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HUMAN:RAD51
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | RAD51 (synonyms: RAD51A, RECA) | |
Protein Name(s) | DNA repair protein RAD51 homolog 1
HsRAD51 hRAD51 RAD51 homolog A | |
External Links | ||
UniProt | Q06609 | |
EMBL | D13804 D14134 AF165094 AF165088 AF165089 AF165090 AF165091 AF165092 AF165093 AF233744 AF233740 AF233741 AF233742 AF236021 AF233743 EU362635 AY196785 AK131299 AK291969 AK313503 CR536559 AC012476 AC022405 CH471125 CH471125 CH471125 BC001459 | |
CCDS | CCDS10062.1 CCDS53931.1 CCDS53932.1 | |
PIR | I58295 | |
RefSeq | NP_001157741.1 NP_001157742.1 NP_002866.2 NP_597994.3 XP_006720689.1 | |
UniGene | Hs.631709 | |
PDB | 1B22 1N0W | |
PDBsum | 1B22 1N0W | |
ProteinModelPortal | Q06609 | |
SMR | Q06609 | |
BioGrid | 111825 | |
DIP | DIP-462N | |
IntAct | Q06609 | |
MINT | MINT-1374477 | |
STRING | 9606.ENSP00000267868 | |
BindingDB | Q06609 | |
ChEMBL | CHEMBL2034807 | |
PhosphoSite | Q06609 | |
DMDM | 548663 | |
MaxQB | Q06609 | |
PaxDb | Q06609 | |
PRIDE | Q06609 | |
DNASU | 5888 | |
Ensembl | ENST00000267868 ENST00000382643 ENST00000423169 ENST00000532743 ENST00000557850 | |
GeneID | 5888 | |
KEGG | hsa:5888 | |
UCSC | uc001zmi.4 uc001zml.4 uc010bbw.3 | |
CTD | 5888 | |
GeneCards | GC15P040987 | |
HGNC | HGNC:9817 | |
HPA | CAB010381 HPA039310 | |
MIM | 114480 179617 614508 | |
neXtProt | NX_Q06609 | |
Orphanet | 238722 145 | |
PharmGKB | PA34176 | |
eggNOG | COG0468 | |
GeneTree | ENSGT00770000120539 | |
HOGENOM | HOG000227426 | |
HOVERGEN | HBG001504 | |
InParanoid | Q06609 | |
KO | K04482 | |
OMA | CQLPIDQ | |
PhylomeDB | Q06609 | |
TreeFam | TF101218 | |
Reactome | REACT_2141 REACT_27271 REACT_408 | |
SignaLink | Q06609 | |
ChiTaRS | RAD51 | |
EvolutionaryTrace | Q06609 | |
GeneWiki | RAD51 | |
GenomeRNAi | 5888 | |
NextBio | 22896 | |
PMAP-CutDB | Q06609 | |
PRO | PR:Q06609 | |
Proteomes | UP000005640 | |
Bgee | Q06609 | |
CleanEx | HS_RAD51 | |
ExpressionAtlas | Q06609 | |
Genevestigator | Q06609 | |
GO | GO:0000793 GO:0000794 GO:0005737 GO:0000800 GO:0005815 GO:0005759 GO:0005739 GO:0000228 GO:0005730 GO:0005654 GO:0005634 GO:0048471 GO:0016605 GO:0005524 GO:0003684 GO:0070182 GO:0003690 GO:0042802 GO:0008022 GO:0003697 GO:0043142 GO:0006200 GO:0072757 GO:0006974 GO:0071479 GO:0000730 GO:0006310 GO:0006281 GO:0006268 GO:0006302 GO:0000724 GO:0007126 GO:0006312 GO:0051106 GO:0051260 GO:0007131 GO:0010569 | |
Gene3D | 3.40.50.300 | |
InterPro | IPR003593 IPR011941 IPR013632 IPR016467 IPR010995 IPR003583 IPR027417 IPR020588 IPR020587 | |
Pfam | PF08423 | |
PIRSF | PIRSF005856 | |
SMART | SM00382 SM00278 | |
SUPFAM | SSF47794 SSF52540 | |
TIGRFAMs | TIGR02239 | |
PROSITE | PS50162 PS50163 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
happens_during:(GO:0006974) |
Seeded From UniProt |
complete | ||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000730 |
DNA recombinase assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043142 |
single-stranded DNA-dependent ATPase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0006974) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0036297 |
interstrand cross-link repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000785 |
chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031297 |
replication fork processing |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010833 |
telomere maintenance via telomere lengthening |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000722 |
telomere maintenance via recombination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
causally_upstream_of:(GO:0016233) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031297 |
replication fork processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0000084) |
Seeded From UniProt |
complete | ||
enables |
GO:0070182 |
DNA polymerase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072757 |
cellular response to camptothecin |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071479 |
cellular response to ionizing radiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071479 |
cellular response to ionizing radiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051260 |
protein homooligomerization |
ECO:0000353 |
physical interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051106 |
positive regulation of DNA ligation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0043142 |
single-stranded DNA-dependent ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0043142 |
single-stranded DNA-dependent ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016605 |
PML body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010569 |
regulation of double-strand break repair via homologous recombination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051321 |
meiotic cell cycle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006268 |
DNA unwinding involved in DNA replication |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0000794 |
condensed nuclear chromosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000793 |
condensed chromosome |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000228 |
nuclear chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070192 |
chromosome organization involved in meiotic cell cycle |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97890 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042148 |
strand invasion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001415033 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008094 |
DNA-dependent ATPase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001415033 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007131 |
reciprocal meiotic recombination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000534635 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006312 |
mitotic recombination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001415033 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97890 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001415033 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0000794 |
condensed nuclear chromosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97890 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000730 |
DNA recombinase assembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001415033 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0000150 |
recombinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001415033 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0035861 |
site of double-strand break |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0000800 |
lateral element |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0000150 |
recombinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006259 |
DNA metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008094 |
DNA-dependent ATPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:1990426 |
mitotic recombination-dependent replication fork processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007131 |
reciprocal meiotic recombination |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006312 |
mitotic recombination |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006310 |
DNA recombination |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-5686483 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0070317 |
negative regulation of G0 to G1 transition |
Reactome:R-HSA-8953750 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006310 |
DNA recombination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006281 |
DNA repair |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Park, J et al. (2013) The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol. Cell. Biol. 33 1632-44 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Ameziane, N et al. (2015) A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51. Nat Commun 6 8829 PubMed GONUTS page
- ↑ 3.0 3.1 Parplys, AC et al. (2015) NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 43 9817-34 PubMed GONUTS page
- ↑ Kovalenko, OV et al. (2006) RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. Nucleic Acids Res. 34 5081-92 PubMed GONUTS page
- ↑ Wang, AT et al. (2015) A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. Mol. Cell 59 478-90 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 Chu, WK et al. (2015) FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51. Nat Commun 6 5931 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Badie, S et al. (2010) BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat. Struct. Mol. Biol. 17 1461-9 PubMed GONUTS page
- ↑ 8.0 8.1 Kim, TM et al. (2012) RAD51 mutants cause replication defects and chromosomal instability. Mol. Cell. Biol. 32 3663-80 PubMed GONUTS page
- ↑ Moldovan, GL et al. (2010) DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol. Cell. Biol. 30 1088-96 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Wan, L et al. (2013) Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. Proc. Natl. Acad. Sci. U.S.A. 110 10646-51 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Yuan, J & Chen, J (2013) FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proc. Natl. Acad. Sci. U.S.A. 110 10640-5 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Pellegrini, L et al. (2002) Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature 420 287-93 PubMed GONUTS page
- ↑ 13.0 13.1 Baumann, P et al. (1996) Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87 757-66 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Bennett, BT & Knight, KL (2005) Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. J. Cell. Biochem. 96 1095-109 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 15.4 Benson, FE et al. (1994) Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. EMBO J. 13 5764-71 PubMed GONUTS page
- ↑ Bischof, O et al. (2001) Regulation and localization of the Bloom syndrome protein in response to DNA damage. J. Cell Biol. 153 367-80 PubMed GONUTS page
- ↑ 17.0 17.1 Davies, OR & Pellegrini, L (2007) Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats. Nat. Struct. Mol. Biol. 14 475-83 PubMed GONUTS page
- ↑ Sage, JM et al. (2010) Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome. J. Biol. Chem. 285 18984-90 PubMed GONUTS page
- ↑ 19.0 19.1 Park, JY et al. (2008) Identification of a novel human Rad51 variant that promotes DNA strand exchange. Nucleic Acids Res. 36 3226-34 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 20.3 20.4 20.5 20.6 20.7 20.8 20.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Khoury-Haddad, H et al. (2014) PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 111 E728-37 PubMed GONUTS page
- ↑ 22.0 22.1 Wesoly, J et al. (2006) Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol. Cell. Biol. 26 976-89 PubMed GONUTS page
- ↑ Chen, J et al. (1998) Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell 2 317-28 PubMed GONUTS page
- ↑ Liu, N et al. (1998) XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol. Cell 1 783-93 PubMed GONUTS page
- ↑ Dosanjh, MK et al. (1998) Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. Nucleic Acids Res. 26 1179-84 PubMed GONUTS page
- ↑ Kovalenko, OV et al. (1997) A novel nucleic acid-binding protein that interacts with human rad51 recombinase. Nucleic Acids Res. 25 4946-53 PubMed GONUTS page
- ↑ Shahid, T et al. (2014) Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor. Nat. Struct. Mol. Biol. 21 962-968 PubMed GONUTS page
- ↑ Shivji, MK et al. (2009) The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange. Proc. Natl. Acad. Sci. U.S.A. 106 13254-9 PubMed GONUTS page
- ↑ Robertson, RB et al. (2009) Structural transitions within human Rad51 nucleoprotein filaments. Proc. Natl. Acad. Sci. U.S.A. 106 12688-93 PubMed GONUTS page
- ↑ Esashi, F et al. (2007) Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat. Struct. Mol. Biol. 14 468-74 PubMed GONUTS page
- ↑ 31.0 31.1 31.2 Shinohara, A et al. (1993) Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. Nat. Genet. 4 239-43 PubMed GONUTS page
- ↑ Lio, YC et al. (2003) Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. J. Biol. Chem. 278 2469-78 PubMed GONUTS page
c
- Catarrhini
- GO:0071479 ! cellular response to ionizing radiation
- GO:0072757 ! cellular response to camptothecin
- Chordata
- GO:0000785 ! chromatin
- GO:0003682 ! chromatin binding
- GO:0005694 ! chromosome
- GO:0070192 ! chromosome organization involved in meiotic cell cycle
- GO:0000793 ! condensed chromosome
- GO:0000794 ! condensed nuclear chromosome
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
d
- GO:0003677 ! DNA binding
- GO:0006974 ! DNA damage response
- GO:0006259 ! DNA metabolic process
- GO:0070182 ! DNA polymerase binding
- GO:0006310 ! DNA recombination
- GO:0000730 ! DNA recombinase assembly
- GO:0006281 ! DNA repair
- GO:0000150 ! DNA strand exchange activity
- GO:0042148 ! DNA strand invasion
- GO:0006268 ! DNA unwinding involved in DNA replication
- GO:0003690 ! double-stranded DNA binding
- GO:0000724 ! double-strand break repair via homologous recombination
m
n
p
r
s
t