CHICK:GCH1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	GCH1
Protein Name(s)	GTP cyclohydrolase 1 GTP cyclohydrolase I GTP-CH-I
External Links
UniProt	P50141
EMBL	Z49267
PIR	I50646
RefSeq	NP_990554.1
UniGene	Gga.674
ProteinModelPortal	P50141
SMR	P50141
STRING	9031.ENSGALP00000019895
GeneID	396146
KEGG	gga:396146
CTD	2643
eggNOG	COG0302
HOGENOM	HOG000221222
HOVERGEN	HBG003136
InParanoid	P50141
KO	K01495
PhylomeDB	P50141
UniPathway	UPA00848
NextBio	20816203
PRO	PR:P50141
Proteomes	UP000000539
GO	GO:0005737 GO:0005634 GO:0005525 GO:0003934 GO:0046872 GO:0035998 GO:0006729 GO:0046654
HAMAP	MF_00223
InterPro	IPR001474 IPR018234 IPR020602
PANTHER	PTHR11109
Pfam	PF01227
TIGRFAMs	TIGR00063
PROSITE	PS00859 PS00860

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006729	tetrahydrobiopterin biosynthetic process	PMID:9226880	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003933	GTP cyclohydrolase activity	PMID:9226880	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:9226880	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006729	tetrahydrobiopterin biosynthetic process	PMID:9226880	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003933	GTP cyclohydrolase activity	PMID:9226880	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11799145	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11375 PANTHER:PTN000121833 RGD:61992 UniProtKB:P30793	F		Seeded From UniProt	complete
involved_in	GO:0006729	tetrahydrobiopterin biosynthetic process		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003162 PANTHER:PTN000121833 UniProtKB:P30793 UniProtKB:P50141 WB:WBGene00000298 dictyBase:DDB_G0288481	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11375 FB:FBgn0003162 PANTHER:PTN000121833 UniProtKB:P30793 UniProtKB:P50141 dictyBase:DDB_G0288481	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11375 PANTHER:PTN000121833 RGD:61992 UniProtKB:P30793	F		Seeded From UniProt	complete
enables	GO:0003934	GTP cyclohydrolase I activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG11375 FB:FBgn0003162 MGI:MGI:95675 PANTHER:PTN000121833 RGD:61992 SGD:S000003499 UniProtKB:P30793 UniProtKB:Q8I5H7 UniProtKB:Q8VYU3 UniProtKB:Q9SFV7 WB:WBGene00000298 dictyBase:DDB_G0288481	F		Seeded From UniProt	complete
enables	GO:0003934	GTP cyclohydrolase I activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001474 InterPro:IPR018234	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001474 InterPro:IPR018234	C		Seeded From UniProt	complete
involved_in	GO:0046654	tetrahydrofolate biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001474 InterPro:IPR018234	P		Seeded From UniProt	complete
enables	GO:0003934	GTP cyclohydrolase I activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.4.16	F		Seeded From UniProt	complete
involved_in	GO:0006729	tetrahydrobiopterin biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0783	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P		Seeded From UniProt	complete
involved_in	GO:0035998	7,8-dihydroneopterin 3'-triphosphate biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00848	P		Seeded From UniProt	complete
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References

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