GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:17470632

From GONUTS
Jump to: navigation, search
Citation

Ball, SG, Shuttleworth, CA and Kielty, CM (2007) Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol. 177:489-500

Abstract

Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow-derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can stimulate platelet-derived growth factor receptors (PDGFRs), thereby regulating MSC migration and proliferation. VEGF-A binds to both PDGFRalpha and PDGFRbeta and induces tyrosine phosphorylation that, when inhibited, results in attenuation of VEGF-A-induced MSC migration and proliferation. This mechanism was also shown to mediate human dermal fibroblast (HDF) migration. VEGF-A/PDGFR signaling has the potential to regulate vascular cell recruitment and proliferation during tissue regeneration and disease.

Links

PubMed PMC2064818 Online version:10.1083/jcb.200608093

Keywords

Adolescent; Adult; Bone Marrow Cells/cytology; Bone Marrow Cells/metabolism; Cell Movement/drug effects; Cell Movement/physiology; Cells, Cultured; Dermis/cytology; Dermis/metabolism; Female; Fibroblasts/cytology; Fibroblasts/metabolism; Humans; Infant, Newborn; Male; Mesenchymal Stem Cells/cytology; Mesenchymal Stem Cells/metabolism; Protein Binding/physiology; Receptor, Platelet-Derived Growth Factor alpha/metabolism; Receptor, Platelet-Derived Growth Factor beta/metabolism; Regeneration/drug effects; Regeneration/physiology; Signal Transduction/drug effects; Signal Transduction/physiology; Vascular Endothelial Growth Factor A/metabolism; Vascular Endothelial Growth Factor A/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:PGFRB

involved_in

GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000134)

Seeded From UniProt

complete

HUMAN:PGFRB

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15692-4

F

Seeded From UniProt

complete

HUMAN:VEGFA

located_in

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000134)

Seeded From UniProt

complete

HUMAN:NRP1

involved_in

GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000134)

Seeded From UniProt

complete

HUMAN:NRP1

involved_in

GO:0031954: positive regulation of protein autophosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

  • has_input:(UniProtKB:P16234)

Seeded From UniProt

complete

HUMAN:NRP1

enables

GO:0048018: receptor ligand activity

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P09619

F

  • has_input:(UniProtKB:P09619)

Seeded From UniProt

complete

HUMAN:NRP1

enables

GO:0048018: receptor ligand activity

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P16234

F

  • has_input:(UniProtKB:P16234)

Seeded From UniProt

complete

HUMAN:PGFRA

involved_in

GO:0030335: positive regulation of cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PGFRA

enables

GO:0005021: vascular endothelial growth factor-activated receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:PGFRA

enables

GO:0038085: vascular endothelial growth factor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15692

F

Seeded From UniProt

complete

HUMAN:PGFRA

involved_in

GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

  • occurs_in:(CL:0000134)

Seeded From UniProt

complete

HUMAN:PGFRA

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15692-4

F

Seeded From UniProt

complete

HUMAN:VEGFA

enables

GO:0005161: platelet-derived growth factor receptor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P09619

F

Seeded From UniProt

complete

HUMAN:VEGFA

enables

GO:0005161: platelet-derived growth factor receptor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P16234

F

Seeded From UniProt

complete

HUMAN:VEGFA

part_of

GO:0009986: cell surface

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0030335: positive regulation of cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:VEGFA

enables

GO:0048018: receptor ligand activity

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P09619

F

has_regulation_target:(UniProtKB:P09619)

Seeded From UniProt

complete

HUMAN:VEGFA

enables

GO:0048018: receptor ligand activity

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P16234

F

has_regulation_target:(UniProtKB:P16234)

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0031954: positive regulation of protein autophosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P16234)

Seeded From UniProt

complete

HUMAN:VEGFA

involved_in

GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

occurs_in:(CL:0000134)

Seeded From UniProt

complete

HUMAN:PGFRB

involved_in

GO:0038091: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

occurs_in:(CL:0000134)

Seeded From UniProt

complete

HUMAN:PGFRB

enables

GO:0038085: vascular endothelial growth factor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P15692

F

Seeded From UniProt

complete

HUMAN:PGFRB

involved_in

GO:0030335: positive regulation of cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PDGFA

involved_in

GO:0008284: positive regulation of cell population proliferation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PDGFA

involved_in

GO:0030335: positive regulation of cell migration

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.