PMID:22697126

Citation	Ratajczak, CK, Asada, M, Allen, GC, McMahon, DG, Muglia, LM, Smith, D, Bhattacharyya, S and Muglia, LJ (2012) Generation of myometrium-specific Bmal1 knockout mice for parturition analysis. Reprod. Fertil. Dev. 24:759-67
Abstract	Human and rodent studies indicate a role for circadian rhythmicity and associated clock gene expression in supporting normal parturition. The importance of clock gene expression in tissues besides the suprachiasmatic nucleus is emerging. Here, a Bmal1 conditional knockout mouse line and a novel Cre transgenic mouse line were used to examine the role of myometrial Bmal1 in parturition. Ninety-two percent (22/24) of control females but only 64% (14/22) of females with disrupted myometrial Bmal1 completed parturition during the expected time window of 5p.m. on Day 19 through to 9a.m. on Day 19.5 of gestation. However, neither serum progesterone levels nor uterine transcript expression of the contractile-associated proteins Connexin43 and Oxytocin receptor differed between females with disrupted myometrial Bmal1 and controls during late gestation. The data indicate a role for myometrial Bmal1 in maintaining normal time of day of parturition.
Links	PubMed Online version:10.1071/RD11164
Keywords	ARNTL Transcription Factors/genetics; ARNTL Transcription Factors/metabolism; ARNTL Transcription Factors/physiology; Animals; Biological Clocks/genetics; Female; Gene Transfer Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myometrium/metabolism; Organ Specificity/genetics; Parturition/genetics; Parturition/metabolism; Parturition/physiology; Pregnancy; Time Factors
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:BMAL1	involved_in	GO:0060137: maternal process involved in parturition	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:BMAL1		GO:0060137: maternal process involved in parturition	ECO:0000315:		P		Table 1: Pregnant female rats with disrupted copies of Bmal1 were significantly less likely rats with normal copies of Bmal1 to give birth at a normal (expected) time.	complete CACAO 9887

References

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