GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
DROME:PEN2
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | pen-2 | |
| Protein Name(s) | Gamma-secretase subunit pen-2
Presenilin enhancer protein 2 | |
| External Links | ||
| UniProt | Q86BE9 | |
| EMBL | AF512426 AE013599 BT030940 BT030980 | |
| RefSeq | NP_001286566.1 NP_788401.2 | |
| UniGene | Dm.14392 | |
| ProteinModelPortal | Q86BE9 | |
| BioGrid | 75540 | |
| MINT | MINT-973227 | |
| STRING | 7227.FBpp0088783 | |
| EnsemblMetazoa | FBtr0089842 | |
| GeneID | 251430 | |
| KEGG | dme:Dmel_CG33198 | |
| CTD | 251430 | |
| FlyBase | FBgn0053198 | |
| eggNOG | NOG279333 | |
| GeneTree | ENSGT00390000016319 | |
| InParanoid | Q86BE9 | |
| KO | K06170 | |
| OMA | CKKYFLI | |
| OrthoDB | EOG7ZSHW4 | |
| PhylomeDB | Q86BE9 | |
| Reactome | REACT_184382 REACT_184383 REACT_218930 REACT_221100 REACT_225574 REACT_240291 REACT_241128 REACT_271460 | |
| SignaLink | Q86BE9 | |
| ChiTaRS | Pen | |
| GenomeRNAi | 251430 | |
| NextBio | 843538 | |
| PRO | PR:Q86BE9 | |
| Proteomes | UP000000803 | |
| Bgee | Q86BE9 | |
| GO | GO:0070765 GO:0016021 GO:0005770 GO:0055037 GO:0004175 GO:0007219 GO:0006508 | |
| InterPro | IPR019379 | |
| Pfam | PF10251 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0070765 |
gamma-secretase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0053198 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007220 |
Notch receptor processing |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913590 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070765 |
gamma-secretase complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
FB:FBgn0031458,FB:FBgn0039234,FB:FBgn0284421 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005770 |
late endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0055037 |
recycling endosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034205 |
amyloid-beta formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
part_of:(GO:0007220) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035333 |
Notch receptor processing, ligand-dependent |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0031458,FB:FBgn0039234,FB:FBgn0284421 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
FB:FBgn0031458,FB:FBgn0039234,FB:FBgn0284421 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034205 |
amyloid-beta formation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006509 |
membrane protein ectodomain proteolysis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Stempfle, D et al. (2010) In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol. Cell. Biol. 30 3165-75 PubMed GONUTS page
- ↑ 3.0 3.1 Francis, R et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3 85-97 PubMed GONUTS page
