PMID:18386220

Citation	Kou, B, Ni, J, Vatish, M and Singer, DR (2008) Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis. Microcirculation 15:251-67
Abstract	Reduced capillary density occurs early in cardiovascular diseases. Oxidant stress is implicated in endothelial apoptosis. We investigated the effects of xanthine oxidase (XO) on endothelial survival signaling: protein kinase B/Akt, its cross-talk with p38 MAPK and apoptosis pathways, and its effect on vascular tube formation in vascular endothelial growth factor (VEGF)-simulated human umbilical vein cells.
Links	PubMed Online version:10.1080/10739680701651495
Keywords	Apoptosis/drug effects; Apoptosis/physiology; Cell Division/drug effects; Cell Division/physiology; Cell Survival/drug effects; Cell Survival/physiology; Cells, Cultured; Endothelial Cells/cytology; Endothelial Cells/enzymology; Enzyme Inhibitors/pharmacology; Humans; MAP Kinase Signaling System/drug effects; MAP Kinase Signaling System/physiology; Microcirculation/physiology; Neovascularization, Physiologic/physiology; Oxypurinol/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Phosphorylation/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Reactive Oxygen Species/metabolism; Umbilical Veins/cytology; Vascular Endothelial Growth Factor A/metabolism; Vascular Endothelial Growth Factor A/pharmacology; Xanthine/metabolism; Xanthine/pharmacology; Xanthine Oxidase/antagonists & inhibitors; Xanthine Oxidase/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:VEGFA	involved_in	GO:0001934: positive regulation of protein phosphorylation	ECO:0000314: direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P31749)	Seeded From UniProt	complete
HUMAN:VEGFA	involved_in	GO:0001938: positive regulation of endothelial cell proliferation	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:VEGFA	involved_in	GO:0010628: positive regulation of gene expression	ECO:0000314: direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P10415)	Seeded From UniProt	complete
HUMAN:VEGFA	involved_in	GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:VEGFA	involved_in	GO:1900745: positive regulation of p38MAPK cascade	ECO:0000314: direct assay evidence used in manual assertion		P		Seeded From UniProt	complete

References

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