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CHICK:PSN1

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) PSEN1
Protein Name(s) Presenilin-1

PS-1 Presenilin-1 NTF subunit Presenilin-1 CTF subunit

External Links
UniProt Q4JIM4
EMBL AY043492
DQ084362
RefSeq NP_989494.1
UniGene Gga.3864
STRING 9031.ENSGALP00000015151
MEROPS A22.001
PaxDb Q4JIM4
Ensembl ENSGALT00000032629
GeneID 373977
KEGG gga:373977
CTD 5663
eggNOG NOG237920
GeneTree ENSGT00390000016593
HOGENOM HOG000240228
HOVERGEN HBG011375
InParanoid Q4JIM4
KO K04505
OMA GQPQNNI
OrthoDB EOG7NGQBG
PhylomeDB Q4JIM4
TreeFam TF315040
Reactome REACT_197190
NextBio 20813506
PRO PR:Q4JIM4
Proteomes UP000000539
GO GO:0016324
GO:0030424
GO:0005938
GO:0009986
GO:0005813
GO:0035253
GO:0031410
GO:0043198
GO:0005783
GO:0005789
GO:0070765
GO:0005794
GO:0000139
GO:0030426
GO:0005887
GO:0000776
GO:0005765
GO:0045121
GO:0005743
GO:0005739
GO:0031594
GO:0043025
GO:0005640
GO:0005634
GO:0048471
GO:0005791
GO:0005790
GO:0030018
GO:0004190
GO:0008013
GO:0045296
GO:0005262
GO:0004175
GO:0000186
GO:0042987
GO:0000045
GO:0034205
GO:0050435
GO:0001568
GO:0048854
GO:0021870
GO:0006816
GO:0060070
GO:0001708
GO:0006974
GO:0021795
GO:0015871
GO:0021904
GO:0030326
GO:0050673
GO:0001947
GO:0002244
GO:0035556
GO:0015813
GO:0006509
GO:0007613
GO:0006839
GO:0002573
GO:0043066
GO:2001234
GO:0050771
GO:0007175
GO:2000059
GO:0000122
GO:0051444
GO:0051402
GO:0048666
GO:0001764
GO:0007220
GO:0007219
GO:0043065
GO:0043085
GO:0050820
GO:0043406
GO:0032436
GO:0001921
GO:0009791
GO:0006486
GO:0016485
GO:0015031
GO:0042325
GO:0043393
GO:0060075
GO:0048167
GO:0051966
GO:0006979
GO:0016337
GO:0048705
GO:0043589
GO:0051563
GO:0001756
GO:0016080
GO:0002286
GO:0050852
GO:0048538
InterPro IPR002031
IPR001108
IPR006639
PANTHER PTHR10202
PTHR10202:SF7
Pfam PF01080
PRINTS PR01072
PR01073
SMART SM00730

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070765

gamma-secretase complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

C

Seeded From UniProt

complete

enables

GO:0042500

aspartic endopeptidase activity, intramembrane cleaving

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

F

Seeded From UniProt

complete

involved_in

GO:0042982

amyloid precursor protein metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

P

Seeded From UniProt

complete

involved_in

GO:0034205

amyloid-beta formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49769

C

Seeded From UniProt

complete

involved_in

GO:0060828

regulation of canonical Wnt signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49769

P

Seeded From UniProt

complete

involved_in

GO:0043085

positive regulation of catalytic activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

P

Seeded From UniProt

complete

involved_in

GO:0042325

regulation of phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

P

Seeded From UniProt

complete

involved_in

GO:0016485

protein processing

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

P

Seeded From UniProt

complete

involved_in

GO:0006509

membrane protein ectodomain proteolysis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P49768

C

Seeded From UniProt

complete

involved_in

GO:0051563

smooth endoplasmic reticulum calcium ion homeostasis

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202717
PANTHER:PTN000024459

P

Seeded From UniProt

complete

enables

GO:0045296

cadherin binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202717
PANTHER:PTN000024459

F

Seeded From UniProt

complete

enables

GO:0008013

beta-catenin binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000024459
UniProtKB:P49768

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019947
PANTHER:PTN000024429
UniProtKB:P49768
UniProtKB:P49810

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202717
PANTHER:PTN000024459
UniProtKB:P49768

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1202717
PANTHER:PTN000024429
UniProtKB:P49768

C

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019947
MGI:MGI:109284
MGI:MGI:1202717
PANTHER:PTN000024429
RGD:3425
UniProtKB:P49768

F

Seeded From UniProt

complete

part_of

GO:0005790

smooth endoplasmic reticulum

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0051563

C

Seeded From UniProt

complete

enables

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001108
InterPro:IPR006639

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002031

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001108
InterPro:IPR006639

C

Seeded From UniProt

complete

involved_in

GO:0016485

protein processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001108

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002031

P

Seeded From UniProt

complete

enables

GO:0042500

aspartic endopeptidase activity, intramembrane cleaving

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002031

F

Seeded From UniProt

complete

involved_in

GO:0042987

amyloid precursor protein catabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002031

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0130

P

Seeded From UniProt

complete

involved_in

GO:0007219

Notch signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0914

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770
UniProtKB-SubCell:SL-0258

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0279

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0134

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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