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HUMAN:SPRE

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SPR
Protein Name(s) Sepiapterin reductase

SPR

External Links
UniProt P35270
EMBL M76231
AK291856
AK222942
AC092630
CH471053
CH471053
BC017310
AB017547
CCDS CCDS1920.1
PIR JQ1176
RefSeq NP_003115.1
UniGene Hs.301540
PDB 1Z6Z
4HWK
4J7U
4J7X
PDBsum 1Z6Z
4HWK
4J7U
4J7X
ProteinModelPortal P35270
SMR P35270
BioGrid 112575
IntAct P35270
MINT MINT-3304575
STRING 9606.ENSP00000234454
PhosphoSite P35270
DMDM 464801
MaxQB P35270
PaxDb P35270
PeptideAtlas P35270
PRIDE P35270
DNASU 6697
Ensembl ENST00000234454
GeneID 6697
KEGG hsa:6697
UCSC uc002sik.2
CTD 6697
GeneCards GC02P073026
HGNC HGNC:11257
HPA HPA039505
MIM 182125
612716
neXtProt NX_P35270
Orphanet 70594
PharmGKB PA36087
eggNOG COG1028
GeneTree ENSGT00440000033609
HOVERGEN HBG006973
InParanoid P35270
KO K00072
OMA NSNCIFH
OrthoDB EOG7327PS
PhylomeDB P35270
TreeFam TF326358
BioCyc MetaCyc:HS03979-MONOMER
Reactome REACT_111176
ChiTaRS SPR
EvolutionaryTrace P35270
GeneWiki Sepiapterin_reductase
GenomeRNAi 6697
NextBio 26111
PRO PR:P35270
Proteomes UP000005640
Bgee P35270
CleanEx HS_SPR
ExpressionAtlas P35270
Genevestigator P35270
GO GO:0005737
GO:0005829
GO:0070062
GO:0005739
GO:0005634
GO:0004033
GO:0050661
GO:0004757
GO:0048667
GO:0016265
GO:0042417
GO:0006558
GO:0006809
GO:0046209
GO:0042415
GO:0055114
GO:0019889
GO:0040014
GO:0050999
GO:0042428
GO:0044281
GO:0006729
GO:0050882
Gene3D 3.40.50.720
InterPro IPR002198
IPR002347
IPR016040
IPR006393
Pfam PF00106
PRINTS PR00081
TIGRFAMs TIGR01500

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0006809

nitric oxide biosynthetic process

PMID:15197144[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004757

sepiapterin reductase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P18297

F

Seeded From UniProt

complete

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002387926
RGD:3753
dictyBase:DDB_G0290009

P

Seeded From UniProt

complete

enables

GO:0004757

sepiapterin reductase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0014032
PANTHER:PTN002387926
RGD:3753
dictyBase:DDB_G0290009

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004757

sepiapterin reductase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006393

F

Seeded From UniProt

complete

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006393

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006393

P

Seeded From UniProt

complete

enables

GO:0004757

sepiapterin reductase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.153

F

Seeded From UniProt

complete

enables

GO:0004757

sepiapterin reductase activity

PMID:9792819[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:1883349[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

PMID:1883349[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

PMID:1883349[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004033

aldo-keto reductase (NADP) activity

PMID:1883349[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051186

cofactor metabolic process

Reactome:R-HSA-8978934

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050999

regulation of nitric-oxide synthase activity

Reactome:R-HSA-203615

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-1497869
Reactome:R-HSA-1497853
Reactome:R-HSA-1475414

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. Franscini, N et al. (2004) Functional tetrahydrobiopterin synthesis in human platelets. Circulation 110 186-92 PubMed GONUTS page
  4. 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. Ohye, T et al. (1998) Genomic organization and chromosomal localization of the human sepiapterin reductase gene. Biochem. Biophys. Res. Commun. 251 597-602 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Ichinose, H et al. (1991) Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis. Biochem. Biophys. Res. Commun. 179 183-9 PubMed GONUTS page