HUMAN:VEGFA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	VEGFA (synonyms: VEGF)
Protein Name(s)	Vascular endothelial growth factor A VEGF-A Vascular permeability factor VPF
External Links
UniProt	P15692
EMBL	M32977 M27281 M63978 M63971 M63972 M63973 M63974 M63975 M63976 M63977 S85192 AH006909 X62568 AJ010438 AF022375 AF091352 AF430806 AB021221 AF214570 AY047581 AF486837 AY766116 DQ229900 AB451322 AB451451 AL136131 AL136131 AL136131 AL136131 CH471081 BC065522 AF437895 AF062645
CCDS	CCDS34457.1 CCDS34458.1 CCDS47432.1 CCDS47433.1 CCDS47434.1 CCDS47435.1 CCDS4907.2 CCDS55007.1 CCDS55008.1 CCDS55009.1 CCDS55010.1 CCDS55011.1 CCDS55012.1 CCDS55013.1 CCDS55014.1 CCDS55015.1
PIR	A41551
RefSeq	NP_001020537.2 NP_001020538.2 NP_001020539.2 NP_001020540.2 NP_001020541.2 NP_001028928.1 NP_001165093.1 NP_001165094.1 NP_001165095.1 NP_001165096.1 NP_001165097.1 NP_001165098.1 NP_001165099.1 NP_001165100.1 NP_001165101.1 NP_001191313.1 NP_001191314.1 NP_001273973.1 NP_003367.4
UniGene	Hs.73793
PDB	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS 4KZN
PDBsum	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS 4KZN
ProteinModelPortal	P15692
SMR	P15692
BioGrid	113265
DIP	DIP-5740N
IntAct	P15692
MINT	MINT-2834049
BindingDB	P15692
ChEMBL	CHEMBL1783
DrugBank	DB08885 DB00112 DB01136 DB06779 DB01120 DB01017 DB01270 DB05294
GuidetoPHARMACOLOGY	2644
PhosphoSite	P15692
DMDM	17380528
PaxDb	P15692
PRIDE	P15692
DNASU	7422
Ensembl	ENST00000372077 ENST00000457104 ENST00000518689 ENST00000518824 ENST00000520948 ENST00000523125 ENST00000523873 ENST00000523950
GeneID	7422
KEGG	hsa:7422
UCSC	uc003owd.3 uc003owe.3 uc003owf.3 uc003owg.3 uc003owh.3 uc003owi.3 uc003owj.3 uc010jyx.3
CTD	7422
GeneCards	GC06P043737
HGNC	HGNC:12680
HPA	CAB005429
MIM	192240 603933
neXtProt	NX_P15692
PharmGKB	PA37302
eggNOG	NOG73329
GeneTree	ENSGT00730000110791
HOVERGEN	HBG000105
InParanoid	P15692
KO	K05448
PhylomeDB	P15692
Reactome	REACT_121092 REACT_12380 REACT_12583 REACT_228024 REACT_228063 REACT_228166
ChiTaRS	VEGFA
EvolutionaryTrace	P15692
GeneWiki	Vascular_endothelial_growth_factor_A
GenomeRNAi	7422
NextBio	29060
PRO	PR:P15692
Proteomes	UP000005640
Bgee	P15692
ExpressionAtlas	P15692
Genevestigator	P15692
GO	GO:0009986 GO:0005737 GO:0005576 GO:0005615 GO:0016020 GO:0031093 GO:0005578 GO:0030141 GO:0042056 GO:0005125 GO:0050840 GO:0001968 GO:0008083 GO:0008201 GO:0042802 GO:0038191 GO:0005161 GO:0046982 GO:0042803 GO:0048018 GO:0043183 GO:0043184 GO:0005172 GO:0032147 GO:0001525 GO:0048844 GO:0002575 GO:0007596 GO:0048754 GO:0048593 GO:0048739 GO:0060948 GO:0048469 GO:0002042 GO:0071456 GO:0035924 GO:0071679 GO:0060982 GO:0003169 GO:0071542 GO:0035767 GO:0030855 GO:0042462 GO:0040007 GO:0003007 GO:0001701 GO:0050930 GO:0001822 GO:0007595 GO:0030324 GO:0036303 GO:0030225 GO:0060749 GO:0007498 GO:0030224 GO:0043066 GO:0043154 GO:0000122 GO:0007399 GO:0003151 GO:0001541 GO:0001569 GO:0030168 GO:0002576 GO:0050918 GO:0045766 GO:0048842 GO:0043536 GO:0090190 GO:0045785 GO:0051781 GO:0030335 GO:0090050 GO:0008284 GO:0038091 GO:0051272 GO:0032793 GO:0038033 GO:0010595 GO:0001938 GO:0050679 GO:0070374 GO:0051894 GO:0010628 GO:1901727 GO:0002687 GO:0043406 GO:0060754 GO:0002053 GO:0002052 GO:1900745 GO:0033138 GO:1900086 GO:0050731 GO:0050927 GO:0031954 GO:0031334 GO:0090037 GO:1903572 GO:1902966 GO:0001934 GO:0002092 GO:1902336 GO:0045944 GO:0061419 GO:0030949 GO:0043117 GO:0031077 GO:0060319 GO:0008360 GO:0030823 GO:0090259 GO:0006357 GO:0061418 GO:0001666 GO:0043129 GO:0035148 GO:0048010 GO:0038084 GO:0001570 GO:0038190
Gene3D	2.10.160.10 2.10.90.10
InterPro	IPR029034 IPR023581 IPR000072 IPR027928
Pfam	PF00341 PF14554
SMART	SM00141
SUPFAM	SSF57501 SSF57593
PROSITE	PS00249 PS50278

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
acts_upstream_of_or_within	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-2	P	occurs_in:(EMAPA:32860)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-2	P	occurs_in:(EMAPA:16916)\|occurs_in:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-2	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:28977001^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000207582) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26683794^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0097533	cellular stress response to acid chemical	PMID:26299712^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:24844779^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00001230A0_9606	P	results_in_movement_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	PMID:24844779^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS00001230A0_9606	P	results_in_division_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:28977001^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000092969) occurs_in:(CL:0000071)	Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	PMID:26299712^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618) part_of:(GO:0097533)	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21771332^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:26268439^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_division_of:(CL:0000669)	Seeded From UniProt	complete
involved_in	GO:0097475	motor neuron migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:1903672	positive regulation of sprouting angiogenesis	PMID:25251394^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000007F792_9606	P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:24865854^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002619)	Seeded From UniProt	complete
NOT\|involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:19390056^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030225	macrophage differentiation	PMID:21149635^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030224	monocyte differentiation	PMID:21149635^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903572	positive regulation of protein kinase D signaling	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1902336	positive regulation of retinal ganglion cell axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-2	P		Seeded From UniProt	complete
involved_in	GO:1901727	positive regulation of histone deacetylase activity	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q9UQL6) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	PMID:20660291^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P35918)	Seeded From UniProt	complete
involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-2	P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:20551324^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0090037	positive regulation of protein kinase C signaling	PMID:18059339^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0071542	dopaminergic neuron differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	PMID:19652095^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q9H4X1)	Seeded From UniProt	complete
involved_in	GO:0060982	coronary artery morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-3	P		Seeded From UniProt	complete
involved_in	GO:0060948	cardiac vascular smooth muscle cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-3	P		Seeded From UniProt	complete
involved_in	GO:0060749	mammary gland alveolus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0060319	primitive erythrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0051272	positive regulation of cellular component movement	PMID:10527820^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051272	positive regulation of cellular component movement	PMID:12744932^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050927	positive regulation of positive chemotaxis	PMID:12744932^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050927	positive regulation of positive chemotaxis	PMID:7929439^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0050840	extracellular matrix binding	PMID:14570917^[19]	ECO:0000305	curator inference used in manual assertion	GO:0001968	F		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:10022831^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:21245381^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0048842	positive regulation of axon extension involved in axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-2	P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0048739	cardiac muscle fiber development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0048593	camera-type eye morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0048469	cell maturation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:20660291^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35918	F		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:21245381^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18093989^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18059339^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:18440775^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:18577655^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:18440775^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:9202027^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:18440775^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:20660291^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35968-2	F		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:10022831^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35968	F		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:1417831^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35968	F		Seeded From UniProt	complete
enables	GO:0043183	vascular endothelial growth factor receptor 1 binding	PMID:1312256^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17948	F		Seeded From UniProt	complete
involved_in	GO:0043129	surfactant homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15691	F		Seeded From UniProt	complete
involved_in	GO:0042462	eye photoreceptor cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:18059339^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:18440775^[23]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:21245381^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0038190	VEGF-activated neuropilin signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-2	P	occurs_in:(CL:0000740) causally_upstream_of:(GO:1902336)	Seeded From UniProt	complete
involved_in	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	PMID:17470632^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PMID:18440775^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PMID:21245381^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0036303	lymph vessel morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-3	P		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:18440775^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035767	endothelial cell chemotaxis	PMID:18440775^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618) has_input:(UniProtKB:P04792)\|occurs_in(CL:0002618) has_input:(UniProtKB:Q9UQL6)	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:18440775^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618) has_input:(UniProtKB:P04792)	Seeded From UniProt	complete
involved_in	GO:0032793	positive regulation of CREB transcription factor activity	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:18059339^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0031077	post-embryonic camera-type eye development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:7929439^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:1312256^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:7929439^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:17470632^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:10022831^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:17470632^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:10527820^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:7929439^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:7929439^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:14570917^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:9202027^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15691	F		Seeded From UniProt	complete
involved_in	GO:0007595	lactation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9202027^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15691	C		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:17470632^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16234	F		Seeded From UniProt	complete
enables	GO:0005161	platelet-derived growth factor receptor binding	PMID:17470632^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09619	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:18440775^[23]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15691	F		Seeded From UniProt	complete
involved_in	GO:0003169	coronary vein morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-3	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731-3	P		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	PMID:20660291^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P35918)	Seeded From UniProt	complete
involved_in	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	PMID:20660291^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	PMID:18059339^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	PMID:14570917^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:10022831^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:20497126^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:9202027^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:18577655^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P15691	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q00731	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18093989^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P24468) occurs_in:(UBERON:0001621) occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	PMID:18386220^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:16489009^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050930	induction of positive chemotaxis	PMID:12744932^[17]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:16489009^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	PMID:19674970^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:18275976^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:19033661^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18386220^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10066377^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:11461089^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:17082651^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035148	tube formation	PMID:19033661^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	PMID:16489009^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031334	positive regulation of protein complex assembly	PMID:19033661^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:17082651^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000043)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:18386220^[29]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P10415)	Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:19033661^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:15001987^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17082651^[36]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000043)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16490744^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	PMID:14570917^[19]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005172	vascular endothelial growth factor receptor binding	PMID:11513746^[39]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17948	F		Seeded From UniProt	complete
enables	GO:0005172	vascular endothelial growth factor receptor binding	PMID:10471394^[40]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17948	F		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:16489009^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:18386220^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:19033661^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:18386220^[29]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P31749)	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:16490744^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:11427521^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060754	positive regulation of mast cell chemotaxis	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767	P		Seeded From UniProt	complete
involved_in	GO:0050930	induction of positive chemotaxis	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767	P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:108037 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619991 RGD:620695 UniProtKB:P15692 UniProtKB:P49767 ZFIN:ZDB-GENE-990415-273	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619850 RGD:619991 UniProtKB:P15692	P		Seeded From UniProt	complete
enables	GO:0043184	vascular endothelial growth factor receptor 2 binding	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246424 RGD:619991 UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0043183	vascular endothelial growth factor receptor 1 binding	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN002635039 UniProtKB:P15692 UniProtKB:P49765	F		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619991 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767	F		Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 UniProtKB:P15692 ZFIN:ZDB-GENE-040303-4	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:108037 PANTHER:PTN000246442 RGD:619991 UniProtKB:P15691 UniProtKB:P15692 UniProtKB:P49763	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:105095 MGI:MGI:108037 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619850 RGD:619991 UniProtKB:P15691 UniProtKB:P15692 UniProtKB:P49765	C		Seeded From UniProt	complete
enables	GO:0005172	vascular endothelial growth factor receptor binding	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 MGI:MGI:108037 MGI:MGI:109124 PANTHER:PTN000246442 RGD:619800 RGD:619991 RGD:620695 UniProtKB:O43915 UniProtKB:P15692 UniProtKB:P49765 UniProtKB:P49767 ZFIN:ZDB-GENE-040303-4	F		Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619850 ZFIN:ZDB-GENE-030131-4605 ZFIN:ZDB-GENE-040303-4	P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619850 UniProtKB:P15691 UniProtKB:P15692 UniProtKB:P49765	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000246442 RGD:619850 RGD:619991 RGD:620695 UniProtKB:P15692	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21873635^[42]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103178 PANTHER:PTN000246442 RGD:619799 RGD:619800 RGD:619991 UniProtKB:P15692 ZFIN:ZDB-GENE-070810-6	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:10575000^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8702615^[44]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010749	regulation of nitric oxide mediated signal transduction	PMID:16150726^[45]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:12714610^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25132001^[47]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:12207021^[48]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15692	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072	F		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027928 InterPro:IPR036841	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000072	C		Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	PMID:16774925^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	PMID:16774925^[49]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9H3U7	P	regulates_o_occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:2000573	positive regulation of DNA biosynthetic process	PMID:16774925^[49]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:22773844^[50]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:22773844^[50]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000210741) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22696064^[51]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000283762) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:24863063^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P49023)	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:24863063^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P27361) part_of:(GO:0038190) causally_upstream_of:(GO:0070371)	Seeded From UniProt	complete
involved_in	GO:0038190	VEGF-activated neuropilin signaling pathway	PMID:24863063^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0070371)	Seeded From UniProt	complete
involved_in	GO:1902966	positive regulation of protein localization to early endosome	PMID:23639442^[53]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:23639442^[53]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0038084)	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:23639442^[53]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0038084)	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:23639442^[53]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0038084)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18093989^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P52799) occurs_in:(CL:0000115) occurs_in:(UBERON:0001621)\|has_input(UniProtKB:Q14469) occurs_in:(CL:0000115) occurs_in:(UBERON:0001621)\|has_input(UniProtKB:Q9NR61) occurs_in:(CL:0000115) occurs_in:(UBERON:0001621)\|has_input(UniProtKB:Q99466) occurs_in:(CL:0000115) occurs_in:(UBERON:0001621)\|has_input(UniProtKB:P46531) occurs_in:(CL:0000115) occurs_in:(UBERON:0001621)	Seeded From UniProt	complete
enables	GO:0038191	neuropilin binding	PMID:24401374^[54]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14786	F		Seeded From UniProt	complete
enables	GO:0038191	neuropilin binding	PMID:24401374^[54]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P97333	F		Seeded From UniProt	complete
involved_in	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	PMID:17470632^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	PMID:23639442^[53]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:18093989^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038190	VEGF-activated neuropilin signaling pathway	PMID:24863063^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0043491)	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:24863063^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P35968) part_of:(GO:0038190)	Seeded From UniProt	complete
involved_in	GO:0060754	positive regulation of mast cell chemotaxis	PMID:19275959^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050930	induction of positive chemotaxis	PMID:19275959^[55]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:17470632^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09619	F	has_regulation_target:(UniProtKB:P09619)	Seeded From UniProt	complete
enables	GO:0048018	receptor ligand activity	PMID:17470632^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16234	F	has_regulation_target:(UniProtKB:P16234)	Seeded From UniProt	complete
involved_in	GO:0043117	positive regulation of vascular permeability	PMID:16109918^[56]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:19275959^[55]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031954	positive regulation of protein autophosphorylation	PMID:17470632^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P16234)	Seeded From UniProt	complete
enables	GO:0005172	vascular endothelial growth factor receptor binding	PMID:9529250^[57]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14786	F		Seeded From UniProt	complete
involved_in	GO:0002575	basophil chemotaxis	PMID:17082651^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22897854^[58]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15692-4	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:1312256^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15692-4	F		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0048018	P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
involved_in	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	PMID:17470632^[28]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000134)	Seeded From UniProt	complete
involved_in	GO:0002687	positive regulation of leukocyte migration	PMID:1312256^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:15351965^[59]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	PMID:15015550^[60]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Reactome:R-HSA-1234174	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194313 Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	Reactome:R-HSA-8866910	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-8864936 Reactome:R-HSA-6789615 Reactome:R-HSA-5357479 Reactome:R-HSA-5357432 Reactome:R-HSA-5357429 Reactome:R-HSA-5218854 Reactome:R-HSA-5218851 Reactome:R-HSA-5218847 Reactome:R-HSA-5218839 Reactome:R-HSA-5218838 Reactome:R-HSA-5218836 Reactome:R-HSA-5218832 Reactome:R-HSA-5218830 Reactome:R-HSA-5218826 Reactome:R-HSA-5218824 Reactome:R-HSA-5218822 Reactome:R-HSA-5218820 Reactome:R-HSA-5218819 Reactome:R-HSA-5218818 Reactome:R-HSA-5218815 Reactome:R-HSA-5218814 Reactome:R-HSA-5218812 Reactome:R-HSA-5218811 Reactome:R-HSA-5218809 Reactome:R-HSA-5218806 Reactome:R-HSA-5218804 Reactome:R-HSA-5218645 Reactome:R-HSA-5218643 Reactome:R-HSA-5218642 Reactome:R-HSA-5218640 Reactome:R-HSA-481007 Reactome:R-HSA-4420206 Reactome:R-HSA-4420202 Reactome:R-HSA-4420153 Reactome:R-HSA-4420143 Reactome:R-HSA-4420140 Reactome:R-HSA-4420128 Reactome:R-HSA-4420121 Reactome:R-HSA-4420117 Reactome:R-HSA-4420107 Reactome:R-HSA-4420099 Reactome:R-HSA-4420083 Reactome:R-HSA-195378 Reactome:R-HSA-194311 Reactome:R-HSA-194310 Reactome:R-HSA-1235037	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0497	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Howe, GA et al. (2017) MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2. PLoS ONE 12 e0185619 PubMed GONUTS page
↑ Mahdaviani, K et al. (2016) Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metab. Clin. Exp. 65 26-35 PubMed GONUTS page
↑ ^3.0 ^3.1 Yu, S et al. (2015) High concentrations of uric acid inhibit angiogenesis via regulation of the Krüppel-like factor 2-vascular endothelial growth factor-A axis by miR-92a. Circ. J. 79 2487-98 PubMed GONUTS page
↑ ^4.0 ^4.1 Kim, JH et al. (2014) Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid. Redox Signal. 21 2469-82 PubMed GONUTS page
↑ Ferla, R et al. (2011) Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer 11 303 PubMed GONUTS page
↑ Caporali, A et al. (2015) p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia. Nat Commun 6 8024 PubMed GONUTS page
↑ Wen, Z et al. (2014) MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF. PLoS ONE 9 e104666 PubMed GONUTS page
↑ Wang, HW et al. (2014) Dysregulated miR-361-5p/VEGF axis in the plasma and endothelial progenitor cells of patients with coronary artery disease. PLoS ONE 9 e98070 PubMed GONUTS page
↑ Brock, M et al. (2009) Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. Circ. Res. 104 1184-91 PubMed GONUTS page
↑ ^10.0 ^10.1 Klimchenko, O et al. (2011) Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood 117 3065-75 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 Evans, IM et al. (2010) Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem. J. 429 565-72 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Mitola, S et al. (2010) Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood 116 3677-80 PubMed GONUTS page
↑ Ohnesorge, N et al. (2010) Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J. Biol. Chem. 285 26199-210 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Liu, D et al. (2008) The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. Oncogene 27 2989-98 PubMed GONUTS page
↑ An, X et al. (2009) Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Circulation 120 617-27 PubMed GONUTS page
↑ ^16.0 ^16.1 Lash, GE et al. (1999) The effects of angiogenic growth factors on extravillous trophoblast invasion and motility. Placenta 20 661-7 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Lash, GE et al. (2003) Vascular endothelial growth factor is a chemoattractant for trophoblast cells. Placenta 24 549-56 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Waltenberger, J et al. (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269 26988-95 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Goerges, AL & Nugent, MA (2004) pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release. J. Biol. Chem. 279 2307-15 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Soldi, R et al. (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J. 18 882-92 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Evans, IM et al. (2011) Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol. 31 1174-85 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 van den Akker, NM et al. (2008) Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. Cardiovasc. Res. 78 366-75 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page
↑ ^24.0 ^24.1 Browning, AC et al. (2008) The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells. Br J Ophthalmol 92 1003-8 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Pedram, A et al. (1997) Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion. J. Biol. Chem. 272 17097-103 PubMed GONUTS page
↑ Terman, BI et al. (1992) Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187 1579-86 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 de Vries, C et al. (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255 989-91 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 ^28.6 ^28.7 ^28.8 ^28.9 Ball, SG et al. (2007) Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol. 177 489-500 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 ^29.4 Kou, B et al. (2008) Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis. Microcirculation 15 251-67 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 Dixelius, J et al. (2006) Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein. Cancer Res. 66 2089-97 PubMed GONUTS page
↑ Song, H et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J. Biol. Chem. 284 29109-24 PubMed GONUTS page
↑ Kaneko, K et al. (2008) Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvasc. Res. 75 297-301 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 ^33.4 Zhang, H et al. (2008) AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J. Clin. Invest. 118 3904-16 PubMed GONUTS page
↑ Gupta, K et al. (1999) VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp. Cell Res. 247 495-504 PubMed GONUTS page
↑ Pidgeon, GP et al. (2001) Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells. Br. J. Cancer 85 273-8 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 ^36.3 de Paulis, A et al. (2006) Expression and functions of the vascular endothelial growth factors and their receptors in human basophils. J. Immunol. 177 7322-31 PubMed GONUTS page
↑ Héroult, M et al. (2004) Heparin affin regulatory peptide binds to vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. Oncogene 23 1745-53 PubMed GONUTS page
↑ ^38.0 ^38.1 Nakamura, M et al. (2006) Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture. Nephrol. Dial. Transplant. 21 1489-95 PubMed GONUTS page
↑ Yu, Y et al. (2001) Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding. Biochem. J. 358 465-72 PubMed GONUTS page
↑ Herley, MT et al. (1999) Characterization of the VEGF binding site on the Flt-1 receptor. Biochem. Biophys. Res. Commun. 262 731-8 PubMed GONUTS page
↑ Murphy, JF & Fitzgerald, DJ (2001) Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor. FASEB J. 15 1667-9 PubMed GONUTS page
↑ ^42.00 ^42.01 ^42.02 ^42.03 ^42.04 ^42.05 ^42.06 ^42.07 ^42.08 ^42.09 ^42.10 ^42.11 ^42.12 ^42.13 ^42.14 ^42.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yonekura, H et al. (1999) Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J. Biol. Chem. 274 35172-8 PubMed GONUTS page
↑ Olofsson, B et al. (1996) Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. J. Biol. Chem. 271 19310-7 PubMed GONUTS page
↑ Isenberg, JS et al. (2005) Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 102 13141-6 PubMed GONUTS page
↑ Oshima, Y et al. (2003) Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes. Invest. Ophthalmol. Vis. Sci. 44 1814-23 PubMed GONUTS page
↑ Ghavamipour, F et al. (2014) Development of a highly-potent anti-angiogenic VEGF8-109 heterodimer by directed blocking of its VEGFR-2 binding site. FEBS J. 281 4479-94 PubMed GONUTS page
↑ Muller, YA et al. (2002) The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor. J. Biol. Chem. 277 43410-6 PubMed GONUTS page
↑ ^49.0 ^49.1 ^49.2 Rocnik, EF et al. (2006) The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity. J. Biol. Chem. 281 22855-64 PubMed GONUTS page
↑ ^50.0 ^50.1 Pin, AL et al. (2012) Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J. Biol. Chem. 287 30541-51 PubMed GONUTS page
↑ Pin, AL et al. (2012) miR-20a represses endothelial cell migration by targeting MKK3 and inhibiting p38 MAP kinase activation in response to VEGF. Angiogenesis 15 593-608 PubMed GONUTS page
↑ ^52.0 ^52.1 ^52.2 ^52.3 ^52.4 Raimondi, C et al. (2014) Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J. Exp. Med. 211 1167-83 PubMed GONUTS page
↑ ^53.0 ^53.1 ^53.2 ^53.3 ^53.4 Lanahan, A et al. (2013) The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev. Cell 25 156-68 PubMed GONUTS page
↑ ^54.0 ^54.1 Fantin, A et al. (2014) Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development 141 556-62 PubMed GONUTS page
↑ ^55.0 ^55.1 ^55.2 Detoraki, A et al. (2009) Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J. Allergy Clin. Immunol. 123 1142-9, 1149.e1-5 PubMed GONUTS page
↑ Mould, AW et al. (2005) Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro. Circ. Res. 97 e60-70 PubMed GONUTS page
↑ Soker, S et al. (1998) Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92 735-45 PubMed GONUTS page
↑ Cecchi, F et al. (2012) Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling. Cancer Cell 22 250-62 PubMed GONUTS page
↑ Storkebaum, E et al. (2004) VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26 943-54 PubMed GONUTS page
↑ Patan, S (2004) Vasculogenesis and angiogenesis. Cancer Treat. Res. 117 3-32 PubMed GONUTS page

[PMID:28977001-1] 1.0 ^1.1 Howe, GA et al. (2017) MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2. PLoS ONE 12 e0185619 PubMed GONUTS page

[PMID:26683794-2] Mahdaviani, K et al. (2016) Autocrine effect of vascular endothelial growth factor-A is essential for mitochondrial function in brown adipocytes. Metab. Clin. Exp. 65 26-35 PubMed GONUTS page

[PMID:26299712-3] 3.0 ^3.1 Yu, S et al. (2015) High concentrations of uric acid inhibit angiogenesis via regulation of the Krüppel-like factor 2-vascular endothelial growth factor-A axis by miR-92a. Circ. J. 79 2487-98 PubMed GONUTS page

[PMID:24844779-4] 4.0 ^4.1 Kim, JH et al. (2014) Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid. Redox Signal. 21 2469-82 PubMed GONUTS page

[PMID:21771332-5] Ferla, R et al. (2011) Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer 11 303 PubMed GONUTS page

[PMID:26268439-6] Caporali, A et al. (2015) p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia. Nat Commun 6 8024 PubMed GONUTS page

[PMID:25251394-7] Wen, Z et al. (2014) MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF. PLoS ONE 9 e104666 PubMed GONUTS page

[PMID:24865854-8] Wang, HW et al. (2014) Dysregulated miR-361-5p/VEGF axis in the plasma and endothelial progenitor cells of patients with coronary artery disease. PLoS ONE 9 e98070 PubMed GONUTS page

[PMID:19390056-9] Brock, M et al. (2009) Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. Circ. Res. 104 1184-91 PubMed GONUTS page

[PMID:21149635-10] 10.0 ^10.1 Klimchenko, O et al. (2011) Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions. Blood 117 3065-75 PubMed GONUTS page

[PMID:20497126-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 Evans, IM et al. (2010) Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem. J. 429 565-72 PubMed GONUTS page

[PMID:20660291-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Mitola, S et al. (2010) Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. Blood 116 3677-80 PubMed GONUTS page

[PMID:20551324-13] Ohnesorge, N et al. (2010) Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). J. Biol. Chem. 285 26199-210 PubMed GONUTS page

[PMID:18059339-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Liu, D et al. (2008) The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. Oncogene 27 2989-98 PubMed GONUTS page

[PMID:19652095-15] An, X et al. (2009) Response gene to complement 32, a novel hypoxia-regulated angiogenic inhibitor. Circulation 120 617-27 PubMed GONUTS page

[PMID:10527820-16] 16.0 ^16.1 Lash, GE et al. (1999) The effects of angiogenic growth factors on extravillous trophoblast invasion and motility. Placenta 20 661-7 PubMed GONUTS page

[PMID:12744932-17] 17.0 ^17.1 ^17.2 Lash, GE et al. (2003) Vascular endothelial growth factor is a chemoattractant for trophoblast cells. Placenta 24 549-56 PubMed GONUTS page

[PMID:7929439-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Waltenberger, J et al. (1994) Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269 26988-95 PubMed GONUTS page

[PMID:14570917-19] 19.0 ^19.1 ^19.2 ^19.3 Goerges, AL & Nugent, MA (2004) pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release. J. Biol. Chem. 279 2307-15 PubMed GONUTS page

[PMID:10022831-20] 20.0 ^20.1 ^20.2 ^20.3 Soldi, R et al. (1999) Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2. EMBO J. 18 882-92 PubMed GONUTS page

[PMID:21245381-21] 21.0 ^21.1 ^21.2 ^21.3 Evans, IM et al. (2011) Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol. Cell. Biol. 31 1174-85 PubMed GONUTS page

[PMID:18093989-22] 22.0 ^22.1 ^22.2 ^22.3 van den Akker, NM et al. (2008) Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. Cardiovasc. Res. 78 366-75 PubMed GONUTS page

[PMID:18440775-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page

[PMID:18577655-24] 24.0 ^24.1 Browning, AC et al. (2008) The effects of growth factors on the proliferation and in vitro angiogenesis of human macular inner choroidal endothelial cells. Br J Ophthalmol 92 1003-8 PubMed GONUTS page

[PMID:9202027-25] 25.0 ^25.1 ^25.2 ^25.3 Pedram, A et al. (1997) Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion. J. Biol. Chem. 272 17097-103 PubMed GONUTS page

[PMID:1417831-26] Terman, BI et al. (1992) Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187 1579-86 PubMed GONUTS page

[PMID:1312256-27] 27.0 ^27.1 ^27.2 ^27.3 de Vries, C et al. (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255 989-91 PubMed GONUTS page

[PMID:17470632-28] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 ^28.6 ^28.7 ^28.8 ^28.9 Ball, SG et al. (2007) Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol. 177 489-500 PubMed GONUTS page

[PMID:18386220-29] 29.0 ^29.1 ^29.2 ^29.3 ^29.4 Kou, B et al. (2008) Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis. Microcirculation 15 251-67 PubMed GONUTS page

[PMID:16489009-30] 30.0 ^30.1 ^30.2 ^30.3 Dixelius, J et al. (2006) Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein. Cancer Res. 66 2089-97 PubMed GONUTS page

[PMID:19674970-31] Song, H et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J. Biol. Chem. 284 29109-24 PubMed GONUTS page

[PMID:18275976-32] Kaneko, K et al. (2008) Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvasc. Res. 75 297-301 PubMed GONUTS page

[PMID:19033661-33] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 Zhang, H et al. (2008) AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J. Clin. Invest. 118 3904-16 PubMed GONUTS page

[PMID:10066377-34] Gupta, K et al. (1999) VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp. Cell Res. 247 495-504 PubMed GONUTS page

[PMID:11461089-35] Pidgeon, GP et al. (2001) Vascular endothelial growth factor (VEGF) upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells. Br. J. Cancer 85 273-8 PubMed GONUTS page

[PMID:17082651-36] 36.0 ^36.1 ^36.2 ^36.3 de Paulis, A et al. (2006) Expression and functions of the vascular endothelial growth factors and their receptors in human basophils. J. Immunol. 177 7322-31 PubMed GONUTS page

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[PMID:21873635-42] 42.00 ^42.01 ^42.02 ^42.03 ^42.04 ^42.05 ^42.06 ^42.07 ^42.08 ^42.09 ^42.10 ^42.11 ^42.12 ^42.13 ^42.14 ^42.15 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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[PMID:25132001-47] Ghavamipour, F et al. (2014) Development of a highly-potent anti-angiogenic VEGF8-109 heterodimer by directed blocking of its VEGFR-2 binding site. FEBS J. 281 4479-94 PubMed GONUTS page

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[PMID:16774925-49] 49.0 ^49.1 ^49.2 Rocnik, EF et al. (2006) The novel SPARC family member SMOC-2 potentiates angiogenic growth factor activity. J. Biol. Chem. 281 22855-64 PubMed GONUTS page

[PMID:22773844-50] 50.0 ^50.1 Pin, AL et al. (2012) Annexin-1-mediated endothelial cell migration and angiogenesis are regulated by vascular endothelial growth factor (VEGF)-induced inhibition of miR-196a expression. J. Biol. Chem. 287 30541-51 PubMed GONUTS page

[PMID:22696064-51] Pin, AL et al. (2012) miR-20a represses endothelial cell migration by targeting MKK3 and inhibiting p38 MAP kinase activation in response to VEGF. Angiogenesis 15 593-608 PubMed GONUTS page

[PMID:24863063-52] 52.0 ^52.1 ^52.2 ^52.3 ^52.4 Raimondi, C et al. (2014) Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J. Exp. Med. 211 1167-83 PubMed GONUTS page

[PMID:23639442-53] 53.0 ^53.1 ^53.2 ^53.3 ^53.4 Lanahan, A et al. (2013) The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev. Cell 25 156-68 PubMed GONUTS page

[PMID:24401374-54] 54.0 ^54.1 Fantin, A et al. (2014) Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development 141 556-62 PubMed GONUTS page

[PMID:19275959-55] 55.0 ^55.1 ^55.2 Detoraki, A et al. (2009) Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J. Allergy Clin. Immunol. 123 1142-9, 1149.e1-5 PubMed GONUTS page

[PMID:16109918-56] Mould, AW et al. (2005) Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro. Circ. Res. 97 e60-70 PubMed GONUTS page

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[PMID:22897854-58] Cecchi, F et al. (2012) Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signaling. Cancer Cell 22 250-62 PubMed GONUTS page

[PMID:15351965-59] Storkebaum, E et al. (2004) VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26 943-54 PubMed GONUTS page

[PMID:15015550-60] Patan, S (2004) Vasculogenesis and angiogenesis. Cancer Treat. Res. 117 3-32 PubMed GONUTS page

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