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CAEEL:PEN2

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) pen-2
Protein Name(s) Gamma-secretase subunit pen-2

Presenilin enhancer protein 2

External Links
UniProt Q9U357
EMBL Z81134
PIR T25417
RefSeq NP_499459.1
UniGene Cel.9963
BioGrid 41747
DIP DIP-26665N
MINT MINT-1063487
STRING 6239.T28D6.9
EnsemblMetazoa T28D6.9
GeneID 176565
KEGG cel:CELE_T28D6.9
UCSC T28D6.9
CTD 251430
WormBase T28D6.9
eggNOG NOG279333
GeneTree ENSGT00390000016319
HOGENOM HOG000006914
InParanoid Q9U357
KO K06170
OMA CKKYFLI
OrthoDB EOG7ZSHW4
PhylomeDB Q9U357
Reactome REACT_234237
REACT_262378
REACT_269213
REACT_269670
REACT_270292
REACT_270586
REACT_270666
SignaLink Q9U357
NextBio 893106
PRO PR:Q9U357
Proteomes UP000001940
GO GO:0005789
GO:0000139
GO:0016021
GO:0016020
GO:0045165
GO:0009792
GO:0048598
GO:0007281
GO:0007219
GO:0060465
InterPro IPR019379
Pfam PF10251

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000139

Golgi membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0134

C

complete

GO:0000139

Golgi membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0134

C

Seeded From UniProt

complete

GO:0005783

endoplasmic reticulum

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0256

C

complete

GO:0005783

endoplasmic reticulum

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0097

C

complete

GO:0005794

Golgi apparatus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

GO:0005794

Golgi apparatus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0333

C

complete

GO:0007219

Notch signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0914

P

Seeded From UniProt

complete

GO:0007219

Notch signaling pathway

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0914

P

complete

GO:0007219

Notch signaling pathway

PMID:12110170[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145189

P

Seeded From UniProt

complete

GO:0007219

Notch signaling pathway

PMID:12110170[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145189

P

complete

GO:0007220

Notch receptor processing

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000418973

P

Seeded From UniProt

complete

GO:0007281

germ cell development

PMID:12110170[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00004769

P

complete

GO:0007281

germ cell development

PMID:12110170[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00004769

P

Seeded From UniProt

complete

GO:0009792

embryo development ending in birth or egg hatching

PMID:12110170[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145189

P

complete

GO:0009792

embryo development ending in birth or egg hatching

PMID:12110170[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145189

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0472

C

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

PMID:12110170[1]

IDA: Inferred from Direct Assay

C

complete

GO:0016020

membrane

PMID:12110170[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0045165

cell fate commitment

PMID:12110170[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00004769

P

complete

GO:0045165

cell fate commitment

PMID:12110170[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00004769

P

Seeded From UniProt

complete

GO:0048598

embryonic morphogenesis

PMID:12110170[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145189

P

complete

GO:0048598

embryonic morphogenesis

PMID:12110170[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145189

P

Seeded From UniProt

complete

GO:0060465

pharynx development

PMID:12110170[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145189

P

complete

GO:0060465

pharynx development

PMID:12110170[1]

IMP: Inferred from Mutant Phenotype

WB:WBVar00145189

P

Seeded From UniProt

complete

GO:0070765

gamma-secretase complex

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000418972

C

Seeded From UniProt

complete

GO:0070765

gamma-secretase complex

PMID:12110170[1]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q86BE9

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 Francis, R et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3 85-97 PubMed GONUTS page