HUMAN:NICA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	NCSTN (synonyms: KIAA0253)
Protein Name(s)	Nicastrin
External Links
UniProt	Q92542
EMBL	AF240468 AY359120 AK314764 AL445230 AL445230 CH471121 CH471121 CH471121 BC047621 D87442
CCDS	CCDS1203.1
RefSeq	NP_001277113.1 NP_001277115.1 NP_056146.1
UniGene	Hs.517249
PDB	4UPC
PDBsum	4UPC
ProteinModelPortal	Q92542
BioGrid	116961
DIP	DIP-36336N
IntAct	Q92542
MINT	MINT-3048708
STRING	9606.ENSP00000294785
BindingDB	Q92542
ChEMBL	CHEMBL2094135
PhosphoSite	Q92542
DMDM	12231037
MaxQB	Q92542
PaxDb	Q92542
PRIDE	Q92542
DNASU	23385
Ensembl	ENST00000294785 ENST00000368063
GeneID	23385
KEGG	hsa:23385
UCSC	uc001fvx.3 uc001fvy.3
CTD	23385
GeneCards	GC01P160313
HGNC	HGNC:17091
HPA	CAB021982 HPA051793
MIM	142690 605254
neXtProt	NX_Q92542
Orphanet	387
PharmGKB	PA142671271
eggNOG	NOG253370
GeneTree	ENSGT00390000014633
HOGENOM	HOG000044212
HOVERGEN	HBG006497
InParanoid	Q92542
KO	K06171
OMA	HMHAVIS
OrthoDB	EOG77WWCF
PhylomeDB	Q92542
TreeFam	TF317086
Reactome	REACT_116022 REACT_118572 REACT_118614 REACT_118636 REACT_118862 REACT_13443 REACT_13643 REACT_160205 REACT_160243 REACT_160254 REACT_228189
SignaLink	Q92542
ChiTaRS	NCSTN
GeneWiki	Nicastrin
GenomeRNAi	23385
NextBio	45500
PRO	PR:Q92542
Proteomes	UP000005640
Bgee	Q92542
CleanEx	HS_NCSTN
ExpressionAtlas	Q92542
Genevestigator	Q92542
GO	GO:0005783 GO:0070062 GO:0005925 GO:0005794 GO:0016021 GO:0005887 GO:0005765 GO:0042470 GO:0016020 GO:0005886 GO:0004175 GO:0042987 GO:0097190 GO:0050435 GO:0050673 GO:0022617 GO:0030198 GO:0006509 GO:0031293 GO:0002262 GO:0048011 GO:0007220 GO:0007219 GO:0043065 GO:0043085 GO:0016485 GO:0006508 GO:0042098
InterPro	IPR008710
PANTHER	PTHR21092
Pfam	PF05450

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0042982	amyloid precursor protein metabolic process	PMID:25043039^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	PMID:25043039^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:25043039^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070765	gamma-secretase complex	PMID:25043039^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0070765	gamma-secretase complex	PMID:26280335^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:26280335^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042982	amyloid precursor protein metabolic process	PMID:26280335^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	PMID:26280335^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	PMID:15274632^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	PMID:15274632^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:15274632^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15274632^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:15274632^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15274632^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:10993067^[8]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:10993067^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:17897319^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000473190 RGD:631418 UniProtKB:Q92542	P		Seeded From UniProt	complete
involved_in	GO:0007220	Notch receptor processing	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039234 PANTHER:PTN000473192	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000473190 UniProtKB:Q92542	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1891700 PANTHER:PTN000473190	F		Seeded From UniProt	complete
involved_in	GO:1990926	short-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:1900271	regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0070997	neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0050673	epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0042983	amyloid precursor protein biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0042982	amyloid precursor protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0042098	T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	C		Seeded From UniProt	complete
involved_in	GO:0030534	adult behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0022010	central nervous system myelination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	C		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	C		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0007215	glutamate receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
involved_in	GO:0007212	dopamine receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	F		Seeded From UniProt	complete
involved_in	GO:0002262	myeloid cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P57716 ensembl:ENSMUSP00000003550	P		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8CGU6 ensembl:ENSRNOP00000008150	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008710	C		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008710	P		Seeded From UniProt	complete
involved_in	GO:0042987	amyloid precursor protein catabolic process	PMID:15274632^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007220	Notch receptor processing	PMID:15274632^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	Reactome:R-HSA-205043	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035577	azurophil granule membrane	Reactome:R-HSA-6798739	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035333	Notch receptor processing, ligand-dependent	Reactome:R-HSA-9017817 Reactome:R-HSA-9013361	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031293	membrane protein intracellular domain proteolysis	Reactome:R-HSA-193692	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	Reactome:R-HSA-9010096	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-9604300 Reactome:R-NUL-2197556 Reactome:R-HSA-9017817 Reactome:R-HSA-9013361 Reactome:R-HSA-6798739 Reactome:R-HSA-3928656 Reactome:R-HSA-2220988 Reactome:R-HSA-205112 Reactome:R-HSA-193682 Reactome:R-HSA-1251997	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Lu, P et al. (2014) Three-dimensional structure of human γ-secretase. Nature 512 166-170 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Bai, XC et al. (2015) An atomic structure of human γ-secretase. Nature 525 212-217 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Fraering, PC et al. (2004) Purification and characterization of the human gamma-secretase complex. Biochemistry 43 9774-89 PubMed GONUTS page
↑ ^8.0 ^8.1 Yu, G et al. (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407 48-54 PubMed GONUTS page
↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25043039-1] 1.0 ^1.1 ^1.2 ^1.3 Lu, P et al. (2014) Three-dimensional structure of human γ-secretase. Nature 512 166-170 PubMed GONUTS page

[PMID:21423176-2] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-5] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:26280335-6] 6.0 ^6.1 ^6.2 ^6.3 Bai, XC et al. (2015) An atomic structure of human γ-secretase. Nature 525 212-217 PubMed GONUTS page

[PMID:15274632-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Fraering, PC et al. (2004) Purification and characterization of the human gamma-secretase complex. Biochemistry 43 9774-89 PubMed GONUTS page

[PMID:10993067-8] 8.0 ^8.1 Yu, G et al. (2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407 48-54 PubMed GONUTS page

[PMID:17897319-9] Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:NICA

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