MOUSE:FAS

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fasn
Protein Name(s)	Fatty acid synthase [Acyl-carrier-protein] S-acetyltransferase [Acyl-carrier-protein] S-malonyltransferase 3-oxoacyl-[acyl-carrier-protein] synthase 3-oxoacyl-[acyl-carrier-protein] reductase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase Enoyl-[acyl-carrier-protein] reductase Oleoyl-[acyl-carrier-protein] hydrolase
External Links
UniProt	P19096
EMBL	AF127033 AL663090 BC046513 BC059850 AK080374 X13135
CCDS	CCDS25759.1
PIR	A32262
RefSeq	NP_032014.3
UniGene	Mm.236443
ProteinModelPortal	P19096
SMR	P19096
BioGrid	199596
IntAct	P19096
MINT	MINT-2514287
BindingDB	P19096
ChEMBL	CHEMBL1795189
PhosphoSite	P19096
MaxQB	P19096
PaxDb	P19096
PRIDE	P19096
Ensembl	ENSMUST00000055655
GeneID	14104
KEGG	mmu:14104
UCSC	uc007mut.1
CTD	2194
MGI	MGI:95485
eggNOG	COG3319
GeneTree	ENSGT00530000063309
HOGENOM	HOG000019642
HOVERGEN	HBG005640
InParanoid	P19096
KO	K00665
OMA	DAMAISM
OrthoDB	EOG71K623
PhylomeDB	P19096
TreeFam	TF300549
Reactome	REACT_198969 REACT_221573 REACT_231395 REACT_255695
NextBio	285138
PRO	PR:P19096
Proteomes	UP000000589
Bgee	P19096
CleanEx	MM_FASN
Genevestigator	P19096
GO	GO:0070062 GO:0042587 GO:0005794 GO:0042470 GO:0005739 GO:0005886 GO:0047451 GO:0004317 GO:0004316 GO:0004315 GO:0004313 GO:0004314 GO:0008144 GO:0047117 GO:0004319 GO:0016295 GO:0070402 GO:0004320 GO:0016296 GO:0044822 GO:0008270 GO:0006084 GO:0071353 GO:0006633 GO:0001649
Gene3D	1.10.1200.10 1.10.1470.20 3.40.366.10 3.40.47.10 3.40.50.150 3.40.50.1820 3.40.50.720
InterPro	IPR029058 IPR001227 IPR009081 IPR014043 IPR016035 IPR013149 IPR023102 IPR011032 IPR018201 IPR014031 IPR014030 IPR016036 IPR013217 IPR016040 IPR020843 IPR013968 IPR006162 IPR029063 IPR001031 IPR016039 IPR016038
Pfam	PF00698 PF00107 PF00109 PF02801 PF08659 PF08242 PF00550 PF00975
SMART	SM00829 SM00822
SUPFAM	SSF47336 SSF50129 SSF52151 SSF53335 SSF53474 SSF53901 SSF55048
PROSITE	PS50075 PS00606 PS00012

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030879	mammary gland development	PMID:24668799^[1]	ECO:0000315			P		Figure 6: Average mammary gland lumen size was measured on various days of lactation across three pregnancies in FASN null mutants and wild type lactating mice. The FASN null mutant mice had decreased mammary gland lumen size when compared to wild type lumen size supporting that FASN is involved in mammary gland development.	complete CACAO 9931
involved_in	GO:0030879	mammary gland development	PMID:24668799^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090557	establishment of endothelial intestinal barrier	PMID:25565205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3765070	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071353	cellular response to interleukin-4	PMID:9798653^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070402	NADPH binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048468	cell development	PMID:25565205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3765070	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620665	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620665	F		Seeded From UniProt	complete
part_of	GO:0042587	glycogen granule	PMID:15169678^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16728) part_of:(CL:0000326)	Seeded From UniProt	complete
involved_in	GO:0030224	monocyte differentiation	PMID:25565205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3765070	P	occurs_in:(EMAPA:32760)	Seeded From UniProt	complete
involved_in	GO:0030223	neutrophil differentiation	PMID:25565205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3765070	P	occurs_in:(EMAPA:32760)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009888	tissue development	PMID:25565205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3765070	P		Seeded From UniProt	complete
involved_in	GO:0008611	ether lipid biosynthetic process	PMID:25565205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3765070	P	occurs_in:(CL:0000775) occurs_in:(EMAPA:32760) occurs_in:(UBERON:0000061) part_of:(GO:0030223)	Seeded From UniProt	complete
involved_in	GO:0008611	ether lipid biosynthetic process	PMID:25565205^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3765070	P	occurs_in:(CL:0000576) occurs_in:(EMAPA:32760) occurs_in:(UBERON:0000061) part_of:(GO:0030224)	Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620665	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006633	fatty acid biosynthetic process	PMID:22331133^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006633	fatty acid biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620665	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006084	acetyl-CoA metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620665	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49327	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49327	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49327	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620665	C		Seeded From UniProt	complete
enables	GO:0004312	fatty acid synthase activity	PMID:22331133^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004312	fatty acid synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620665	F		Seeded From UniProt	complete
enables	GO:0070402	NADPH binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12785 ensembl:ENSRNOP00000064445	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12785 ensembl:ENSRNOP00000064445	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12785 ensembl:ENSRNOP00000064445	F		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12785 ensembl:ENSRNOP00000064445	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12785 ensembl:ENSRNOP00000064445	P		Seeded From UniProt	complete
involved_in	GO:0006084	acetyl-CoA metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12785 ensembl:ENSRNOP00000064445	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12785 ensembl:ENSRNOP00000064445	C		Seeded From UniProt	complete
enables	GO:0004312	fatty acid synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P12785 ensembl:ENSRNOP00000064445	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49327 ensembl:ENSP00000304592	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49327 ensembl:ENSP00000304592	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49327 ensembl:ENSP00000304592	C		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016039	F		Seeded From UniProt	complete
enables	GO:0004312	fatty acid synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR023102	F		Seeded From UniProt	complete
involved_in	GO:0009058	biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001031	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020843	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001227	F		Seeded From UniProt	complete
enables	GO:0016788	hydrolase activity, acting on ester bonds	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001031	F		Seeded From UniProt	complete
enables	GO:0031177	phosphopantetheine binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020806	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013149	P		Seeded From UniProt	complete
enables	GO:0047451	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.1.59	F		Seeded From UniProt	complete
enables	GO:0004312	fatty acid synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.85	F		Seeded From UniProt	complete
enables	GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.1.59	F		Seeded From UniProt	complete
enables	GO:0047117	enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.3.1.39	F		Seeded From UniProt	complete
enables	GO:0016296	palmitoyl-[acyl-carrier-protein] hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.2.14	F		Seeded From UniProt	complete
enables	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.41	F		Seeded From UniProt	complete
enables	GO:0016419	S-malonyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.39	F		Seeded From UniProt	complete
enables	GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.2.14	F		Seeded From UniProt	complete
enables	GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.100	F		Seeded From UniProt	complete
enables	GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.2.14	F		Seeded From UniProt	complete
enables	GO:0102131	3-oxo-glutaryl-[acp] methyl ester reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.100	F		Seeded From UniProt	complete
enables	GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.39	F		Seeded From UniProt	complete
enables	GO:0008659	(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:4.2.1.59	F		Seeded From UniProt	complete
enables	GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.38	F		Seeded From UniProt	complete
enables	GO:0016295	myristoyl-[acyl-carrier-protein] hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.2.14	F		Seeded From UniProt	complete
enables	GO:0102132	3-oxo-pimeloyl-[acp] methyl ester reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.100	F		Seeded From UniProt	complete
enables	GO:0016418	S-acetyltransferase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.38	F		Seeded From UniProt	complete
enables	GO:0004312	fatty acid synthase activity	PMID:25565205^[2] PMID:25565205^[2] PMID:25565205^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275	P		Seeded From UniProt	complete
enables	GO:0016829	lyase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0456	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Suburu, J et al. (2014) Fatty acid synthase is required for mammary gland development and milk production during lactation. Am. J. Physiol. Endocrinol. Metab. 306 E1132-43 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Lodhi, IJ et al. (2015) Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metab. 21 51-64 PubMed GONUTS page
↑ Chu, CC & Paul, WE (1998) Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol. Immunol. 35 487-502 PubMed GONUTS page
↑ Ridsdale, R & Post, M (2004) Surfactant lipid synthesis and lamellar body formation in glycogen-laden type II cells. Am. J. Physiol. Lung Cell Mol. Physiol. 287 L743-51 PubMed GONUTS page
↑ ^5.0 ^5.1 Jeon, BN et al. (2012) Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter. J. Lipid Res. 53 755-66 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:24668799-1] 1.0 ^1.1 Suburu, J et al. (2014) Fatty acid synthase is required for mammary gland development and milk production during lactation. Am. J. Physiol. Endocrinol. Metab. 306 E1132-43 PubMed GONUTS page

[PMID:25565205-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Lodhi, IJ et al. (2015) Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metab. 21 51-64 PubMed GONUTS page

[PMID:9798653-3] Chu, CC & Paul, WE (1998) Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol. Immunol. 35 487-502 PubMed GONUTS page

[PMID:15169678-4] Ridsdale, R & Post, M (2004) Surfactant lipid synthesis and lamellar body formation in glycogen-laden type II cells. Am. J. Physiol. Lung Cell Mol. Physiol. 287 L743-51 PubMed GONUTS page

[PMID:22331133-5] 5.0 ^5.1 Jeon, BN et al. (2012) Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter. J. Lipid Res. 53 755-66 PubMed GONUTS page

[PMID:18614015-6] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

MOUSE:FAS

Contents

Annotations

Notes

References

(

3

a

b

c

e

f

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools