GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:8486153
| Citation |
Werner-Felmayer, G, Prast, H, Werner, ER, Philippu, A and Wachter, H (1993) Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat. FEBS Lett. 322:223-6 |
|---|---|
| Abstract |
A 2- to 3-fold increase of GTP cyclohydrolase I (E.C. 3.5.4.16), the key enzyme of tetrahydrobiopterin biosynthesis from GTP, was observed in cerebellum, remaining brain, liver, spleen, and adrenal gland of rats treated with a single dose of lipopolysaccharide (LPS). This led to increased biopterin levels in tissues but not in plasma. Parallel induction of nitric oxide (NO) synthase was indicated by a 10- to 100-fold increase of plasma nitrate levels 6 and 12 hours after injection of LPS. Furthermore, systolic blood pressure was reduced significantly by 23%. Our results demonstrate induction of tetrahydrobiopterin biosynthesis after LPS treatment in vivo. |
| Links | |
| Keywords |
Animals; Biopterin/analogs & derivatives; Biopterin/metabolism; Blood Pressure; Enzyme Induction; GTP Cyclohydrolase/biosynthesis; Lipopolysaccharides/pharmacology; Male; Nitrates/blood; Organ Specificity; Rats; Rats, Sprague-Dawley |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
