RAT:P53

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Tp53 (synonyms: P53)
Protein Name(s)	Cellular tumor antigen p53 Tumor suppressor p53
External Links
UniProt	P10361
EMBL	X13058 L07910 L07904 L07905 L07906 L07907 L07908 L07909 U90328 BC081788 BC098663
PIR	S02192
RefSeq	NP_112251.2 XP_006246656.1 XP_006246657.1
UniGene	Rn.54443
ProteinModelPortal	P10361
SMR	P10361
BioGrid	246960
DIP	DIP-46016N
IntAct	P10361
MINT	MINT-4651801
STRING	10116.ENSRNOP00000047840
PhosphoSite	P10361
PaxDb	P10361
PRIDE	P10361
Ensembl	ENSRNOT00000046490
GeneID	24842
KEGG	rno:24842
UCSC	RGD:3889
CTD	7157
RGD	3889
eggNOG	NOG80479
GeneTree	ENSGT00390000015092
HOGENOM	HOG000039957
HOVERGEN	HBG005201
InParanoid	P10361
KO	K04451
OMA	IRVEANH
OrthoDB	EOG7JQBNW
PhylomeDB	P10361
TreeFam	TF106101
NextBio	604596
PRO	PR:P10361
Proteomes	UP000002494
ExpressionAtlas	P10361
Genevestigator	P10361
GO	GO:0000785 GO:0005737 GO:0005829 GO:0005783 GO:0005759 GO:0005739 GO:0005730 GO:0005634 GO:0005657 GO:0005667 GO:0005524 GO:0003682 GO:0005507 GO:0003684 GO:0003677 GO:0003690 GO:0097371 GO:0002039 GO:0008022 GO:0043565 GO:0003700 GO:0001221 GO:0044212 GO:0031625 GO:0007568 GO:0007569 GO:0034605 GO:0071417 GO:0034644 GO:0006978 GO:0000733 GO:0042771 GO:0031571 GO:0007275 GO:0030308 GO:2000279 GO:0048662 GO:0000122 GO:0045892 GO:0006289 GO:0097252 GO:0043065 GO:0045787 GO:0031065 GO:0002687 GO:0043525 GO:0090200 GO:0045944 GO:0051262 GO:0051453 GO:0006357 GO:0043200 GO:0031000 GO:0034097 GO:0042493 GO:0010332 GO:0055093 GO:0010035 GO:0010038 GO:0014070 GO:0010243 GO:0006979 GO:0032526 GO:0009411 GO:0010224 GO:0033552 GO:0010165 GO:0006351 GO:0042060
Gene3D	2.60.40.720 4.10.170.10
InterPro	IPR008967 IPR012346 IPR011615 IPR010991 IPR013872 IPR002117
PANTHER	PTHR11447
Pfam	PF00870 PF08563 PF07710
PRINTS	PR00386
SUPFAM	SSF47719 SSF49417
PROSITE	PS00348

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009790	embryo development	PMID:23230510^[1]	ECO:0000315			P		Figure 3c: Mutant chimeras were created through blastocyte injection. The p53-/ESC- chimeras were the least likely to develop to become neonates when compared to p53+/ESC+ and p53+/ESC- chimeras. Figure 3d: Of the injected chimeras, p53-/ESC- chimeras were the least likey to have normal body size at the end of embryo development when compared to p53+/ESC+ and p53+/ESC- chimera.	complete CACAO 9932
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:27031958^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23164821^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1120 ComplexPortal:CPX-1134 UniProtKB:P05067:PRO_0000000092 UniProtKB:P05067:PRO_0000000093	P	regulates_o_occurs_in:(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000008015)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000019422)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSRNOG00000011692)	Seeded From UniProt	complete
involved_in	GO:1903205	regulation of hydrogen peroxide-induced cell death	PMID:17998337^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
involved_in	GO:0048512	circadian behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0043153	entrainment of circadian clock by photoperiod	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11278372^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097252	oligodendrocyte apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:8389468^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:0000733	DNA strand renaturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04637	P		Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	PMID:11502571^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	PMID:23941874^[8]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1305332	F		Seeded From UniProt	complete
involved_in	GO:0071417	cellular response to organonitrogen compound	PMID:11502571^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055093	response to hyperoxia	PMID:18337831^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051453	regulation of intracellular pH	PMID:16688778^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	PMID:17659301^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:18026139^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:20961644^[13]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:15632413^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	PMID:17542038^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:16688778^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:18336558^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	PMID:18337831^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:24817286^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:11295070^[18]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:17651018^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033552	response to vitamin B3	PMID:17516866^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:17962954^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:16330492^[22]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1305332	F		Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	PMID:16544096^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:18093815^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010243	response to organonitrogen compound	PMID:18311796^[25]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	PMID:22559303^[26]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	PMID:17699727^[27]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010038	response to metal ion	PMID:17466256^[28]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010035	response to inorganic substance	PMID:18335527^[29]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:17724205^[30]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	PMID:11278372^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16594	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:18037131^[31]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:17600529^[32]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16282427^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:17661174^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16688778^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:15632413^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16688778^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16282427^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15632413^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002687	positive regulation of leukocyte migration	PMID:18317410^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	PMID:21792911^[36]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:15632413^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17571083^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011615	F		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010991 InterPro:IPR036674	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:11502571^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1210	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kawamata, M & Ochiya, T (2012) Two distinct knockout approaches highlight a critical role for p53 in rat development. Sci Rep 2 945 PubMed GONUTS page
↑ Cai, D et al. (2016) Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis 7 e2161 PubMed GONUTS page
↑ Killick, R et al. (2014) Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol. Psychiatry 19 88-98 PubMed GONUTS page
↑ Li, YZ et al. (2008) p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Mol. Cell. Biol. 28 564-74 PubMed GONUTS page
↑ ^5.0 ^5.1 Buschmann, T et al. (2001) Stabilization and activation of p53 by the coactivator protein TAFII31. J. Biol. Chem. 276 13852-7 PubMed GONUTS page
↑ Maheswaran, S et al. (1993) Physical and functional interaction between WT1 and p53 proteins. Proc. Natl. Acad. Sci. U.S.A. 90 5100-4 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Li, L et al. (2001) Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation. Am. J. Physiol., Cell Physiol. 281 C941-53 PubMed GONUTS page
↑ Bitar, MS et al. (2013) Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Am. J. Physiol. Endocrinol. Metab. 305 E951-63 PubMed GONUTS page
↑ ^9.0 ^9.1 Zhang, Q et al. (2008) Hyperbaric oxygen attenuates apoptosis and decreases inflammation in an ischemic wound model. J. Invest. Dermatol. 128 2102-12 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Huc, L et al. (2006) Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells. J. Cell. Physiol. 208 527-37 PubMed GONUTS page
↑ Wassmann, S et al. (2007) Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. J. Mol. Cell. Cardiol. 43 301-7 PubMed GONUTS page
↑ Wierød, L et al. (2008) Activation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes. Oncogene 27 2763-71 PubMed GONUTS page
↑ Derdak, Z et al. (2011) Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. J. Hepatol. 54 164-72 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Saifudeen, Z et al. (2005) Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation. Am. J. Physiol. Renal Physiol. 288 F899-909 PubMed GONUTS page
↑ Lagranha, CJ et al. () Glutamine supplementation prevents exercise-induced neutrophil apoptosis and reduces p38 MAPK and JNK phosphorylation and p53 and caspase 3 expression. Cell Biochem. Funct. 25 563-9 PubMed GONUTS page
↑ Cansu, A et al. (2008) Effects of chronic treatment with valproate and oxcarbazepine on ovarian folliculogenesis in rats. Epilepsia 49 1192-201 PubMed GONUTS page
↑ Ju, SM et al. (2014) Role of reactive oxygen species in p53 activation during cisplatin-induced apoptosis of rat mesangial cells. Eur Rev Med Pharmacol Sci 18 1135-41 PubMed GONUTS page
↑ Islam, MS et al. () Hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines with different radiothermosensitivity in vitro. Oncol. Rep. 8 501-7 PubMed GONUTS page
↑ Sun, QH et al. (2007) IFN-gamma promotes apoptosis of the uterus and placenta in pregnant rat and human cytotrophoblast cells. J. Interferon Cytokine Res. 27 567-78 PubMed GONUTS page
↑ Spronck, JC et al. (2007) Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cells. Nutr Cancer 57 88-99 PubMed GONUTS page
↑ Zhao, JJ et al. (2008) Retinoic acid downregulates microRNAs to induce abnormal development of spinal cord in spina bifida rat model. Childs Nerv Syst 24 485-92 PubMed GONUTS page
↑ Lee, YS et al. (2006) Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen. J. Pharmacol. Exp. Ther. 317 202-8 PubMed GONUTS page
↑ Nair, VD (2006) Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease. Apoptosis 11 955-66 PubMed GONUTS page
↑ Weaver, CV & Liu, SP (2008) Differentially expressed pro- and anti-apoptogenic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2, and Bcl-w in lung epithelia. Exp. Toxicol. Pathol. 59 265-72 PubMed GONUTS page
↑ Lee, SW et al. (2008) Cilostazol protects rat chondrocytes against nitric oxide-induced apoptosis in vitro and prevents cartilage destruction in a rat model of osteoarthritis. Arthritis Rheum. 58 790-800 PubMed GONUTS page
↑ Galichanin, K et al. (2012) Kinetics of GADD45α, TP53 and CASP3 gene expression in the rat lens in vivo in response to exposure to double threshold dose of UV-B radiation. Exp. Eye Res. 97 19-23 PubMed GONUTS page
↑ Yeoh, AS et al. (2007) A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Mol. Cancer Ther. 6 2319-27 PubMed GONUTS page
↑ Procházka, L et al. (2007) Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex. Arch. Biochem. Biophys. 462 54-61 PubMed GONUTS page
↑ Sun, J & Ding, T (2009) p53 reaction to apoptosis induced by hydroxyapatite nanoparticles in rat macrophages. J Biomed Mater Res A 88 673-9 PubMed GONUTS page
↑ Ayala, M et al. (2007) p53 expression and apoptosis in the lens after ultraviolet radiation exposure. Invest. Ophthalmol. Vis. Sci. 48 4187-91 PubMed GONUTS page
↑ Tamilselvan, J et al. (2007) Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: role of carnitine and lipoic acid. Free Radic. Biol. Med. 43 1656-69 PubMed GONUTS page
↑ Kavurma, MM et al. (2007) Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment. Biochem. J. 407 79-87 PubMed GONUTS page
↑ ^33.0 ^33.1 Siu, PM et al. (2006) Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats. J. Appl. Physiol. 100 907-16 PubMed GONUTS page
↑ Racay, P et al. (2007) Effect of ischemic preconditioning on mitochondrial dysfunction and mitochondrial p53 translocation after transient global cerebral ischemia in rats. Neurochem. Res. 32 1823-32 PubMed GONUTS page
↑ Liu, P et al. (2008) Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion. Shock 30 545-51 PubMed GONUTS page
↑ Chatterjee, A et al. (2011) Analysis of p53 and NF-κB signaling in modulating the cardiomyocyte fate during hypertrophy. J. Cell. Physiol. 226 2543-54 PubMed GONUTS page
↑ Tan, Z et al. (2007) Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death Differ. 14 1721-32 PubMed GONUTS page

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[PMID:11502571-7] 7.0 ^7.1 ^7.2 Li, L et al. (2001) Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation. Am. J. Physiol., Cell Physiol. 281 C941-53 PubMed GONUTS page

[PMID:23941874-8] Bitar, MS et al. (2013) Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Am. J. Physiol. Endocrinol. Metab. 305 E951-63 PubMed GONUTS page

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[PMID:20961644-13] Derdak, Z et al. (2011) Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. J. Hepatol. 54 164-72 PubMed GONUTS page

[PMID:15632413-14] 14.0 ^14.1 ^14.2 ^14.3 Saifudeen, Z et al. (2005) Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation. Am. J. Physiol. Renal Physiol. 288 F899-909 PubMed GONUTS page

[PMID:17542038-15] Lagranha, CJ et al. () Glutamine supplementation prevents exercise-induced neutrophil apoptosis and reduces p38 MAPK and JNK phosphorylation and p53 and caspase 3 expression. Cell Biochem. Funct. 25 563-9 PubMed GONUTS page

[PMID:18336558-16] Cansu, A et al. (2008) Effects of chronic treatment with valproate and oxcarbazepine on ovarian folliculogenesis in rats. Epilepsia 49 1192-201 PubMed GONUTS page

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[PMID:11295070-18] Islam, MS et al. () Hyperthermia-induced apoptosis in two rat yolk sac tumor cell lines with different radiothermosensitivity in vitro. Oncol. Rep. 8 501-7 PubMed GONUTS page

[PMID:17651018-19] Sun, QH et al. (2007) IFN-gamma promotes apoptosis of the uterus and placenta in pregnant rat and human cytotrophoblast cells. J. Interferon Cytokine Res. 27 567-78 PubMed GONUTS page

[PMID:17516866-20] Spronck, JC et al. (2007) Niacin deficiency alters p53 expression and impairs etoposide-induced cell cycle arrest and apoptosis in rat bone marrow cells. Nutr Cancer 57 88-99 PubMed GONUTS page

[PMID:17962954-21] Zhao, JJ et al. (2008) Retinoic acid downregulates microRNAs to induce abnormal development of spinal cord in spina bifida rat model. Childs Nerv Syst 24 485-92 PubMed GONUTS page

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[PMID:18093815-24] Weaver, CV & Liu, SP (2008) Differentially expressed pro- and anti-apoptogenic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2, and Bcl-w in lung epithelia. Exp. Toxicol. Pathol. 59 265-72 PubMed GONUTS page

[PMID:18311796-25] Lee, SW et al. (2008) Cilostazol protects rat chondrocytes against nitric oxide-induced apoptosis in vitro and prevents cartilage destruction in a rat model of osteoarthritis. Arthritis Rheum. 58 790-800 PubMed GONUTS page

[PMID:22559303-26] Galichanin, K et al. (2012) Kinetics of GADD45α, TP53 and CASP3 gene expression in the rat lens in vivo in response to exposure to double threshold dose of UV-B radiation. Exp. Eye Res. 97 19-23 PubMed GONUTS page

[PMID:17699727-27] Yeoh, AS et al. (2007) A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Mol. Cancer Ther. 6 2319-27 PubMed GONUTS page

[PMID:17466256-28] Procházka, L et al. (2007) Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex. Arch. Biochem. Biophys. 462 54-61 PubMed GONUTS page

[PMID:18335527-29] Sun, J & Ding, T (2009) p53 reaction to apoptosis induced by hydroxyapatite nanoparticles in rat macrophages. J Biomed Mater Res A 88 673-9 PubMed GONUTS page

[PMID:17724205-30] Ayala, M et al. (2007) p53 expression and apoptosis in the lens after ultraviolet radiation exposure. Invest. Ophthalmol. Vis. Sci. 48 4187-91 PubMed GONUTS page

[PMID:18037131-31] Tamilselvan, J et al. (2007) Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: role of carnitine and lipoic acid. Free Radic. Biol. Med. 43 1656-69 PubMed GONUTS page

[PMID:17600529-32] Kavurma, MM et al. (2007) Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment. Biochem. J. 407 79-87 PubMed GONUTS page

[PMID:16282427-33] 33.0 ^33.1 Siu, PM et al. (2006) Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats. J. Appl. Physiol. 100 907-16 PubMed GONUTS page

[PMID:17661174-34] Racay, P et al. (2007) Effect of ischemic preconditioning on mitochondrial dysfunction and mitochondrial p53 translocation after transient global cerebral ischemia in rats. Neurochem. Res. 32 1823-32 PubMed GONUTS page

[PMID:18317410-35] Liu, P et al. (2008) Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion. Shock 30 545-51 PubMed GONUTS page

[PMID:21792911-36] Chatterjee, A et al. (2011) Analysis of p53 and NF-κB signaling in modulating the cardiomyocyte fate during hypertrophy. J. Cell. Physiol. 226 2543-54 PubMed GONUTS page

[PMID:17571083-37] Tan, Z et al. (2007) Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death Differ. 14 1721-32 PubMed GONUTS page

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