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PMID:10804188

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Citation

Goutte, C, Hepler, W, Mickey, KM and Priess, JR (2000) aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127:2481-92

Abstract

In animal development, numerous cell-cell interactions are mediated by the GLP-1/LIN-12/NOTCH family of transmembrane receptors. These proteins function in a signaling pathway that appears to be conserved from nematodes to humans. We show here that the aph-2 gene is a new component of the GLP-1 signaling pathway in the early Caenorhabditis elegans embryo, and that proteins with sequence similarity to the APH-2 protein are found in Drosophila and vertebrates. During the GLP-1-mediated cell interactions in the C. elegans embryo, APH-2 is associated with the cell surfaces of both the signaling, and the responding, blastomeres. Analysis of chimeric embryos that are composed of aph-2(+) and aph-2(-) blastomeres suggests that aph-2(+) function may be provided by either the signaling or responding blastomere.

Links

PubMed

Keywords

Amino Acid Sequence; Animals; Base Sequence; Blastomeres; Caenorhabditis elegans/embryology; Caenorhabditis elegans Proteins; DNA, Helminth; Helminth Proteins/genetics; Helminth Proteins/metabolism; Humans; Membrane Glycoproteins/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Molecular Sequence Data; Mutagenesis; Rabbits; Signal Transduction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:A5Z2T7

involved_in

GO:0018991: oviposition

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete

CAEEL:A5Z2T7

involved_in

GO:0007219: Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete

CAEEL:A5Z2T7

located_in

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:A5Z2T7

involved_in

GO:0048598: embryonic morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete

CAEEL:A5Z2T7

involved_in

GO:0060581: cell fate commitment involved in pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete

CAEEL:A5Z2T7

involved_in

GO:0060465: pharynx development

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete

CAEEL:NICA

part_of

GO:0070765: gamma-secretase complex

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:Q9VC27

C

Seeded From UniProt

complete

CAEEL:NICA

involved_in

GO:0018991: oviposition

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete

CAEEL:NICA

involved_in

GO:0007219: Notch signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete

CAEEL:NICA

located_in

GO:0005886: plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:NICA

involved_in

GO:0048598: embryonic morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete

CAEEL:NICA

involved_in

GO:0060581: cell fate commitment involved in pattern specification

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete

CAEEL:NICA

involved_in

GO:0060465: pharynx development

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00275512

P

Seeded From UniProt

complete


See also

References

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