PMID:18311796

Citation	Lee, SW, Song, YS, Shin, SH, Kim, KT, Park, YC, Park, BS, Yun, I, Kim, K, Lee, SY, Chung, WT, Lee, HJ and Yoo, YH (2008) Cilostazol protects rat chondrocytes against nitric oxide-induced apoptosis in vitro and prevents cartilage destruction in a rat model of osteoarthritis. Arthritis Rheum. 58:790-800
Abstract	To examine whether cilostazol, a selective phosphodiesterase type III inhibitor, protects rat articular chondrocytes against nitric oxide (NO)-induced apoptosis and prevents cartilage destruction in mono-iodoacetate-induced osteoarthritis (OA) in a rat model in which inducible nitric oxide synthase (iNOS) is expressed.
Links	PubMed Online version:10.1002/art.23220
Keywords	Animals; Apoptosis/drug effects; BH3 Interacting Domain Death Agonist Protein/metabolism; Cartilage, Articular/drug effects; Cartilage, Articular/metabolism; Cartilage, Articular/pathology; Casein Kinase II/metabolism; Caspases/metabolism; Cells, Cultured; Chondrocytes/drug effects; Chondrocytes/metabolism; Chondrocytes/pathology; Disease Models, Animal; Dose-Response Relationship, Drug; Nitric Oxide/adverse effects; Nitric Oxide/pharmacology; Nitric Oxide Synthase Type II/metabolism; Osteoarthritis, Knee/metabolism; Osteoarthritis, Knee/pathology; Osteoarthritis, Knee/prevention & control; Phosphodiesterase Inhibitors/pharmacology; Phosphodiesterase Inhibitors/therapeutic use; Rats; Rats, Sprague-Dawley; Tetrazoles/pharmacology; Tetrazoles/therapeutic use; Tumor Suppressor Protein p53/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:P53	involved_in	GO:0010243: response to organonitrogen compound	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete

References

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