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PMID:1312256

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Citation

de Vries, C, Escobedo, JA, Ueno, H, Houck, K, Ferrara, N and Williams, LT (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-91

Abstract

The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF.

Links

PubMed

Keywords

Animals; Cloning, Molecular; Cross-Linking Reagents; Endothelial Growth Factors/physiology; Enzyme Activation; Humans; Lymphokines/physiology; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Receptors, Cell Surface/genetics; Signal Transduction; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors; Xenopus laevis

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:VEGFA

involved_in

GO:0048010: vascular endothelial growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:NRP1

enables

GO:0042802: identical protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15692-4

F

Seeded From UniProt

complete

HUMAN:NRP1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P17948

F

Seeded From UniProt

complete

HUMAN:VGFR1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15692-4

F

Seeded From UniProt

complete

HUMAN:VGFR1

involved_in

GO:0048010: vascular endothelial growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:VEGFA

enables

GO:0043183: vascular endothelial growth factor receptor 1 binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P17948

F

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:VEGFA

enables

GO:0042802: identical protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15692-4

F

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0002687: positive regulation of leukocyte migration

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:VGFR1

involved_in

GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:VGFR1

enables

GO:0019838: growth factor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15692

F

Seeded From UniProt

complete

HUMAN:VGFR1

enables

GO:0005021: vascular endothelial growth factor-activated receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete


See also

References

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