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DROME:GCH1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Pu
Protein Name(s) GTP cyclohydrolase 1

GTP cyclohydrolase I GTP-CH-I Protein punch

External Links
UniProt P48596
EMBL U01118
U01119
AF159422
AY382619
AY382620
AY382622
AY382623
AY382624
AY382625
AY382626
AY382628
AE013599
AE013599
AE013599
AY051890
PIR A49302
B49302
RefSeq NP_523801.2
NP_726037.1
NP_726038.1
UniGene Dm.7417
ProteinModelPortal P48596
SMR P48596
BioGrid 63049
DIP DIP-24104N
MINT MINT-937025
PaxDb P48596
EnsemblMetazoa FBtr0071580
GeneID 37415
KEGG dme:Dmel_CG9441
CTD 37415
FlyBase FBgn0003162
eggNOG COG0302
GeneTree ENSGT00390000013481
InParanoid P48596
KO K01495
OMA IPNGHIV
OrthoDB EOG77DJ6T
PhylomeDB P48596
BioCyc MetaCyc:MONOMER-18450
Reactome REACT_180850
UniPathway UPA00848
ChiTaRS Pu
GenomeRNAi 37415
NextBio 803517
PRO PR:P48596
Proteomes UP000000803
Bgee P48596
ExpressionAtlas P48596
GO GO:0005737
GO:0005525
GO:0003934
GO:0060308
GO:0046872
GO:0035998
GO:0048072
GO:0048067
GO:0009880
GO:0008363
GO:0035185
GO:0006728
GO:2000274
GO:0043095
GO:0006729
GO:0046654
HAMAP MF_00223
InterPro IPR001474
IPR018234
IPR020602
PANTHER PTHR11109
Pfam PF01227
TIGRFAMs TIGR00063
PROSITE PS00859
PS00860

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

PMID:3080426[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11375
PANTHER:PTN000121833
RGD:61992
UniProtKB:P30793

F

Seeded From UniProt

complete

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003162
PANTHER:PTN000121833
UniProtKB:P30793
UniProtKB:P50141
WB:WBGene00000298
dictyBase:DDB_G0288481

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11375
FB:FBgn0003162
PANTHER:PTN000121833
UniProtKB:P30793
UniProtKB:P50141
dictyBase:DDB_G0288481

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11375
PANTHER:PTN000121833
RGD:61992
UniProtKB:P30793

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11375
FB:FBgn0003162
MGI:MGI:95675
PANTHER:PTN000121833
RGD:61992
SGD:S000003499
UniProtKB:P30793
UniProtKB:Q8I5H7
UniProtKB:Q8VYU3
UniProtKB:Q9SFV7
WB:WBGene00000298
dictyBase:DDB_G0288481

F

Seeded From UniProt

complete

involved_in

GO:2000274

regulation of epithelial cell migration, open tracheal system

PMID:17585895[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043095

regulation of GTP cyclohydrolase I activity

PMID:16966327[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006728

pteridine biosynthetic process

PMID:16966327[4]

ECO:0000305

curator inference used in manual assertion

GO:0003934

P

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:16966327[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0060308

GTP cyclohydrolase I regulator activity

PMID:16966327[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:7706401[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0035185

preblastoderm mitotic cell cycle

PMID:7706401[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006728

pteridine biosynthetic process

PMID:7706401[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048072

compound eye pigmentation

PMID:3136053[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:3136053[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008363

larval chitin-based cuticle development

PMID:3115849[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009880

embryonic pattern specification

PMID:3115849[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048067

cuticle pigmentation

PMID:3115849[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:3080426[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001474
InterPro:IPR018234

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001474
InterPro:IPR018234

C

Seeded From UniProt

complete

involved_in

GO:0046654

tetrahydrofolate biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001474
InterPro:IPR018234

P

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.4.16

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0783

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

P

Seeded From UniProt

complete

involved_in

GO:0035998

7,8-dihydroneopterin 3'-triphosphate biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00848

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Weisberg, EP & O'Donnell, JM (1986) Purification and characterization of GTP cyclohydrolase I from Drosophila melanogaster. J. Biol. Chem. 261 1453-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ Hsouna, A et al. (2007) Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis. Dev. Biol. 308 30-43 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Funderburk, CD et al. (2006) A typical N-terminal extensions confer novel regulatory properties on GTP cyclohydrolase isoforms in Drosophila melanogaster. J. Biol. Chem. 281 33302-12 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Chen, X et al. (1994) A maternal product of the Punch locus of Drosophila melanogaster is required for precellular blastoderm nuclear divisions. J. Cell. Sci. 107 ( Pt 12) 3501-13 PubMed GONUTS page
  6. ↑ 6.0 6.1 Reynolds, ER & O'Donnell, JM (1988) Characterization of new Punch mutations: identification of two additional mutant classes. Genetics 119 609-17 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Reynolds, ER & O'Donnell, JM (1987) An analysis of the embryonic defects in Punch mutants of Drosophila melanogaster. Dev. Biol. 123 430-41 PubMed GONUTS page
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