HUMAN:ATF4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ATF4 (synonyms: CREB2, TXREB)
Protein Name(s)	Cyclic AMP-dependent transcription factor ATF-4 cAMP-dependent transcription factor ATF-4 Activating transcription factor 4 Cyclic AMP-responsive element-binding protein 2 CREB-2 cAMP-responsive element-binding protein 2 DNA-binding protein TAXREB67 Tax-responsive enhancer element-binding protein 67 TaxREB67
External Links
UniProt	P18848
EMBL	D90209 M86842 AL022312 BC008090 BC011994 BC024775 BC073990
CCDS	CCDS13996.1
PIR	A45377
RefSeq	NP_001666.2 NP_877962.1
UniGene	Hs.496487
PDB	1CI6
PDBsum	1CI6
ProteinModelPortal	P18848
SMR	P18848
BioGrid	106958
DIP	DIP-207N DIP-354N
IntAct	P18848
MINT	MINT-146610
STRING	9606.ENSP00000336790
DrugBank	DB00852
PhosphoSite	P18848
DMDM	116241262
MaxQB	P18848
PaxDb	P18848
PRIDE	P18848
DNASU	468
Ensembl	ENST00000337304 ENST00000396680 ENST00000404241
GeneID	468
KEGG	hsa:468
UCSC	uc003axz.3
CTD	468
GeneCards	GC22P039916
HGNC	HGNC:786
HPA	CAB011596 HPA036934
MIM	604064
neXtProt	NX_P18848
PharmGKB	PA25086
eggNOG	NOG325856
HOGENOM	HOG000004844
HOVERGEN	HBG004301
InParanoid	P18848
KO	K04374
OMA	GECRELE
OrthoDB	EOG72JWGW
PhylomeDB	P18848
TreeFam	TF316136
Reactome	REACT_18277 REACT_18355 REACT_18423
ChiTaRS	ATF4
EvolutionaryTrace	P18848
GeneWiki	ATF4
GenomeRNAi	468
NextBio	1935
PRO	PR:P18848
Proteomes	UP000005640
Bgee	P18848
CleanEx	HS_ATF4
ExpressionAtlas	P18848
Genevestigator	P18848
GO	GO:0005737 GO:0032590 GO:1990037 GO:0005815 GO:0043005 GO:0034399 GO:0005654 GO:0005634 GO:0005667 GO:0001046 GO:0003677 GO:0000978 GO:0001077 GO:0000981 GO:0003700 GO:0044212 GO:0006987 GO:0006520 GO:0044267 GO:0032922 GO:0030968 GO:0007214 GO:0006094 GO:0070059 GO:1903204 GO:0043267 GO:0043065 GO:0043525 GO:0045944 GO:1990440 GO:0036091 GO:0045893 GO:0006355 GO:0034976 GO:0006366
InterPro	IPR029811 IPR004827
PANTHER	PTHR13044:SF2
Pfam	PF00170
SMART	SM00338
PROSITE	PS50217 PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010467	gene expression	PMID:22363646^[1]	ECO:0000314			P		Figure 1A: Protein and mRNA levels of ATF4 were determined using Western Blot and qPCR. β-actin and GAPDH were used as a control.	complete CACAO 3932
	GO:0001558	regulation of cell growth	PMID:22363646^[1]	ECO:0000315			P		Figure 1B, C, D, E, H: When transfected into SGC7901 and AGS cells, colony number increased due to overexpression of ATF4. When ATF4 was knocked out of expression in SGC7901/ADR and SGC7901/VCR cells the colony number decreased. This shows that ATF4 produced multi-drug resistance in cancer cells, allowing for cell growth.	complete CACAO 3933
	GO:0045766	positive regulation of angiogenesis	PMID:28553953^[2]	ECO:0000314			P		Figure 10 shows that ATF4 expression promotes tumor angiogenesis.	complete CACAO 12957
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR004827	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:O70191	F		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:22980225^[4]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
colocalizes_with	GO:0005813	centrosome	PMID:20873783^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:20873783^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:20873783^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HC98	F		Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	PMID:24136195^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24136195^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P0DMM9)	Seeded From UniProt	complete
involved_in	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	PMID:25681212^[7]	ECO:0000305	curator inference used in manual assertion	GO:1990440	P	has_regulation_target:(UniProtKB:Q9UQV4) part_of:(GO:0034976)\|has_regulation_target(UniProtKB:P11021) part_of:(GO:0034976)\|has_regulation_target(UniProtKB:P18847) part_of:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZWX6	P		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZWX6	P		Seeded From UniProt	complete
involved_in	GO:0032057	negative regulation of translational initiation in response to stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZWX6	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24939851^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000162772) part_of:(GO:0034976)\|regulates_expression_of(ENSEMBL:ENSG00000175197) part_of:(GO:0034976)\|regulates_expression_of(ENSEMBL:ENSG00000120889) part_of:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:24939851^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18940792^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P08243)	Seeded From UniProt	complete
part_of	GO:1990617	CHOP-ATF4 complex	PMID:18940792^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35638	C		Seeded From UniProt	complete
part_of	GO:1990617	CHOP-ATF4 complex	PMID:15775988^[10]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:15775988^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_direct_input:(UniProtKB:P35638)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15775988^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q96RU7)	Seeded From UniProt	complete
part_of	GO:1990589	ATF4-CREB1 transcription factor complex	PMID:12871976^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
enables	GO:0043522	leucine zipper domain binding	PMID:11478948^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P35638)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:11478948^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:11478948^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35638	F	part_of:(GO:0000122)	Seeded From UniProt	complete
part_of	GO:1990617	CHOP-ATF4 complex	PMID:11478948^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11478948^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11478948^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:22915762^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0042149)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:22915762^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:22915762^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045943	positive regulation of transcription by RNA polymerase I	PMID:22915762^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P11021) happens_during:(GO:0042149)\|happens_during:(GO:0042149) has_regulation_target:(UniProtKB:P05231)\|happens_during(GO:0042149) has_regulation_target:(UniProtKB:P09038)	Seeded From UniProt	complete
part_of	GO:1990590	ATF1-ATF4 transcription factor complex	PMID:12871976^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
contributes_to	GO:0044212	transcription regulatory region DNA binding	PMID:12871976^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:12871976^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(ENSEMBL:ENSG00000044574)	Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PMID:12871976^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000044574)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21113145^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:21113145^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PMID:21113145^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:23392669^[15]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ES19	P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:1903204	negative regulation of oxidative stress-induced neuron death	PMID:23392669^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9ES19	P		Seeded From UniProt	complete
part_of	GO:1990037	Lewy body core	PMID:23392669^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002038) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0034399	nuclear periphery	PMID:23392669^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002038) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23392669^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002038) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23392669^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002038) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:23392669^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002038) part_of:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	F		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:19061639^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16682973^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15788408^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11960987^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18940792^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15775988^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9190894^[20]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18940792^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15788408^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q06507	F		Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88096 PANTHER:PTN000315889 UniProtKB:P18848	P		Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000315889 RGD:621863 UniProtKB:P18848	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2141857 MGI:MGI:88096 PANTHER:PTN000315883 WB:WBGene00013878	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2141857 MGI:MGI:88096 PANTHER:PTN000315883 RGD:621863 RGD:628902 UniProtKB:P18848 UniProtKB:Q9Y2D1 WB:WBGene00000221 WB:WBGene00013878	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88096 PANTHER:PTN000315883 UniProtKB:P18848 WB:WBGene00013878	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:21873635^[21]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000315883 UniProtKB:Q9Y2D1	F		Seeded From UniProt	complete
involved_in	GO:2000120	positive regulation of sodium-dependent phosphate transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
part_of	GO:1990590	ATF1-ATF4 transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C		Seeded From UniProt	complete
part_of	GO:1990589	ATF4-CREB1 transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C		Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C		Seeded From UniProt	complete
involved_in	GO:0070169	positive regulation of biomineral tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0042789	mRNA transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0036499	PERK-mediated unfolded protein response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06507 ensembl:ENSMUSP00000105234	F		Seeded From UniProt	complete
involved_in	GO:1990737	response to manganese-induced endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	P		Seeded From UniProt	complete
involved_in	GO:1903204	negative regulation of oxidative stress-induced neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	P		Seeded From UniProt	complete
involved_in	GO:0090650	cellular response to oxygen-glucose deprivation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	P		Seeded From UniProt	complete
involved_in	GO:0043267	negative regulation of potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	P		Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	P		Seeded From UniProt	complete
part_of	GO:0032590	dendrite membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	C		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	F		Seeded From UniProt	complete
involved_in	GO:0007214	gamma-aminobutyric acid signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ES19 ensembl:ENSRNOP00000060302	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827 InterPro:IPR029811	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029811	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029811	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029811	P		Seeded From UniProt	complete
involved_in	GO:0036499	PERK-mediated unfolded protein response	PMID:22934019^[22] PMID:22013210^[23] Reactome:R-HSA-381042	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061395	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance	PMID:14685163^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:P35638)	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:23392669^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_input:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:23392669^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006520	cellular amino acid metabolic process	PMID:12689582^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12689582^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-381128	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhu, H et al. (2012) Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. PLoS ONE 7 e31431 PubMed GONUTS page
↑ Chen, D et al. (2017) ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner. Oncogene 36 5593-5608 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Wang, C et al. (2013) Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress. Metab. Clin. Exp. 62 282-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Vaz Meirelles, G et al. (2010) Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. 9 6298-316 PubMed GONUTS page
↑ ^6.0 ^6.1 Sidharthan, NP et al. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J. Biol. Chem. 288 34364-74 PubMed GONUTS page
↑ Dominguez-Bautista, JA et al. () Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition. Eur. J. Cell Biol. 94 148-61 PubMed GONUTS page
↑ ^8.0 ^8.1 Edagawa, M et al. (2014) Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J. Biol. Chem. 289 21544-61 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Su, N & Kilberg, MS (2008) C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J. Biol. Chem. 283 35106-17 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Ohoka, N et al. (2005) TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24 1243-55 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Luo, S et al. (2003) Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J. Biol. Chem. 278 37375-85 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gachon, F et al. (2001) The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP). FEBS Lett. 502 57-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Wang, Y et al. (2012) The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway. Cancer Res. 72 5396-406 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Bouman, L et al. (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 18 769-82 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 Sun, X et al. (2013) ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. J. Neurosci. 33 2398-407 PubMed GONUTS page
↑ Chami, M et al. (2008) Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. Mol. Cell 32 641-51 PubMed GONUTS page
↑ Sayer, JA et al. (2006) The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat. Genet. 38 674-81 PubMed GONUTS page
↑ ^18.0 ^18.1 Roybal, CN et al. (2005) The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. J. Biol. Chem. 280 20331-9 PubMed GONUTS page
↑ Siu, F et al. (2002) ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J. Biol. Chem. 277 24120-7 PubMed GONUTS page
↑ Reddy, TR et al. (1997) Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4). Oncogene 14 2785-92 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page
↑ Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page
↑ Oyadomari, S & Mori, M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11 381-9 PubMed GONUTS page
↑ ^25.0 ^25.1 Rutkowski, DT & Kaufman, RJ (2003) All roads lead to ATF4. Dev. Cell 4 442-4 PubMed GONUTS page

[PMID:22363646-1] 1.0 ^1.1 Zhu, H et al. (2012) Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression. PLoS ONE 7 e31431 PubMed GONUTS page

[PMID:28553953-2] Chen, D et al. (2017) ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner. Oncogene 36 5593-5608 PubMed GONUTS page

[PMID:19274049-3] 3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:22980225-4] Wang, C et al. (2013) Effects of ATF4 on PGC1α expression in brown adipose tissue and metabolic responses to cold stress. Metab. Clin. Exp. 62 282-9 PubMed GONUTS page

[PMID:20873783-5] 5.0 ^5.1 ^5.2 Vaz Meirelles, G et al. (2010) Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. J. Proteome Res. 9 6298-316 PubMed GONUTS page

[PMID:24136195-6] 6.0 ^6.1 Sidharthan, NP et al. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J. Biol. Chem. 288 34364-74 PubMed GONUTS page

[PMID:25681212-7] Dominguez-Bautista, JA et al. () Loss of lysosome-associated membrane protein 3 (LAMP3) enhances cellular vulnerability against proteasomal inhibition. Eur. J. Cell Biol. 94 148-61 PubMed GONUTS page

[PMID:24939851-8] 8.0 ^8.1 Edagawa, M et al. (2014) Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J. Biol. Chem. 289 21544-61 PubMed GONUTS page

[PMID:18940792-9] 9.0 ^9.1 ^9.2 ^9.3 Su, N & Kilberg, MS (2008) C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J. Biol. Chem. 283 35106-17 PubMed GONUTS page

[PMID:15775988-10] 10.0 ^10.1 ^10.2 ^10.3 Ohoka, N et al. (2005) TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 24 1243-55 PubMed GONUTS page

[PMID:12871976-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Luo, S et al. (2003) Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J. Biol. Chem. 278 37375-85 PubMed GONUTS page

[PMID:11478948-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gachon, F et al. (2001) The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP). FEBS Lett. 502 57-62 PubMed GONUTS page

[PMID:22915762-13] 13.0 ^13.1 ^13.2 ^13.3 Wang, Y et al. (2012) The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway. Cancer Res. 72 5396-406 PubMed GONUTS page

[PMID:21113145-14] 14.0 ^14.1 ^14.2 Bouman, L et al. (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. 18 769-82 PubMed GONUTS page

[PMID:23392669-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 ^15.8 Sun, X et al. (2013) ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. J. Neurosci. 33 2398-407 PubMed GONUTS page

[PMID:19061639-16] Chami, M et al. (2008) Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. Mol. Cell 32 641-51 PubMed GONUTS page

[PMID:16682973-17] Sayer, JA et al. (2006) The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat. Genet. 38 674-81 PubMed GONUTS page

[PMID:15788408-18] 18.0 ^18.1 Roybal, CN et al. (2005) The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. J. Biol. Chem. 280 20331-9 PubMed GONUTS page

[PMID:11960987-19] Siu, F et al. (2002) ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J. Biol. Chem. 277 24120-7 PubMed GONUTS page

[PMID:9190894-20] Reddy, TR et al. (1997) Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4). Oncogene 14 2785-92 PubMed GONUTS page

[PMID:21873635-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22934019-22] Brown, MK & Naidoo, N (2012) The endoplasmic reticulum stress response in aging and age-related diseases. Front Physiol 3 263 PubMed GONUTS page

[PMID:22013210-23] Hetz, C et al. (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol. Rev. 91 1219-43 PubMed GONUTS page

[PMID:14685163-24] Oyadomari, S & Mori, M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 11 381-9 PubMed GONUTS page

[PMID:12689582-25] 25.0 ^25.1 Rutkowski, DT & Kaufman, RJ (2003) All roads lead to ATF4. Dev. Cell 4 442-4 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

HUMAN:ATF4

Contents

Annotations

Notes

References

a

c

d

e

g

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools