PMID:24548465

Citation	Matz-Soja, M, Aleithe, S, Marbach, E, Böttger, J, Arnold, K, Schmidt-Heck, W, Kratzsch, J and Gebhardt, R (2014) Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun. Signal 12:11
Abstract	Hedgehog signaling plays an important role in embryonic development, organogenesis and cancer. In the adult liver, Hedgehog signaling in non-parenchymal cells has been found to play a role in certain disease states such as fibrosis and cirrhosis. However, whether the Hedgehog pathway is active in mature healthy hepatocytes and is of significance to liver function are controversial.
Links	PubMed PMC3946028 Online version:10.1186/1478-811X-12-11
Keywords
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:SMO	involved_in	GO:0045892: negative regulation of transcription, DNA-templated	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:SMO	involved_in	GO:0045893: positive regulation of transcription, DNA-templated	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:SMO	involved_in	GO:0046622: positive regulation of organ growth	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:SMO	involved_in	GO:0040018: positive regulation of multicellular organism growth	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:SMO		GO:0045892: negative regulation of transcription, DNA-templated	ECO:0000315:		P		Figures 3 B, 4 C,D, and F show that hwne smoothened is knocked down hepatocytes show an increase in mRNA of Boc, Cdo, Ptch1, and Igfbp1 when compared to the WT control.	complete CACAO 9709
MOUSE:SMO		GO:0045893: positive regulation of transcription, DNA-templated	ECO:0000315:		P		Figure 3 A,D,E,F,4 A,B,E, and F demonstrate that when smoothened is knocked down hepatocytes have a decrease in mRNA of Indian Hedgehog, Gli1,Gli3, and IGF-1.	complete CACAO 9712
MOUSE:SMO		GO:0046622: positive regulation of organ growth	ECO:0000315:		P		Table one shows that mutants of the smoothened receptor in the Hedge hog signalling pathway have smaller livers therefore it can positively regulate factors involved in growth.	complete CACAO 9947
MOUSE:SMO		GO:0040018: positive regulation of multicellular organism growth	ECO:0000315:		P		Figure one shows that when the Smoothened part of the Hedgehog signaling receptor is knocked down, the over all growth and body weight of the organism decreases. This leads to the possibility that a SMO is involved in positively enhancing developmental growth.	complete CACAO 9950
MOUSE:PTC1	involved_in	GO:0045893: positive regulation of transcription, DNA-templated	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:PTC1	involved_in	GO:0045892: negative regulation of transcription, DNA-templated	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:PTC1		GO:0045893: positive regulation of transcription, DNA-templated	ECO:0000315:		P		When Patched1 is knocked down by siRNA, this lead to a decrease in mRNA production of IGFBP-1 72 hours after transfection of the siRNA as shown in Fig 5B graph 2.	complete CACAO 9967
MOUSE:PTC1		GO:0045892: negative regulation of transcription, DNA-templated	ECO:0000315:		P		When Patched1 was knocked down with siRNA there was an increase in IGF1 and Gli3 mRNA production shown in Figure 5B	complete CACAO 9968
MOUSE:GLI3	involved_in	GO:0045893: positive regulation of transcription, DNA-templated	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:GLI3	involved_in	GO:0045892: negative regulation of transcription, DNA-templated	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
MOUSE:GLI3		GO:0045893: positive regulation of transcription, DNA-templated	ECO:0000315:		P		When Gli3 was subjected to siRNA Figure 5 C and D showed that this negatively impacted the amount of mRNA of IGF-1 made.	complete CACAO 9955
MOUSE:GLI3		GO:0045892: negative regulation of transcription, DNA-templated	ECO:0000315:		P		With siRNA to knockdown Gli3, there is an increase in the amount of IGFBP-1 mRNA and serum concentration as shown in Fig 5 C and the serum concentration in D.	complete CACAO 9961

References

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