HUMAN:PSN1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PSEN1 (synonyms: AD3, PS1, PSNL1)
Protein Name(s)	Presenilin-1 PS-1 Protein S182 Presenilin-1 NTF subunit Presenilin-1 CTF subunit Presenilin-1 CTF12 PS1-CTF12
External Links
UniProt	P49768
EMBL	L42110 L76517 L76528 L76519 L76520 L76521 L76522 L76523 L76524 L76525 L76526 L76527 U40379 U40380 AJ008005 AF109907 AF416717 AK312531 AC004858 AC004858 CH471061 BC011729 D84149
CCDS	CCDS9812.1 CCDS9813.1
PIR	S58396 S63683 S63684
RefSeq	NP_000012.1 NP_015557.2 XP_005267921.1 XP_005267923.1
UniGene	Hs.3260
PDB	2KR6
PDBsum	2KR6
ProteinModelPortal	P49768
SMR	P49768
BioGrid	111642
DIP	DIP-1134N
IntAct	P49768
MINT	MINT-88325
STRING	9606.ENSP00000326366
BindingDB	P49768
ChEMBL	CHEMBL2473
GuidetoPHARMACOLOGY	2402
MEROPS	A22.001
TCDB	1.A.54.1.1
PhosphoSite	P49768
DMDM	1709856
MaxQB	P49768
PaxDb	P49768
PRIDE	P49768
DNASU	5663
Ensembl	ENST00000324501 ENST00000357710 ENST00000394157 ENST00000394164 ENST00000553855 ENST00000555386 ENST00000557511
GeneID	5663
KEGG	hsa:5663
UCSC	uc001xnq.4 uc001xnr.3 uc001xnv.3
CTD	5663
GeneCards	GC14P073603
GeneReviews	PSEN1
HGNC	HGNC:9508
HPA	CAB006844 HPA030760
MIM	104311 600274 607822 613694 613737
neXtProt	NX_P49768
Orphanet	275864 1020 154 387 100070 100069
PharmGKB	PA33855
eggNOG	NOG237920
GeneTree	ENSGT00390000016593
HOVERGEN	HBG011375
InParanoid	P49768
KO	K04505
OMA	EAQRKVS
PhylomeDB	P49768
TreeFam	TF315040
Reactome	REACT_118572
SignaLink	P49768
ChiTaRS	PSEN1
EvolutionaryTrace	P49768
GeneWiki	PSEN1
GenomeRNAi	5663
NextBio	22006
PMAP-CutDB	P49768
PRO	PR:P49768
Proteomes	UP000005640
Bgee	P49768
CleanEx	HS_PSEN1
ExpressionAtlas	P49768
Genevestigator	P49768
GO	GO:0016324 GO:0030424 GO:0005938 GO:0009986 GO:0005813 GO:0035253 GO:0031410 GO:0043198 GO:0005783 GO:0005789 GO:0070765 GO:0005794 GO:0000139 GO:0030426 GO:0016021 GO:0005887 GO:0000776 GO:0005765 GO:0016020 GO:0045121 GO:0005743 GO:0005739 GO:0031594 GO:0043025 GO:0031965 GO:0005640 GO:0048471 GO:0005791 GO:0005790 GO:0030018 GO:0004190 GO:0008013 GO:0045296 GO:0005262 GO:0004175 GO:0030165 GO:0000186 GO:0042987 GO:0000045 GO:0034205 GO:0050435 GO:0001568 GO:0048854 GO:0021870 GO:0070588 GO:0060070 GO:0001708 GO:0006974 GO:0021795 GO:0015871 GO:0021904 GO:0030326 GO:0032469 GO:0050673 GO:0022617 GO:0030198 GO:0001947 GO:0002244 GO:0035556 GO:0015813 GO:0006509 GO:0007613 GO:0006839 GO:0002573 GO:0043066 GO:2001234 GO:0050771 GO:0007175 GO:0043524 GO:2000059 GO:0000122 GO:0051444 GO:0051402 GO:0048666 GO:0001764 GO:0007220 GO:0007219 GO:0043065 GO:0043085 GO:0050820 GO:0043406 GO:0032436 GO:0001921 GO:0009791 GO:0006486 GO:0016485 GO:0015031 GO:0042325 GO:0043393 GO:0060075 GO:0048167 GO:0051966 GO:0006979 GO:0016337 GO:0048705 GO:0043589 GO:0051563 GO:0001756 GO:0016080 GO:0002286 GO:0050852 GO:0048538
InterPro	IPR002031 IPR001108 IPR006639
PANTHER	PTHR10202 PTHR10202:SF7
Pfam	PF01080
PRINTS	PR01072 PR01073
SMART	SM00730

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:23794287^[1]	ECO:0000315			P		In figure 2, it is shown that PS1 mutants in different mouse cells show significantly lower levels of p62 mRNA than in the wild type, indicating that PS1 has a positive effect on the transcription of the p62 gene.	complete CACAO 8799
	GO:0060999	positive regulation of dendritic spine development	PMID:21951279^[2]	ECO:0000315			P		Fig 1. clearly shows the difference between WT and mutant cortical layer density.	complete CACAO 2095
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:25394380^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:15004326^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:15004326^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010975	regulation of neuron projection development	PMID:15004326^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	PMID:17428795^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:28008308^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	happens_during:(GO:0007568) regulates_expression_of:(ENSEMBL:ENSG00000171862) occurs_in:(UBERON:0000956) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:28008308^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	happens_during:(GO:0007568) regulates_expression_of:(ENSEMBL:ENSG00000207713) occurs_in:(UBERON:0000956) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:24052308^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P97484	P	happens_during:(UBERON:0018241) occurs_in:(UBERON:0007023)	Seeded From UniProt	complete
NOT\|involved_in	GO:1905598	negative regulation of low-density lipoprotein receptor activity	PMID:20005821^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P35951	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	PMID:11880515^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	part_of:(GO:0090647)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:11880515^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
involved_in	GO:1905908	positive regulation of amyloid fibril formation	PMID:11880515^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	PMID:26280335^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:25707991^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	occurs_in:(UBERON:0002421) has_regulation_target:(UniProtKB:Q14289) regulates_o_occurs_in:(UBERON:0003881)\|occurs_in(UBERON:0000956) has_regulation_target:(UniProtKB:Q14289)	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:23152628^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:A0A0R4J0I9,UniProtKB:P05067	P	occurs_in:(CL:0002590)	Seeded From UniProt	complete
involved_in	GO:0002265	astrocyte activation involved in immune response	PMID:23152628^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:A0A0R4J0I9,UniProtKB:P05067	P	part_of:(GO:1904646) occurs_in:(CL:0002590)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10508860^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904797	negative regulation of core promoter binding	PMID:10508860^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10508860^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:10508860^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10508860^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005790	smooth endoplasmic reticulum	PMID:10508860^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:10508860^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P49769	P		Seeded From UniProt	complete
enables	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	PMID:26280335^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042982	amyloid precursor protein metabolic process	PMID:26280335^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:26280335^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070765	gamma-secretase complex	PMID:26280335^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	PMID:24217950^[14]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P54764)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:20445063^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04156,UniProtKB:P05067	P	happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:20445063^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04156,UniProtKB:P05067	P	part_of:(GO:0090647) happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	PMID:20445063^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04156,UniProtKB:P05067	P	occurs_in:(CL:0000850) occurs_in:(GO:0030424)	Seeded From UniProt	complete
involved_in	GO:0048143	astrocyte activation	PMID:20445063^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0050808	synapse organization	PMID:24012003^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P41594	P	part_of:(GO:0090647) happens_during:(GO:0007568) occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:24012003^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P41594	P	happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:24012003^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067,UniProtKB:P41594	P	part_of:(GO:0090647) happens_during:(GO:0007568)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21143716^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	PMID:21143716^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:23794287^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	PMID:21951279^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:20299451^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	PMID:15274632^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	PMID:15274632^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	PMID:15274632^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15274632^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:15274632^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15274632^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:24052308^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49768,UniProtKB:P97484	P	has_regulation_target:(UniProtKB:P97484) has_regulation_target:(UniProtKB:P18760) regulates_o_occurs_in:(UBERON:0001890) occurs_in:(UBERON:0001890)	Seeded From UniProt	complete
part_of	GO:0070765	gamma-secretase complex	PMID:10801983^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10805794^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042325	regulation of phosphorylation	PMID:9689133^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:16959576^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49769	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:9298903^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030165	PDZ domain binding	PMID:10551805^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NZJ7	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:9632714^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:9298903^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:9632714^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	PMID:9632714^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	PMID:9632714^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:12377771^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:16959576^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	PMID:9298903^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202717 PANTHER:PTN000024459	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202717 PANTHER:PTN000024459	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000024459 UniProtKB:P49768	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019947 PANTHER:PTN000024429 UniProtKB:P49768 UniProtKB:P49810	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202717 PANTHER:PTN000024459 UniProtKB:P49768	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1202717 PANTHER:PTN000024429 UniProtKB:P49768	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:21873635^[28]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019947 MGI:MGI:109284 MGI:MGI:1202717 PANTHER:PTN000024429 RGD:3425 UniProtKB:P49768	F		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	PMID:11953314^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:17431506^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:22375059^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:11104755^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02248	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:9246482^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:9246482^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	PMID:9246482^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:8755489^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005262	P		Seeded From UniProt	complete
involved_in	GO:0043589	skin morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0043393	regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
part_of	GO:0043227	membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
part_of	GO:0043198	dendritic shaft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
involved_in	GO:0043011	myeloid dendritic cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0042987	amyloid precursor protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0035282	segmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
part_of	GO:0035253	ciliary rootlet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
involved_in	GO:0034205	amyloid-beta formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0021904	dorsal/ventral neural tube patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0021870	Cajal-Retzius cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0021795	cerebral cortex cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0016080	synaptic vesicle targeting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
involved_in	GO:0015871	choline transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0007613	memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0007220	Notch receptor processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0007176	regulation of epidermal growth factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0006839	mitochondrial transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0006486	protein glycosylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	F		Seeded From UniProt	complete
involved_in	GO:0002573	myeloid leukocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0002286	T cell activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0002244	hematopoietic progenitor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0002038	positive regulation of L-glutamate import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0001921	positive regulation of receptor recycling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0060075	regulation of resting membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0051966	regulation of synaptic transmission, glutamatergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0051604	protein maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0051444	negative regulation of ubiquitin-protein transferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0050820	positive regulation of coagulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0050771	negative regulation of axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0050673	epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0048854	brain morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	F		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P49769 ensembl:ENSMUSP00000098786	P		Seeded From UniProt	complete
part_of	GO:0099056	integral component of presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0097060	synaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	F		Seeded From UniProt	complete
involved_in	GO:0003407	neural retina development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97887 ensembl:ENSRNOP00000012495	P		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001108 InterPro:IPR006639	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002031	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001108 InterPro:IPR006639	C		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001108	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002031	P		Seeded From UniProt	complete
enables	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002031	F		Seeded From UniProt	complete
involved_in	GO:0042987	amyloid precursor protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002031	P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:24012003^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:0090647) happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	PMID:24012003^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8878479^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042987	amyloid precursor protein catabolic process	PMID:15274632^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007220	Notch receptor processing	PMID:15274632^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:7596406^[36]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048013	ephrin receptor signaling pathway	Reactome:R-HSA-2682334	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	Reactome:R-HSA-205043	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035577	azurophil granule membrane	Reactome:R-HSA-6798739	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035333	Notch receptor processing, ligand-dependent	Reactome:R-HSA-9017817 Reactome:R-HSA-9013361	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031293	membrane protein intracellular domain proteolysis	Reactome:R-HSA-193692	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-9604300 Reactome:R-NUL-2197556 Reactome:R-HSA-9017817 Reactome:R-HSA-9013361 Reactome:R-HSA-6798739 Reactome:R-HSA-3928656 Reactome:R-HSA-2220988 Reactome:R-HSA-205112 Reactome:R-HSA-193682 Reactome:R-HSA-1251997	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0914	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0288	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Tung, YT et al. (2014) Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation. Mol. Neurobiol. 49 10-27 PubMed GONUTS page
↑ ^2.0 ^2.1 Jung, CK et al. (2011) Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo. J. Neurochem. 119 1064-73 PubMed GONUTS page
↑ Chen, WT et al. (2015) G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation. Mol. Neurobiol. 52 1835-1849 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Dowjat, WK et al. (2004) A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations. J. Alzheimers Dis. 6 31-43 PubMed GONUTS page
↑ Litterst, C et al. (2007) Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J. Biol. Chem. 282 16155-63 PubMed GONUTS page
↑ ^6.0 ^6.1 Wu, Q et al. (2016) The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress. Front Mol Neurosci 9 140 PubMed GONUTS page
↑ ^7.0 ^7.1 Kim, T et al. (2013) Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science 341 1399-404 PubMed GONUTS page
↑ Kim, J et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64 632-44 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Westerman, MA et al. (2002) The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 22 1858-67 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Bai, XC et al. (2015) An atomic structure of human γ-secretase. Nature 525 212-217 PubMed GONUTS page
↑ Kaufman, AC et al. (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann. Neurol. 77 953-71 PubMed GONUTS page
↑ ^12.0 ^12.1 Kanekiyo, T et al. (2012) LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β. J. Neurosci. 32 16458-65 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Imafuku, I et al. (1999) Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J. Cell Biol. 147 121-34 PubMed GONUTS page
↑ Lai, WB et al. (2014) Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway. Mol. Neurobiol. 49 1055-68 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Gimbel, DA et al. (2010) Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J. Neurosci. 30 6367-74 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Um, JW et al. (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron 79 887-902 PubMed GONUTS page
↑ ^17.0 ^17.1 Viswanathan, J et al. (2011) Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 12 330-48 PubMed GONUTS page
↑ Mitsuishi, Y et al. (2010) Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. J. Biol. Chem. 285 14920-31 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Fraering, PC et al. (2004) Purification and characterization of the human gamma-secretase complex. Biochemistry 43 9774-89 PubMed GONUTS page
↑ Li, YM et al. (2000) Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc. Natl. Acad. Sci. U.S.A. 97 6138-43 PubMed GONUTS page
↑ Amson, R et al. (2000) Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 97 5346-50 PubMed GONUTS page
↑ Takashima, A et al. (1998) Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc. Natl. Acad. Sci. U.S.A. 95 9637-41 PubMed GONUTS page
↑ ^23.0 ^23.1 Tu, H et al. (2006) Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126 981-93 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Li, J et al. (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 90 917-27 PubMed GONUTS page
↑ Xu, X et al. (1999) Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1. J. Biol. Chem. 274 32543-6 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Yu, G et al. (1998) The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J. Biol. Chem. 273 16470-5 PubMed GONUTS page
↑ Xu, X et al. (2002) The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein. J. Biol. Chem. 277 48913-22 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 ^28.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Marambaud, P et al. (2002) A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 21 1948-56 PubMed GONUTS page
↑ Nelson, O et al. (2007) Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J. Clin. Invest. 117 1230-9 PubMed GONUTS page
↑ Lang, S et al. (2012) Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J. Cell. Sci. 125 1958-69 PubMed GONUTS page
↑ Kirschenbaum, F et al. (2001) Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling. J. Biol. Chem. 276 7366-75 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 Sr George-Hyslop, PH et al. (1996) Two homologous genes causing early-onset familial Alzheimer's disease. Cold Spring Harb. Symp. Quant. Biol. 61 559-64 PubMed GONUTS page
↑ Thinakaran, G et al. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17 181-90 PubMed GONUTS page
↑ Duff, K et al. (1996) Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383 710-3 PubMed GONUTS page
↑ Sherrington, R et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375 754-60 PubMed GONUTS page

[PMID:23794287-1] 1.0 ^1.1 Tung, YT et al. (2014) Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation. Mol. Neurobiol. 49 10-27 PubMed GONUTS page

[PMID:21951279-2] 2.0 ^2.1 Jung, CK et al. (2011) Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo. J. Neurochem. 119 1064-73 PubMed GONUTS page

[PMID:25394380-3] Chen, WT et al. (2015) G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation. Mol. Neurobiol. 52 1835-1849 PubMed GONUTS page

[PMID:15004326-4] 4.0 ^4.1 ^4.2 Dowjat, WK et al. (2004) A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations. J. Alzheimers Dis. 6 31-43 PubMed GONUTS page

[PMID:17428795-5] Litterst, C et al. (2007) Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. J. Biol. Chem. 282 16155-63 PubMed GONUTS page

[PMID:28008308-6] 6.0 ^6.1 Wu, Q et al. (2016) The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress. Front Mol Neurosci 9 140 PubMed GONUTS page

[PMID:24052308-7] 7.0 ^7.1 Kim, T et al. (2013) Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science 341 1399-404 PubMed GONUTS page

[PMID:20005821-8] Kim, J et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64 632-44 PubMed GONUTS page

[PMID:11880515-9] 9.0 ^9.1 ^9.2 Westerman, MA et al. (2002) The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J. Neurosci. 22 1858-67 PubMed GONUTS page

[PMID:26280335-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Bai, XC et al. (2015) An atomic structure of human γ-secretase. Nature 525 212-217 PubMed GONUTS page

[PMID:25707991-11] Kaufman, AC et al. (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann. Neurol. 77 953-71 PubMed GONUTS page

[PMID:23152628-12] 12.0 ^12.1 Kanekiyo, T et al. (2012) LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β. J. Neurosci. 32 16458-65 PubMed GONUTS page

[PMID:10508860-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Imafuku, I et al. (1999) Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J. Cell Biol. 147 121-34 PubMed GONUTS page

[PMID:24217950-14] Lai, WB et al. (2014) Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway. Mol. Neurobiol. 49 1055-68 PubMed GONUTS page

[PMID:20445063-15] 15.0 ^15.1 ^15.2 ^15.3 Gimbel, DA et al. (2010) Memory impairment in transgenic Alzheimer mice requires cellular prion protein. J. Neurosci. 30 6367-74 PubMed GONUTS page

[PMID:24012003-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Um, JW et al. (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron 79 887-902 PubMed GONUTS page

[PMID:21143716-17] 17.0 ^17.1 Viswanathan, J et al. (2011) Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic 12 330-48 PubMed GONUTS page

[PMID:20299451-18] Mitsuishi, Y et al. (2010) Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. J. Biol. Chem. 285 14920-31 PubMed GONUTS page

[PMID:15274632-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 ^19.7 Fraering, PC et al. (2004) Purification and characterization of the human gamma-secretase complex. Biochemistry 43 9774-89 PubMed GONUTS page

[PMID:10801983-20] Li, YM et al. (2000) Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc. Natl. Acad. Sci. U.S.A. 97 6138-43 PubMed GONUTS page

[PMID:10805794-21] Amson, R et al. (2000) Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 97 5346-50 PubMed GONUTS page

[PMID:9689133-22] Takashima, A et al. (1998) Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc. Natl. Acad. Sci. U.S.A. 95 9637-41 PubMed GONUTS page

[PMID:16959576-23] 23.0 ^23.1 Tu, H et al. (2006) Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell 126 981-93 PubMed GONUTS page

[PMID:9298903-24] 24.0 ^24.1 ^24.2 Li, J et al. (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation. Cell 90 917-27 PubMed GONUTS page

[PMID:10551805-25] Xu, X et al. (1999) Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1. J. Biol. Chem. 274 32543-6 PubMed GONUTS page

[PMID:9632714-26] 26.0 ^26.1 ^26.2 ^26.3 Yu, G et al. (1998) The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin. J. Biol. Chem. 273 16470-5 PubMed GONUTS page

[PMID:12377771-27] Xu, X et al. (2002) The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein. J. Biol. Chem. 277 48913-22 PubMed GONUTS page

[PMID:21873635-28] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 ^28.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11953314-29] Marambaud, P et al. (2002) A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 21 1948-56 PubMed GONUTS page

[PMID:17431506-30] Nelson, O et al. (2007) Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. J. Clin. Invest. 117 1230-9 PubMed GONUTS page

[PMID:22375059-31] Lang, S et al. (2012) Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J. Cell. Sci. 125 1958-69 PubMed GONUTS page

[PMID:11104755-32] Kirschenbaum, F et al. (2001) Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling. J. Biol. Chem. 276 7366-75 PubMed GONUTS page

[PMID:9246482-33] 33.0 ^33.1 ^33.2 Sr George-Hyslop, PH et al. (1996) Two homologous genes causing early-onset familial Alzheimer's disease. Cold Spring Harb. Symp. Quant. Biol. 61 559-64 PubMed GONUTS page

[PMID:8755489-34] Thinakaran, G et al. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17 181-90 PubMed GONUTS page

[PMID:8878479-35] Duff, K et al. (1996) Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature 383 710-3 PubMed GONUTS page

[PMID:7596406-36] Sherrington, R et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375 754-60 PubMed GONUTS page

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