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Category:GO:0006729 ! tetrahydrobiopterin biosynthetic process

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DAG for GO:0006729id: GO:0006729

name: tetrahydrobiopterin biosynthetic process
namespace: biological_process
def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [ISBN:0198506732]
synonym: "5,6,7,8-tetrahydrobiopterin biosynthetic process" EXACT []
synonym: "tetrahydrobiopterin anabolism" EXACT []
synonym: "tetrahydrobiopterin biosynthesis" EXACT []
synonym: "tetrahydrobiopterin formation" EXACT []
synonym: "tetrahydrobiopterin synthesis" EXACT []
is_a: GO:0034312 ! diol biosynthetic process
is_a: GO:0042559 ! pteridine-containing compound biosynthetic process
is_a: GO:0046146 ! tetrahydrobiopterin metabolic process

AmiGO <GOterm>GO:0006729</GOterm>
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Usage Notes

Most bacteria, including E. coli do not make tetrahydrobiopterin (BH4) [1]. However, some bacteria, including cyanobacteria and Chlorobium sp.[2] do.


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  1. Yamamoto, K et al. (2003) Genetic engineering of Escherichia coli for production of tetrahydrobiopterin. Metab. Eng. 5 246-54 PubMed GONUTS page
  2. Kong, JS et al. (2006) 6-Pyruvoyltetrahydropterin synthase orthologs of either a single or dual domain structure are responsible for tetrahydrobiopterin synthesis in bacteria. FEBS Lett. 580 4900-4 PubMed GONUTS page