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PMID:20961644

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Citation

Derdak, Z, Lang, CH, Villegas, KA, Tong, M, Mark, NM, de la Monte, SM and Wands, JR (2011) Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. J. Hepatol. 54:164-72

Abstract

Chronic ethanol consumption in the Long-Evans (LE) rat has been associated with hepatic p53 activation, and inhibition of the insulin/PI3K/AKT signal transduction cascade due to increased expression of PTEN. We hypothesize that p53 activation and altered insulin signaling may influence the susceptibility of rats to ethanol-induced liver damage. Furthermore, p53 not only activates programmed cell death pathways and suppresses hepatocellular survival signals, but also promotes gluconeogenesis to increase systemic insulin resistance due to a novel metabolic function.

Links

PubMed PMC2994971 Online version:10.1016/j.jhep.2010.08.007

Keywords

Alanine Transaminase/metabolism; Animals; Apoptosis/physiology; Apoptosis Regulatory Proteins/metabolism; Caspase 3/metabolism; DNA Damage; DNA, Mitochondrial/metabolism; Disease Models, Animal; Fatty Liver, Alcoholic/metabolism; Fatty Liver, Alcoholic/pathology; Fructosediphosphates/metabolism; Gluconeogenesis; Insulin Resistance/physiology; Liver Diseases, Alcoholic/metabolism; Liver Diseases, Alcoholic/pathology; Male; Oxidative Stress; PTEN Phosphohydrolase/metabolism; Poly(ADP-ribose) Polymerases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Rats; Rats, Inbred F344; Rats, Long-Evans; Rats, Sprague-Dawley; Signal Transduction; Species Specificity; Sterol Regulatory Element Binding Protein 1/metabolism; Tumor Suppressor Protein p53/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:P53

involved_in

GO:0045471: response to ethanol

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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