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RAT:GCH1

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Gch1 (synonyms: Gch)
Protein Name(s) GTP cyclohydrolase 1

GTP cyclohydrolase I GTP-CH-I

External Links
UniProt P22288
EMBL M58364
PIR A39080
RefSeq NP_077332.1
UniGene Rn.28195
PDB 1IS7
1IS8
1WPL
PDBsum 1IS7
1IS8
1WPL
ProteinModelPortal P22288
SMR P22288
BioGrid 247920
IntAct P22288
STRING 10116.ENSRNOP00000014821
PhosphoSite P22288
PRIDE P22288
Ensembl ENSRNOT00000014821
GeneID 29244
KEGG rno:29244
UCSC RGD:61992
CTD 2643
RGD 61992
eggNOG COG0302
GeneTree ENSGT00390000013481
HOGENOM HOG000221222
HOVERGEN HBG003136
InParanoid P22288
KO K01495
OMA YIPAKDG
OrthoDB EOG77DJ6T
PhylomeDB P22288
BRENDA 3.5.4.16
Reactome REACT_310165
UniPathway UPA00848
EvolutionaryTrace P22288
NextBio 608526
PRO PR:P22288
Proteomes UP000002494
ExpressionAtlas P22288
Genevisible P22288
GO GO:0005737
GO:0031410
GO:0005829
GO:0031965
GO:0005654
GO:0043234
GO:0005509
GO:0050662
GO:0005525
GO:0003934
GO:0030742
GO:0008270
GO:0035998
GO:0051066
GO:0042416
GO:0045776
GO:0050884
GO:0051000
GO:0006461
GO:0051291
GO:0051260
GO:0014916
GO:0034341
GO:0032496
GO:0048265
GO:0034612
GO:0006729
GO:0046654
GO:0042311
HAMAP MF_00223
InterPro IPR001474
IPR018234
IPR020602
PANTHER PTHR11109
Pfam PF01227
TIGRFAMs TIGR00063
PROSITE PS00859
PS00860

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0048265

response to pain

PMID:17057711[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

PMID:9685352[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

PMID:15448133[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

PMID:11818540[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051291

protein heterooligomerization

PMID:9685352[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051291

protein heterooligomerization

PMID:15448133[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051291

protein heterooligomerization

PMID:11818540[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

PMID:9636709[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

PMID:2557335[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051066

dihydrobiopterin metabolic process

PMID:8702680[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051066

dihydrobiopterin metabolic process

PMID:8486153[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051066

dihydrobiopterin metabolic process

PMID:2557335[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050662

coenzyme binding

PMID:15448133[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045776

negative regulation of blood pressure

PMID:12855421[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042311

vasodilation

PMID:12855421[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:8702680[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:15448133[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:11818540[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0031369

translation initiation factor binding

PMID:22479495[10]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:1584560

F

Seeded From UniProt

complete

enables

GO:0030742

GTP-dependent protein binding

PMID:9685352[2]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:621746

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:15448133[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:11818540[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:8702680[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:8486153[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:2557335[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:9636709[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:9636709[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:8702680[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:8486153[8]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:2557335[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:15292175[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:12051753[12]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11375
PANTHER:PTN000121833
RGD:61992
UniProtKB:P30793

F

Seeded From UniProt

complete

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003162
PANTHER:PTN000121833
UniProtKB:P30793
UniProtKB:P50141
WB:WBGene00000298
dictyBase:DDB_G0288481

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11375
FB:FBgn0003162
PANTHER:PTN000121833
UniProtKB:P30793
UniProtKB:P50141
dictyBase:DDB_G0288481

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11375
PANTHER:PTN000121833
RGD:61992
UniProtKB:P30793

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

PMID:21873635[13]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG11375
FB:FBgn0003162
MGI:MGI:95675
PANTHER:PTN000121833
RGD:61992
SGD:S000003499
UniProtKB:P30793
UniProtKB:Q8I5H7
UniProtKB:Q8VYU3
UniProtKB:Q9SFV7
WB:WBGene00000298
dictyBase:DDB_G0288481

F

Seeded From UniProt

complete

involved_in

GO:2000121

regulation of removal of superoxide radicals

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

enables

GO:0051019

mitogen-activated protein kinase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

F

Seeded From UniProt

complete

involved_in

GO:0051000

positive regulation of nitric-oxide synthase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

involved_in

GO:0050884

neuromuscular process controlling posture

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

F

Seeded From UniProt

complete

involved_in

GO:0042559

pteridine-containing compound biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

involved_in

GO:0042416

dopamine biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

involved_in

GO:0034612

response to tumor necrosis factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

involved_in

GO:0034341

response to interferon-gamma

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

F

Seeded From UniProt

complete

involved_in

GO:0008217

regulation of blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

F

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P30793
ensembl:ENSP00000419045

F

Seeded From UniProt

complete

involved_in

GO:0014916

regulation of lung blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05915
ensembl:ENSMUSP00000087405

P

Seeded From UniProt

complete

involved_in

GO:0010460

positive regulation of heart rate

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05915
ensembl:ENSMUSP00000087405

P

Seeded From UniProt

complete

involved_in

GO:0008217

regulation of blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05915
ensembl:ENSMUSP00000087405

P

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q05915
ensembl:ENSMUSP00000087405

F

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024R642
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024R642
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A024R642
ensembl:ENSP00000419045

C

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001474
InterPro:IPR018234

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001474
InterPro:IPR018234

C

Seeded From UniProt

complete

involved_in

GO:0046654

tetrahydrofolate biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001474
InterPro:IPR018234

P

Seeded From UniProt

complete

enables

GO:0003934

GTP cyclohydrolase I activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.5.4.16

F

Seeded From UniProt

complete

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

PMID:12051753[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006729

tetrahydrobiopterin biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0783

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

involved_in

GO:0035998

7,8-dihydroneopterin 3'-triphosphate biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00848

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Tegeder, I et al. (2006) GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat. Med. 12 1269-77 PubMed GONUTS page
  2. 2.0 2.1 2.2 Yoneyama, T & Hatakeyama, K (1998) Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP. J. Biol. Chem. 273 20102-8 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Maita, N et al. (2004) Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein. J. Biol. Chem. 279 51534-40 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Maita, N et al. (2002) Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP. Proc. Natl. Acad. Sci. U.S.A. 99 1212-7 PubMed GONUTS page
  5. 5.0 5.1 5.2 Steinmetz, MO et al. (1998) Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites. J. Mol. Biol. 279 189-99 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Hatakeyama, K et al. (1989) Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme. J. Biol. Chem. 264 21660-4 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Milstien, S et al. (1996) Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP. J. Biol. Chem. 271 19743-51 PubMed GONUTS page
  8. 8.0 8.1 8.2 Werner-Felmayer, G et al. (1993) Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat. FEBS Lett. 322 223-6 PubMed GONUTS page
  9. 9.0 9.1 Mitchell, BM et al. (2003) GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats. Am. J. Physiol. Heart Circ. Physiol. 285 H2165-70 PubMed GONUTS page
  10. Du, J et al. (2012) The protein partners of GTP cyclohydrolase I in rat organs. PLoS ONE 7 e33991 PubMed GONUTS page
  11. Kolinsky, MA & Gross, SS (2004) The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein. J. Biol. Chem. 279 40677-82 PubMed GONUTS page
  12. 12.0 12.1 Suzuki, T et al. (2002) Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells. Biochem. Biophys. Res. Commun. 293 962-8 PubMed GONUTS page
  13. 13.0 13.1 13.2 13.3 13.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page