PMID:12843397

Citation	Dudley, CA, Erbel-Sieler, C, Estill, SJ, Reick, M, Franken, P, Pitts, S and McKnight, SL (2003) Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science 301:379-83
Abstract	Animal behavior is synchronized to the 24-hour light:dark (LD) cycle by regulatory programs that produce circadian fluctuations in gene expression throughout the body. In mammals, the transcription factor CLOCK controls circadian oscillation in the suprachiasmatic nucleus of the brain; its paralog, neuronal PAS domain protein 2 (NPAS2), performs a similar function in other forebrain sites. To investigate the role of NPAS2 in behavioral manifestations of circadian rhythm, we studied locomotor activity, sleep patterns, and adaptability to both light- and restricted food-driven entrainment in NPAS2-deficient mice. Our results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal LD and feeding conditions and that NPAS2 is critical for adaptability to food restriction.
Links	PubMed Online version:10.1126/science.1082795
Keywords	Adaptation, Physiological; Animals; Basic Helix-Loop-Helix Transcription Factors; Behavior, Animal; Biological Clocks/physiology; Body Weight; CLOCK Proteins; Circadian Rhythm/physiology; Crosses, Genetic; Darkness; Eating; Electroencephalography; Electromyography; Female; Food; Gene Targeting; Light; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Prosencephalon/physiology; Sleep; Suprachiasmatic Nucleus/physiology; Trans-Activators/genetics; Trans-Activators/physiology; Transcription Factors/genetics; Transcription Factors/physiology
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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