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Kimmel, SG, Mo, R, Hui, CC and Kim, PC (2000) New mouse models of congenital anorectal malformations. J. Pediatr. Surg. 35:227-30; discussion 230-1
The genetic, embryological, and pathogenetic aspects of hindgut development remain poorly understood. Recently, the morphogenetic pathway involving the Sonic hedgehog (Shh) gene has been shown essential to the normal development of many midaxial organs, including the foregut. This study reports genetically based murine models of congenital anorectal malformations (CAM) involving the Shh-responsive transcription factors, Gli2 and Gli3. Its purpose is to show the necessity of these 2 factors to normal hindgut development.
Anal Canal/abnormalities; Animals; Cell Division; Cloaca/embryology; Disease Models, Animal; Endoderm/cytology; Gene Expression Regulation, Developmental; Mice; Mice, Mutant Strains; Phenotype; Rectum/abnormalities; Transcription Factors/genetics; Transcription Factors/physiology
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