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PMID:7585606

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Citation

Hewitt, SM, Hamada, S, McDonnell, TJ, Rauscher, FJ 3rd and Saunders, GF (1995) Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res. 55:5386-9

Abstract

The Wilms' tumor gene WT1 functions as a tumor suppressor gene, repressing transcription of several growth factors and growth factor receptors. The bcl-2 and c-myc proto-oncogenes are essential for regulation of apoptosis and cell proliferation with roles in development and oncogenesis. We found that WT1 can repress transcription of both the bcl-2 and c-myc promoters. This suggests that WT1 regulates bcl-2 and c-myc during renal development, and the loss of functional WT1 results in deregulation of bcl-2 and c-myc, contributing to tumor formation.

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PubMed

Keywords

Amino Acid Sequence; Base Sequence; DNA-Binding Proteins/genetics; Gene Expression Regulation; Genes, Tumor Suppressor; Genes, myc; Humans; Kidney Neoplasms/genetics; Molecular Sequence Data; Promoter Regions, Genetic; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Transcription Factors/genetics; WT1 Proteins; Wilms Tumor/genetics

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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