MOUSE:PSN1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Psen1 (synonyms: Ad3h, Psnl1)
Protein Name(s)	Presenilin-1 PS-1 Protein S182 Presenilin-1 NTF subunit Presenilin-1 CTF subunit Presenilin-1 CTF12 PS1-CTF12
External Links
UniProt	P49769
EMBL	L42177 AF007560 AF149111 BC014744 BC030409 BC071233
CCDS	CCDS26030.1
PIR	I78388
RefSeq	NP_032969.1 XP_006515668.1
UniGene	Mm.998
ProteinModelPortal	P49769
SMR	P49769
BioGrid	202414
DIP	DIP-36237N
IntAct	P49769
MINT	MINT-193580
MEROPS	A22.001
PhosphoSite	P49769
MaxQB	P49769
PaxDb	P49769
PRIDE	P49769
Ensembl	ENSMUST00000041806 ENSMUST00000101225
GeneID	19164
KEGG	mmu:19164
UCSC	uc007odo.1 uc007odp.1
CTD	5663
MGI	MGI:1202717
eggNOG	NOG237920
HOGENOM	HOG000240228
HOVERGEN	HBG011375
InParanoid	P49769
KO	K04505
OMA	EAQRKVS
OrthoDB	EOG7NGQBG
PhylomeDB	P49769
TreeFam	TF315040
Reactome	REACT_275864 REACT_286692
NextBio	295822
PRO	PR:P49769
Proteomes	UP000000589
Bgee	P49769
CleanEx	MM_PSEN1
ExpressionAtlas	P49769
Genevestigator	P49769
GO	GO:0016324 GO:0030424 GO:0005938 GO:0009986 GO:0005813 GO:0035253 GO:0031410 GO:0030425 GO:0043198 GO:0005783 GO:0005789 GO:0070765 GO:0005794 GO:0000139 GO:0030426 GO:0005887 GO:0005622 GO:0000776 GO:0005765 GO:0016020 GO:0045121 GO:0043227 GO:0005743 GO:0005739 GO:0031594 GO:0043025 GO:0031965 GO:0005640 GO:0005634 GO:0048471 GO:0005886 GO:0005791 GO:0005790 GO:0030018 GO:0004190 GO:0008013 GO:0045296 GO:0005262 GO:0004175 GO:0030165 GO:0000186 GO:0042987 GO:0000045 GO:0006914 GO:0034205 GO:0050435 GO:0001568 GO:0007420 GO:0048854 GO:0021870 GO:0070588 GO:0006816 GO:0060070 GO:0001708 GO:0006874 GO:0044267 GO:0006974 GO:0021795 GO:0021987 GO:0015871 GO:0021904 GO:0030326 GO:0032469 GO:0050673 GO:0030900 GO:0007507 GO:0001947 GO:0002244 GO:0035556 GO:0015813 GO:0007611 GO:0040011 GO:0006509 GO:0007613 GO:0006839 GO:0043011 GO:0002573 GO:0043066 GO:2001234 GO:0050771 GO:0007175 GO:0043524 GO:0006469 GO:0001933 GO:2000059 GO:0000122 GO:0051444 GO:0022008 GO:0051402 GO:0048666 GO:0030182 GO:0001764 GO:0007220 GO:0007219 GO:0043065 GO:0043085 GO:0050820 GO:0043406 GO:0032436 GO:0045860 GO:0001934 GO:0001921 GO:0009791 GO:0006486 GO:0051604 GO:0016485 GO:0015031 GO:0007176 GO:0042325 GO:0043393 GO:0060075 GO:0048167 GO:0051966 GO:0006979 GO:0035282 GO:0016337 GO:0048705 GO:0043589 GO:0051563 GO:0001756 GO:0016080 GO:0002286 GO:0050852 GO:0048538
InterPro	IPR002031 IPR001108 IPR006639
PANTHER	PTHR10202 PTHR10202:SF7
Pfam	PF01080
PRINTS	PR01072 PR01073
SMART	SM00730

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048666	neuron development	PMID:21325529^[1]	ECO:0000315			P		Presenilin-1 (PSN1), mouse. Figure 3. Infection of neural progenitor by lentiviral vectors expressing PS1 1.1, and PS1 4.11 can give rise to the number of differentiated cells (neurons, astrocytes, and oligodendrocytes) without affecting their multipotentiality.	complete CACAO 12542
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
part_of	GO:0070765	gamma-secretase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
enables	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	F		Seeded From UniProt	complete
involved_in	GO:0042982	amyloid precursor protein metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:11517342^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:11517342^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11517342^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	PMID:11517342^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	PMID:20208556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051444	negative regulation of ubiquitin-protein transferase activity	PMID:20208556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043589	skin morphogenesis	PMID:20208556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:20208556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	PMID:20208556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001921	positive regulation of receptor recycling	PMID:20208556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20208556^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
involved_in	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202717 PANTHER:PTN000024459	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202717 PANTHER:PTN000024459	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000024459 UniProtKB:P49768	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019947 PANTHER:PTN000024429 UniProtKB:P49768 UniProtKB:P49810	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202717 PANTHER:PTN000024459 UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202717 PANTHER:PTN000024429 UniProtKB:P49768	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019947 MGI:MGI:109284 MGI:MGI:1202717 PANTHER:PTN000024429 RGD:3425 UniProtKB:P49768	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:15148382^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P	regulates_o_occurs_in:(EMAPA:16895) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990535	neuron projection maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905908	positive regulation of amyloid fibril formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904797	negative regulation of core promoter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	PMID:11953314^[6]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
part_of	GO:0070765	gamma-secretase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060075	regulation of resting membrane potential	PMID:15548218^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051966	regulation of synaptic transmission, glutamatergic	PMID:10097174^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051604	protein maturation	PMID:15280425^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051604	protein maturation	PMID:11943765^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	PMID:12431992^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88059	P	occurs_in:(EMAPA:32845) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051402	neuron apoptotic process	PMID:16478525^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88059	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050852	T cell receptor signaling pathway	PMID:17698590^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050820	positive regulation of coagulation	PMID:12646573^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2446469	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050771	negative regulation of axonogenesis	PMID:15548218^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050673	epithelial cell proliferation	PMID:17913918^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1891700	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050435	amyloid-beta metabolic process	PMID:12684521^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048854	brain morphogenesis	PMID:17614943^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048705	skeletal system morphogenesis	PMID:9160754^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048666	neuron development	PMID:12391611^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3051523	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:17698590^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:17698590^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:15066262^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:11814648^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048143	astrocyte activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	PMID:15192701^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:11953314^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09803	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044267	cellular protein metabolic process	PMID:17097608^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044267	cellular protein metabolic process	PMID:11953314^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044267	cellular protein metabolic process	PMID:17097608^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043406	positive regulation of MAP kinase activity	PMID:15896720^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043393	regulation of protein binding	PMID:17920016^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
part_of	GO:0043227	membrane-bounded organelle	PMID:12805290^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	PMID:12805290^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043085	positive regulation of catalytic activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:15192701^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:16169548^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P	occurs_in:(EMAPA:17428)\|occurs_in:(EMAPA:17459)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:8922407^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000598)\|part_of:(EMAPA:17544) part_of:(CL:0000120)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:12805290^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043011	myeloid dendritic cell differentiation	PMID:23913046^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449306	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042987	amyloid precursor protein catabolic process	PMID:15452145^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042987	amyloid precursor protein catabolic process	PMID:11567612^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179062 MGI:MGI:2449304	P	occurs_in:(EMAPA:17544) has_direct_input:(MGI:MGI:88059)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042987	amyloid precursor protein catabolic process	PMID:10206645^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P	has_direct_input:(MGI:MGI:88059)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042982	amyloid precursor protein metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
enables	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042327	positive regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042325	regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040011	locomotion	PMID:15148382^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035282	segmentation	PMID:16079160^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035282	segmentation	PMID:11262239^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1932738	P		Seeded From UniProt	complete
part_of	GO:0035253	ciliary rootlet	PMID:16018997^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034205	amyloid-beta formation	PMID:20130175^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034205	amyloid-beta formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:17431506^[37]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:15123735^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:15009636^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:12460542^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:10662826^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:17431506^[37]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:11740561^[42]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18577) part_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15148382^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:12805290^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:8922407^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000598)\|part_of:(EMAPA:17544) part_of:(CL:0000120)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:11740561^[42]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18577) part_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:16169548^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P	has_participant:(EMAPA:17428)\|has_participant:(EMAPA:17459)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:10821758^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022008	neurogenesis	PMID:9160754^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022008	neurogenesis	PMID:11738035^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155978	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021987	cerebral cortex development	PMID:16079160^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021904	dorsal/ventral neural tube patterning	PMID:10557208^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021870	Cajal-Retzius cell differentiation	PMID:15548218^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021795	cerebral cortex cell migration	PMID:16079160^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:11567612^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179062 MGI:MGI:2449304	P	occurs_in:(EMAPA:17544) has_participant:(MGI:MGI:88059)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:10206645^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P	has_participant:(MGI:MGI:88059)\|has_participant:(MGI:MGI:97363)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016080	synaptic vesicle targeting	PMID:12805290^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15886206^[46]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15634781^[47]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15474363^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12684521^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:10854253^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015871	choline transport	PMID:17196556^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0015031	protein transport	PMID:11943765^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010975	regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009791	post-embryonic development	PMID:10518543^[51]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:17614943^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:15148382^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:11738035^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2155978	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:11567612^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2179062 MGI:MGI:2449304	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	PMID:15066262^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007611	learning or memory	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:15254914^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3051523	P	results_in_development_of:(EMAPA:17333)\|results_in_development_of:(EMAPA:17340)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:9153393^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	P	results_in_development_of:(EMAPA:16894)\|results_in_development_of:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007220	Notch receptor processing	PMID:20130175^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007220	Notch receptor processing	PMID:12391611^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3051523	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007220	Notch receptor processing	PMID:10206645^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:17698590^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:16715081^[54]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P	occurs_in:(EMAPA:17577)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:11262239^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1932738	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007219	Notch signaling pathway	PMID:10821758^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007176	regulation of epidermal growth factor-activated receptor activity	PMID:17556541^[55]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:16478525^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88059	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:10097174^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	PMID:12460542^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930937	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006914	autophagy	PMID:15123735^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006874	cellular calcium ion homeostasis	PMID:12431992^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2684616,MGI:MGI:2684620	P	occurs_in:(EMAPA:32845) occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006839	mitochondrial transport	PMID:12805290^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006486	protein glycosylation	PMID:12646573^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2446469	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006469	negative regulation of protein kinase activity	PMID:12805290^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17097608^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:19376115^[56]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:16018997^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
colocalizes_with	GO:0005790	smooth endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:19376115^[56]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16894)	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:10854253^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12794186^[57]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:17920016^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:17913918^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:17556541^[55]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:17097608^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:15452145^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:12684521^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:12391611^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3051523	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:11953314^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:11262239^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1932738	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:10206645^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	F	has_direct_input:(MGI:MGI:88059)\|has_direct_input:(MGI:MGI:97363)	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3425	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002573	myeloid leukocyte differentiation	PMID:15122901^[58]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002286	T cell activation involved in immune response	PMID:17698590^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002265	astrocyte activation involved in immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002244	hematopoietic progenitor cell differentiation	PMID:15122901^[58]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002038	positive regulation of L-glutamate import across plasma membrane	PMID:15009636^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001947	heart looping	PMID:10557208^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:15896720^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	PMID:15148382^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:15163631^[59]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000117)\|occurs_in(EMAPA:17787) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:12391611^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3051523	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:10821758^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	PMID:10421573^[60]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P	occurs_in:(EMAPA:17544) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:19779553^[61]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:10557208^[45]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001756	somitogenesis	PMID:9153393^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	P	has_participant:(EMAPA:16184)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001708	cell fate specification	PMID:15525534^[62]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109284	P	has_participant:(EMAPA:32792)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:9153393^[53]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1930934	P	occurs_in:(EMAPA:16894)\|occurs_in:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:16079160^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857974	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:15254914^[52]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3051523	P	occurs_in:(EMAPA:17008)	Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000186	activation of MAPKK activity	PMID:15896720^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49768	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000045	autophagosome assembly	PMID:15452145^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2149116	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005262	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005262	P		Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:1905908	positive regulation of amyloid fibril formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:1904797	negative regulation of core promoter binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
part_of	GO:0070765	gamma-secretase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0048143	astrocyte activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
involved_in	GO:0042982	amyloid precursor protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
enables	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	F		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0042325	regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	F		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	F		Seeded From UniProt	complete
involved_in	GO:0002265	astrocyte activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49768 ensembl:ENSP00000326366	P		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	F		Seeded From UniProt	complete
involved_in	GO:0003407	neural retina development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R6A3 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R6A3 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R6A3 ensembl:ENSP00000326366	C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001108 InterPro:IPR006639	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002031	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001108 InterPro:IPR006639	C		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001108	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002031	P		Seeded From UniProt	complete
enables	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002031	F		Seeded From UniProt	complete
involved_in	GO:0042987	amyloid precursor protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002031	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:19118188^[63]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	PMID:19118188^[63]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-2534209 Reactome:R-MMU-209285	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gadadhar, A et al. (2011) Presenilin-1 regulates neural progenitor cell differentiation in the adult brain. J. Neurosci. 31 2615-23 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Xia, X et al. (2001) Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 98 10863-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Rocher-Ros, V et al. (2010) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29 2950-61 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Feng, R et al. (2004) Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proc. Natl. Acad. Sci. U.S.A. 101 8162-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Marambaud, P et al. (2002) A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 21 1948-56 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Kilb, W et al. (2004) Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice. Eur. J. Neurosci. 20 2749-56 PubMed GONUTS page
↑ ^8.0 ^8.1 Guo, Q et al. (1999) Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc. Natl. Acad. Sci. U.S.A. 96 4125-30 PubMed GONUTS page
↑ Gowrishankar, K et al. (2004) Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD. J. Cell. Sci. 117 4099-111 PubMed GONUTS page
↑ ^10.0 ^10.1 Leem, JY et al. (2002) Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J. Biol. Chem. 277 19236-40 PubMed GONUTS page
↑ ^11.0 ^11.1 Herms, J et al. (2003) Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J. Biol. Chem. 278 2484-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Mohmmad Abdul, H et al. (2006) Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease. J. Neurochem. 96 1322-35 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Laky, K & Fowlkes, BJ (2007) Presenilins regulate alphabeta T cell development by modulating TCR signaling. J. Exp. Med. 204 2115-29 PubMed GONUTS page
↑ ^14.0 ^14.1 Chen, F et al. (2003) Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J. Biol. Chem. 278 19974-9 PubMed GONUTS page
↑ ^15.0 ^15.1 Li, T et al. (2007) Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J. Neurosci. 27 10849-59 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Lai, MT et al. (2003) Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J. Biol. Chem. 278 22475-81 PubMed GONUTS page
↑ ^17.0 ^17.1 Dong, S et al. (2007) Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. Eur. J. Neurosci. 26 101-12 PubMed GONUTS page
↑ ^18.0 ^18.1 Shen, J et al. (1997) Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89 629-39 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Yuasa, S et al. (2002) Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice. J. Neurosci. Res. 70 501-13 PubMed GONUTS page
↑ ^20.0 ^20.1 Saura, CA et al. (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42 23-36 PubMed GONUTS page
↑ Morton, RA et al. (2002) Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1. Neurosci. Lett. 319 37-40 PubMed GONUTS page
↑ ^22.0 ^22.1 Baki, L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 2586-96 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 Kim, JS et al. (2006) Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover. Biochem. Biophys. Res. Commun. 351 903-8 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Kim, MY et al. (2005) Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway. Biochem. Biophys. Res. Commun. 332 609-13 PubMed GONUTS page
↑ ^25.0 ^25.1 Liu, Q et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56 66-78 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 ^26.6 Pigino, G et al. (2003) Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J. Neurosci. 23 4499-508 PubMed GONUTS page
↑ ^27.0 ^27.1 Pan, Y et al. (2005) Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev. Biol. 286 472-82 PubMed GONUTS page
↑ ^28.0 ^28.1 Lee, MK et al. (1996) Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J. Neurosci. 16 7513-25 PubMed GONUTS page
↑ Satpathy, AT et al. (2013) Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat. Immunol. 14 937-48 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 Esselens, C et al. (2004) Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J. Cell Biol. 166 1041-54 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Yu, H et al. (2001) APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 31 713-26 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 De Strooper, B et al. (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398 518-22 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 Wen, PH et al. (2005) Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice. Development 132 3873-83 PubMed GONUTS page
↑ ^34.0 ^34.1 ^34.2 Koizumi, K et al. (2001) The role of presenilin 1 during somite segmentation. Development 128 1391-402 PubMed GONUTS page
↑ ^35.0 ^35.1 Yang, J & Li, T (2005) The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp. Cell Res. 309 379-89 PubMed GONUTS page
↑ ^36.0 ^36.1 Zhao, G et al. (2010) Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J. Neurosci. 30 1648-56 PubMed GONUTS page
↑ ^37.0 ^37.1 Nelson, O et al. (2007) Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J. Clin. Invest. 117 1230-9 PubMed GONUTS page
↑ ^38.0 ^38.1 Wilson, CA et al. (2004) Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J. Cell Biol. 165 335-46 PubMed GONUTS page
↑ ^39.0 ^39.1 Yang, Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J. Neurochem. 88 1361-72 PubMed GONUTS page
↑ ^40.0 ^40.1 Chan, SL et al. (2002) Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Neurobiol. Dis. 11 2-19 PubMed GONUTS page
↑ Mattson, MP et al. (2000) Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J. Neurosci. 20 1358-64 PubMed GONUTS page
↑ ^42.0 ^42.1 Kamal, A et al. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414 643-8 PubMed GONUTS page
↑ ^43.0 ^43.1 ^43.2 Handler, M et al. (2000) Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127 2593-606 PubMed GONUTS page
↑ ^44.0 ^44.1 Feng, R et al. (2001) Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 32 911-26 PubMed GONUTS page
↑ ^45.0 ^45.1 ^45.2 Donoviel, DB et al. (1999) Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev. 13 2801-10 PubMed GONUTS page
↑ Vetrivel, KS et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 25892-900 PubMed GONUTS page
↑ Ma, G et al. (2005) APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J. Neurosci. 25 192-8 PubMed GONUTS page
↑ Hébert, SS et al. (2004) Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol. Dis. 17 260-72 PubMed GONUTS page
↑ ^49.0 ^49.1 Kashiwa, A et al. (2000) Isolation and characterization of novel presenilin binding protein. J. Neurochem. 75 109-16 PubMed GONUTS page
↑ Payette, DJ et al. (2007) Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice. Brain Res. 1135 12-21 PubMed GONUTS page
↑ Herreman, A et al. (1999) Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. U.S.A. 96 11872-7 PubMed GONUTS page
↑ ^52.0 ^52.1 Nakajima, M et al. (2004) Presenilin 1 is essential for cardiac morphogenesis. Dev. Dyn. 230 795-9 PubMed GONUTS page
↑ ^53.0 ^53.1 ^53.2 Wong, PC et al. (1997) Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 387 288-92 PubMed GONUTS page
↑ Mizuguchi, R et al. (2006) Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nat. Neurosci. 9 770-8 PubMed GONUTS page
↑ ^55.0 ^55.1 Zhang, YW et al. (2007) Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc. Natl. Acad. Sci. U.S.A. 104 10613-8 PubMed GONUTS page
↑ ^56.0 ^56.1 Suzuki, Y et al. (2009) An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor. FEBS Lett. 583 1403-8 PubMed GONUTS page
↑ Six, E et al. (2003) The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. Proc. Natl. Acad. Sci. U.S.A. 100 7638-43 PubMed GONUTS page
↑ ^58.0 ^58.1 Qyang, Y et al. (2004) Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry 43 5352-9 PubMed GONUTS page
↑ Louvi, A et al. (2004) Presenilin 1 in migration and morphogenesis in the central nervous system. Development 131 3093-105 PubMed GONUTS page
↑ Hartmann, D et al. (1999) Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly. Curr. Biol. 9 719-27 PubMed GONUTS page
↑ Ferjentsik, Z et al. (2009) Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet. 5 e1000662 PubMed GONUTS page
↑ Pan, Y et al. (2004) gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev. Cell 7 731-43 PubMed GONUTS page
↑ ^63.0 ^63.1 Puzzo, D et al. (2008) Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J. Neurosci. 28 14537-45 PubMed GONUTS page

[PMID:21325529-1] Gadadhar, A et al. (2011) Presenilin-1 regulates neural progenitor cell differentiation in the adult brain. J. Neurosci. 31 2615-23 PubMed GONUTS page

[PMID:11517342-2] 2.0 ^2.1 ^2.2 ^2.3 Xia, X et al. (2001) Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 98 10863-8 PubMed GONUTS page

[PMID:20208556-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Rocher-Ros, V et al. (2010) Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. Oncogene 29 2950-61 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15148382-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Feng, R et al. (2004) Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proc. Natl. Acad. Sci. U.S.A. 101 8162-7 PubMed GONUTS page

[PMID:11953314-6] 6.0 ^6.1 ^6.2 ^6.3 Marambaud, P et al. (2002) A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 21 1948-56 PubMed GONUTS page

[PMID:15548218-7] 7.0 ^7.1 ^7.2 Kilb, W et al. (2004) Altered morphological and electrophysiological properties of Cajal-Retzius cells in cerebral cortex of embryonic Presenilin-1 knockout mice. Eur. J. Neurosci. 20 2749-56 PubMed GONUTS page

[PMID:10097174-8] 8.0 ^8.1 Guo, Q et al. (1999) Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc. Natl. Acad. Sci. U.S.A. 96 4125-30 PubMed GONUTS page

[PMID:15280425-9] Gowrishankar, K et al. (2004) Release of a membrane-bound death domain by gamma-secretase processing of the p75NTR homolog NRADD. J. Cell. Sci. 117 4099-111 PubMed GONUTS page

[PMID:11943765-10] 10.0 ^10.1 Leem, JY et al. (2002) Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J. Biol. Chem. 277 19236-40 PubMed GONUTS page

[PMID:12431992-11] 11.0 ^11.1 Herms, J et al. (2003) Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein. J. Biol. Chem. 278 2484-9 PubMed GONUTS page

[PMID:16478525-12] 12.0 ^12.1 Mohmmad Abdul, H et al. (2006) Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease. J. Neurochem. 96 1322-35 PubMed GONUTS page

[PMID:17698590-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Laky, K & Fowlkes, BJ (2007) Presenilins regulate alphabeta T cell development by modulating TCR signaling. J. Exp. Med. 204 2115-29 PubMed GONUTS page

[PMID:12646573-14] 14.0 ^14.1 Chen, F et al. (2003) Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J. Biol. Chem. 278 19974-9 PubMed GONUTS page

[PMID:17913918-15] 15.0 ^15.1 Li, T et al. (2007) Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities. J. Neurosci. 27 10849-59 PubMed GONUTS page

[PMID:12684521-16] 16.0 ^16.1 ^16.2 Lai, MT et al. (2003) Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J. Biol. Chem. 278 22475-81 PubMed GONUTS page

[PMID:17614943-17] 17.0 ^17.1 Dong, S et al. (2007) Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. Eur. J. Neurosci. 26 101-12 PubMed GONUTS page

[PMID:9160754-18] 18.0 ^18.1 Shen, J et al. (1997) Skeletal and CNS defects in Presenilin-1-deficient mice. Cell 89 629-39 PubMed GONUTS page

[PMID:12391611-19] 19.0 ^19.1 ^19.2 ^19.3 Yuasa, S et al. (2002) Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice. J. Neurosci. Res. 70 501-13 PubMed GONUTS page

[PMID:15066262-20] 20.0 ^20.1 Saura, CA et al. (2004) Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron 42 23-36 PubMed GONUTS page

[PMID:11814648-21] Morton, RA et al. (2002) Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1. Neurosci. Lett. 319 37-40 PubMed GONUTS page

[PMID:15192701-22] 22.0 ^22.1 Baki, L et al. (2004) PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 2586-96 PubMed GONUTS page

[PMID:17097608-23] 23.0 ^23.1 ^23.2 ^23.3 Kim, JS et al. (2006) Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover. Biochem. Biophys. Res. Commun. 351 903-8 PubMed GONUTS page

[PMID:15896720-24] 24.0 ^24.1 ^24.2 Kim, MY et al. (2005) Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway. Biochem. Biophys. Res. Commun. 332 609-13 PubMed GONUTS page

[PMID:17920016-25] 25.0 ^25.1 Liu, Q et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56 66-78 PubMed GONUTS page

[PMID:12805290-26] 26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 ^26.6 Pigino, G et al. (2003) Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J. Neurosci. 23 4499-508 PubMed GONUTS page

[PMID:16169548-27] 27.0 ^27.1 Pan, Y et al. (2005) Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev. Biol. 286 472-82 PubMed GONUTS page

[PMID:8922407-28] 28.0 ^28.1 Lee, MK et al. (1996) Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J. Neurosci. 16 7513-25 PubMed GONUTS page

[PMID:23913046-29] Satpathy, AT et al. (2013) Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat. Immunol. 14 937-48 PubMed GONUTS page

[PMID:15452145-30] 30.0 ^30.1 ^30.2 Esselens, C et al. (2004) Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J. Cell Biol. 166 1041-54 PubMed GONUTS page

[PMID:11567612-31] 31.0 ^31.1 ^31.2 Yu, H et al. (2001) APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 31 713-26 PubMed GONUTS page

[PMID:10206645-32] 32.0 ^32.1 ^32.2 ^32.3 De Strooper, B et al. (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398 518-22 PubMed GONUTS page

[PMID:16079160-33] 33.0 ^33.1 ^33.2 ^33.3 Wen, PH et al. (2005) Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice. Development 132 3873-83 PubMed GONUTS page

[PMID:11262239-34] 34.0 ^34.1 ^34.2 Koizumi, K et al. (2001) The role of presenilin 1 during somite segmentation. Development 128 1391-402 PubMed GONUTS page

[PMID:16018997-35] 35.0 ^35.1 Yang, J & Li, T (2005) The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp. Cell Res. 309 379-89 PubMed GONUTS page

[PMID:20130175-36] 36.0 ^36.1 Zhao, G et al. (2010) Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J. Neurosci. 30 1648-56 PubMed GONUTS page

[PMID:17431506-37] 37.0 ^37.1 Nelson, O et al. (2007) Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J. Clin. Invest. 117 1230-9 PubMed GONUTS page

[PMID:15123735-38] 38.0 ^38.1 Wilson, CA et al. (2004) Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. J. Cell Biol. 165 335-46 PubMed GONUTS page

[PMID:15009636-39] 39.0 ^39.1 Yang, Y et al. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J. Neurochem. 88 1361-72 PubMed GONUTS page

[PMID:12460542-40] 40.0 ^40.1 Chan, SL et al. (2002) Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Neurobiol. Dis. 11 2-19 PubMed GONUTS page

[PMID:10662826-41] Mattson, MP et al. (2000) Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J. Neurosci. 20 1358-64 PubMed GONUTS page

[PMID:11740561-42] 42.0 ^42.1 Kamal, A et al. (2001) Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP. Nature 414 643-8 PubMed GONUTS page

[PMID:10821758-43] 43.0 ^43.1 ^43.2 Handler, M et al. (2000) Presenilin-1 regulates neuronal differentiation during neurogenesis. Development 127 2593-606 PubMed GONUTS page

[PMID:11738035-44] 44.0 ^44.1 Feng, R et al. (2001) Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 32 911-26 PubMed GONUTS page

[PMID:10557208-45] 45.0 ^45.1 ^45.2 Donoviel, DB et al. (1999) Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev. 13 2801-10 PubMed GONUTS page

[PMID:15886206-46] Vetrivel, KS et al. (2005) Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 25892-900 PubMed GONUTS page

[PMID:15634781-47] Ma, G et al. (2005) APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. J. Neurosci. 25 192-8 PubMed GONUTS page

[PMID:15474363-48] Hébert, SS et al. (2004) Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiol. Dis. 17 260-72 PubMed GONUTS page

[PMID:10854253-49] 49.0 ^49.1 Kashiwa, A et al. (2000) Isolation and characterization of novel presenilin binding protein. J. Neurochem. 75 109-16 PubMed GONUTS page

[PMID:17196556-50] Payette, DJ et al. (2007) Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice. Brain Res. 1135 12-21 PubMed GONUTS page

[PMID:10518543-51] Herreman, A et al. (1999) Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc. Natl. Acad. Sci. U.S.A. 96 11872-7 PubMed GONUTS page

[PMID:15254914-52] 52.0 ^52.1 Nakajima, M et al. (2004) Presenilin 1 is essential for cardiac morphogenesis. Dev. Dyn. 230 795-9 PubMed GONUTS page

[PMID:9153393-53] 53.0 ^53.1 ^53.2 Wong, PC et al. (1997) Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 387 288-92 PubMed GONUTS page

[PMID:16715081-54] Mizuguchi, R et al. (2006) Ascl1 and Gsh1/2 control inhibitory and excitatory cell fate in spinal sensory interneurons. Nat. Neurosci. 9 770-8 PubMed GONUTS page

[PMID:17556541-55] 55.0 ^55.1 Zhang, YW et al. (2007) Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression. Proc. Natl. Acad. Sci. U.S.A. 104 10613-8 PubMed GONUTS page

[PMID:19376115-56] 56.0 ^56.1 Suzuki, Y et al. (2009) An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor. FEBS Lett. 583 1403-8 PubMed GONUTS page

[PMID:12794186-57] Six, E et al. (2003) The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. Proc. Natl. Acad. Sci. U.S.A. 100 7638-43 PubMed GONUTS page

[PMID:15122901-58] 58.0 ^58.1 Qyang, Y et al. (2004) Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry 43 5352-9 PubMed GONUTS page

[PMID:15163631-59] Louvi, A et al. (2004) Presenilin 1 in migration and morphogenesis in the central nervous system. Development 131 3093-105 PubMed GONUTS page

[PMID:10421573-60] Hartmann, D et al. (1999) Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly. Curr. Biol. 9 719-27 PubMed GONUTS page

[PMID:19779553-61] Ferjentsik, Z et al. (2009) Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. PLoS Genet. 5 e1000662 PubMed GONUTS page

[PMID:15525534-62] Pan, Y et al. (2004) gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev. Cell 7 731-43 PubMed GONUTS page

[PMID:19118188-63] 63.0 ^63.1 Puzzo, D et al. (2008) Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. J. Neurosci. 28 14537-45 PubMed GONUTS page

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