MOUSE:GLI3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gli3
Protein Name(s)	Transcriptional activator GLI3 GLI3 form of 190 kDa GLI3-190 GLI3 full length protein GLI3FL Transcriptional repressor GLI3R GLI3 C-terminally truncated form GLI3 form of 83 kDa GLI3-83
External Links
UniProt	Q61602
EMBL	X95255 AC163610 AC173115 AC173210
CCDS	CCDS36603.1
RefSeq	NP_032156.2 XP_006516617.1
UniGene	Mm.5098
ProteinModelPortal	Q61602
SMR	Q61602
BioGrid	199944
STRING	10090.ENSMUSP00000106137
PhosphoSite	Q61602
MaxQB	Q61602
PaxDb	Q61602
PRIDE	Q61602
Ensembl	ENSMUST00000110510
GeneID	14634
KEGG	mmu:14634
UCSC	uc007pns.1
CTD	2737
MGI	MGI:95729
eggNOG	COG5048
GeneTree	ENSGT00760000118771
HOGENOM	HOG000290688
HOVERGEN	HBG005844
InParanoid	Q61602
KO	K06230
OMA	PRDSGSH
PhylomeDB	Q61602
TreeFam	TF350216
Reactome	REACT_268522 REACT_269412
NextBio	286490
PRO	PR:Q61602
Proteomes	UP000000589
Bgee	Q61602
CleanEx	MM_GLI3
ExpressionAtlas	Q61602
Genevestigator	Q61602
GO	GO:0005929 GO:0005737 GO:0005829 GO:0016592 GO:0016607 GO:0005634 GO:0072372 GO:0017053 GO:0003682 GO:0046872 GO:0000978 GO:0043565 GO:0003700 GO:0048856 GO:0048646 GO:0060873 GO:0009952 GO:0060840 GO:0007411 GO:0007420 GO:0001658 GO:0048754 GO:0043010 GO:0048593 GO:0061005 GO:0007417 GO:0021801 GO:0048589 GO:0009953 GO:0048566 GO:0048557 GO:0042733 GO:0030326 GO:0048598 GO:0048704 GO:0030900 GO:0021798 GO:0021861 GO:0060364 GO:0007507 GO:0007442 GO:0021766 GO:0001701 GO:0048839 GO:0001822 GO:0060366 GO:0022018 GO:0060875 GO:0060173 GO:0035108 GO:0030324 GO:0030879 GO:0060594 GO:0030318 GO:0001656 GO:0046639 GO:0043066 GO:0090090 GO:0045596 GO:0008285 GO:0045665 GO:0045879 GO:0000122 GO:0045892 GO:0045060 GO:0021915 GO:0048663 GO:0042475 GO:0048709 GO:0021631 GO:0060021 GO:0021543 GO:0007389 GO:0046638 GO:0032332 GO:0002052 GO:0045669 GO:0042307 GO:0045944 GO:0045893 GO:0016485 GO:0009954 GO:0042981 GO:0045595 GO:0042127 GO:0010468 GO:0006355 GO:0043627 GO:0060367 GO:0007224 GO:0060831 GO:0021776 GO:0021775 GO:0021513 GO:0021522 GO:0021544 GO:0033077 GO:0021537 GO:0070242 GO:0043586 GO:0006351 GO:0035295 GO:0042060
Gene3D	3.30.160.60
InterPro	IPR007087 IPR015880 IPR013087
Pfam	PF00096
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005930	axoneme	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Fig 4A shows ciliary localisation in WT	complete CACAO 2898
	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24548465^[2]	ECO:0000315			P		When Gli3 was subjected to siRNA Figure 5 C and D showed that this negatively impacted the amount of mRNA of IGF-1 made.	complete CACAO 9955
	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24548465^[2]	ECO:0000315			P		With siRNA to knockdown Gli3, there is an increase in the amount of IGFBP-1 mRNA and serum concentration as shown in Fig 5 C and the serum concentration in D.	complete CACAO 9961
part_of	GO:0005930	axoneme	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24548465^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24548465^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21209331^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070242	thymocyte apoptotic process	PMID:19667090^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046639	negative regulation of alpha-beta T cell differentiation	PMID:19667090^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	PMID:15855276^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19667090^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045879	negative regulation of smoothened signaling pathway	PMID:19667090^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045060	negative thymic T cell selection	PMID:19667090^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	PMID:15855276^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060173	limb development	PMID:17400206^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17400206^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11053430^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17400206^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20360384^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20360384^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11053430^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061005	cell differentiation involved in kidney development	PMID:19809516^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:105373	P	occurs_in:(EMAPA:28477)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060875	lateral semicircular canal development	PMID:17395647^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:17821)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060873	anterior semicircular canal development	PMID:17395647^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060840	artery development	PMID:16968815^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	PMID:20159594^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2442827	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	PMID:17395647^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060594	mammary gland specification	PMID:16720875^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1099809	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060367	sagittal suture morphogenesis	PMID:20570969^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:19224)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060366	lambdoid suture morphogenesis	PMID:20570969^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:19227)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060364	frontal suture morphogenesis	PMID:20570969^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:19198)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060021	roof of mouth development	PMID:18816854^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:17930)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048856	anatomical structure development	PMID:11485934^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	results_in_development_of:(EMAPA:18256)\|results_in_development_of:(EMAPA:18692)\|results_in_development_of:(EMAPA:16832)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048839	inner ear development	PMID:17395647^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048754	branching morphogenesis of an epithelial tube	PMID:16247775^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:17625)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048709	oligodendrocyte differentiation	PMID:15880651^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	occurs_in:(EMAPA:17577) results_in_acquisition_of_features_of:(CL:0000128)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048704	embryonic skeletal system morphogenesis	PMID:15728667^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1277234	P	has_participant:(EMAPA:18722)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048663	neuron fate commitment	PMID:16168404^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:17544) results_in_commitment_to:(CL:0000695)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048646	anatomical structure formation involved in morphogenesis	PMID:9731531^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	results_in_formation_of:(EMAPA:16853)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048598	embryonic morphogenesis	PMID:8387379^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:16680)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048593	camera-type eye morphogenesis	PMID:8387379^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:16198)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048589	developmental growth	PMID:9268579^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048566	embryonic digestive tract development	PMID:10693670^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048557	embryonic digestive tract morphogenesis	PMID:16247775^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:17623)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17328886^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12435627^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:20570969^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95516	P	regulates_o_occurs_in:(EMAPA:18016) regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045669	positive regulation of osteoblast differentiation	PMID:20570969^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	regulates_o_occurs_in:(EMAPA:18016) regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	PMID:19048639^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	occurs_in:(EMAPA:16910) regulates_o_results_in_acquisition_of_features_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045596	negative regulation of cell differentiation	PMID:16284117^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96533	P	occurs_in:(EMAPA:17412) regulates_o_results_in_acquisition_of_features_of:(CL:0000744)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045595	regulation of cell differentiation	PMID:16284117^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96533	P	regulates_o_occurs_in:(EMAPA:17412) regulates_o_occurs_in:(CL:0000743)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043586	tongue development	PMID:18816854^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:17185)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:16611981^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:19048639^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	regulates_o_occurs_in:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043010	camera-type eye development	PMID:18582859^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:8026071^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856282	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:9268572^[31]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88180	P	has_participant:(MGI:MGI:88180)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:17714700^[32]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96203 MGI:MGI:96204 MGI:MGI:96205	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:9268572^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:22841643^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3798847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:19036983^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042733	embryonic digit morphogenesis	PMID:16254602^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:9655803^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	has_participant:(EMAPA:17942)\|has_participant:(EMAPA:17921)\|has_participant:(EMAPA:17918)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	PMID:17043310^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:17191253^[38]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96533	P		Seeded From UniProt	complete
enables	GO:0036033	mediator complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035295	tube development	PMID:9731531^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	results_in_development_of:(EMAPA:16833)\|results_in_development_of:(EMAPA:16853)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035108	limb morphogenesis	PMID:9268572^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035108	limb morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	P		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033077	T cell differentiation in thymus	PMID:15855276^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	occurs_in:(EMAPA:18768) results_in_acquisition_of_features_of:(CL:0000809)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032332	positive regulation of chondrocyte differentiation	PMID:17328886^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:16168404^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:17547)\|results_in_development_of:(EMAPA:17546)\|results_in_development_of:(EMAPA:17545)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:16914490^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:17759)\|results_in_development_of:(EMAPA:36507)\|results_in_development_of:(EMAPA:36633)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:19422820^[40]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	has_participant:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:16284117^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96533	P	has_participant:(EMAPA:17412)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:8387379^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:17459)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:19809516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:12435627^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:12435361^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:12142027^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:15136151^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:9268579^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030318	melanocyte differentiation	PMID:18397875^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3720956	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022018	lateral ganglionic eminence cell proliferation	PMID:20943929^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856282	P	occurs_in:(EMAPA:16910) acts_on_population_of:(CL:0000337)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021915	neural tube development	PMID:8387379^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:16974)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021861	forebrain radial glial cell differentiation	PMID:9232833^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856282	P	occurs_in:(EMAPA:17544) results_in_acquisition_of_features_of:(CL:0000681)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021819	layer formation in cerebral cortex	PMID:21525285^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176173,MGI:MGI:3798847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021801	cerebral cortex radial glia guided migration	PMID:9232833^[46]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856282	P	occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021798	forebrain dorsal/ventral pattern formation	PMID:10625551^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021776	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	PMID:15215207^[49]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	occurs_in:(EMAPA:16525) occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification	PMID:15215207^[49]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	occurs_in:(EMAPA:16525) occurs_in:(CL:0000099)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021766	hippocampus development	PMID:22235033^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2684610,MGI:MGI:3798847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021631	optic nerve morphogenesis	PMID:16342201^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	has_participant:(EMAPA:17846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021544	subpallium development	PMID:20943929^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856282	P	results_in_development_of:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021543	pallium development	PMID:10409502^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:16652)\|results_in_development_of:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:19048639^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:19036983^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021537	telencephalon development	PMID:10625551^[48]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P	results_in_development_of:(EMAPA:16910)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021522	spinal cord motor neuron differentiation	PMID:21552265^[53]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107736	P	occurs_in:(EMAPA:16530) results_in_acquisition_of_features_of:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021513	spinal cord dorsal/ventral patterning	PMID:16364285^[54]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99833	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021513	spinal cord dorsal/ventral patterning	PMID:15215207^[49]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	has_participant:(EMAPA:16525)	Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	PMID:12435627^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:19684112^[55]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:19036983^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:18799682^[56]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	occurs_in:(EMAPA:16039) has_regulation_target:(MGI:MGI:2151153)\|occurs_in(EMAPA:16039) has_regulation_target:(MGI:MGI:108460)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009954	proximal/distal pattern formation	PMID:16342201^[51]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009954	proximal/distal pattern formation	PMID:16342201^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:16571630^[57]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:14723851^[58]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856275	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:12435629^[59]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:22841643^[33]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:22841643^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3798847	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:15315762^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:20570969^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95516	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16396903^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	regulates_o_occurs_in:(EMAPA:36437)\|regulates_o_occurs_in:(EMAPA:17950)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:20570969^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:17328886^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16396903^[61]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856275	P	regulates_o_occurs_in:(EMAPA:36437)\|regulates_o_occurs_in:(EMAPA:17950)	Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:11172440^[62]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	results_in_development_of:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007442	hindgut morphogenesis	PMID:11485934^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	has_participant:(EMAPA:17896)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:8026071^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856282	P	results_in_development_of:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:17395647^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:12435361^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007417	central nervous system development	PMID:12435628^[63]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108075	P	results_in_development_of:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007417	central nervous system development	PMID:12435629^[59]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:20943929^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856282	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:15065125^[64]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007389	pattern specification process	PMID:14602680^[65]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728 MGI:MGI:98297	P	occurs_in:(EMAPA:16184)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:17043310^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108075 MGI:MGI:98297	P	occurs_in:(EMAPA:16674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:16571630^[57]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	occurs_in:(EMAPA:17562)\|occurs_in:(EMAPA:16981)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:16396903^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	occurs_in:(EMAPA:36437)\|occurs_in:(EMAPA:17950)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:16284117^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96533	P	occurs_in:(EMAPA:17412)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:12435628^[63]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108075	P	occurs_in:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:9152009^[66]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856275	P	has_regulation_target:(MGI:MGI:98297)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:24927541^[67]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000515)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:21289087^[68]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:19684112^[55]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:16254602^[35]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23955340^[69]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000134)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19684112^[55]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12435627^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620272	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23955340^[69]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000134)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19684112^[55]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)\|part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12435627^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16254602^[35]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620272	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16396903^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108075	F	occurs_in:(EMAPA:17373) has_participant:(MGI:MGI:97486)\|occurs_in(EMAPA:17373) has_participant:(MGI:MGI:1889585)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	PMID:20943929^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856282	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:11172440^[62]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P	results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:16254602^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856276	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001658	branching involved in ureteric bud morphogenesis	PMID:16396903^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	has_participant:(EMAPA:17950)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001656	metanephros development	PMID:16396903^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98297	P	results_in_development_of:(EMAPA:17373)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P10071	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903010	regulation of bone development	PMID:22841643^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3798847	P		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M9H1 ensembl:ENSRNOP00000019396	C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	F		Seeded From UniProt	complete
enables	GO:0036033	mediator complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	F		Seeded From UniProt	complete
involved_in	GO:0035108	limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	P		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10071 ensembl:ENSP00000379258	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
involved_in	GO:0007224	smoothened signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
involved_in	GO:0009953	dorsal/ventral pattern formation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032851	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9008236	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Matz-Soja, M et al. (2014) Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun. Signal 12 11 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Hager-Theodorides, AL et al. (2009) The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms. J. Immunol. 183 3023-32 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Hager-Theodorides, AL et al. (2005) The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. Blood 106 1296-304 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Wang, C et al. (2007) The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev. Biol. 305 460-9 PubMed GONUTS page
↑ ^6.0 ^6.1 Mizugishi, K et al. (2001) Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J. Biol. Chem. 276 2180-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Humke, EW et al. (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 24 670-82 PubMed GONUTS page
↑ ^8.0 ^8.1 Cain, JE et al. (2009) GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS ONE 4 e7313 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Bok, J et al. (2007) Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134 1713-22 PubMed GONUTS page
↑ Alt, B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133 3797-804 PubMed GONUTS page
↑ Ko, HW et al. (2010) Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev. Cell 18 237-47 PubMed GONUTS page
↑ Veltmaat, JM et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133 2325-35 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Rice, DP et al. (2010) Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum. Mol. Genet. 19 3457-67 PubMed GONUTS page
↑ ^14.0 ^14.1 Huang, X et al. (2008) Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev. Dyn. 237 3079-87 PubMed GONUTS page
↑ ^15.0 ^15.1 Mo, R et al. (2001) Anorectal malformations caused by defects in sonic hedgehog signaling. Am. J. Pathol. 159 765-74 PubMed GONUTS page
↑ ^16.0 ^16.1 Kim, JH et al. (2005) Gli3 null mice display glandular overgrowth of the developing stomach. Dev. Dyn. 234 984-91 PubMed GONUTS page
↑ Oh, S et al. (2005) Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Dev. Dyn. 234 489-96 PubMed GONUTS page
↑ Kuijper, S et al. (2005) Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132 1601-10 PubMed GONUTS page
↑ ^19.0 ^19.1 Theil, T (2005) Gli3 is required for the specification and differentiation of preplate neurons. Dev. Biol. 286 559-71 PubMed GONUTS page
↑ ^20.0 ^20.1 Motoyama, J et al. (1998) Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20 54-7 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Hui, CC & Joyner, AL (1993) A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat. Genet. 3 241-6 PubMed GONUTS page
↑ ^22.0 ^22.1 Grindley, JC et al. (1997) Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev. Biol. 188 337-48 PubMed GONUTS page
↑ Kimmel, SG et al. (2000) New mouse models of congenital anorectal malformations. J. Pediatr. Surg. 35 227-30; discussion 230-1 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Mau, E et al. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev. Biol. 305 28-39 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 Dai, P et al. (2002) Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev. 16 2843-8 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Yu, T et al. (2009) Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein. J. Comp. Neurol. 512 613-27 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Koziel, L et al. (2005) Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132 5249-60 PubMed GONUTS page
↑ Pan, Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26 3365-77 PubMed GONUTS page
↑ Dakubo, GD et al. (2008) Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev. Biol. 320 242-55 PubMed GONUTS page
↑ ^30.0 ^30.1 Keino, H et al. (1994) Apoptotic degeneration in the arhinencephalic brain of the mouse mutant Pdn/Pdn. Brain Res. Dev. Brain Res. 78 161-8 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Dunn, NR et al. (1997) Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev. Biol. 188 235-47 PubMed GONUTS page
↑ Sheth, R et al. (2007) Hoxd and Gli3 interactions modulate digit number in the amniote limb. Dev. Biol. 310 430-41 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 Bowers, M et al. (2012) Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3. Dev. Biol. 370 110-24 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Willaredt, MA et al. (2008) A crucial role for primary cilia in cortical morphogenesis. J. Neurosci. 28 12887-900 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 ^35.3 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page
↑ Hardcastle, Z et al. (1998) The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125 2803-11 PubMed GONUTS page
↑ ^37.0 ^37.1 Kim, JW & Lemke, G (2006) Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev. 20 2833-47 PubMed GONUTS page
↑ Shibukawa, Y et al. (2007) Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev. Dyn. 236 426-34 PubMed GONUTS page
↑ Hatsell, SJ & Cowin, P (2006) Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development 133 3661-70 PubMed GONUTS page
↑ Lallemand, Y et al. (2009) Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev. Biol. 331 189-98 PubMed GONUTS page
↑ ^41.0 ^41.1 Aoto, K et al. (2002) Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev. Biol. 251 320-32 PubMed GONUTS page
↑ O'Rourke, MP et al. (2002) Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev. Biol. 248 143-56 PubMed GONUTS page
↑ Li, Y et al. (2004) Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev. Biol. 270 214-31 PubMed GONUTS page
↑ Matera, I et al. (2008) A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum. Mol. Genet. 17 2118-31 PubMed GONUTS page
↑ ^45.0 ^45.1 ^45.2 ^45.3 Magnani, D et al. (2010) The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence. J. Neurosci. 30 13883-94 PubMed GONUTS page
↑ ^46.0 ^46.1 Ueda, S et al. (1997) Local disturbance of neuronal migration in the S-100beta-retarded mutant mouse. Cell Tissue Res. 289 547-51 PubMed GONUTS page
↑ Wang, H et al. (2011) Gli3 is required for maintenance and fate specification of cortical progenitors. J. Neurosci. 31 6440-8 PubMed GONUTS page
↑ ^48.0 ^48.1 Tole, S et al. (2000) Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev. Biol. 217 254-65 PubMed GONUTS page
↑ ^49.0 ^49.1 ^49.2 Lei, Q et al. (2004) Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131 3593-604 PubMed GONUTS page
↑ Hasenpusch-Theil, K et al. (2012) Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Cereb. Cortex 22 2878-93 PubMed GONUTS page
↑ ^51.0 ^51.1 ^51.2 Furimsky, M & Wallace, VA (2006) Complementary Gli activity mediates early patterning of the mouse visual system. Dev. Dyn. 235 594-605 PubMed GONUTS page
↑ Theil, T et al. (1999) Gli3 is required for Emx gene expression during dorsal telencephalon development. Development 126 3561-71 PubMed GONUTS page
↑ Ocbina, PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43 547-53 PubMed GONUTS page
↑ Eggenschwiler, JT et al. (2006) Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. Dev. Biol. 290 1-12 PubMed GONUTS page
↑ ^55.0 ^55.1 ^55.2 ^55.3 Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page
↑ Tucker, ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J. Neurosci. 28 9504-18 PubMed GONUTS page
↑ ^57.0 ^57.1 Blaess, S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133 1799-809 PubMed GONUTS page
↑ Bai, CB et al. (2004) All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6 103-15 PubMed GONUTS page
↑ ^59.0 ^59.1 Persson, M et al. (2002) Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 16 2865-78 PubMed GONUTS page
↑ Ahn, S & Joyner, AL (2004) Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell 118 505-16 PubMed GONUTS page
↑ ^61.0 ^61.1 ^61.2 ^61.3 ^61.4 ^61.5 Hu, MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133 569-78 PubMed GONUTS page
↑ ^62.0 ^62.1 Kim, PC et al. (2001) Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. J. Pediatr. Surg. 36 381-4 PubMed GONUTS page
↑ ^63.0 ^63.1 Wijgerde, M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 16 2849-64 PubMed GONUTS page
↑ Balmer, CW & LaMantia, AS (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J. Comp. Neurol. 472 292-307 PubMed GONUTS page
↑ Buttitta, L et al. (2003) Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130 6233-43 PubMed GONUTS page
↑ Büscher, D et al. (1997) Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev. 62 175-82 PubMed GONUTS page
↑ Fu, W et al. (2014) Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma. Proc. Natl. Acad. Sci. U.S.A. 111 9151-6 PubMed GONUTS page
↑ Lai, CK et al. (2011) Functional characterization of putative cilia genes by high-content analysis. Mol. Biol. Cell 22 1104-19 PubMed GONUTS page
↑ ^69.0 ^69.1 Wang, C et al. (2013) Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J. Biol. Chem. 288 29518-29 PubMed GONUTS page

[PMID:21209331-1] 1.0 ^1.1 ^1.2 Qin, J et al. (2011) Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc. Natl. Acad. Sci. U.S.A. 108 1456-61 PubMed GONUTS page

[PMID:24548465-2] 2.0 ^2.1 ^2.2 ^2.3 Matz-Soja, M et al. (2014) Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun. Signal 12 11 PubMed GONUTS page

[PMID:19667090-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Hager-Theodorides, AL et al. (2009) The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms. J. Immunol. 183 3023-32 PubMed GONUTS page

[PMID:15855276-4] 4.0 ^4.1 ^4.2 Hager-Theodorides, AL et al. (2005) The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. Blood 106 1296-304 PubMed GONUTS page

[PMID:17400206-5] 5.0 ^5.1 ^5.2 Wang, C et al. (2007) The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev. Biol. 305 460-9 PubMed GONUTS page

[PMID:11053430-6] 6.0 ^6.1 Mizugishi, K et al. (2001) Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J. Biol. Chem. 276 2180-8 PubMed GONUTS page

[PMID:20360384-7] 7.0 ^7.1 Humke, EW et al. (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev. 24 670-82 PubMed GONUTS page

[PMID:19809516-8] 8.0 ^8.1 Cain, JE et al. (2009) GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS ONE 4 e7313 PubMed GONUTS page

[PMID:17395647-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Bok, J et al. (2007) Opposing gradients of Gli repressor and activators mediate Shh signaling along the dorsoventral axis of the inner ear. Development 134 1713-22 PubMed GONUTS page

[PMID:16968815-10] Alt, B et al. (2006) Arteries define the position of the thyroid gland during its developmental relocalisation. Development 133 3797-804 PubMed GONUTS page

[PMID:20159594-11] Ko, HW et al. (2010) Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev. Cell 18 237-47 PubMed GONUTS page

[PMID:16720875-12] Veltmaat, JM et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133 2325-35 PubMed GONUTS page

[PMID:20570969-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Rice, DP et al. (2010) Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum. Mol. Genet. 19 3457-67 PubMed GONUTS page

[PMID:18816854-14] 14.0 ^14.1 Huang, X et al. (2008) Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev. Dyn. 237 3079-87 PubMed GONUTS page

[PMID:11485934-15] 15.0 ^15.1 Mo, R et al. (2001) Anorectal malformations caused by defects in sonic hedgehog signaling. Am. J. Pathol. 159 765-74 PubMed GONUTS page

[PMID:16247775-16] 16.0 ^16.1 Kim, JH et al. (2005) Gli3 null mice display glandular overgrowth of the developing stomach. Dev. Dyn. 234 984-91 PubMed GONUTS page

[PMID:15880651-17] Oh, S et al. (2005) Specific requirements of sonic hedgehog signaling during oligodendrocyte development. Dev. Dyn. 234 489-96 PubMed GONUTS page

[PMID:15728667-18] Kuijper, S et al. (2005) Genetics of shoulder girdle formation: roles of Tbx15 and aristaless-like genes. Development 132 1601-10 PubMed GONUTS page

[PMID:16168404-19] 19.0 ^19.1 Theil, T (2005) Gli3 is required for the specification and differentiation of preplate neurons. Dev. Biol. 286 559-71 PubMed GONUTS page

[PMID:9731531-20] 20.0 ^20.1 Motoyama, J et al. (1998) Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat. Genet. 20 54-7 PubMed GONUTS page

[PMID:8387379-21] 21.0 ^21.1 ^21.2 ^21.3 Hui, CC & Joyner, AL (1993) A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nat. Genet. 3 241-6 PubMed GONUTS page

[PMID:9268579-22] 22.0 ^22.1 Grindley, JC et al. (1997) Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev. Biol. 188 337-48 PubMed GONUTS page

[PMID:10693670-23] Kimmel, SG et al. (2000) New mouse models of congenital anorectal malformations. J. Pediatr. Surg. 35 227-30; discussion 230-1 PubMed GONUTS page

[PMID:17328886-24] 24.0 ^24.1 ^24.2 Mau, E et al. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev. Biol. 305 28-39 PubMed GONUTS page

[PMID:12435627-25] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 Dai, P et al. (2002) Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev. 16 2843-8 PubMed GONUTS page

[PMID:19048639-26] 26.0 ^26.1 ^26.2 Yu, T et al. (2009) Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein. J. Comp. Neurol. 512 613-27 PubMed GONUTS page

[PMID:16284117-27] 27.0 ^27.1 ^27.2 ^27.3 Koziel, L et al. (2005) Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation. Development 132 5249-60 PubMed GONUTS page

[PMID:16611981-28] Pan, Y et al. (2006) Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell. Biol. 26 3365-77 PubMed GONUTS page

[PMID:18582859-29] Dakubo, GD et al. (2008) Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev. Biol. 320 242-55 PubMed GONUTS page

[PMID:8026071-30] 30.0 ^30.1 Keino, H et al. (1994) Apoptotic degeneration in the arhinencephalic brain of the mouse mutant Pdn/Pdn. Brain Res. Dev. Brain Res. 78 161-8 PubMed GONUTS page

[PMID:9268572-31] 31.0 ^31.1 ^31.2 Dunn, NR et al. (1997) Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev. Biol. 188 235-47 PubMed GONUTS page

[PMID:17714700-32] Sheth, R et al. (2007) Hoxd and Gli3 interactions modulate digit number in the amniote limb. Dev. Biol. 310 430-41 PubMed GONUTS page

[PMID:22841643-33] 33.0 ^33.1 ^33.2 ^33.3 Bowers, M et al. (2012) Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3. Dev. Biol. 370 110-24 PubMed GONUTS page

[PMID:19036983-34] 34.0 ^34.1 ^34.2 Willaredt, MA et al. (2008) A crucial role for primary cilia in cortical morphogenesis. J. Neurosci. 28 12887-900 PubMed GONUTS page

[PMID:16254602-35] 35.0 ^35.1 ^35.2 ^35.3 Haycraft, CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet. 1 e53 PubMed GONUTS page

[PMID:9655803-36] Hardcastle, Z et al. (1998) The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125 2803-11 PubMed GONUTS page

[PMID:17043310-37] 37.0 ^37.1 Kim, JW & Lemke, G (2006) Hedgehog-regulated localization of Vax2 controls eye development. Genes Dev. 20 2833-47 PubMed GONUTS page

[PMID:17191253-38] Shibukawa, Y et al. (2007) Temporomandibular joint formation and condyle growth require Indian hedgehog signaling. Dev. Dyn. 236 426-34 PubMed GONUTS page

[PMID:16914490-39] Hatsell, SJ & Cowin, P (2006) Gli3-mediated repression of Hedgehog targets is required for normal mammary development. Development 133 3661-70 PubMed GONUTS page

[PMID:19422820-40] Lallemand, Y et al. (2009) Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev. Biol. 331 189-98 PubMed GONUTS page

[PMID:12435361-41] 41.0 ^41.1 Aoto, K et al. (2002) Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev. Biol. 251 320-32 PubMed GONUTS page

[PMID:12142027-42] O'Rourke, MP et al. (2002) Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev. Biol. 248 143-56 PubMed GONUTS page

[PMID:15136151-43] Li, Y et al. (2004) Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev. Biol. 270 214-31 PubMed GONUTS page

[PMID:18397875-44] Matera, I et al. (2008) A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. Hum. Mol. Genet. 17 2118-31 PubMed GONUTS page

[PMID:20943929-45] 45.0 ^45.1 ^45.2 ^45.3 Magnani, D et al. (2010) The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence. J. Neurosci. 30 13883-94 PubMed GONUTS page

[PMID:9232833-46] 46.0 ^46.1 Ueda, S et al. (1997) Local disturbance of neuronal migration in the S-100beta-retarded mutant mouse. Cell Tissue Res. 289 547-51 PubMed GONUTS page

[PMID:21525285-47] Wang, H et al. (2011) Gli3 is required for maintenance and fate specification of cortical progenitors. J. Neurosci. 31 6440-8 PubMed GONUTS page

[PMID:10625551-48] 48.0 ^48.1 Tole, S et al. (2000) Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev. Biol. 217 254-65 PubMed GONUTS page

[PMID:15215207-49] 49.0 ^49.1 ^49.2 Lei, Q et al. (2004) Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord. Development 131 3593-604 PubMed GONUTS page

[PMID:22235033-50] Hasenpusch-Theil, K et al. (2012) Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Cereb. Cortex 22 2878-93 PubMed GONUTS page

[PMID:16342201-51] 51.0 ^51.1 ^51.2 Furimsky, M & Wallace, VA (2006) Complementary Gli activity mediates early patterning of the mouse visual system. Dev. Dyn. 235 594-605 PubMed GONUTS page

[PMID:10409502-52] Theil, T et al. (1999) Gli3 is required for Emx gene expression during dorsal telencephalon development. Development 126 3561-71 PubMed GONUTS page

[PMID:21552265-53] Ocbina, PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat. Genet. 43 547-53 PubMed GONUTS page

[PMID:16364285-54] Eggenschwiler, JT et al. (2006) Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. Dev. Biol. 290 1-12 PubMed GONUTS page

[PMID:19684112-55] 55.0 ^55.1 ^55.2 ^55.3 Chen, MH et al. (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 23 1910-28 PubMed GONUTS page

[PMID:18799682-56] Tucker, ES et al. (2008) Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences. J. Neurosci. 28 9504-18 PubMed GONUTS page

[PMID:16571630-57] 57.0 ^57.1 Blaess, S et al. (2006) Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133 1799-809 PubMed GONUTS page

[PMID:14723851-58] Bai, CB et al. (2004) All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev. Cell 6 103-15 PubMed GONUTS page

[PMID:12435629-59] 59.0 ^59.1 Persson, M et al. (2002) Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 16 2865-78 PubMed GONUTS page

[PMID:15315762-60] Ahn, S & Joyner, AL (2004) Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell 118 505-16 PubMed GONUTS page

[PMID:16396903-61] 61.0 ^61.1 ^61.2 ^61.3 ^61.4 ^61.5 Hu, MC et al. (2006) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133 569-78 PubMed GONUTS page

[PMID:11172440-62] 62.0 ^62.1 Kim, PC et al. (2001) Murine models of VACTERL syndrome: Role of sonic hedgehog signaling pathway. J. Pediatr. Surg. 36 381-4 PubMed GONUTS page

[PMID:12435628-63] 63.0 ^63.1 Wijgerde, M et al. (2002) A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 16 2849-64 PubMed GONUTS page

[PMID:15065125-64] Balmer, CW & LaMantia, AS (2004) Loss of Gli3 and Shh function disrupts olfactory axon trajectories. J. Comp. Neurol. 472 292-307 PubMed GONUTS page

[PMID:14602680-65] Buttitta, L et al. (2003) Interplays of Gli2 and Gli3 and their requirement in mediating Shh-dependent sclerotome induction. Development 130 6233-43 PubMed GONUTS page

[PMID:9152009-66] Büscher, D et al. (1997) Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev. 62 175-82 PubMed GONUTS page

[PMID:24927541-67] Fu, W et al. (2014) Primary cilia control hedgehog signaling during muscle differentiation and are deregulated in rhabdomyosarcoma. Proc. Natl. Acad. Sci. U.S.A. 111 9151-6 PubMed GONUTS page

[PMID:21289087-68] Lai, CK et al. (2011) Functional characterization of putative cilia genes by high-content analysis. Mol. Biol. Cell 22 1104-19 PubMed GONUTS page

[PMID:23955340-69] 69.0 ^69.1 Wang, C et al. (2013) Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J. Biol. Chem. 288 29518-29 PubMed GONUTS page

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[57]

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[65]

[66]

[67]

[68]

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MOUSE:GLI3

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