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Category:Team Gene Shalit

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableHUMAN:MMP26Kelly.huth, Team Gene Shalit2013-04-11 11:42:38 CDTGO:0050728 negative regulation of inflammatory response (P)PMID:23569462ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 shows that "over-expression of MMP-26...decreased the expression of inflammatory genes, while its down-regulation exhibited an opposite effect," indicating a "novel anti-inflammatory role for MMP-26."

challenge
updatedbyinstructorECOLI:YBJNDimitrios.Spantithos, Team Gene Shalit2013-03-30 13:27:00 CDTGO:0009297 pilus assembly (P)PMID:21980417ECO:0000315 mutant phenotype evidence used in manual assertion

As shown in figure 3C, fimbriae are either malformed or not formed at all in cells with ybjN expression, whereas wild type cells produced substantial fimbriae.

challenge
acceptableECOLI:YBJNDimitrios.Spantithos, Team Gene Shalit2013-03-30 13:27:00 CDTGO:0030308 negative regulation of cell growth (P)PMID:21980417ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 shows over-expression of ybjN leads to growth inhibition

challenge
updatedbyinstructorECOLI:YBJNDimitrios.Spantithos, Team Gene Shalit2013-03-30 13:27:00 CDTGO:1900232 negative regulation of single-species biofilm formation on inanimate substrate (P)PMID:21980417ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 6 shows YbjN is a negative regulator of biofilm formation.

challenge
updatedbyinstructorECOLI:YBJNDimitrios.Spantithos, Team Gene Shalit2013-03-30 13:26:59 CDTGO:1902209 negative regulation of bacterial-type flagellum assembly (P)PMID:21980417ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4C over-expression of ybjN negatively regulates flagellar gene expression.

challenge
correctedthroughchallengesECOK1:A1A992Dimitrios.Spantithos, Team Gene Shalit2013-03-28 14:00:40 CDTGO:0009242 colanic acid biosynthetic process (P)PMID:21980417ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5 shows negatively regulates colanic acid biosynthesis.

challenge
correctedthroughchallengesECOLW:E0IZI8Dimitrios.Spantithos, Team Gene Shalit2013-03-28 13:19:20 CDTGO:0030092 regulation of flagellum assembly (P)PMID:21980417ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4C shows over-expression of ybjN negatively regulates flagellar gene expression.

challenge
correctedthroughchallengesECOK1:A1A992Dimitrios.Spantithos, Team Gene Shalit2013-03-28 13:05:13 CDTGO:0051271 negative regulation of cellular component movement (P)PMID:21980417ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4B shows YbjN suppresses bacterial motility.

challenge
correctedthroughchallengesDEIRA:Q9RUY5Kelly.huth, Team Gene Shalit2013-03-28 12:15:33 CDTGO:0019954 asexual reproduction (P)PMID:23441204ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3A shows that "cells devoid of DR1245 protein showed an important growth defect... The generation time of the Δdr1245 mutant... was approximately three fold that of the wild type strain." This indicates that DR1245 is necessary for cell growth.

challenge

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Pages in category "Team Gene Shalit"

The following 3 pages are in this category, out of 3 total.


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