HUMAN:P85A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PIK3R1 (synonyms: GRB1)
Protein Name(s)	Phosphatidylinositol 3-kinase regulatory subunit alpha PI3-kinase regulatory subunit alpha PI3K regulatory subunit alpha PtdIns-3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha PI3-kinase subunit p85-alpha PtdIns-3-kinase regulatory subunit p85-alpha
External Links
UniProt	P27986
EMBL	M61906 U49349 AF279367 AK094785 AK223613 AC016564 AC104120 CH471137 CH471137 BC030815 BC094795
CCDS	CCDS3993.1 CCDS3994.1 CCDS3995.1 CCDS56374.1
PIR	A38748
RefSeq	NP_001229395.1 NP_852556.2 NP_852664.1 NP_852665.1 XP_005248599.1
UniGene	Hs.132225 Hs.604502 Hs.734132
PDB	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4WAF
PDBsum	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y 3HHM 3HIZ 3I5R 3I5S 4A55 4JPS 4L1B 4L23 4L2Y 4OVU 4OVV 4WAF
ProteinModelPortal	P27986
SMR	P27986
BioGrid	111313
DIP	DIP-119N
IntAct	P27986
MINT	MINT-93751
STRING	9606.ENSP00000274335
BindingDB	P27986
ChEMBL	CHEMBL2111367
DrugBank	DB01064
PhosphoSite	P27986
BioMuta	PIK3R1
DMDM	118572681
MaxQB	P27986
PaxDb	P27986
PRIDE	P27986
DNASU	5295
Ensembl	ENST00000320694 ENST00000336483 ENST00000521381 ENST00000521657 ENST00000523872
GeneID	5295
KEGG	hsa:5295
UCSC	uc003jva.3 uc003jvc.3 uc003jvd.3
CTD	5295
GeneCards	GC05P067511
HGNC	HGNC:8979
HPA	CAB004268 HPA001216
MIM	171833 269880 615214 616005
neXtProt	NX_P27986
Orphanet	397596 33110 3163
PharmGKB	PA33312
eggNOG	NOG263689
GeneTree	ENSGT00390000010431
HOGENOM	HOG000008438
HOVERGEN	HBG082100
InParanoid	P27986
KO	K02649
OMA	LNGYNET
OrthoDB	EOG7BP831
PhylomeDB	P27986
TreeFam	TF102033
BioCyc	MetaCyc:ENSG00000145675-MONOMER
BRENDA	2.7.1.153
Reactome	REACT_111040 REACT_115529 REACT_115852 REACT_115961 REACT_116008 REACT_118700 REACT_121025 REACT_121141 REACT_12464 REACT_12555 REACT_12578 REACT_12621 REACT_147727 REACT_147814 REACT_160158 REACT_163769 REACT_1695 REACT_17025 REACT_18283 REACT_18407 REACT_19290 REACT_19344 REACT_19358 REACT_23787 REACT_23832 REACT_23837 REACT_23847 REACT_23891 REACT_264464 REACT_267817 REACT_355160 REACT_355202 REACT_355221 REACT_355304 REACT_355313 REACT_355450 REACT_355511 REACT_355552 REACT_75829 REACT_976
SignaLink	P27986
ChiTaRS	PIK3R1
EvolutionaryTrace	P27986
GeneWiki	PIK3R1
GenomeRNAi	5295
NextBio	20462
PRO	PR:P27986
Proteomes	UP000005640
Bgee	P27986
CleanEx	HS_PIK3R1
ExpressionAtlas	P27986
Genevisible	P27986
GO	GO:0005911 GO:0005801 GO:0005737 GO:0005829 GO:0016020 GO:0005634 GO:1990578 GO:0005942 GO:0005943 GO:0005886 GO:0046935 GO:0043125 GO:0043559 GO:0005158 GO:0043560 GO:0005159 GO:0005168 GO:0043548 GO:0035014 GO:0019903 GO:0008134 GO:0005068 GO:0030183 GO:0007596 GO:0001678 GO:0032869 GO:0034644 GO:0007173 GO:0008625 GO:0038095 GO:0038096 GO:0008543 GO:0060396 GO:0045087 GO:0008286 GO:0048009 GO:0008630 GO:0050900 GO:0043066 GO:0001953 GO:0045671 GO:0048011 GO:0051531 GO:0014065 GO:0006661 GO:0046854 GO:0048015 GO:0006644 GO:0030168 GO:0030335 GO:1900103 GO:0090004 GO:0046326 GO:2001275 GO:0033120 GO:0042993 GO:0045944 GO:0032760 GO:0006468 GO:0050821 GO:0043551 GO:0051492 GO:0034976 GO:0044281 GO:0031295 GO:0050852 GO:0048010 GO:0016032
Gene3D	1.10.555.10 3.30.505.10
InterPro	IPR001720 IPR008936 IPR000198 IPR000980 IPR011511 IPR001452
PANTHER	PTHR10155
Pfam	PF00620 PF00017 PF07653
PRINTS	PR00678 PR00401
SMART	SM00324 SM00252 SM00326
SUPFAM	SSF48350 SSF50044 SSF55550
PROSITE	PS50238 PS50001 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:21321938^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	causally_upstream_of:(GO:0048661) part_of:(GO:0035655) occurs_in:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:20348923^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20348923^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:20348923^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:20348923^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response	PMID:20348923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20348923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033120	positive regulation of RNA splicing	PMID:20348923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20348923^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20348923^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17861-2	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	P		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26450	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:20624904^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6GX35	F		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:8052599^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23727	P		Seeded From UniProt	complete
involved_in	GO:0060396	growth hormone receptor signaling pathway	PMID:7782332^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:7782332^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23727	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	PMID:8052599^[5]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23727	P		Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23727	P		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23727	F		Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23727	F		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:7782332^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23727	C		Seeded From UniProt	complete
enables	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P23727	F		Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:7541045^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08069	P		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18683	P		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	PMID:8440175^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043125	ErbB-3 class receptor binding	PMID:10572067^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18683	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:14699157^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12959	F		Seeded From UniProt	complete
part_of	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18683	C		Seeded From UniProt	complete
enables	GO:0005168	neurotrophin TRKA receptor binding	PMID:15488758^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04629	F		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	PMID:7541045^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:7537849^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 PANTHER:PTN000806614 RGD:3329 RGD:621042	F		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020622 PANTHER:PTN000806614 UniProtKB:P23727	P		Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000016388 RGD:3329 UniProtKB:P23727	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 MGI:MGI:1098772 MGI:MGI:97583 PANTHER:PTN000016388 RGD:3329 UniProtKB:P23727 WB:WBGene00000001	P		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 PANTHER:PTN000806614 RGD:3329 UniProtKB:P23727 WB:WBGene00000001	C		Seeded From UniProt	complete
part_of	GO:1990578	perinuclear endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	C		Seeded From UniProt	complete
involved_in	GO:1903076	regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0051492	regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	F		Seeded From UniProt	complete
involved_in	GO:0046626	regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0045671	negative regulation of osteoclast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
enables	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	F		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	C		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	C		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	F		Seeded From UniProt	complete
involved_in	GO:0007162	negative regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	C		Seeded From UniProt	complete
part_of	GO:0005801	cis-Golgi network	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	C		Seeded From UniProt	complete
involved_in	GO:0001953	negative regulation of cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P26450 ensembl:ENSMUSP00000056774	P		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001720	C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000198 InterPro:IPR008936	P		Seeded From UniProt	complete
enables	GO:0035014	phosphatidylinositol 3-kinase regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001720	F		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	Reactome:R-HSA-198203	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	Reactome:R-HSA-194138	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038128	ERBB2 signaling pathway	Reactome:R-HSA-1227986	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	Reactome:R-HSA-389356 Reactome:R-HSA-388841	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807 Reactome:R-HSA-512988 Reactome:R-HSA-451927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Reactome:R-HSA-9027276	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	Reactome:R-HSA-177929	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006661	phosphatidylinositol biosynthetic process	Reactome:R-HSA-1660499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-9606887 Reactome:R-HSA-2400009 Reactome:R-HSA-2394007 Reactome:R-HSA-2316434 Reactome:R-HSA-2076220 Reactome:R-HSA-2045911 Reactome:R-HSA-1306965 Reactome:R-HSA-1306957 Reactome:R-HSA-1250462 Reactome:R-HSA-1250189	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9606887 Reactome:R-HSA-914182 Reactome:R-HSA-912627 Reactome:R-HSA-9027275 Reactome:R-HSA-9021627 Reactome:R-HSA-9012657 Reactome:R-HSA-8854905 Reactome:R-HSA-8853323 Reactome:R-HSA-8853316 Reactome:R-HSA-8853308 Reactome:R-HSA-8852019 Reactome:R-HSA-8851954 Reactome:R-HSA-879917 Reactome:R-HSA-74737 Reactome:R-HSA-6790041 Reactome:R-HSA-5655323 Reactome:R-HSA-5655320 Reactome:R-HSA-5655315 Reactome:R-HSA-5655290 Reactome:R-HSA-5655289 Reactome:R-HSA-5655285 Reactome:R-HSA-5655263 Reactome:R-HSA-5655252 Reactome:R-HSA-5655248 Reactome:R-HSA-5655245 Reactome:R-HSA-5655240 Reactome:R-HSA-5655235 Reactome:R-HSA-5654717 Reactome:R-HSA-5654714 Reactome:R-HSA-5654709 Reactome:R-HSA-5654705 Reactome:R-HSA-5654701 Reactome:R-HSA-5654697 Reactome:R-HSA-5654692 Reactome:R-HSA-5654690 Reactome:R-HSA-5654669 Reactome:R-HSA-5654667 Reactome:R-HSA-5654662 Reactome:R-HSA-5654659 Reactome:R-HSA-5654643 Reactome:R-HSA-5654641 Reactome:R-HSA-5654640 Reactome:R-HSA-5654637 Reactome:R-HSA-5654622 Reactome:R-HSA-5654620 Reactome:R-HSA-5654614 Reactome:R-HSA-5654612 Reactome:R-HSA-5654596 Reactome:R-HSA-5654594 Reactome:R-HSA-5654592 Reactome:R-HSA-5654591 Reactome:R-HSA-5637801 Reactome:R-HSA-5637765 Reactome:R-HSA-5637764 Reactome:R-HSA-5357479 Reactome:R-HSA-5218819 Reactome:R-HSA-508247 Reactome:R-HSA-443402 Reactome:R-HSA-437162 Reactome:R-HSA-437118 Reactome:R-HSA-416358 Reactome:R-HSA-389158 Reactome:R-HSA-388832 Reactome:R-HSA-388830 Reactome:R-HSA-2730870 Reactome:R-HSA-2730842 Reactome:R-HSA-2424482 Reactome:R-HSA-2424480 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-205262 Reactome:R-HSA-204798 Reactome:R-HSA-2029273 Reactome:R-HSA-2029271 Reactome:R-HSA-202365 Reactome:R-HSA-202203 Reactome:R-HSA-198315 Reactome:R-HSA-198266 Reactome:R-HSA-186800 Reactome:R-HSA-186780 Reactome:R-HSA-1839114 Reactome:R-HSA-1839107 Reactome:R-HSA-1839102 Reactome:R-HSA-1839091 Reactome:R-HSA-1839080 Reactome:R-HSA-1839078 Reactome:R-HSA-177939 Reactome:R-HSA-177931 Reactome:R-HSA-177927 Reactome:R-HSA-1676109 Reactome:R-HSA-1676048 Reactome:R-HSA-1562641 Reactome:R-HSA-1433514 Reactome:R-HSA-1306979 Reactome:R-HSA-1306965 Reactome:R-HSA-1250370 Reactome:R-HSA-1250353 Reactome:R-HSA-1250346 Reactome:R-HSA-1250189 Reactome:R-HSA-1226016 Reactome:R-HSA-1226014 Reactome:R-HSA-1226012 Reactome:R-HSA-114542 Reactome:R-HSA-109699	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Reddy, VS et al. (2011) Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. J. Cell. Physiol. 226 3303-15 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Winnay, JN et al. (2010) A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat. Med. 16 438-45 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page
↑ ^5.0 ^5.1 Hara, K et al. (1994) 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc. Natl. Acad. Sci. U.S.A. 91 7415-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Argetsinger, LS et al. (1995) Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270 14685-92 PubMed GONUTS page
↑ ^7.0 ^7.1 Craparo, A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270 15639-43 PubMed GONUTS page
↑ Yamaguchi, Y et al. (1993) Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology 132 1132-8 PubMed GONUTS page
↑ Fernandes, AM et al. (1999) Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity. Am. J. Respir. Cell Mol. Biol. 21 701-9 PubMed GONUTS page
↑ Laprise, P et al. (2004) Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. J. Biol. Chem. 279 10157-66 PubMed GONUTS page
↑ Tacconelli, A et al. (2004) TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. Cancer Cell 6 347-60 PubMed GONUTS page
↑ Gustafson, TA et al. (1995) Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15 2500-8 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21321938-1] Reddy, VS et al. (2011) Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. J. Cell. Physiol. 226 3303-15 PubMed GONUTS page

[PMID:20348923-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Winnay, JN et al. (2010) A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat. Med. 16 438-45 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:20624904-4] Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page

[PMID:8052599-5] 5.0 ^5.1 Hara, K et al. (1994) 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. Proc. Natl. Acad. Sci. U.S.A. 91 7415-9 PubMed GONUTS page

[PMID:7782332-6] 6.0 ^6.1 ^6.2 Argetsinger, LS et al. (1995) Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270 14685-92 PubMed GONUTS page

[PMID:7541045-7] 7.0 ^7.1 Craparo, A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270 15639-43 PubMed GONUTS page

[PMID:8440175-8] Yamaguchi, Y et al. (1993) Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology 132 1132-8 PubMed GONUTS page

[PMID:10572067-9] Fernandes, AM et al. (1999) Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity. Am. J. Respir. Cell Mol. Biol. 21 701-9 PubMed GONUTS page

[PMID:14699157-10] Laprise, P et al. (2004) Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. J. Biol. Chem. 279 10157-66 PubMed GONUTS page

[PMID:15488758-11] Tacconelli, A et al. (2004) TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. Cancer Cell 6 347-60 PubMed GONUTS page

[PMID:7537849-12] Gustafson, TA et al. (1995) Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15 2500-8 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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