User:Cermakme

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	CAMJE:Q0PBH4	2014-04-04 15:43:54 CDT	GO:1902210 positive regulation of bacterial-type flagellum assembly (P)	PMID:12055288	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2: Electron microscopy images show that C. jejuni flhB mutants lack flagella while wild type C. jejuni have normal flagella and normal cell shape. Figure 3a: Western immunoblot probed with a flagellum-specific monoclonal antibody (P2D3) show that flhB mutants do not express FlaA (a flagellar protein). This decreased expression of flagellar proteins in flhB mutants is believed to partly cause the lack of motility.	challenge
unacceptable	MOUSE:GCST	2014-04-05 13:19:14 CDT		PMID:22171071	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4: Mice that were heterozygous for the AMT- mutation had significantly decreased glycine cleavage system activity than wild type mice. Mice that were homozygous for the AMT- mutation had undetectable levels of GCS activity.	challenge
acceptable	MOUSE:CUL4A	2014-04-05 13:48:43 CDT	GO:0001701 in utero embryonic development (P)	PMID:12077329	ECO:0000315 mutant phenotype evidence used in manual assertion	Table 1: In the group of offspring produced from heterozygous CUL4A mutant crosses, no homozygous CUL4A mutants were viable past the blastocyte stage. There were also significanly fewer heterozygote pups than expected based on mendialian genetics. This shows that CUL4A plays an important role in embryo development.	challenge
acceptable	MOUSE:BMAL1	2014-04-05 14:20:44 CDT	GO:0060137 maternal process involved in parturition (P)	PMID:22697126	ECO:0000315 mutant phenotype evidence used in manual assertion	Table 1: Pregnant female rats with disrupted copies of Bmal1 were significantly less likely rats with normal copies of Bmal1 to give birth at a normal (expected) time.	challenge
unacceptable	?	2014-04-05 23:38:14 CDT	GO:0018991 oviposition (Figure 1: PAK1 Deficient strains of C. elegans (RB689) have decreased numbers of eggs laid per female worm compared to wild type worms.)	PMID:23524941	IMP: Inferred from Mutant Phenotype		challenge
acceptable	MOUSE:FAS	2014-04-05 23:53:52 CDT	GO:0030879 mammary gland development (P)	PMID:24668799	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 6: Average mammary gland lumen size was measured on various days of lactation across three pregnancies in FASN null mutants and wild type lactating mice. The FASN null mutant mice had decreased mammary gland lumen size when compared to wild type lumen size supporting that FASN is involved in mammary gland development.	challenge
unacceptable	RAT:P53	2014-04-06 07:14:12 CDT	GO:0009790 embryo development (P)	PMID:23230510	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3c: Mutant chimeras were created through blastocyte injection. The p53-/ESC- chimeras were the least likely to develop to become neonates when compared to p53+/ESC+ and p53+/ESC- chimeras. Figure 3d: Of the injected chimeras, p53-/ESC- chimeras were the least likey to have normal body size at the end of embryo development when compared to p53+/ESC+ and p53+/ESC- chimera.	challenge

acceptable:3
unacceptable:3
requires_changes:0
flagged:0

Annotations challenged by Cermakme

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
unacceptable	Gandii2, Team Protein Titans	HUMAN:A8KAQ8	GO:0046158 - ocellus pigment metabolic process (P)	PMID:22234890	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2

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