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HUMAN:SPRE
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | SPR | |
Protein Name(s) | Sepiapterin reductase
SPR | |
External Links | ||
UniProt | P35270 | |
EMBL | M76231 AK291856 AK222942 AC092630 CH471053 CH471053 BC017310 AB017547 | |
CCDS | CCDS1920.1 | |
PIR | JQ1176 | |
RefSeq | NP_003115.1 | |
UniGene | Hs.301540 | |
PDB | 1Z6Z 4HWK 4J7U 4J7X | |
PDBsum | 1Z6Z 4HWK 4J7U 4J7X | |
ProteinModelPortal | P35270 | |
SMR | P35270 | |
BioGrid | 112575 | |
IntAct | P35270 | |
MINT | MINT-3304575 | |
STRING | 9606.ENSP00000234454 | |
PhosphoSite | P35270 | |
DMDM | 464801 | |
MaxQB | P35270 | |
PaxDb | P35270 | |
PeptideAtlas | P35270 | |
PRIDE | P35270 | |
DNASU | 6697 | |
Ensembl | ENST00000234454 | |
GeneID | 6697 | |
KEGG | hsa:6697 | |
UCSC | uc002sik.2 | |
CTD | 6697 | |
GeneCards | GC02P073026 | |
HGNC | HGNC:11257 | |
HPA | HPA039505 | |
MIM | 182125 612716 | |
neXtProt | NX_P35270 | |
Orphanet | 70594 | |
PharmGKB | PA36087 | |
eggNOG | COG1028 | |
GeneTree | ENSGT00440000033609 | |
HOVERGEN | HBG006973 | |
InParanoid | P35270 | |
KO | K00072 | |
OMA | NSNCIFH | |
OrthoDB | EOG7327PS | |
PhylomeDB | P35270 | |
TreeFam | TF326358 | |
BioCyc | MetaCyc:HS03979-MONOMER | |
Reactome | REACT_111176 | |
ChiTaRS | SPR | |
EvolutionaryTrace | P35270 | |
GeneWiki | Sepiapterin_reductase | |
GenomeRNAi | 6697 | |
NextBio | 26111 | |
PRO | PR:P35270 | |
Proteomes | UP000005640 | |
Bgee | P35270 | |
CleanEx | HS_SPR | |
ExpressionAtlas | P35270 | |
Genevestigator | P35270 | |
GO | GO:0005737 GO:0005829 GO:0070062 GO:0005739 GO:0005634 GO:0004033 GO:0050661 GO:0004757 GO:0048667 GO:0016265 GO:0042417 GO:0006558 GO:0006809 GO:0046209 GO:0042415 GO:0055114 GO:0019889 GO:0040014 GO:0050999 GO:0042428 GO:0044281 GO:0006729 GO:0050882 | |
Gene3D | 3.40.50.720 | |
InterPro | IPR002198 IPR002347 IPR016040 IPR006393 | |
Pfam | PF00106 | |
PRINTS | PR00081 | |
TIGRFAMs | TIGR01500 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006809 |
nitric oxide biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004757 |
sepiapterin reductase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006729 |
tetrahydrobiopterin biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002387926 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004757 |
sepiapterin reductase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0014032 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004757 |
sepiapterin reductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006729 |
tetrahydrobiopterin biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004757 |
sepiapterin reductase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004757 |
sepiapterin reductase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050661 |
NADP binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006729 |
tetrahydrobiopterin biosynthetic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004033 |
aldo-keto reductase (NADP) activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051186 |
cofactor metabolic process |
Reactome:R-HSA-8978934 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050999 |
regulation of nitric-oxide synthase activity |
Reactome:R-HSA-203615 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-1497869 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Franscini, N et al. (2004) Functional tetrahydrobiopterin synthesis in human platelets. Circulation 110 186-92 PubMed GONUTS page
- ↑ 4.0 4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Ohye, T et al. (1998) Genomic organization and chromosomal localization of the human sepiapterin reductase gene. Biochem. Biophys. Res. Commun. 251 597-602 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Ichinose, H et al. (1991) Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis. Biochem. Biophys. Res. Commun. 179 183-9 PubMed GONUTS page