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PMID:11782315
| Citation |
Hu, Y, Ye, Y and Fortini, ME (2002) Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell 2:69-78 |
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| Abstract |
Nicastrin is genetically linked to Notch/lin-12 signaling in C. elegans and is part of a large multiprotein complex along with Presenilin. Here we describe the isolation and characterization of Drosophila Nicastrin (Nic) mutants. Nic mutants and tissue clones display characteristic Notch-like phenotypes. Genetic and inhibitor studies indicate a function for Nicastrin in the gamma-secretase step of Notch processing, similar to Presenilin. Further, Nicastrin is genetically required for signaling from membrane-anchored activated Notch. In the absence of Nicastrin, Presenilin is destabilized and mature C-terminal subunits are absent. Nicastrin might recruit gamma-secretase substrates into the proteolytic complex as a prerequisite for Presenilin maturation and active complex assembly. |
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| Keywords |
Amyloid Precursor Protein Secretases; Animals; Drosophila/genetics; Drosophila Proteins; Endopeptidases/metabolism; Membrane Glycoproteins/genetics; Membrane Glycoproteins/metabolism; Membrane Proteins/metabolism; Mutation/physiology; Presenilin-1; Receptors, Notch; Signal Transduction/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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