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PMID:1312256
Citation |
de Vries, C, Escobedo, JA, Ueno, H, Houck, K, Ferrara, N and Williams, LT (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255:989-91 |
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Abstract |
The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF. |
Links | |
Keywords |
Animals; Cloning, Molecular; Cross-Linking Reagents; Endothelial Growth Factors/physiology; Enzyme Activation; Humans; Lymphokines/physiology; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Receptors, Cell Surface/genetics; Signal Transduction; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factors; Xenopus laevis |
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Significance
Annotations
Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|
involved_in |
GO:0048010: vascular endothelial growth factor receptor signaling pathway |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802: identical protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P15692-4 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P17948 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005515: protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P15692-4 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048010: vascular endothelial growth factor receptor signaling pathway |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043183: vascular endothelial growth factor receptor 1 binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P17948 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802: identical protein binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P15692-4 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002687: positive regulation of leukocyte migration |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030949: positive regulation of vascular endothelial growth factor receptor signaling pathway |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019838: growth factor binding |
ECO:0000353: physical interaction evidence used in manual assertion |
UniProtKB:P15692 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005021: vascular endothelial growth factor-activated receptor activity |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
See also
References
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