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DROME:PSN

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Psn (synonyms: PS)
Protein Name(s) Presenilin homolog

DmPS dPS

External Links
UniProt O02194
EMBL U77934
U78084
AF084184
AF084184
AF017024
AF017025
AF017026
AF093402
AF093402
AE014296
AE014296
AY061316
RefSeq NP_001262110.1
NP_001262111.1
NP_524184.1
NP_730535.1
UniGene Dm.3254
ProteinModelPortal O02194
SMR O02194
BioGrid 65518
DIP DIP-1139N
MEROPS A22.014
PaxDb O02194
PRIDE O02194
EnsemblMetazoa FBtr0078192
FBtr0333479
GeneID 40260
KEGG dme:Dmel_CG18803
UCSC CG18803-RA
CTD 40260
FlyBase FBgn0019947
eggNOG NOG237920
GeneTree ENSGT00390000016593
InParanoid O02194
KO K04505
OMA RFARHCL
OrthoDB EOG7NGQBG
PhylomeDB O02194
Reactome REACT_184382
REACT_184383
REACT_218930
REACT_221100
REACT_225574
REACT_240291
REACT_241128
REACT_271460
SignaLink O02194
GenomeRNAi 40260
NextBio 817840
PRO PR:O02194
Proteomes UP000000803
Bgee O02194
ExpressionAtlas O02194
GO GO:0016324
GO:0030424
GO:0005938
GO:0009986
GO:0035253
GO:0005737
GO:0043198
GO:0005789
GO:0070765
GO:0000139
GO:0030426
GO:0005887
GO:0005770
GO:0005765
GO:0045121
GO:0005743
GO:0031594
GO:0043025
GO:0005634
GO:0048471
GO:0055037
GO:0030018
GO:0004190
GO:0004175
GO:0042803
GO:0042987
GO:0050435
GO:0006816
GO:0015677
GO:0007010
GO:0046331
GO:0006509
GO:0043066
GO:0048812
GO:0007220
GO:0007219
GO:0008593
GO:0016337
GO:0048190
InterPro IPR001108
IPR006639
PANTHER PTHR10202
Pfam PF01080
PRINTS PR01072
SMART SM00730

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006915

apoptotic process

PMID:10491396[1]

IMP: Inferred from Mutant Phenotype

P

Figure 1:Removal of Psn gene function results in an increased number of cells undergoing apoptosis in certain disc regions

complete
CACAO 5943

GO:0000139

Golgi membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0134

C

Seeded From UniProt

complete

GO:0002027

regulation of heart rate

PMID:21524270[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0004175

endopeptidase activity

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024429

F

Seeded From UniProt

complete

GO:0004190

aspartic-type endopeptidase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001108
InterPro:IPR006639

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024429

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11782316[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005743

mitochondrial inner membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0005765

lysosomal membrane

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0005770

late endosome

PMID:20421416[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005783

endoplasmic reticulum

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0097

C

Seeded From UniProt

complete

GO:0005794

Golgi apparatus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

GO:0005887

integral component of plasma membrane

PMID:10662508[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005938

cell cortex

PMID:11782316[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006508

proteolysis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

GO:0006509

membrane protein ectodomain proteolysis

PMID:11781576[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0006816

calcium ion transport

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

P

Seeded From UniProt

complete

GO:0006915

apoptotic process

PMID:10491396[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007010

cytoskeleton organization

PMID:11782316[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007219

Notch signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0914

P

Seeded From UniProt

complete

GO:0007219

Notch signaling pathway

PMID:16713961[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007220

Notch receptor processing

PMID:10491396[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007220

Notch receptor processing

PMID:11781576[6]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0007220

Notch receptor processing

PMID:15611340[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008233

peptidase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

GO:0008593

regulation of Notch signaling pathway

PMID:21822800[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009986

cell surface

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0015677

copper ion import

PMID:23667524[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001108
InterPro:IPR006639

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0016324

apical plasma membrane

PMID:11781576[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0016337

single organismal cell-cell adhesion

PMID:15611340[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0030018

Z disc

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0030424

axon

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0030426

growth cone

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0031594

neuromuscular junction

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0035253

ciliary rootlet

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0042803

protein homodimerization activity

PMID:11557046[11]

IPI: Inferred from Physical Interaction

FB:FBgn0019947

F

Seeded From UniProt

complete

GO:0042987

amyloid precursor protein catabolic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

P

Seeded From UniProt

complete

GO:0043025

neuronal cell body

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0043066

negative regulation of apoptotic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

P

Seeded From UniProt

complete

GO:0043198

dendritic shaft

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0045121

membrane raft

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0046331

lateral inhibition

PMID:19363474[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048190

wing disc dorsal/ventral pattern formation

PMID:16307735[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

C

Seeded From UniProt

complete

GO:0048812

neuron projection morphogenesis

PMID:18604272[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050435

beta-amyloid metabolic process

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN000024431

P

Seeded From UniProt

complete

GO:0055037

recycling endosome

PMID:20421416[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0070765

gamma-secretase complex

PMID:20421416[4]

IPI: Inferred from Physical Interaction

FB:FBgn0031458
FB:FBgn0039234
FB:FBgn0053198

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Ye, Y & Fortini, ME (1999) Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. J. Cell Biol. 146 1351-64 PubMed GONUTS page
  2. Li, A et al. (2011) Changes in the expression of the Alzheimer’s disease-associated presenilin gene in drosophila heart leads to cardiac dysfunction. Curr Alzheimer Res 8 313-22 PubMed GONUTS page
  3. 3.0 3.1 3.2 López-Schier, H & St Johnston, D (2002) Drosophila nicastrin is essential for the intramembranous cleavage of notch. Dev. Cell 2 79-89 PubMed GONUTS page
  4. 4.0 4.1 4.2 Stempfle, D et al. (2010) In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Mol. Cell. Biol. 30 3165-75 PubMed GONUTS page
  5. Nowotny, P et al. (2000) Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin. Mol. Cell. Neurosci. 15 88-98 PubMed GONUTS page
  6. 6.0 6.1 6.2 Chung, HM & Struhl, G (2001) Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Nat. Cell Biol. 3 1129-32 PubMed GONUTS page
  7. Seidner, GA et al. (2006) Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila. Curr. Biol. 16 1026-33 PubMed GONUTS page
  8. 8.0 8.1 Ahimou, F et al. (2004) The adhesion force of Notch with Delta and the rate of Notch signaling. J. Cell Biol. 167 1217-29 PubMed GONUTS page
  9. Wangler, MF et al. (2011) Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila. Protein Cell 2 554-63 PubMed GONUTS page
  10. Southon, A et al. (2013) Presenilin promotes dietary copper uptake. PLoS ONE 8 e62811 PubMed GONUTS page
  11. Cervantes, S et al. (2001) Homodimerization of presenilin N-terminal fragments is affected by mutations linked to Alzheimer's disease. FEBS Lett. 505 81-6 PubMed GONUTS page
  12. Mummery-Widmer, JL et al. (2009) Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature 458 987-92 PubMed GONUTS page
  13. Koelzer, S & Klein, T (2006) Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. Dev. Biol. 289 77-90 PubMed GONUTS page
  14. Sepp, KJ et al. (2008) Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet. 4 e1000111 PubMed GONUTS page