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PMID:10625551

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Citation

Tole, S, Ragsdale, CW and Grove, EA (2000) Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev. Biol. 217:254-65

Abstract

Little is known about the mechanisms that control the development of regional identity in the mammalian telencephalon. The Gli family of transcription factor genes is involved in the regulation of pattern at many sites in the embryo and is expressed in the embryonic mouse telencephalon. We have analyzed telencephalic patterning in the extra-toes (J) (Xt(J)) mouse mutant, which carries a deletion in the Gli family member Gli3. We report that dorsoventral patterning of the telencephalon is dramatically disrupted in the Xt(J) mutant. Specific dorsal telencephalic cell types and gene expression patterns are lost in homozygous Xt(J) mutants, and features of ventral telencephalic identity develop ectopically in the dorsal telencephalon. This partial ventralization of the dorsal telencephalon does not appear to be induced by an expansion of Sonic hedgehog expression in the telencephalon, but may be due to a loss of Bmp and Wnt gene expression in a putative dorsal telencephalic signaling center, the cortical hem. Our findings suggest that in dorsal telencephalon Gli3 is needed to repress ventral telencephalic identity.

Links

PubMed Online version:10.1006/dbio.1999.9509

Keywords

Animals; Antigens, Differentiation; Body Patterning/genetics; Bone Morphogenetic Proteins/biosynthesis; Cell Communication; DNA-Binding Proteins/genetics; Gene Deletion; Hedgehog Proteins; Hippocampus/embryology; Kruppel-Like Transcription Factors; Mice; Mice, Mutant Strains; Nerve Tissue Proteins/genetics; Nuclear Proteins/biosynthesis; Oncogene Proteins/biosynthesis; Proteins; Proto-Oncogene Proteins; Repressor Proteins; Telencephalon/embryology; Tissue Distribution; Trans-Activators; Transcription Factors/biosynthesis; Transcription Factors/genetics; Wnt Proteins; Xenopus Proteins; Zebrafish Proteins

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:GLI3

acts_upstream_of_or_within

GO:0021798: forebrain dorsal/ventral pattern formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1856276

P

Seeded From UniProt

complete

MOUSE:GLI3

acts_upstream_of_or_within

GO:0021537: telencephalon development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1856276

P

  • results_in_development_of:(EMAPA:16910)

Seeded From UniProt

complete

MOUSE:GLI3

acts_upstream_of_or_within

GO:0021537: telencephalon development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1856276

P

results_in_development_of:(EMAPA:16910)

Seeded From UniProt

complete

MOUSE:GLI3

acts_upstream_of_or_within

GO:0021798: forebrain dorsal/ventral pattern formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1856276

P

has_participant:(EMAPA:16910)

Seeded From UniProt

complete


See also

References

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