GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:10854253

From GONUTS
Jump to: navigation, search
Citation

Kashiwa, A, Yoshida, H, Lee, S, Paladino, T, Liu, Y, Chen, Q, Dargusch, R, Schubert, D and Kimura, H (2000) Isolation and characterization of novel presenilin binding protein. J. Neurochem. 75:109-16

Abstract

Approximately 50% of familial Alzheimer's disease (AD) cases are linked to the presenilin (PS) gene. This suggests that an altered function of mutated PSs accounts for a fundamental process leading to AD. Here we identify a new PS binding protein, PBP, which is highly expressed in cerebral cortex and hippocampus. immunohistochemical studies and cell fractionation analysis show that PBP redistributes from cytoplasm to membranes in the presence of PS. In addition, PBP is deficient in the soluble fraction of sporadic AD brains.

Links

PubMed

Keywords

Alzheimer Disease/genetics; Alzheimer Disease/metabolism; Amino Acid Sequence; Animals; Blotting, Northern; Blotting, Western; COS Cells; Carrier Proteins/analysis; Carrier Proteins/chemistry; Carrier Proteins/genetics; Cell Fractionation; Cell Line; Cell Membrane/chemistry; Cerebral Cortex/chemistry; Cerebral Cortex/ultrastructure; Cytoplasm/chemistry; DNA, Complementary; Guanine Nucleotide Exchange Factors; Hippocampus/chemistry; Hippocampus/ultrastructure; Humans; Immunohistochemistry; In Situ Hybridization; Kidney; Membrane Proteins/metabolism; Mice; Molecular Sequence Data; Nerve Tissue Proteins; Peptide Fragments/chemistry; Presenilin-1; Saccharomyces cerevisiae; Transfection

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

See Help:References for how to manage references in GONUTS.