Category:GO:0070765 ! gamma-secretase complex

name: gamma-secretase complex
namespace: cellular_component
def: "A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein." [GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437]
synonym: "CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)" NARROW [CORUM:142]
synonym: "gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)" NARROW [CORUM:130, CORUM:2891, CORUM:43, CORUM:45, CORUM:466]
synonym: "gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:468]
synonym: "gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)" NARROW [CORUM:3128]
synonym: "gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)" NARROW [CORUM:467]
synonym: "presenilin complex" EXACT []
synonym: "PS1 complex" NARROW []
synonym: "PS2 complex" NARROW []
is_a: GO:0098797 ! plasma membrane protein complex
is_a: GO:1902494 ! catalytic complex

AmiGO <GOterm>GO:0070765</GOterm>
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