PMID:17614943

Citation	Dong, S, Li, C, Wu, P, Tsien, JZ and Hu, Y (2007) Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice. Eur. J. Neurosci. 26:101-12
Abstract	Presenilin (PS) 1 and 2 conditional double knockout (cDKO) mice show progressive memory dysfunction and forebrain degeneration. Gene expression profiling results revealed a strong activation of immunity and inflammation responses in the brains of 10-month-old cDKO mice. As environmental enrichment (EE) has been shown to be able to improve memory and induce neurogenesis of the brain, we assessed the effects of EE on the memory performance and the neurodegeneration in cDKO mice. We found that EE effectively enhanced memory and partially rescued the forebrain atrophy of the cDKO mice. Our results suggest that immunity and inflammation could play important roles in the neurodegeneration of cDKO mice. Furthermore, the beneficial effects of EE may be associated with the inhibition of the expression of immunity and inflammation-related genes in the brain.
Links	PubMed Online version:10.1111/j.1460-9568.2007.05641.x
Keywords	Animals; Astrocytes/physiology; Blotting, Western; Cerebral Cortex/metabolism; Conditioning (Psychology)/physiology; Environment; Fear/psychology; Hippocampus/metabolism; Mice; Mice, Inbred CBA; Mice, Knockout; Neurodegenerative Diseases/genetics; Neurodegenerative Diseases/pathology; Oligonucleotide Array Sequence Analysis; Phenotype; Presenilin-1/genetics; Presenilin-2/genetics; Recognition (Psychology)/physiology; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation/physiology
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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