PMID:23441204

Citation	Norais, C, Servant, P, Bouthier-de-la-Tour, C, Coureux, PD, Ithurbide, S, Vannier, F, Guerin, PP, Dulberger, CL, Satyshur, KA, Keck, JL, Armengaud, J, Cox, MM and Sommer, S (2013) The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones. PLoS ONE 8:e56558
Abstract	The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates.
Links	PubMed PMC3575483 Online version:10.1371/journal.pone.0056558
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
DEIRA:Q9RUY5		GO:0019954: asexual reproduction	ECO:0000315:		P		Figure 3A shows that "cells devoid of DR1245 protein showed an important growth defect... The generation time of the Δdr1245 mutant... was approximately three fold that of the wild type strain." This indicates that DR1245 is necessary for cell growth.	complete CACAO 7113
DEIRA:Q9RUY5	involved_in	GO:0016049: cell growth	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete

References

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