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DROME:PEN2

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) pen-2
Protein Name(s) Gamma-secretase subunit pen-2

Presenilin enhancer protein 2

External Links
UniProt Q86BE9
EMBL AF512426
AE013599
BT030940
BT030980
RefSeq NP_001286566.1
NP_788401.2
UniGene Dm.14392
ProteinModelPortal Q86BE9
BioGrid 75540
MINT MINT-973227
STRING 7227.FBpp0088783
EnsemblMetazoa FBtr0089842
GeneID 251430
KEGG dme:Dmel_CG33198
CTD 251430
FlyBase FBgn0053198
eggNOG NOG279333
GeneTree ENSGT00390000016319
InParanoid Q86BE9
KO K06170
OMA CKKYFLI
OrthoDB EOG7ZSHW4
PhylomeDB Q86BE9
Reactome REACT_184382
REACT_184383
REACT_218930
REACT_221100
REACT_225574
REACT_240291
REACT_241128
REACT_271460
SignaLink Q86BE9
ChiTaRS Pen
GenomeRNAi 251430
NextBio 843538
PRO PR:Q86BE9
Proteomes UP000000803
Bgee Q86BE9
GO GO:0070765
GO:0016021
GO:0005770
GO:0055037
GO:0004175
GO:0007219
GO:0006508
InterPro IPR019379
Pfam PF10251

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004175

endopeptidase activity

PMID:12660785[1]

IDA: Inferred from Direct Assay

F

complete

GO:0005770

late endosome

PMID:20421416[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007219

Notch signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0914

P

Seeded From UniProt

complete

GO:0007219

Notch signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0914

P

complete

GO:0007220

Notch receptor processing

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000418973

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0162

C

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0055037

recycling endosome

PMID:20421416[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0070765

gamma-secretase complex

PMID:20421416[2]

IPI: Inferred from Physical Interaction

FB:FBgn0019947
FB:FBgn0031458
FB:FBgn0039234

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Takasugi, N et al. (2003) The role of presenilin cofactors in the gamma-secretase complex. Nature 422 438-41 PubMed GONUTS page
  2. 2.0 2.1 2.2 Stempfle, D et al. (2010) In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol. Cell. Biol. 30 3165-75 PubMed GONUTS page