GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
CAEEL:PEN2
Contents
| Species (Taxon ID) | Caenorhabditis elegans. (6239) | |
| Gene Name(s) | pen-2 | |
| Protein Name(s) | Gamma-secretase subunit pen-2
Presenilin enhancer protein 2 | |
| External Links | ||
| UniProt | Q9U357 | |
| EMBL | Z81134 | |
| PIR | T25417 | |
| RefSeq | NP_499459.1 | |
| UniGene | Cel.9963 | |
| BioGrid | 41747 | |
| DIP | DIP-26665N | |
| MINT | MINT-1063487 | |
| STRING | 6239.T28D6.9 | |
| EnsemblMetazoa | T28D6.9 | |
| GeneID | 176565 | |
| KEGG | cel:CELE_T28D6.9 | |
| UCSC | T28D6.9 | |
| CTD | 251430 | |
| WormBase | T28D6.9 | |
| eggNOG | NOG279333 | |
| GeneTree | ENSGT00390000016319 | |
| HOGENOM | HOG000006914 | |
| InParanoid | Q9U357 | |
| KO | K06170 | |
| OMA | CKKYFLI | |
| OrthoDB | EOG7ZSHW4 | |
| PhylomeDB | Q9U357 | |
| Reactome | REACT_234237 REACT_262378 REACT_269213 REACT_269670 REACT_270292 REACT_270586 REACT_270666 | |
| SignaLink | Q9U357 | |
| NextBio | 893106 | |
| PRO | PR:Q9U357 | |
| Proteomes | UP000001940 | |
| GO | GO:0005789 GO:0000139 GO:0016021 GO:0016020 GO:0045165 GO:0009792 GO:0048598 GO:0007281 GO:0007219 GO:0060465 | |
| InterPro | IPR019379 | |
| Pfam | PF10251 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0070765 |
gamma-secretase complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060465 |
pharynx development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
WB:WBVar00145189 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048598 |
embryonic morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
WB:WBVar00145189 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045165 |
cell fate commitment |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00004769 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009792 |
embryo development ending in birth or egg hatching |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
WB:WBVar00145189 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007281 |
germ cell development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
WB:WBGene00004769 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
WB:WBVar00145189 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070765 |
gamma-secretase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0053198 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007220 |
Notch receptor processing |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1913590 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007219 |
Notch signaling pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000139 |
Golgi membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Francis, R et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3 85-97 PubMed GONUTS page
- ↑ 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
e
g
