LEIMA:PTR1

Species (Taxon ID)	Leishmania major. (5664)
Gene Name(s)	PTR1 (synonyms: HMTXR)
Protein Name(s)	Pteridine reductase 1 H region methotrexate resistance protein
External Links
UniProt	Q01782
EMBL	L01699 FR796419
PIR	A45168
RefSeq	XP_001683351.1
PDB	1E7W 1E92 1W0C 2BF7 2BFA 2BFM 2BFO 2BFP 2QHX 3H4V
PDBsum	1E7W 1E92 1W0C 2BF7 2BFA 2BFM 2BFO 2BFP 2QHX 3H4V
ProteinModelPortal	Q01782
SMR	Q01782
BindingDB	Q01782
ChEMBL	CHEMBL6194
GeneID	5651987
KEGG	lma:LMJF_23_0270
InParanoid	Q01782
KO	K03793
UniPathway	UPA00849
EvolutionaryTrace	Q01782
Proteomes	UP000000542
GO	GO:0047040 GO:0004799 GO:0034599 GO:0032259 GO:0019889 GO:0031427 GO:0006729
Gene3D	3.40.50.720
InterPro	IPR002198 IPR002347 IPR016040 IPR014058 IPR020904
PRINTS	PR00081 PR00080
TIGRFAMs	TIGR02685
PROSITE	PS00061

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0047040	pteridine reductase activity	PMID:21239486	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0047040	pteridine reductase activity	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	GeneDB:Tb927.8.2210	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000011	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR002198	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000266	sequence orthology evidence used in manual assertion	GeneDB:Tb927.8.2210	C		Seeded From UniProt	complete
enables	GO:0004155	6,7-dihydropteridine reductase activity	PMID:21239486	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020904	F		Seeded From UniProt	complete
enables	GO:0047040	pteridine reductase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.5.1.33	F		Seeded From UniProt	complete
involved_in	GO:0031427	response to methotrexate	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0487	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006729	tetrahydrobiopterin biosynthetic process	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00849	P		Seeded From UniProt	complete
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References

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