GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:24668799
| Citation |
'Suburu, J, Shi, L, Wu, J, Wang, S, Samuel, M, Thomas, MJ, Kock, ND, Yang, G, Kridel, S and Chen, YQ (2014) Fatty Acid Synthase is Required for Mammary Gland Development and Milk Production during Lactation. Am. J. Physiol. Endocrinol. Metab. ' |
|---|---|
| Abstract |
The mammary gland is one of few adult tissues that strongly induce de novo fatty acid synthesis upon physiological stimulation, suggesting that fatty acid is important for milk production during lactation. The committed enzyme to perform this function is fatty acid synthase (FASN). To determine whether de novo fatty acid synthesis is obligatory or dietary fat is sufficient for mammary gland development and function during lactation, Fasn was specifically knocked out in mouse mammary epithelial cells. We found that deletion of Fasn hindered the development and induced premature involution of the lactating mammary gland, significantly decreased short- and medium-chain fatty acids and total fatty acid contents in the milk. Consequently, pups nursing from Fasn knockout mothers experienced growth retardation and pre-weanling death, which was rescued by cross-fostering pups to a lactating wild type mother. These results demonstrate that FASN is essential for the development, functional competence, and maintenance of the lactating mammary gland. |
| Links |
PubMed Online version:10.1152/ajpendo.00514.2013 |
| Keywords |
|
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0030879: mammary gland development |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0030879: mammary gland development |
ECO:0000315: |
P |
Figure 6: Average mammary gland lumen size was measured on various days of lactation across three pregnancies in FASN null mutants and wild type lactating mice. The FASN null mutant mice had decreased mammary gland lumen size when compared to wild type lumen size supporting that FASN is involved in mammary gland development. |
complete | ||||
See also
References
See Help:References for how to manage references in GONUTS.
