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PMID:18386220

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Citation

Kou, B, Ni, J, Vatish, M and Singer, DR (2008) Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis. Microcirculation 15:251-67

Abstract

Reduced capillary density occurs early in cardiovascular diseases. Oxidant stress is implicated in endothelial apoptosis. We investigated the effects of xanthine oxidase (XO) on endothelial survival signaling: protein kinase B/Akt, its cross-talk with p38 MAPK and apoptosis pathways, and its effect on vascular tube formation in vascular endothelial growth factor (VEGF)-simulated human umbilical vein cells.

Links

PubMed Online version:10.1080/10739680701651495

Keywords

Apoptosis/drug effects; Apoptosis/physiology; Cell Division/drug effects; Cell Division/physiology; Cell Survival/drug effects; Cell Survival/physiology; Cells, Cultured; Endothelial Cells/cytology; Endothelial Cells/enzymology; Enzyme Inhibitors/pharmacology; Humans; MAP Kinase Signaling System/drug effects; MAP Kinase Signaling System/physiology; Microcirculation/physiology; Neovascularization, Physiologic/physiology; Oxypurinol/pharmacology; Phosphatidylinositol 3-Kinases/metabolism; Phosphorylation/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Reactive Oxygen Species/metabolism; Umbilical Veins/cytology; Vascular Endothelial Growth Factor A/metabolism; Vascular Endothelial Growth Factor A/pharmacology; Xanthine/metabolism; Xanthine/pharmacology; Xanthine Oxidase/antagonists & inhibitors; Xanthine Oxidase/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:VEGFA

involved_in

GO:0001934: positive regulation of protein phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P31749)

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0010628: positive regulation of gene expression

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P10415)

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:0001937: negative regulation of endothelial cell proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:0001933: negative regulation of protein phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P31749)

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:0006919: activation of cysteine-type endopeptidase activity involved in apoptotic process

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P42574)

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:0010629: negative regulation of gene expression

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P10415)

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:0051898: negative regulation of protein kinase B signaling

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:2001213: negative regulation of vasculogenesis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:2000379: positive regulation of reactive oxygen species metabolic process

ECO:0000314: direct assay evidence used in manual assertion

P

  • part_of:(CL:0002618)

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:0045602: negative regulation of endothelial cell differentiation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:1900747: negative regulation of vascular endothelial growth factor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:XDH

involved_in

GO:1900745: positive regulation of p38MAPK cascade

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0001934: positive regulation of protein phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P31749)

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0001938: positive regulation of endothelial cell proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0010628: positive regulation of gene expression

ECO:0000314: direct assay evidence used in manual assertion

P

has_input:(UniProtKB:P10415)

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0043154: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:1900745: positive regulation of p38MAPK cascade

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

See also

References

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