MOUSE:WT1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wt1 (synonyms: Wt-1)
Protein Name(s)	Wilms tumor protein homolog
External Links
UniProt	P22561
EMBL	M55512 AL512584
CCDS	CCDS16496.2
PIR	A39692
UniGene	Mm.389339
ProteinModelPortal	P22561
SMR	P22561
BioGrid	204587
IntAct	P22561
MINT	MINT-243493
PhosphoSite	P22561
PaxDb	P22561
PRIDE	P22561
DNASU	22431
MGI	MGI:98968
eggNOG	COG5048
HOGENOM	HOG000230937
HOVERGEN	HBG006960
InParanoid	P22561
PhylomeDB	P22561
NextBio	302875
PRO	PR:P22561
Proteomes	UP000000589
CleanEx	MM_WT1
Genevestigator	P22561
GO	GO:0005737 GO:0016607 GO:0005730 GO:0005654 GO:0005634 GO:0070742 GO:0003690 GO:0003723 GO:0001077 GO:0043565 GO:0003700 GO:0044212 GO:0008270 GO:0035802 GO:0030325 GO:0006915 GO:0001658 GO:0043010 GO:0060923 GO:0071320 GO:0071371 GO:0060976 GO:0060539 GO:0030855 GO:0007281 GO:0072015 GO:0072112 GO:0032835 GO:0008406 GO:0007507 GO:0001822 GO:0030539 GO:0008584 GO:0060231 GO:0001823 GO:0072278 GO:0072075 GO:0072284 GO:0001656 GO:0043066 GO:0030308 GO:2000195 GO:1900212 GO:0072302 GO:0000122 GO:0045892 GO:0017148 GO:0043065 GO:0060421 GO:2000020 GO:2001076 GO:0045944 GO:0045893 GO:0072166 GO:0010468 GO:0003156 GO:0006357 GO:0006355 GO:0008380 GO:0072520 GO:0060009 GO:0007530 GO:0007338 GO:0030317 GO:0007283 GO:0007356 GO:0009888 GO:0001657 GO:0001570 GO:0061032
Gene3D	3.30.160.60
InterPro	IPR017987 IPR000976 IPR007087 IPR015880 IPR013087
Pfam	PF02165 PF00096
PRINTS	PR00049
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0044729	hemi-methylated DNA-binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
involved_in	GO:0060923	cardiac muscle cell fate commitment	PMID:21654746^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001076	positive regulation of metanephric ureteric bud development	PMID:8395349^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000195	negative regulation of female gonad development	PMID:19301398^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000020	positive regulation of male gonad development	PMID:19301398^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	PMID:10077614^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072284	metanephric S-shaped body morphogenesis	PMID:10101119^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072284	metanephric S-shaped body morphogenesis	PMID:18618131^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072278	metanephric comma-shaped body morphogenesis	PMID:18618131^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072166	posterior mesonephric tubule development	PMID:9118800^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072112	glomerular visceral epithelial cell differentiation	PMID:19050011^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072075	metanephric mesenchyme development	PMID:8395349^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072015	glomerular visceral epithelial cell development	PMID:18618131^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071371	cellular response to gonadotropin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
enables	GO:0070742	C2H2 zinc finger domain binding	PMID:8119964^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
involved_in	GO:0061032	visceral serous pericardium development	PMID:10101119^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060539	diaphragm development	PMID:8395349^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060421	positive regulation of heart growth	PMID:8395349^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060231	mesenchymal to epithelial transition	PMID:8395349^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060231	mesenchymal to epithelial transition	PMID:9927198^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21719793^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q8K007)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19301398^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9D9C6)\|has_regulation_target:(UniProtKB:O70555)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11912180^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17537799^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:8530339^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9927198^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P09535)\|has_regulation_target:(UniProtKB:P09803)\|has_regulation_target:(UniProtKB:P20152)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544-4	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:8530339^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544-3	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:14701728^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P80723	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:8119964^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:8119964^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10101119^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035802	adrenal cortex formation	PMID:17537799^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032835	glomerulus development	PMID:10101119^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	PMID:9927198^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030539	male genitalia development	PMID:10077614^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030325	adrenal gland development	PMID:10101119^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544-3	P		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544-3	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	C		Seeded From UniProt	complete
involved_in	GO:0008406	gonad development	PMID:8395349^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008380	RNA splicing	PMID:9784496^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:10101119^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007356	thorax and anterior abdomen determination	PMID:8395349^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544-3	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P19544-4	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12609742^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1000451)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19050011^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14701728^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16467207^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8530339^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P08046)	Seeded From UniProt	complete
involved_in	GO:0003156	regulation of animal organ formation	PMID:17537799^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:11912180^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:10101119^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	PMID:10322633^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	PMID:8395349^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21719793^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(UniProtKB:Q8K007) occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:12609742^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(UniProtKB:Q63934) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:0072112	glomerular visceral epithelial cell differentiation	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98968 PANTHER:PTN002397252	P		Seeded From UniProt	complete
involved_in	GO:0071371	cellular response to gonadotropin stimulus	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002397252 UniProtKB:P19544	P		Seeded From UniProt	complete
involved_in	GO:0071320	cellular response to cAMP	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002397252 UniProtKB:P19544	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98968 PANTHER:PTN002397252 UniProtKB:P19544	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002397252 UniProtKB:P19544	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1354948 MGI:MGI:2153049 MGI:MGI:2153568 MGI:MGI:2181068 MGI:MGI:98968 PANTHER:PTN001145452 RGD:3738 UniProtKB:A0A1D8PNL1 UniProtKB:Q02446 UniProtKB:Q7RTV3 ZFIN:ZDB-GENE-021115-9	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0043364 FB:FBgn0261434 FB:FBgn0263239 MGI:MGI:1101353 MGI:MGI:1277166 MGI:MGI:1333856 MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1342772 MGI:MGI:1346318 MGI:MGI:1929988 MGI:MGI:1932575 MGI:MGI:2153568 MGI:MGI:95295 MGI:MGI:95296 MGI:MGI:98372 MGI:MGI:98968 PANTHER:PTN001145452 RGD:1306768 RGD:2544 RGD:3738 RGD:3741 RGD:3974 RGD:621445 RGD:621652 RGD:62389 UniProtKB:A0A0B4KHC8 UniProtKB:A0A0G2K5M1 UniProtKB:P18146 UniProtKB:P19544 UniProtKB:Q02086 UniProtKB:Q13351 UniProtKB:Q13886 UniProtKB:Q7RTV3 UniProtKB:Q8TDD2 UniProtKB:Q99612 UniProtKB:Q9UIH9 WB:WBGene00007772 WB:WBGene00012735	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001145452 UniProtKB:O14901 UniProtKB:Q9Y5W3 WB:WBGene00012735 ZFIN:ZDB-GENE-021115-9	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905643	positive regulation of DNA methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900212	negative regulation of mesenchymal cell apoptotic process involved in metanephros development	PMID:8395349^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857268	P	regulates_o_occurs_in:(EMAPA:17645) regulates_o_occurs_in:(CL:0000324)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072520	seminiferous tubule development	PMID:16418481^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072284	metanephric S-shaped body morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071371	cellular response to gonadotropin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
enables	GO:0070742	C2H2 zinc finger domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061032	visceral serous pericardium development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060009	Sertoli cell development	PMID:16418481^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
enables	GO:0044729	hemi-methylated DNA-binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3974	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:11889045^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857268	P	results_in_development_of:(EMAPA:17171)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032836	glomerular basement membrane development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032835	glomerulus development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030325	adrenal gland development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030317	flagellated sperm motility	PMID:16418481^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017148	negative regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:16418481^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:19457926^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1306784	P	results_in_development_of:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:16418481^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008584	male gonad development	PMID:15063178^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857268	P	results_in_development_of:(EMAPA:17972)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007530	sex determination	PMID:11509181^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183642	P	has_participant:(EMAPA:17383)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007530	sex determination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007338	single fertilization	PMID:16418481^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:16418481^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	PMID:15063178^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857268	P	occurs_in:(EMAPA:18686) results_in_development_of:(CL:0000015)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:16418481^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:12151099^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:11889045^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14678822^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16046)\|part_of:(EMAPA:16041)	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3974	C		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:7585606^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001823	mesonephros development	PMID:9118800^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857268	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001656	metanephros development	PMID:11509181^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183640	P	results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001656	metanephros development	PMID:10322633^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857268 MGI:MGI:2183642	P	results_in_development_of:(EMAPA:17207)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001570	vasculogenesis	PMID:16264195^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857268	P	occurs_in:(EMAPA:16105)\|occurs_in:(EMAPA:16240)\|occurs_in:(EMAPA:16201)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:7585606^[28]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P19544	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000976	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009888	tissue development	PMID:15716344^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183640	P	results_in_development_of:(EMAPA:17606)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14681305^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:14681305^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16264195^[29]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97384)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:15716344^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183642	P	results_in_development_of:(EMAPA:17171)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16264195^[29]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:97384)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14681305^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:14681305^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061032	visceral serous pericardium development	PMID:20299672^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060976	coronary vasculature development	PMID:20299672^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:9784496^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0186	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Smart, N et al. (2011) De novo cardiomyocytes from within the activated adult heart after injury. Nature 474 640-4 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Kreidberg, JA et al. (1993) WT-1 is required for early kidney development. Cell 74 679-91 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Lee, HJ et al. (2009) Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern. Dev. Dyn. 238 812-25 PubMed GONUTS page
↑ ^4.0 ^4.1 Patek, CE et al. (1999) A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc. Natl. Acad. Sci. U.S.A. 96 2931-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Moore, AW et al. (1999) YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126 1845-57 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Georgas, K et al. (2008) Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem. Cell Biol. 130 927-42 PubMed GONUTS page
↑ ^7.0 ^7.1 Sainio, K et al. (1997) Differential regulation of two sets of mesonephric tubules by WT-1. Development 124 1293-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Green, LM et al. (2009) Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. Nucleic Acids Res. 37 431-40 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Rupprecht, HD et al. (1994) The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J. Biol. Chem. 269 6198-206 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Hosono, S et al. (1999) WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts. Oncogene 18 417-27 PubMed GONUTS page
↑ ^11.0 ^11.1 Schumacher, VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J. Am. Soc. Nephrol. 22 1286-96 PubMed GONUTS page
↑ ^12.0 ^12.1 Guo, JK et al. (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum. Mol. Genet. 11 651-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Val, P et al. (2007) Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development 134 2349-58 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Cohen, JS (1995) Provide fluoxetine information vital to clinicians. J Clin Psychiatry 56 591 PubMed GONUTS page
↑ ^15.0 ^15.1 Carpenter, B et al. (2004) BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. Mol. Cell. Biol. 24 537-49 PubMed GONUTS page
↑ ^16.0 ^16.1 Davies, RC et al. (1998) WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Genes Dev. 12 3217-25 PubMed GONUTS page
↑ ^17.0 ^17.1 Wagner, KD et al. (2003) The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene 305 217-23 PubMed GONUTS page
↑ Dame, C et al. (2006) Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood 107 4282-90 PubMed GONUTS page
↑ ^19.0 ^19.1 Donovan, MJ et al. (1999) Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev. Genet. 24 252-62 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Rao, MK et al. (2006) Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev. 20 147-52 PubMed GONUTS page
↑ ^22.0 ^22.1 Wagner, KD et al. (2002) The Wilms' tumor gene Wt1 is required for normal development of the retina. EMBO J. 21 1398-405 PubMed GONUTS page
↑ Buaas, FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum. Mol. Genet. 18 2989-3001 PubMed GONUTS page
↑ ^24.0 ^24.1 Natoli, TA et al. (2004) Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev. Biol. 268 429-40 PubMed GONUTS page
↑ ^25.0 ^25.1 Hammes, A et al. (2001) Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 106 319-29 PubMed GONUTS page
↑ Du, X et al. (2002) The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation. Biochim. Biophys. Acta 1577 93-101 PubMed GONUTS page
↑ Clipsham, R et al. (2004) Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis. Gene Expr. Patterns 4 3-14 PubMed GONUTS page
↑ ^28.0 ^28.1 Hewitt, SM et al. (1995) Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res. 55 5386-9 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Wagner, N et al. (2005) Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev. 19 2631-42 PubMed GONUTS page
↑ ^30.0 ^30.1 Wagner, N et al. (2005) A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development 132 1327-36 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 ^31.3 Niksic, M et al. (2004) The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum. Mol. Genet. 13 463-71 PubMed GONUTS page
↑ ^32.0 ^32.1 Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

[PMID:21654746-1] Smart, N et al. (2011) De novo cardiomyocytes from within the activated adult heart after injury. Nature 474 640-4 PubMed GONUTS page

[PMID:8395349-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Kreidberg, JA et al. (1993) WT-1 is required for early kidney development. Cell 74 679-91 PubMed GONUTS page

[PMID:19301398-3] 3.0 ^3.1 ^3.2 Lee, HJ et al. (2009) Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern. Dev. Dyn. 238 812-25 PubMed GONUTS page

[PMID:10077614-4] 4.0 ^4.1 Patek, CE et al. (1999) A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc. Natl. Acad. Sci. U.S.A. 96 2931-6 PubMed GONUTS page

[PMID:10101119-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Moore, AW et al. (1999) YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126 1845-57 PubMed GONUTS page

[PMID:18618131-6] 6.0 ^6.1 ^6.2 Georgas, K et al. (2008) Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochem. Cell Biol. 130 927-42 PubMed GONUTS page

[PMID:9118800-7] 7.0 ^7.1 Sainio, K et al. (1997) Differential regulation of two sets of mesonephric tubules by WT-1. Development 124 1293-9 PubMed GONUTS page

[PMID:19050011-8] 8.0 ^8.1 Green, LM et al. (2009) Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. Nucleic Acids Res. 37 431-40 PubMed GONUTS page

[PMID:8119964-9] 9.0 ^9.1 ^9.2 Rupprecht, HD et al. (1994) The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J. Biol. Chem. 269 6198-206 PubMed GONUTS page

[PMID:9927198-10] 10.0 ^10.1 ^10.2 Hosono, S et al. (1999) WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts. Oncogene 18 417-27 PubMed GONUTS page

[PMID:21719793-11] 11.0 ^11.1 Schumacher, VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J. Am. Soc. Nephrol. 22 1286-96 PubMed GONUTS page

[PMID:11912180-12] 12.0 ^12.1 Guo, JK et al. (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum. Mol. Genet. 11 651-9 PubMed GONUTS page

[PMID:17537799-13] 13.0 ^13.1 ^13.2 Val, P et al. (2007) Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development 134 2349-58 PubMed GONUTS page

[PMID:8530339-14] 14.0 ^14.1 ^14.2 Cohen, JS (1995) Provide fluoxetine information vital to clinicians. J Clin Psychiatry 56 591 PubMed GONUTS page

[PMID:14701728-15] 15.0 ^15.1 Carpenter, B et al. (2004) BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. Mol. Cell. Biol. 24 537-49 PubMed GONUTS page

[PMID:9784496-16] 16.0 ^16.1 Davies, RC et al. (1998) WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Genes Dev. 12 3217-25 PubMed GONUTS page

[PMID:12609742-17] 17.0 ^17.1 Wagner, KD et al. (2003) The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene 305 217-23 PubMed GONUTS page

[PMID:16467207-18] Dame, C et al. (2006) Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood 107 4282-90 PubMed GONUTS page

[PMID:10322633-19] 19.0 ^19.1 Donovan, MJ et al. (1999) Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev. Genet. 24 252-62 PubMed GONUTS page

[PMID:21873635-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 ^20.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16418481-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 ^21.6 ^21.7 Rao, MK et al. (2006) Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev. 20 147-52 PubMed GONUTS page

[PMID:11889045-22] 22.0 ^22.1 Wagner, KD et al. (2002) The Wilms' tumor gene Wt1 is required for normal development of the retina. EMBO J. 21 1398-405 PubMed GONUTS page

[PMID:19457926-23] Buaas, FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum. Mol. Genet. 18 2989-3001 PubMed GONUTS page

[PMID:15063178-24] 24.0 ^24.1 Natoli, TA et al. (2004) Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev. Biol. 268 429-40 PubMed GONUTS page

[PMID:11509181-25] 25.0 ^25.1 Hammes, A et al. (2001) Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 106 319-29 PubMed GONUTS page

[PMID:12151099-26] Du, X et al. (2002) The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation. Biochim. Biophys. Acta 1577 93-101 PubMed GONUTS page

[PMID:14678822-27] Clipsham, R et al. (2004) Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis. Gene Expr. Patterns 4 3-14 PubMed GONUTS page

[PMID:7585606-28] 28.0 ^28.1 Hewitt, SM et al. (1995) Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res. 55 5386-9 PubMed GONUTS page

[PMID:16264195-29] 29.0 ^29.1 ^29.2 Wagner, N et al. (2005) Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev. 19 2631-42 PubMed GONUTS page

[PMID:15716344-30] 30.0 ^30.1 Wagner, N et al. (2005) A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development 132 1327-36 PubMed GONUTS page

[PMID:14681305-31] 31.0 ^31.1 ^31.2 ^31.3 Niksic, M et al. (2004) The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum. Mol. Genet. 13 463-71 PubMed GONUTS page

[PMID:20299672-32] 32.0 ^32.1 Olivey, HE & Svensson, EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ. Res. 106 818-32 PubMed GONUTS page

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