DROME:PSN

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	Psn (synonyms: PS)
Protein Name(s)	Presenilin homolog DmPS dPS
External Links
UniProt	O02194
EMBL	U77934 U78084 AF084184 AF084184 AF017024 AF017025 AF017026 AF093402 AF093402 AE014296 AE014296 AY061316
RefSeq	NP_001262110.1 NP_001262111.1 NP_524184.1 NP_730535.1
UniGene	Dm.3254
ProteinModelPortal	O02194
SMR	O02194
BioGrid	65518
DIP	DIP-1139N
MEROPS	A22.014
PaxDb	O02194
PRIDE	O02194
EnsemblMetazoa	FBtr0078192 FBtr0333479
GeneID	40260
KEGG	dme:Dmel_CG18803
UCSC	CG18803-RA
CTD	40260
FlyBase	FBgn0019947
eggNOG	NOG237920
GeneTree	ENSGT00390000016593
InParanoid	O02194
KO	K04505
OMA	RFARHCL
OrthoDB	EOG7NGQBG
PhylomeDB	O02194
Reactome	REACT_184382 REACT_184383 REACT_218930 REACT_221100 REACT_225574 REACT_240291 REACT_241128 REACT_271460
SignaLink	O02194
GenomeRNAi	40260
NextBio	817840
PRO	PR:O02194
Proteomes	UP000000803
Bgee	O02194
ExpressionAtlas	O02194
GO	GO:0016324 GO:0030424 GO:0005938 GO:0009986 GO:0035253 GO:0005737 GO:0043198 GO:0005789 GO:0070765 GO:0000139 GO:0030426 GO:0005887 GO:0005770 GO:0005765 GO:0045121 GO:0005743 GO:0031594 GO:0043025 GO:0005634 GO:0048471 GO:0055037 GO:0030018 GO:0004190 GO:0004175 GO:0042803 GO:0042987 GO:0050435 GO:0006816 GO:0015677 GO:0007010 GO:0046331 GO:0006509 GO:0043066 GO:0048812 GO:0007220 GO:0007219 GO:0008593 GO:0016337 GO:0048190
InterPro	IPR001108 IPR006639
PANTHER	PTHR10202
Pfam	PF01080
PRINTS	PR01072
SMART	SM00730

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006915	apoptotic process	PMID:10491396^[1]	ECO:0000315			P		Figure 1:Removal of Psn gene function results in an increased number of cells undergoing apoptosis in certain disc regions	complete CACAO 5943
involved_in	GO:0006915	apoptotic process	PMID:10491396^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:28495961^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:15611340^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035333	Notch receptor processing, ligand-dependent	PMID:15611340^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:15611340^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:15611340^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(FB:FBgn0004647) part_of:(GO:0007220) part_of:(GO:0007219)	Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	PMID:12110170^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007220	Notch receptor processing	PMID:11782316^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:11782316^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0007220)	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:20421416^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	part_of:(GO:0035333) has_direct_input:(FB:FBgn0004647) part_of:(GO:0070765)	Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:12110170^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0007220)	Seeded From UniProt	complete
involved_in	GO:0035333	Notch receptor processing, ligand-dependent	PMID:20421416^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0031458,FB:FBgn0039234,FB:FBgn0053198	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:20421416^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0031458,FB:FBgn0039234,FB:FBgn0053198	P		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:20421416^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	PMID:20421416^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007220	Notch receptor processing	PMID:11782315^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	PMID:11782315^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001108 InterPro:IPR006639	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001108 InterPro:IPR006639	C		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001108	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ye, Y & Fortini, ME (1999) Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. J. Cell Biol. 146 1351-64 PubMed GONUTS page
↑ Kang, J et al. (2017) An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Brain. Genetics 206 1479-1493 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Ahimou, F et al. (2004) The adhesion force of Notch with Delta and the rate of Notch signaling. J. Cell Biol. 167 1217-29 PubMed GONUTS page
↑ ^4.0 ^4.1 Francis, R et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3 85-97 PubMed GONUTS page
↑ ^5.0 ^5.1 López-Schier, H & St Johnston, D (2002) Drosophila nicastrin is essential for the intramembranous cleavage of notch. Dev. Cell 2 79-89 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Stempfle, D et al. (2010) In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol. Cell. Biol. 30 3165-75 PubMed GONUTS page
↑ ^7.0 ^7.1 Hu, Y et al. (2002) Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell 2 69-78 PubMed GONUTS page

[PMID:10491396-1] 1.0 ^1.1 Ye, Y & Fortini, ME (1999) Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. J. Cell Biol. 146 1351-64 PubMed GONUTS page

[PMID:28495961-2] Kang, J et al. (2017) An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Brain. Genetics 206 1479-1493 PubMed GONUTS page

[PMID:15611340-3] 3.0 ^3.1 ^3.2 ^3.3 Ahimou, F et al. (2004) The adhesion force of Notch with Delta and the rate of Notch signaling. J. Cell Biol. 167 1217-29 PubMed GONUTS page

[PMID:12110170-4] 4.0 ^4.1 Francis, R et al. (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3 85-97 PubMed GONUTS page

[PMID:11782316-5] 5.0 ^5.1 López-Schier, H & St Johnston, D (2002) Drosophila nicastrin is essential for the intramembranous cleavage of notch. Dev. Cell 2 79-89 PubMed GONUTS page

[PMID:20421416-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Stempfle, D et al. (2010) In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol. Cell. Biol. 30 3165-75 PubMed GONUTS page

[PMID:11782315-7] 7.0 ^7.1 Hu, Y et al. (2002) Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell 2 69-78 PubMed GONUTS page

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DROME:PSN

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