC	RGD:2806
CTD	3162
RGD	2806
eggNOG	COG5398
GeneTree	ENSGT00390000017673
HOGENOM	HOG000233221
HOVERGEN	HBG005982
InParanoid	P06762
KO	K00510
OMA	YAPLYFP
OrthoDB	EOG7JQBNR
PhylomeDB	P06762
TreeFam	TF314786
Reactome	REACT_248611 REACT_251296
SABIO-RK	P06762
EvolutionaryTrace	P06762
NextBio	603359
PRO	PR:P06762
Proteomes	UP000002494
Genevestigator	P06762
GO	GO:0005901 GO:0005829 GO:0005783 GO:0005789 GO:0005730 GO:0005634 GO:0005886 GO:0019899 GO:0020037 GO:0004392 GO:0046872 GO:0016491 GO:0004630 GO:0004871 GO:0001525 GO:0008219 GO:0071243 GO:0071276 GO:0071456 GO:0031670 GO:0034101 GO:0042167 GO:0006788 GO:0035556 GO:0008630 GO:0055072 GO:0008285 GO:0043392 GO:1902042 GO:0032764 GO:0043305 GO:0010656 GO:0043524 GO:0043433 GO:0048662 GO:0006644 GO:0045766 GO:0043123 GO:0048661 GO:0051260 GO:0008217 GO:0051090 GO:0034395 GO:0043619 GO:0043627 GO:0042542 GO:0001666 GO:0035094 GO:0006979 GO:0007264 GO:0002246
Gene3D	1.20.910.10
InterPro	IPR002051 IPR016053 IPR016084 IPR018207
PANTHER	PTHR10720
Pfam	PF01126
PIRSF	PIRSF000343
PRINTS	PR00088
SUPFAM	SSF48613
PROSITE	PS00593

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	PMID:22989377^[1]	ECO:0000314			P	Figure 1 shows that cells overexpressing HO-1 are protected against peroxide killing	complete CACAO 5914
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	PMID:17430897^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:17430897^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:17430897^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:15516695^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00388	F	Seeded From UniProt	complete
involved_in	GO:0008219	cell death	PMID:17430897^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:3865203^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17430897^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	PMID:3865203^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	PMID:22709785^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1904036	negative regulation of epithelial cell apoptotic process	PMID:22093310^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	PMID:24815159^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:19885007^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:20925964^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:15734876^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:19177228^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:17234154^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	PMID:17234154^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043305	negative regulation of mast cell degranulation	PMID:17234154^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042167	heme catabolic process	PMID:15226268^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:12225959^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032764	negative regulation of mast cell cytokine production	PMID:17234154^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031670	cellular response to nutrient	PMID:15531134^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:12044160^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010656	negative regulation of muscle cell apoptotic process	PMID:12396617^[17]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:11854317^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:16319139^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	PMID:12215473^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	PMID:12511545^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:17020887^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:15226268^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:14766239^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15226268^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:14766239^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14766239^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004630	phospholipase D activity	PMID:12511545^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	PMID:11854317^[18]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:12114196^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:14970910^[25]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:12593860^[26]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 UniProtKB:P09601	P	Seeded From UniProt	complete
involved_in	GO:0042167	heme catabolic process	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 RGD:2806 SGD:S000004195 UniProtKB:P09601	P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 RGD:2806 UniProtKB:P09601	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 SGD:S000004195	C	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 RGD:2806 RGD:67402 SGD:S000004195 UniProtKB:P09601	P	Seeded From UniProt	complete
involved_in	GO:0006788	heme oxidation	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000076411 UniProtKB:P09601	P	Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	PMID:21873635^[27]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037933 PANTHER:PTN000076411 RGD:2806 RGD:67402 SGD:S000004195 UniProtKB:P09601 UniProtKB:P30519 ZFIN:ZDB-GENE-030131-3102	F	Seeded From UniProt	complete
involved_in	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0055072	iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	C	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	F	Seeded From UniProt	complete
involved_in	GO:0042167	heme catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0034101	erythrocyte homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	F	Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0006879	cellular iron ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0006788	heme oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	C	Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	F	Seeded From UniProt	complete
involved_in	GO:0002246	wound healing involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09601 ensembl:ENSP00000216117	P	Seeded From UniProt	complete
involved_in	GO:0072719	cellular response to cisplatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P	Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P	Seeded From UniProt	complete
involved_in	GO:0071243	cellular response to arsenic-containing substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P	Seeded From UniProt	complete
involved_in	GO:0042168	heme metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P	Seeded From UniProt	complete
involved_in	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P	Seeded From UniProt	complete
involved_in	GO:0016242	negative regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P	Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14901 ensembl:ENSMUSP00000005548	C	Seeded From UniProt	complete
enables	GO:0004392	heme oxygenase (decyclizing) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002051 InterPro:IPR016053 InterPro:IPR018207	F	Seeded From UniProt	complete
involved_in	GO:0006788	heme oxidation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002051 InterPro:IPR016053	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002051 InterPro:IPR016053 InterPro:IPR018207	P	Seeded From UniProt	complete
involved_in	GO:0006644	phospholipid metabolic process	PMID:12511545^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12511545^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0492 UniProtKB-SubCell:SL-0166	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lanceta, L et al. (2013) Haem oxygenase-1 overexpression alters intracellular iron distribution. Biochem. J. 449 189-94 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lin, Q et al. (2007) Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J. Biol. Chem. 282 20621-33 PubMed GONUTS page
↑ Higashimoto, Y et al. (2005) Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. J. Biol. Chem. 280 729-37 PubMed GONUTS page
↑ ^4.0 ^4.1 Shibahara, S et al. (1985) Cloning and expression of cDNA for rat heme oxygenase. Proc. Natl. Acad. Sci. U.S.A. 82 7865-9 PubMed GONUTS page
↑ Chen, S et al. (2012) Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1. Food Chem. Toxicol. 50 3025-31 PubMed GONUTS page
↑ Wu, Y et al. (2011) [The role of heme oxygenase 1 in hydrogen peroxide induced apoptosis and mitochondrial trans membrane potential change in rat primary type II alveolar epithelium cells]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23 658-60 PubMed GONUTS page
↑ Chen, KD et al. (2014) Regulation of heme oxygenase 1 expression by miR-27b with stem cell therapy for liver regeneration in rats. Transplant. Proc. 46 1198-200 PubMed GONUTS page
↑ Lee, DH et al. (2009) Aprotinin Inhibits Vascular Smooth Muscle Cell Inflammation and Proliferation via Induction of HO-1. Korean J. Physiol. Pharmacol. 13 123-9 PubMed GONUTS page
↑ Zeng, B et al. (2010) Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium. J. Biomed. Sci. 17 80 PubMed GONUTS page
↑ Szalay, L et al. (2005) Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase. Am. J. Physiol. Heart Circ. Physiol. 289 H92-8 PubMed GONUTS page
↑ González-Reyes, S et al. (2009) Neuroprotective role of heme-oxygenase 1 against iodoacetate-induced toxicity in rat cerebellar granule neurons: Role of bilirubin. Free Radic. Res. 43 214-23 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Yasui, Y et al. (2007) Heme oxygenase-1 inhibits cytokine production by activated mast cells. Biochem. Biophys. Res. Commun. 354 485-90 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Kim, HP et al. (2004) Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J. 18 1080-9 PubMed GONUTS page
↑ Zhang, X et al. (2002) Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 283 L815-29 PubMed GONUTS page
↑ Oermann, E et al. (2004) Effects of 1alpha,25 dihydroxyvitamin D3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex. J. Chem. Neuroanat. 28 225-38 PubMed GONUTS page
↑ Sugishima, M et al. (2002) Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms. Biochemistry 41 7293-300 PubMed GONUTS page
↑ Ke, B et al. (2002) Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum. Gene Ther. 13 1845-57 PubMed GONUTS page
↑ ^18.0 ^18.1 Ozawa, N et al. (2002) Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress. J. Clin. Invest. 109 457-67 PubMed GONUTS page
↑ Hill, M et al. (2005) Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. FASEB J. 19 1957-68 PubMed GONUTS page
↑ Ndisang, JF et al. (2002) Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension 40 315-21 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Johnson, FK et al. (2003) Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats. Hypertension 41 149-55 PubMed GONUTS page
↑ Reiter, TA et al. (2006) Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation. J. Biol. Chem. 281 36603-12 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Li Volti, G et al. (2004) Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate. Biochem. Biophys. Res. Commun. 315 517-24 PubMed GONUTS page
↑ Carter, EP et al. (2002) Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome. Am. J. Physiol. Lung Cell Mol. Physiol. 283 L346-53 PubMed GONUTS page
↑ Li, QF & Dai, AG (2004) Hypoxia inducible factor-1 alpha correlates the expression of heme oxygenase 1 gene in pulmonary arteries of rat with hypoxia-induced pulmonary hypertension. Acta Biochim. Biophys. Sin. (Shanghai) 36 133-40 PubMed GONUTS page
↑ Suzuki, M et al. (2003) Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia. Biochem. Biophys. Res. Commun. 302 138-43 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 ^27.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22989377-1] Lanceta, L et al. (2013) Haem oxygenase-1 overexpression alters intracellular iron distribution. Biochem. J. 449 189-94 PubMed GONUTS page

[PMID:17430897-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lin, Q et al. (2007) Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J. Biol. Chem. 282 20621-33 PubMed GONUTS page

[PMID:15516695-3] Higashimoto, Y et al. (2005) Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. J. Biol. Chem. 280 729-37 PubMed GONUTS page

[PMID:3865203-4] 4.0 ^4.1 Shibahara, S et al. (1985) Cloning and expression of cDNA for rat heme oxygenase. Proc. Natl. Acad. Sci. U.S.A. 82 7865-9 PubMed GONUTS page

[PMID:22709785-5] Chen, S et al. (2012) Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1. Food Chem. Toxicol. 50 3025-31 PubMed GONUTS page

[PMID:22093310-6] Wu, Y et al. (2011) [The role of heme oxygenase 1 in hydrogen peroxide induced apoptosis and mitochondrial trans membrane potential change in rat primary type II alveolar epithelium cells]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23 658-60 PubMed GONUTS page

[PMID:24815159-7] Chen, KD et al. (2014) Regulation of heme oxygenase 1 expression by miR-27b with stem cell therapy for liver regeneration in rats. Transplant. Proc. 46 1198-200 PubMed GONUTS page

[PMID:19885007-8] Lee, DH et al. (2009) Aprotinin Inhibits Vascular Smooth Muscle Cell Inflammation and Proliferation via Induction of HO-1. Korean J. Physiol. Pharmacol. 13 123-9 PubMed GONUTS page

[PMID:20925964-9] Zeng, B et al. (2010) Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium. J. Biomed. Sci. 17 80 PubMed GONUTS page

[PMID:15734876-10] Szalay, L et al. (2005) Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase. Am. J. Physiol. Heart Circ. Physiol. 289 H92-8 PubMed GONUTS page

[PMID:19177228-11] González-Reyes, S et al. (2009) Neuroprotective role of heme-oxygenase 1 against iodoacetate-induced toxicity in rat cerebellar granule neurons: Role of bilirubin. Free Radic. Res. 43 214-23 PubMed GONUTS page

[PMID:17234154-12] 12.0 ^12.1 ^12.2 ^12.3 Yasui, Y et al. (2007) Heme oxygenase-1 inhibits cytokine production by activated mast cells. Biochem. Biophys. Res. Commun. 354 485-90 PubMed GONUTS page

[PMID:15226268-13] 13.0 ^13.1 ^13.2 Kim, HP et al. (2004) Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. FASEB J. 18 1080-9 PubMed GONUTS page

[PMID:12225959-14] Zhang, X et al. (2002) Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 283 L815-29 PubMed GONUTS page

[PMID:15531134-15] Oermann, E et al. (2004) Effects of 1alpha,25 dihydroxyvitamin D3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex. J. Chem. Neuroanat. 28 225-38 PubMed GONUTS page

[PMID:12044160-16] Sugishima, M et al. (2002) Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms. Biochemistry 41 7293-300 PubMed GONUTS page

[PMID:12396617-17] Ke, B et al. (2002) Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum. Gene Ther. 13 1845-57 PubMed GONUTS page

[PMID:11854317-18] 18.0 ^18.1 Ozawa, N et al. (2002) Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress. J. Clin. Invest. 109 457-67 PubMed GONUTS page

[PMID:16319139-19] Hill, M et al. (2005) Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. FASEB J. 19 1957-68 PubMed GONUTS page

[PMID:12215473-20] Ndisang, JF et al. (2002) Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension 40 315-21 PubMed GONUTS page

[PMID:12511545-21] 21.0 ^21.1 ^21.2 ^21.3 Johnson, FK et al. (2003) Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats. Hypertension 41 149-55 PubMed GONUTS page

[PMID:17020887-22] Reiter, TA et al. (2006) Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation. J. Biol. Chem. 281 36603-12 PubMed GONUTS page

[PMID:14766239-23] 23.0 ^23.1 ^23.2 Li Volti, G et al. (2004) Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate. Biochem. Biophys. Res. Commun. 315 517-24 PubMed GONUTS page

[PMID:12114196-24] Carter, EP et al. (2002) Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome. Am. J. Physiol. Lung Cell Mol. Physiol. 283 L346-53 PubMed GONUTS page

[PMID:14970910-25] Li, QF & Dai, AG (2004) Hypoxia inducible factor-1 alpha correlates the expression of heme oxygenase 1 gene in pulmonary arteries of rat with hypoxia-induced pulmonary hypertension. Acta Biochim. Biophys. Sin. (Shanghai) 36 133-40 PubMed GONUTS page

[PMID:12593860-26] Suzuki, M et al. (2003) Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia. Biochem. Biophys. Res. Commun. 302 138-43 PubMed GONUTS page

[PMID:21873635-27] 27.0 ^27.1 ^27.2 ^27.3 ^27.4 ^27.5 ^27.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

RAT:HMOX1

Contents

Annotations

Notes

References

a

c

e

g

h

i

l

m

n

o

p

r

s

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools