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MOUSE:GCST
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Amt | |
| Protein Name(s) | Aminomethyltransferase, mitochondrial
Glycine cleavage system T protein GCVT | |
| External Links | ||
| UniProt | Q8CFA2 | |
| EMBL | AJ437692 | |
| CCDS | CCDS23519.1 | |
| RefSeq | NP_001013836.1 | |
| UniGene | Mm.390225 | |
| ProteinModelPortal | Q8CFA2 | |
| SMR | Q8CFA2 | |
| IntAct | Q8CFA2 | |
| MINT | MINT-1846242 | |
| PhosphoSite | Q8CFA2 | |
| MaxQB | Q8CFA2 | |
| PaxDb | Q8CFA2 | |
| PRIDE | Q8CFA2 | |
| Ensembl | ENSMUST00000035230 | |
| GeneID | 434437 | |
| KEGG | mmu:434437 | |
| UCSC | uc009rpc.1 | |
| CTD | 275 | |
| MGI | MGI:3646700 | |
| eggNOG | COG0404 | |
| GeneTree | ENSGT00510000047333 | |
| HOGENOM | HOG000239380 | |
| HOVERGEN | HBG005822 | |
| InParanoid | Q8CFA2 | |
| KO | K00605 | |
| OMA | LGWLVHL | |
| OrthoDB | EOG7KM5SQ | |
| PhylomeDB | Q8CFA2 | |
| TreeFam | TF313026 | |
| NextBio | 409655 | |
| PRO | PR:Q8CFA2 | |
| Proteomes | UP000000589 | |
| Bgee | Q8CFA2 | |
| CleanEx | MM_AMT | |
| ExpressionAtlas | Q8CFA2 | |
| Genevestigator | Q8CFA2 | |
| GO | GO:0005739 GO:0004047 GO:0008483 GO:0006546 | |
| Gene3D | 2.40.30.110 3.30.1360.120 | |
| InterPro | IPR006223 IPR028896 IPR013977 IPR006222 IPR029043 IPR027266 | |
| PANTHER | PTHR13847:SF5 | |
| Pfam | PF01571 PF08669 | |
| PIRSF | PIRSF006487 | |
| SUPFAM | SSF101790 | |
| TIGRFAMs | TIGR00528 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0019464 |
ECO:0000315 |
Figure 4: Mice that were heterozygous for the AMT- mutation had significantly decreased glycine cleavage system activity than wild type mice. Mice that were homozygous for the AMT- mutation had undetectable levels of GCS activity. |
complete | |||||||
|
enables |
GO:0004047 |
aminomethyltransferase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019464 |
glycine decarboxylation via glycine cleavage system |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019464 |
glycine decarboxylation via glycine cleavage system |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002464725 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000354060 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004047 |
aminomethyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002464725 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0019464 |
glycine decarboxylation via glycine cleavage system |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004047 |
aminomethyltransferase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004047 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004047 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004047 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004047 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004047 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004047 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019464 |
glycine decarboxylation via glycine cleavage system |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48728 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48728 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48728 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004047 |
aminomethyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48728 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024R2U7 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A024R2U7 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004047 |
aminomethyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006546 |
glycine catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004047 |
aminomethyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008483 |
transaminase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Narisawa, A et al. (2012) Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans. Hum. Mol. Genet. 21 1496-503 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
