MOUSE:BMAL1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Arntl (synonyms: Bmal1)
Protein Name(s)	Aryl hydrocarbon receptor nuclear translocator-like protein 1 Arnt3 Brain and muscle ARNT-like 1
External Links
UniProt	Q9WTL8
EMBL	AB012601 AB015203 AB012602 AB014494 BC025973 BC011080
CCDS	CCDS40092.1
PIR	JE0270
RefSeq	NP_001229977.1 NP_031515.1 XP_006507314.1
UniGene	Mm.440371
PDB	4F3L
PDBsum	4F3L
DisProt	DP00735
ProteinModelPortal	Q9WTL8
SMR	Q9WTL8
BioGrid	198207
DIP	DIP-43977N
IntAct	Q9WTL8
MINT	MINT-1657344
PhosphoSite	Q9WTL8
MaxQB	Q9WTL8
PaxDb	Q9WTL8
PRIDE	Q9WTL8
Ensembl	ENSMUST00000047321
GeneID	11865
KEGG	mmu:11865
UCSC	uc009jhf.2 uc009jhi.2 uc009jhj.2
CTD	406
MGI	MGI:1096381
eggNOG	NOG293303
GeneTree	ENSGT00760000118788
HOGENOM	HOG000234379
HOVERGEN	HBG107503
InParanoid	Q9WTL8
KO	K02296
OMA	EKINTNC
OrthoDB	EOG7V1FQ8
PhylomeDB	Q9WTL8
TreeFam	TF319983
Reactome	REACT_115781 REACT_118837 REACT_198351 REACT_198352 REACT_198602 REACT_198620 REACT_241925 REACT_24972
NextBio	279875
PRO	PR:Q9WTL8
Proteomes	UP000000589
Bgee	Q9WTL8
ExpressionAtlas	Q9WTL8
Genevestigator	Q9WTL8
GO	GO:0033391 GO:0005737 GO:0005829 GO:0016604 GO:0005654 GO:0005634 GO:0016605 GO:0005667 GO:0043425 GO:0001047 GO:0001046 GO:0003677 GO:0070888 GO:0046982 GO:0000982 GO:0001077 GO:0001190 GO:0043565 GO:0003700 GO:0004871 GO:0008134 GO:0000976 GO:0032922 GO:0007623 GO:0045599 GO:2000323 GO:0032007 GO:0045892 GO:0090403 GO:0090263 GO:0042753 GO:2001016 GO:0045944 GO:0045893 GO:0043161 GO:0000060 GO:0051726 GO:2000772 GO:0042634 GO:0050796 GO:0050767 GO:0042176 GO:0006355 GO:2000074 GO:0051775 GO:0007283 GO:0006366
Gene3D	4.10.280.10
InterPro	IPR011598 IPR001067 IPR001610 IPR000014 IPR013767
Pfam	PF00010 PF00989
PRINTS	PR00785
SMART	SM00353 SM00086 SM00091
SUPFAM	SSF47459 SSF55785
TIGRFAMs	TIGR00229
PROSITE	PS50888 PS50112

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0016563	transcription activator activity	PMID:9616112^[1]	ECO:0000314			F		Fig 4B to 4D show CLOCK, BMAL1 assayed at transcriptional activation sites in the luciferase reporter derived from the 5' flanking region of the mper1 gene. Transcriptional activator activity is present only when both CLOCK and BMAL1 are present.	complete
	GO:0005634	nucleus	PMID:12897057^[2]	ECO:0000314			C		Fig 3. Fluorescently-labeled BMAL1 was found to be concentrated in the nucleus	complete
	GO:0060137	maternal process involved in parturition	PMID:22697126^[3]	ECO:0000315			P		Table 1: Pregnant female rats with disrupted copies of Bmal1 were significantly less likely rats with normal copies of Bmal1 to give birth at a normal (expected) time.	complete CACAO 9887
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:15147242^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26776516^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:25749863^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901985	positive regulation of protein acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00327	P		Seeded From UniProt	complete
involved_in	GO:1901985	positive regulation of protein acetylation	PMID:28985504^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060137	maternal process involved in parturition	PMID:22697126^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:24043798^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:24051492^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:21113167^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22208286^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19299583^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:19299583^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24089055^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:24089055^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20861012^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20861012^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:19740747^[15]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:19217292^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:22894897^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:21768648^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21768648^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:20106950^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:15193144^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14503	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:12397359^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99PV5	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:12397359^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14503	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15193144^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSMUSG00000020893)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14672706^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15147242^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:15193144^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14503	F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:15560782^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14503	F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:12397359^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99PV5	F		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	PMID:12397359^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14503	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:15560782^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:14672706^[22]	ECO:0000305	curator inference used in manual assertion	GO:0045944	F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:15147242^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2001016	positive regulation of skeletal muscle cell differentiation	PMID:23525013^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000772	regulation of cellular senescence	PMID:22101268^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	PMID:24378737^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000074	regulation of type B pancreatic cell development	PMID:20562852^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090403	oxidative stress-induced premature senescence	PMID:22101268^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:23525013^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:22611086^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:24736997^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:19605937^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051775	response to redox state	PMID:23831463^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:24268780^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:20562852^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	PMID:24268780^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:23525013^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20430893^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24481314^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24048828^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18316400^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:12397359^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24736997^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19605937^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24378737^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	PMID:22611086^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21613214^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	PMID:23395176^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042753	positive regulation of circadian rhythm	PMID:19605937^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042634	regulation of hair cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00327	P		Seeded From UniProt	complete
part_of	GO:0033391	chromatoid body	PMID:22900038^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:23525013^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:22611086^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:20562852^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:19141540^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:24736997^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:22653727^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	PMID:24481314^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:14645221^[42]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:22900038^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:22653727^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:22653727^[41]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:23831463^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:24385426^[43]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21680841^[44]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901985	positive regulation of protein acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	F		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	F		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051775	response to redox state	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16606840^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99698	P	has_regulation_target:(MGI:MGI:1098283)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19217292^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62003	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042634	regulation of hair cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042176	regulation of protein catabolic process	PMID:12897057^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032922	circadian regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	P		Seeded From UniProt	complete
enables	GO:0017162	aryl hydrocarbon receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	F		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	PMID:18644859^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:11707566^[47]	ECO:0000247	sequence alignment evidence used in manual assertion	EMBL:AJ318060	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:17264215^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:11163178^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2180361	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:12897057^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:12843397^[50]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:12150932^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007623	circadian rhythm	PMID:12024206^[52]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	PMID:12897057^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12024206^[52]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:16606840^[45]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12897057^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:62003	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9704006^[53]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12024206^[52]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11707566^[47]	ECO:0000247	sequence alignment evidence used in manual assertion	EMBL:AJ318060	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:9704006^[53]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q61221	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00327	F		Seeded From UniProt	complete
involved_in	GO:1901985	positive regulation of protein acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	F		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	F		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	F		Seeded From UniProt	complete
involved_in	GO:0051775	response to redox state	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	C		Seeded From UniProt	complete
involved_in	GO:0042634	regulation of hair cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	P		Seeded From UniProt	complete
enables	GO:0017162	aryl hydrocarbon receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00327 ensembl:ENSP00000384517	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001067 InterPro:IPR013767	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011598 InterPro:IPR036638	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-549451 Reactome:R-MMU-508681 Reactome:R-MMU-508656 Reactome:R-MMU-508619	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8878686 Reactome:R-MMU-5669295 Reactome:R-MMU-5663189 Reactome:R-MMU-5663185 Reactome:R-MMU-5663172 Reactome:R-MMU-5663169 Reactome:R-MMU-5663161 Reactome:R-MMU-5663158 Reactome:R-MMU-5663147 Reactome:R-MMU-5663146 Reactome:R-MMU-5663129 Reactome:R-MMU-5663114 Reactome:R-MMU-508741 Reactome:R-MMU-508656	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gekakis, N et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280 1564-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kondratov, RV et al. (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev. 17 1921-32 PubMed GONUTS page
↑ ^3.0 ^3.1 Ratajczak, CK et al. (2012) Generation of myometrium-specific Bmal1 knockout mice for parturition analysis. Reprod. Fertil. Dev. 24 759-67 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Hamaguchi, H et al. (2004) Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem. J. 382 43-50 PubMed GONUTS page
↑ Shi, G et al. (2016) Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep 14 823-834 PubMed GONUTS page
↑ Nam, D et al. (2015) The adipocyte clock controls brown adipogenesis through the TGF-β and BMP signaling pathways. J. Cell. Sci. 128 1835-47 PubMed GONUTS page
↑ Lin, R et al. (2017) CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol. Cell 68 198-209.e6 PubMed GONUTS page
↑ Lande-Diner, L et al. (2013) A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc. Natl. Acad. Sci. U.S.A. 110 16021-6 PubMed GONUTS page
↑ Miki, T et al. (2013) p53 regulates Period2 expression and the circadian clock. Nat Commun 4 2444 PubMed GONUTS page
↑ Katada, S & Sassone-Corsi, P (2010) The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat. Struct. Mol. Biol. 17 1414-21 PubMed GONUTS page
↑ Devos, J et al. (2011) Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells. J Circadian Rhythms 9 12 PubMed GONUTS page
↑ ^12.0 ^12.1 Ramsey, KM et al. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324 651-4 PubMed GONUTS page
↑ ^13.0 ^13.1 Li, DQ et al. (2013) Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 4 2545 PubMed GONUTS page
↑ ^14.0 ^14.1 Ward, SM et al. (2010) The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J. Biol. Chem. 285 38987-9000 PubMed GONUTS page
↑ Hou, TY et al. (2009) ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver. J. Biol. Chem. 284 31735-45 PubMed GONUTS page
↑ ^16.0 ^16.1 Duffield, GE et al. (2009) A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr. Biol. 19 297-304 PubMed GONUTS page
↑ Bellet, MM et al. (2012) The RelB subunit of NFκB acts as a negative regulator of circadian gene expression. Cell Cycle 11 3304-11 PubMed GONUTS page
↑ ^18.0 ^18.1 Koyanagi, S et al. (2011) cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J. Biol. Chem. 286 32416-23 PubMed GONUTS page
↑ Xu, CX et al. (2010) Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene. Toxicol. Sci. 115 98-108 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Li, Y et al. (2004) DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1. Biochem. J. 382 895-904 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 Honma, S et al. (2002) Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419 841-4 PubMed GONUTS page
↑ ^22.0 ^22.1 Kawamoto, T et al. (2004) A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem. Biophys. Res. Commun. 313 117-24 PubMed GONUTS page
↑ ^23.0 ^23.1 Sato, F et al. (2004) Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur. J. Biochem. 271 4409-19 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 Chatterjee, S et al. (2013) Brain and muscle Arnt-like 1 is a key regulator of myogenesis. J. Cell. Sci. 126 2213-24 PubMed GONUTS page
↑ ^25.0 ^25.1 Khapre, RV et al. (2011) Circadian clock protein BMAL1 regulates cellular senescence in vivo. Cell Cycle 10 4162-9 PubMed GONUTS page
↑ ^26.0 ^26.1 Han, DH et al. (2014) Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol. Cell. Endocrinol. 383 170-80 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Marcheva, B et al. (2010) Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466 627-31 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Guo, B et al. (2012) The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 26 3453-63 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Goriki, A et al. (2014) A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 12 e1001839 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Sasaki, M et al. (2009) Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J. Biol. Chem. 284 25149-59 PubMed GONUTS page
↑ ^31.0 ^31.1 Yoshii, K et al. (2013) Effects of NAD(P)H and its derivatives on the DNA-binding activity of NPAS2, a mammalian circadian transcription factor. Biochem. Biophys. Res. Commun. 437 386-91 PubMed GONUTS page
↑ ^32.0 ^32.1 Bouchard-Cannon, P et al. (2013) The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit. Cell Rep 5 961-73 PubMed GONUTS page
↑ Doi, R et al. (2010) CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. J. Biol. Chem. 285 22114-21 PubMed GONUTS page
↑ ^34.0 ^34.1 Khapre, RV et al. (2014) BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY) 6 48-57 PubMed GONUTS page
↑ Hwang, CK et al. (2013) Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J. Neurosci. 33 14989-97 PubMed GONUTS page
↑ Bertolucci, C et al. (2008) Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol. Cell. Biol. 28 3070-5 PubMed GONUTS page
↑ Ye, R et al. (2011) Biochemical analysis of the canonical model for the mammalian circadian clock. J. Biol. Chem. 286 25891-902 PubMed GONUTS page
↑ Li, MD et al. (2013) O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab. 17 303-10 PubMed GONUTS page
↑ ^39.0 ^39.1 Peruquetti, RL et al. (2012) Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS ONE 7 e42695 PubMed GONUTS page
↑ Nader, N et al. (2009) Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J. 23 1572-83 PubMed GONUTS page
↑ ^41.0 ^41.1 ^41.2 Huang, N et al. (2012) Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science 337 189-94 PubMed GONUTS page
↑ Curtis, AM et al. (2004) Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J. Biol. Chem. 279 7091-7 PubMed GONUTS page
↑ Annayev, Y et al. (2014) Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J. Biol. Chem. 289 5013-24 PubMed GONUTS page
↑ Duong, HA et al. (2011) A molecular mechanism for circadian clock negative feedback. Science 332 1436-9 PubMed GONUTS page
↑ ^45.0 ^45.1 Yujnovsky, I et al. (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc. Natl. Acad. Sci. U.S.A. 103 6386-91 PubMed GONUTS page
↑ Lee, J et al. (2008) Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol. Cell. Biol. 28 6056-65 PubMed GONUTS page
↑ ^47.0 ^47.1 Avivi, A et al. (2001) Biological clock in total darkness: the Clock/MOP3 circadian system of the blind subterranean mole rat. Proc. Natl. Acad. Sci. U.S.A. 98 13751-6 PubMed GONUTS page
↑ Kojima, S et al. (2007) LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1. Proc. Natl. Acad. Sci. U.S.A. 104 1859-64 PubMed GONUTS page
↑ Bunger, MK et al. (2000) Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103 1009-17 PubMed GONUTS page
↑ Dudley, CA et al. (2003) Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science 301 379-83 PubMed GONUTS page
↑ Preitner, N et al. (2002) The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110 251-60 PubMed GONUTS page
↑ ^52.0 ^52.1 ^52.2 Cheng, MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417 405-10 PubMed GONUTS page
↑ ^53.0 ^53.1 Takahata, S et al. (1998) Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. Biochem. Biophys. Res. Commun. 248 789-94 PubMed GONUTS page

[PMID:9616112-1] Gekakis, N et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280 1564-9 PubMed GONUTS page

[PMID:12897057-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kondratov, RV et al. (2003) BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system. Genes Dev. 17 1921-32 PubMed GONUTS page

[PMID:22697126-3] 3.0 ^3.1 Ratajczak, CK et al. (2012) Generation of myometrium-specific Bmal1 knockout mice for parturition analysis. Reprod. Fertil. Dev. 24 759-67 PubMed GONUTS page

[PMID:15147242-4] 4.0 ^4.1 ^4.2 Hamaguchi, H et al. (2004) Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Biochem. J. 382 43-50 PubMed GONUTS page

[PMID:26776516-5] Shi, G et al. (2016) Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep 14 823-834 PubMed GONUTS page

[PMID:25749863-6] Nam, D et al. (2015) The adipocyte clock controls brown adipogenesis through the TGF-β and BMP signaling pathways. J. Cell. Sci. 128 1835-47 PubMed GONUTS page

[PMID:28985504-7] Lin, R et al. (2017) CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol. Cell 68 198-209.e6 PubMed GONUTS page

[PMID:24043798-8] Lande-Diner, L et al. (2013) A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. Proc. Natl. Acad. Sci. U.S.A. 110 16021-6 PubMed GONUTS page

[PMID:24051492-9] Miki, T et al. (2013) p53 regulates Period2 expression and the circadian clock. Nat Commun 4 2444 PubMed GONUTS page

[PMID:21113167-10] Katada, S & Sassone-Corsi, P (2010) The histone methyltransferase MLL1 permits the oscillation of circadian gene expression. Nat. Struct. Mol. Biol. 17 1414-21 PubMed GONUTS page

[PMID:22208286-11] Devos, J et al. (2011) Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells. J Circadian Rhythms 9 12 PubMed GONUTS page

[PMID:19299583-12] 12.0 ^12.1 Ramsey, KM et al. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 324 651-4 PubMed GONUTS page

[PMID:24089055-13] 13.0 ^13.1 Li, DQ et al. (2013) Metastasis-associated protein 1 is an integral component of the circadian molecular machinery. Nat Commun 4 2545 PubMed GONUTS page

[PMID:20861012-14] 14.0 ^14.1 Ward, SM et al. (2010) The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J. Biol. Chem. 285 38987-9000 PubMed GONUTS page

[PMID:19740747-15] Hou, TY et al. (2009) ID2 (inhibitor of DNA binding 2) is a rhythmically expressed transcriptional repressor required for circadian clock output in mouse liver. J. Biol. Chem. 284 31735-45 PubMed GONUTS page

[PMID:19217292-16] 16.0 ^16.1 Duffield, GE et al. (2009) A role for Id2 in regulating photic entrainment of the mammalian circadian system. Curr. Biol. 19 297-304 PubMed GONUTS page

[PMID:22894897-17] Bellet, MM et al. (2012) The RelB subunit of NFκB acts as a negative regulator of circadian gene expression. Cell Cycle 11 3304-11 PubMed GONUTS page

[PMID:21768648-18] 18.0 ^18.1 Koyanagi, S et al. (2011) cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J. Biol. Chem. 286 32416-23 PubMed GONUTS page

[PMID:20106950-19] Xu, CX et al. (2010) Disruption of CLOCK-BMAL1 transcriptional activity is responsible for aryl hydrocarbon receptor-mediated regulation of Period1 gene. Toxicol. Sci. 115 98-108 PubMed GONUTS page

[PMID:15193144-20] 20.0 ^20.1 ^20.2 Li, Y et al. (2004) DNA binding, but not interaction with Bmal1, is responsible for DEC1-mediated transcription regulation of the circadian gene mPer1. Biochem. J. 382 895-904 PubMed GONUTS page

[PMID:12397359-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 Honma, S et al. (2002) Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419 841-4 PubMed GONUTS page

[PMID:14672706-22] 22.0 ^22.1 Kawamoto, T et al. (2004) A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Biochem. Biophys. Res. Commun. 313 117-24 PubMed GONUTS page

[PMID:15560782-23] 23.0 ^23.1 Sato, F et al. (2004) Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur. J. Biochem. 271 4409-19 PubMed GONUTS page

[PMID:23525013-24] 24.0 ^24.1 ^24.2 ^24.3 Chatterjee, S et al. (2013) Brain and muscle Arnt-like 1 is a key regulator of myogenesis. J. Cell. Sci. 126 2213-24 PubMed GONUTS page

[PMID:22101268-25] 25.0 ^25.1 Khapre, RV et al. (2011) Circadian clock protein BMAL1 regulates cellular senescence in vivo. Cell Cycle 10 4162-9 PubMed GONUTS page

[PMID:24378737-26] 26.0 ^26.1 Han, DH et al. (2014) Modulation of glucocorticoid receptor induction properties by core circadian clock proteins. Mol. Cell. Endocrinol. 383 170-80 PubMed GONUTS page

[PMID:20562852-27] 27.0 ^27.1 ^27.2 Marcheva, B et al. (2010) Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466 627-31 PubMed GONUTS page

[PMID:22611086-28] 28.0 ^28.1 ^28.2 Guo, B et al. (2012) The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway. FASEB J. 26 3453-63 PubMed GONUTS page

[PMID:24736997-29] 29.0 ^29.1 ^29.2 Goriki, A et al. (2014) A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 12 e1001839 PubMed GONUTS page

[PMID:19605937-30] 30.0 ^30.1 ^30.2 Sasaki, M et al. (2009) Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J. Biol. Chem. 284 25149-59 PubMed GONUTS page

[PMID:23831463-31] 31.0 ^31.1 Yoshii, K et al. (2013) Effects of NAD(P)H and its derivatives on the DNA-binding activity of NPAS2, a mammalian circadian transcription factor. Biochem. Biophys. Res. Commun. 437 386-91 PubMed GONUTS page

[PMID:24268780-32] 32.0 ^32.1 Bouchard-Cannon, P et al. (2013) The circadian molecular clock regulates adult hippocampal neurogenesis by controlling the timing of cell-cycle entry and exit. Cell Rep 5 961-73 PubMed GONUTS page

[PMID:20430893-33] Doi, R et al. (2010) CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2. J. Biol. Chem. 285 22114-21 PubMed GONUTS page

[PMID:24481314-34] 34.0 ^34.1 Khapre, RV et al. (2014) BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY) 6 48-57 PubMed GONUTS page

[PMID:24048828-35] Hwang, CK et al. (2013) Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J. Neurosci. 33 14989-97 PubMed GONUTS page

[PMID:18316400-36] Bertolucci, C et al. (2008) Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators. Mol. Cell. Biol. 28 3070-5 PubMed GONUTS page

[PMID:21613214-37] Ye, R et al. (2011) Biochemical analysis of the canonical model for the mammalian circadian clock. J. Biol. Chem. 286 25891-902 PubMed GONUTS page

[PMID:23395176-38] Li, MD et al. (2013) O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metab. 17 303-10 PubMed GONUTS page

[PMID:22900038-39] 39.0 ^39.1 Peruquetti, RL et al. (2012) Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS ONE 7 e42695 PubMed GONUTS page

[PMID:19141540-40] Nader, N et al. (2009) Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J. 23 1572-83 PubMed GONUTS page

[PMID:22653727-41] 41.0 ^41.1 ^41.2 Huang, N et al. (2012) Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science 337 189-94 PubMed GONUTS page

[PMID:14645221-42] Curtis, AM et al. (2004) Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J. Biol. Chem. 279 7091-7 PubMed GONUTS page

[PMID:24385426-43] Annayev, Y et al. (2014) Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J. Biol. Chem. 289 5013-24 PubMed GONUTS page

[PMID:21680841-44] Duong, HA et al. (2011) A molecular mechanism for circadian clock negative feedback. Science 332 1436-9 PubMed GONUTS page

[PMID:16606840-45] 45.0 ^45.1 Yujnovsky, I et al. (2006) Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc. Natl. Acad. Sci. U.S.A. 103 6386-91 PubMed GONUTS page

[PMID:18644859-46] Lee, J et al. (2008) Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol. Cell. Biol. 28 6056-65 PubMed GONUTS page

[PMID:11707566-47] 47.0 ^47.1 Avivi, A et al. (2001) Biological clock in total darkness: the Clock/MOP3 circadian system of the blind subterranean mole rat. Proc. Natl. Acad. Sci. U.S.A. 98 13751-6 PubMed GONUTS page

[PMID:17264215-48] Kojima, S et al. (2007) LARK activates posttranscriptional expression of an essential mammalian clock protein, PERIOD1. Proc. Natl. Acad. Sci. U.S.A. 104 1859-64 PubMed GONUTS page

[PMID:11163178-49] Bunger, MK et al. (2000) Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103 1009-17 PubMed GONUTS page

[PMID:12843397-50] Dudley, CA et al. (2003) Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science 301 379-83 PubMed GONUTS page

[PMID:12150932-51] Preitner, N et al. (2002) The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110 251-60 PubMed GONUTS page

[PMID:12024206-52] 52.0 ^52.1 ^52.2 Cheng, MY et al. (2002) Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 417 405-10 PubMed GONUTS page

[PMID:9704006-53] 53.0 ^53.1 Takahata, S et al. (1998) Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock. Biochem. Biophys. Res. Commun. 248 789-94 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

[33]

[34]

[35]

[36]

[37]

[38]

[39]

[40]

[41]

[42]

[43]

[44]

[45]

[46]

[47]

[48]

[49]

[50]

[51]

[52]

[53]

MOUSE:BMAL1

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools